Negative visuospatial priming in isolation-reared rats: Evidence of resistance to the disruptive effects of amphetamine

Amitai, Powell, Weber, Swerdlow, Young · Cognitive, affective & behavioral neuroscience · 2015 · neuroscience · 10.3758/s13415-015-0369-0 · record Amitai2015-negative-visuospatial-priming-in-isolation-r
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Claim type is 'null-result' because the paper's own framing is the failure of its stated hypothesis (isolation rearing was expected to impair priming and did not); the positive amphetamine-resistance finding rides on that null. Replication status refers to this paper's own new claims, which nothing in the text reports as retested — the 'replicates' relation points the other way, at the 2013 paper. Prior work here is cited author-year, so relation targets are properly named, unlike in the Science and PNAS entries in this batch. 2026-08-19 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.
Other fields define these differently the same word, defined another way in another discipline
statistical-significance 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 4 concept tags on this paper, all 4 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
negative visuospatial priming inhibitory information processing isolation rearing amphetamine Isolation rearing lowers dopamine responsivity in the prefrontal cortex, so amphetamine no longer pushes PFC dopamine past the level that disrupts negative priming Negative priming depends on an optimal (inverted-U) level of prefrontal dopamine transmission, which amphetamine shifts away from optimum Rats inhibit responding at the distractor location during the prime, and must overcome that inhibition when the target later appears there, which lowers accuracy on negative trials Blunted prefrontal serotonin release after amphetamine in isolates removes the drug-driven rise in premature responding negative priming accuracy priming value negative trials baseline trials drug treatment trial type prime stimulus duration premature responses ISI responses ANOVA mixed-factor two-way analyses of variance (ANOVA) chi-squared t-test one-sample t-tests two-tailed t-tests Bonferroni correction for multiple comparisons Bonferroni-corrected post hoc analyses statistical-significance behavioural-experiment

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.3758/s13415-015-0369-0. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 3 · claim_relations 2 · claim_type 1 · concept_edges 1 · concepts 4 · content_tags 29 · controls 2 · limitations 4 · mechanisms 4 · method 1 · phenomenon 1 · senses 4

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 1 relation here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
claim_typenull-result
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claim_typethe paper's words
phenomenonnegative visuospatial priming
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phenomenonthe paper's words
methodbehavioural-experiment
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsmechanisms
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mechanisms[3]the tagger's words
limitationsOnly one amphetamine dose was tested, so hypo- versus hypersensitivity in isolates cannot be decided.
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limitations[0]the tagger's words
limitationsBecause many more isolates failed to reach criterion and were excluded, a priming deficit in the excluded animals could have been missed.
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limitations[1]the tagger's words
limitationsThe task may have a ceiling that hides group differences or drug-induced increases in priming.
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limitations[2]the tagger's words
limitationsThe proposed prefrontal monoaminergic explanation is not measured in this study.
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limitations[3]the tagger's words
controlstarget and non-target locations varied pseudorandomly so each location held the stimuli an equal number of times per session while remaining unpredictable trial to trial
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eliminates: a location bias and an anticipation strategy at once - equal frequency removes the first, unpredictability removes the second, and the paper states both · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
controlsbaseline and negative trials alternated pseudorandomly, each type equally often per session and not predictable in advance
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eliminates: the animal preparing for the trial type it expects next, which would make the priming effect a preparation effect · outcome (stated by the tagger, no quotation): held
controls[1]0.85the tagger's words
conceptsnegative visuospatial priming
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concepts[0]0.95the paper's words
conceptsinhibitory information processing
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concepts[1]0.95the paper's words
conceptsisolation rearing
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concepts[2]0.95the paper's words
conceptsamphetamine
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also in: amphetamine
concepts[3]0.95the paper's words
sensesA NULL AGAINST THE AUTHORS' OWN HYPOTHESIS, WITH A POSITIVE CONTROL IN THE SAME ANIMALS: `In contrast with our hypothesis, however, Quotation withheld in rats, despite inducing PPI deficits consistent with various developmental and psychiatric disorders.` The manipulation demonstrably worked - prepulse inhibition was disrupted - and the measure demonstrably did not move. A null with an internal manipulation check is a different object from a null on its own, and this corpus should be able to tell them apart
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senses[0]0.95the tagger's words
sensesTHE SELECTION PROBLEM STATED IN THE SENTENCE THAT REPORTS THE RESULT: `Quotation withheld` The comparison runs on survivors - the isolates who got far enough to be measured - so the null holds on a sample the manipulation has already filtered. The authors put that in the abstract rather than leaving it to a reader, which is the shape this corpus wants from a limitation
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senses[1]0.95the tagger's words
sensesPRIMING AS AN INSTRUMENT, DECLARED IN THE FIRST SENTENCE: negative visuospatial priming `represents a quantifiable measure of inhibitory information processing that is disrupted in several neurodevelopmental and psychiatric disorders, including schizophrenia`. The clinical claim attaches to the PROCESS, not to the priming effect - priming is the dial, inhibition is the quantity, and the disorder is a property of the quantity. Second Amitai record where priming is a measuring device rather than a phenomenon
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senses[2]0.95the tagger's words
sensesTHE TITLE'S FINDING, AND IT IS A NULL INSIDE A NULL: `Quotation withheld` The drug disrupts negative priming in socially reared animals and does not in isolates - so the rearing that failed to disrupt the measure directly nonetheless changed how the measure responds to a drug. The discussion offers reduced prefrontal dopamine responsivity as the reason, hedged twice: `suggest that` and `might account for`
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senses[3]0.85the tagger's words
alternativesclaim_type: mechanism
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a second reading DIFFERING from the recorded value. Recorded: null-result — note: A BLIND second reading by the project on 2026-08-25: the record's own claim type/method/phenomenon were not looked at until every value here was written and substring-verified. Not applied - a person decides. Sampling frame: the 504 staged records carrying no alternatives block, so this never re-measures the 202. All 11 records with 130+ tags were taken as a census and 19 more spread one per discipline across 22 disciplines - the dense non-neuroscience cell is the one the 202 do not contain (inside them, 94-100% of the densest bands are neuroscience; among these 11, one is).,
alternatives.claim_type0.7the tagger's words
alternativesmethod: behavioural-experiment
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a second reading reaching the same value. Recorded: behavioural-experiment — note: A BLIND second reading by the project on 2026-08-25: the record's own claim type/method/phenomenon were not looked at until every value here was written and substring-verified. Not applied - a person decides. Sampling frame: the 504 staged records carrying no alternatives block, so this never re-measures the 202. All 11 records with 130+ tags were taken as a census and 19 more spread one per discipline across 22 disciplines - the dense non-neuroscience cell is the one the 202 do not contain (inside them, 94-100% of the densest bands are neuroscience; among these 11, one is).,
alternatives.method0.8the tagger's words
alternativesphenomenon: negative visuospatial priming as a measure of inhibitory information processing, and its resistance to amphetamine in isolation-reared rats
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
a second reading DIFFERING from the recorded value. Recorded: negative visuospatial priming — note: A BLIND second reading by the project on 2026-08-25: the record's own claim type/method/phenomenon were not looked at until every value here was written and substring-verified. Not applied - a person decides. Sampling frame: the 504 staged records carrying no alternatives block, so this never re-measures the 202. All 11 records with 130+ tags were taken as a census and 19 more spread one per discipline across 22 disciplines - the dense non-neuroscience cell is the one the 202 do not contain (inside them, 94-100% of the densest bands are neuroscience; among these 11, one is).,
alternatives.phenomenon0.85the tagger's words
claim_relationsreplicates → Amitai et al., 2013 (the rat negative-priming task and its disruption by amphetamine)
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claim_relations[0]the tagger's words
claim_relationsbuilds-on → Amitai et al., 2013
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claim_relations[1]the tagger's words
concept_edgesisolation rearing —causes→ negative visuospatial priming
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direction on the measure: no-change · strength of the relation: 0.9 · note: A NULL RECORDED AS A DIRECTION, and this one is safe to record that way - unlike Takarada2018, the authors state the null as their finding and contrast it with their own hypothesis rather than hedging it later. The 'despite inducing PPI deficits' clause is inside the quote because without it the null is uninterpretable.
concept_edges[1]0.95the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[0]the tagger's words
content_tagschi-squared
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also in: chi-squared
content_tags.statistics[1]the tagger's words
content_tagst-test
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also in: t-test
content_tags.statistics[2]the tagger's words
content_tagst-test
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also in: t-test
content_tags.statistics[3]the tagger's words
content_tagsBonferroni correction for multiple comparisons
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content_tags.statistics[4]the tagger's words
content_tagsstatistical-significance
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content_tags.statistics[5]the tagger's words
content_tagsFewer isolation-reared rats learned the task, but those that did showed negative priming no different from socially reared rats.
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content_tags.findings[0]the tagger's words
content_tagsD-amphetamine impaired negative priming and raised motor impulsivity in socially reared rats.
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content_tags.findings[1]the tagger's words
content_tagsD-amphetamine left negative priming and motor impulsivity unaffected in isolation-reared rats.
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content_tags.findings[2]the tagger's words
content_tagsSignificantly fewer isolation-reared than socially reared rats reached criterion performance in Experiment 1, showing a learning deficit for this complex task.
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content_tags.findings[3]the tagger's words
content_tagsAmphetamine abolished negative priming by selectively lowering accuracy on baseline trials rather than by changing accuracy on negative trials.
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content_tags.findings[4]the tagger's words
content_tagsBecause the same isolates showed prepulse-inhibition deficits but intact negative priming, the two inhibitory-processing measures are dissociable.
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content_tags.findings[5]the tagger's words
content_tagsnegative priming
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content_tags.definitions[0]the tagger's words
content_tagsinhibitory information processing
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content_tags.definitions[1]the tagger's words
content_tagsaccuracy priming value
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content_tags.definitions[2]the tagger's words
content_tagsnegative trials
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content_tags.definitions[3]the tagger's words
content_tagsbaseline trials
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content_tags.definitions[4]the tagger's words
content_tagsdrug treatment
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content_tags.variables[1]the tagger's words
content_tagstrial type
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also in: trial type
content_tags.variables[2]the tagger's words
content_tagsprime stimulus duration
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content_tags.variables[3]the tagger's words
content_tagsaccuracy priming value
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content_tags.variables[4]the tagger's words
content_tagspremature responses
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content_tags.variables[5]the tagger's words
content_tagsISI responses
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also in: ISI responses
content_tags.variables[6]the tagger's words
content_tagsn = 23 socials and n = 14 isolates — Final animal numbers analysed in Experiment 1 after exclusions
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content_tags.quantities[0]the tagger's words
content_tagsn = 19 socials and n = 18 isolates — Final animal numbers analysed in the amphetamine experiment
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content_tags.quantities[1]the tagger's words
content_tags0.25 mg/kg — Subcutaneous D-amphetamine dose used in the drug challenge
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content_tags.quantities[2]the tagger's words
content_tagsFifty-five — Total number of male Long-Evans rats weaned into the study
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content_tags.quantities[3]the tagger's words
content_tags33.3 % — Chance accuracy level in the three-aperture task, which drugged animals still exceeded
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content_tags.quantities[4]the tagger's words
content_tagsF (1, 35) = 24.4, p < 0.001 — Main effect of amphetamine on the number of premature responses
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content_tags.quantities[5]the tagger's words

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