Changes in human brain dynamics during behavioral priming and repetition suppression

Changes in human brain dynamics during behavioral priming and repetition suppression Korzeniewska Wang Benz Fifer Collard Milsap Cervenka Martin

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Changes in human brain dynamics during behavioral priming and repetition suppression 2020 Progress in Neurobiology 10.1016/j.pneurobio.2020.101788 Korzeniewska2020-changes-in-human-brain-dynamics-during-behav Korzeniewska2020-changes-in-human-brain-dynamics-during-behav.txt, the project's staged copy eb6250edb4580a4fecae086495a7d1656cc7dee0 not-redistributable neuroscience

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0 spans located by searching the stored text for the quote's exact words, allowing any whitespace between them mechanism Quotation withheld because this record is not cleared for redistribution. behavioural priming and repetition suppression Quotation withheld because this record is not cleared for redistribution. electrophysiology electrophysiology Quotation withheld because this record is not cleared for redistribution. mechanisms With repetition the cortex's generative model predicts the stimulus better, so top-down predictive input grows stronger and the prediction-error cells it suppresses fire less, which is what is measured as repetition suppression Quotation withheld because this record is not cleared for redistribution. mechanisms Strengthened top-down propagation from left prefrontal cortex drives down activation in ventral occipito-temporal cortex and elsewhere, producing repetition suppression Quotation withheld because this record is not cleared for redistribution. mechanisms At sensorimotor and superior-temporal sites the apparent temporal shift is not a change in perception but a consequence of the shorter speaking latency: the activity is locked to the response, so aligning to response onset abolishes the shift Quotation withheld because this record is not cleared for redistribution. Repetition enhancement was significant only at individual sites; group analyses failed to reach significance in any region of interest, possibly through timing variability and uneven sampling. Quotation withheld because this record is not cleared for redistribution. Only very short (few-second) repetition delays were examined, while the models at stake concern much longer delays. Quotation withheld because this record is not cleared for redistribution. High gamma responses cannot adjudicate models that posit changes in single-neuron tuning, such as the sharpening model. Quotation withheld because this record is not cleared for redistribution. Electrode placement was clinically, not experimentally, determined, constraining which sites could show each repetition effect. Quotation withheld because this record is not cleared for redistribution. Electrode placement was clinically determined, so the sites at which each repetition effect could be detected were constrained by each patient's coverage. Quotation withheld because this record is not cleared for redistribution. Repetition enhancement was significant at individual sites but failed to reach significance in any region-of-interest group analysis. duplicate of: limitations[0] Quotation withheld because this record is not cleared for redistribution. Only short (few-second) repetition delays were tested, whereas the models at issue concern long-lasting representational change. duplicate of: limitations[1] Quotation withheld because this record is not cleared for redistribution. The design and analyses cannot adjudicate the sharpening or synchrony models. Quotation withheld because this record is not cleared for redistribution. The Granger-causality framework for time series is taken over, as event related causality built on multivariate autoregressive models, to estimate the direction and timing of neural propagation between cortical recording sites. Quotation withheld because this record is not cleared for redistribution. The predictive coding account the paper adopts treats the cortex itself as a hierarchical generative Bayesian statistical model, with top-down predictions and bottom-up prediction error. Quotation withheld because this record is not cleared for redistribution. object names matched for word frequency, and the lists of repeated versus novel objects counterbalanced across patients eliminates: that a difference between novel and repeated objects is a difference in word frequency, or a property of which particular objects happened to land in which list · outcome (stated by the tagger, no quotation): held Quotation withheld because this record is not cleared for redistribution. behavioral priming behavioral priming Quotation withheld because this record is not cleared for redistribution. repetition suppression repetition suppression Quotation withheld because this record is not cleared for redistribution. repetition enhancement repetition enhancement Quotation withheld because this record is not cleared for redistribution. electrocorticography electrocorticography Quotation withheld because this record is not cleared for redistribution. predictive coding predictive coding Quotation withheld because this record is not cleared for redistribution. THE SAME PARADOX Gotts2012 REVIEWS, AND THIS IS THE EXPERIMENT IT ASKED FOR. Gotts said the four candidate models were `in need of testing`; this paper says why they had not been tested - `noninvasive techniques for human studies have had insufficient spatial-temporal precision for testing their predictions` - and then supplies the precision with electrocorticography. A review naming a gap and a study filling it, two records in one corpus Quotation withheld because this record is not cleared for redistribution. THREE EFFECTS, NOT TWO. Beside suppression the study finds repetition ENHANCEMENT at some sites and a TEMPORAL SHIFT to earlier responses at others - `repetition suppression (RS) at some sites, and repetition enhancement (RE) in others, the latter often followed by repetition suppression (~600 ms)`. The paradox as usually stated has two terms; measured at this resolution the cortex does three different things, sometimes in sequence at one site Quotation withheld because this record is not cleared for redistribution. AND THE NOVEL EFFECT DOES NOT SURVIVE THE GROUP ANALYSIS, IN THE PAPER'S OWN WORDS: `Quotation withheld` So RE is a per-site observation, reported honestly as one, with the closing verdict that further investigation `is warranted` rather than that the effect is established. The result the abstract calls `interesting` is the one the results section declines to claim at group level Quotation withheld because this record is not cleared for redistribution. WHAT THE ELECTRODES COULD SEE IS A LIMIT ON WHAT WAS FOUND, and the paper says so: `the numbers of sites revealing repetition suppression, repetition enhancement, or temporal shift were limited by the electrode locations unique to each patient`. Coverage is clinical, not experimental - electrodes go where the epilepsy surgery needs them - so absence of an effect at a site is not evidence of its absence in that region. A sampling constraint that no amount of statistics repairs Quotation withheld because this record is not cleared for redistribution. builds-on → Ghuman et al. (2008) MEG study of LPFC-temporal phase locking during priming Quotation withheld because this record is not cleared for redistribution. contradicts → the “facilitation” model of repetition suppression (James et al., 2000; Henson, 2003) Quotation withheld because this record is not cleared for redistribution. extends → Ghuman et al. (2008) MEG study of top-down phase locking in priming Quotation withheld because this record is not cleared for redistribution. contradicts → the "facilitation" model of repetition suppression (James et al., 2000; Henson, 2003) Quotation withheld because this record is not cleared for redistribution. builds-on → the "predictive coding" model of repetition suppression and priming (Henson, 2003; Friston, 2005) Quotation withheld because this record is not cleared for redistribution. replicates → Marinkovic et al. (2003) MEG finding of a shift from repetition enhancement to repetition suppression Quotation withheld because this record is not cleared for redistribution. behavioral priming —contrasted-with→ repetition suppression behavioral priming repetition suppression differs in: THE DIRECTION EACH MOVES ON THE SAME REPETITION - responses get FASTER while neural activity gets WEAKER. The paper calls it a paradox in the sentence that states it, and the whole study exists to resolve it · strength of the relation: 0.95 · note: The same contrast tagged on Gotts2012 forty minutes earlier, from a review; here it is from the experiment that tests it. Two records, one paradox, and the corpus can now hold the review's inventory beside the measurement. Quotation withheld because this record is not cleared for redistribution. predictive coding —causes→ repetition suppression predictive coding repetition suppression direction on the measure: increases · strength of the relation: 0.85 · note: THE EVIDENCE IS A TIMING CLAIM: the top-down propagation PRECEDED the suppression, which is what makes it a candidate cause rather than a correlate. Weighted 0.85 - 'provide support for' is the paper's own strength, and precedence is necessary but not sufficient for the model. Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the results 'PROVIDE SUPPORT FOR' predictive coding; the 'increases' sign is not stated. Quotation withheld because this record is not cleared for redistribution. repetition enhancement —distinct-from→ repetition suppression repetition enhancement repetition suppression differs in: THE SIGN OF THE NEURAL CHANGE AT A SITE - enhancement is more activity with repetition, suppression is less, and the two occur at different electrodes in the same patients, sometimes in sequence at one site with enhancement followed by suppression around 600 ms · strength of the relation: 0.8 · note: Weight 0.8 and NOT higher, because of the group analysis: RE 'did not reach statistical significance for VOTC…'. The distinction is real at individual sites and unestablished at group level, and the sense row carries that. Recording this at 0.95 would assert what the results section declines to claim. Quotation withheld because this record is not cleared for redistribution. paired t-test paired t-test Quotation withheld because this record is not cleared for redistribution. sign test sign test Quotation withheld because this record is not cleared for redistribution. false discovery rate correction for multiple comparisons false discovery rate correction for multiple comparisons Quotation withheld because this record is not cleared for redistribution. one-tailed t-test one-tailed t-test Quotation withheld because this record is not cleared for redistribution. multivariate autoregressive model order selection by Akaike Information Criterion multivariate autoregressive model order selection by Akaike Information Criterion Quotation withheld because this record is not cleared for redistribution. confidence interval confidence interval Quotation withheld because this record is not cleared for redistribution. multitaper spectral estimation multitaper spectral estimation Quotation withheld because this record is not cleared for redistribution. penalized spline regression penalized spline regression Quotation withheld because this record is not cleared for redistribution. standard deviation and median absolute deviation standard deviation and median absolute deviation Quotation withheld because this record is not cleared for redistribution. Behavioral priming was accompanied by suppressed high gamma activity in ventral occipito-temporal cortex, left prefrontal cortex and other activated sites, plus a shift of activity to earlier time points in sensorimotor regions that mediate speaking. Quotation withheld because this record is not cleared for redistribution. Repetition also increased activation at 30 sites in lateral frontal, parietal and temporal cortex, but never in ventral occipito-temporal cortex, so repetition enhancement and suppression occupy different territory. Quotation withheld because this record is not cleared for redistribution. Repeated stimuli produced a statistically significant increase in high gamma propagation from left prefrontal cortex into ventral occipito-temporal cortex beginning about 100 ms after stimulus onset. Quotation withheld because this record is not cleared for redistribution. The repetition-related rise in top-down propagation became significant numerically earlier than repetition suppression in VOTC. Quotation withheld because this record is not cleared for redistribution. Within individual patients, novel stimuli drove propagation mainly bottom-up, from VOTC to LPFC. Quotation withheld because this record is not cleared for redistribution. Repeated trials showed no consistent shift of VOTC activation to earlier latencies, as the facilitation model predicted. Quotation withheld because this record is not cleared for redistribution. Repetition suppression emerged in ventral occipito-temporal cortex at about 140 ms but only reached significance in left prefrontal cortex at about 280 ms. Quotation withheld because this record is not cleared for redistribution. Repetition enhancement, although present at individual electrodes, did not survive group-level statistics in any region of interest. Quotation withheld because this record is not cleared for redistribution. repetition suppression repetition suppression Quotation withheld because this record is not cleared for redistribution. behavioral priming behavioral priming Quotation withheld because this record is not cleared for redistribution. event related causality (ERC) event related causality (ERC) Quotation withheld because this record is not cleared for redistribution. predictive coding predictive coding Quotation withheld because this record is not cleared for redistribution. facilitation model facilitation model Quotation withheld because this record is not cleared for redistribution. synchrony model synchrony model Quotation withheld because this record is not cleared for redistribution. response time response time Quotation withheld because this record is not cleared for redistribution. high gamma power high gamma power Quotation withheld because this record is not cleared for redistribution. ERC ERC Quotation withheld because this record is not cleared for redistribution. word frequency word frequency Quotation withheld because this record is not cleared for redistribution. baseline power baseline power Quotation withheld because this record is not cleared for redistribution. t(9) = 6.015, p < 0.001 — Group-level paired t-test confirming faster responses to repeated than to novel pictures across the ten patients Quotation withheld because this record is not cleared for redistribution. 962 — Total number of recording sites sampled across all ten patients Quotation withheld because this record is not cleared for redistribution. 58 sites — Number of recording sites showing repetition suppression Quotation withheld because this record is not cleared for redistribution. 30 sites — Number of recording sites showing repetition enhancement, none of them in VOTC Quotation withheld because this record is not cleared for redistribution. 10 sites — Number of recording sites showing only a temporal shift in peak activation Quotation withheld because this record is not cleared for redistribution. ~ 280 ms vs ~ 140 ms — Onset latency of significant repetition suppression in LPFC compared with VOTC Quotation withheld because this record is not cleared for redistribution. 12–21 — Number of electrodes selected per patient for inclusion in the multivariate autoregressive model Quotation withheld because this record is not cleared for redistribution. Ten patients — Sample size: epilepsy surgery patients with subdural ECoG who performed the object-naming task Quotation withheld because this record is not cleared for redistribution.

The full text of this article is not redistributable, so it is not included here. The evidence sentences are withheld with it; the tag layer and its grounding status remain. The article itself is at https://doi.org/10.1016/j.pneurobio.2020.101788.