Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus

Kraus, Canlon · Hearing Research · 2012 · neuroscience · 10.1016/j.heares.2012.02.009 · record Kraus2012-neuronal-connectivity-and-interactions-betwe
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (pdftext); every evidence string verified as an exact substring of that text before merging. Claim relations is empty: the review cites prior work extensively but never explicitly positions its own argument as building on, extending, contradicting or replicating a named study, so per the rules no relation is asserted. The article is a pdftext extraction and contains OCR artefacts where en-dashes became 'e' ('auditoryelimbic' for 'auditory-limbic', 'hypothalamicepituitaryeadrenal'); these are preserved verbatim in the evidence quotes. Replication status 'untested' reflects that the review makes no replication claim about its own synthesis. 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
This record’s own method is review, and the tags below follow from that. A review’s findings, quantities and statistics are things stated IN this paper, and some of them report results obtained elsewhere. 3 tags on this page name the author the result belongs to. Measured across every review in this corpus, 81% of a review’s tags carry no citation at all — most of them are the review speaking. The corpus does not adjudicate the rest: read an unmarked tag as a claim this paper makes, not necessarily one it made first.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 5 concept tags on this paper, all 5 are grounded in a quoted sentence.
stimulus pattern amygdalar activation amygdala-activity auditory cortex memory storage Noise activates the amygdala, which drives the HPA axis to release glucocorticoids, which then act on receptors throughout the body including the inner ear Noise drives neural hyperactivity in the hippocampus, and this hyperactivity (rather than circulating stress hormone) suppresses neurogenesis over the long term Fear conditioning is implemented by long-term potentiation of lateral amygdala pyramidal neurons via NMDA receptors and voltage-gated calcium channels Acute stress protects the ear because released glucocorticoids activate glucocorticoid receptors in inner-ear tissue before the traumatic sound arrives An amygdala-to-auditory feedback loop (via nucleus accumbens and thalamic reticular nucleus) gates the tinnitus signal out before it reaches cortex and awareness acoustic startle response pre-pulse inhibition hippocampal inhibition or gating neurogenesis Pavlovian fear conditioning place cells review

Legend

relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1016/j.heares.2012.02.009. The reading view exists for the papers whose licence permits it.

Every tag on this page

claim_relations 3 · claim_type 1 · concept_edges 1 · concepts 5 · content_tags 18 · limitations 6 · mechanisms 5 · method 1 · phenomenon 1 · senses 3

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 1 relation here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

This record holds no controls. A layer is empty when the tagger recorded nothing in it — which is not the same as the paper having nothing to record.

facettagfieldconf.whose words
claim_typemechanism
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
claim_typethe paper's words
phenomenonauditory-limbic interaction under noise and tinnitus
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
phenomenonthe paper's words
methodreview
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also in: review
methodthe paper's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[0]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[1]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[2]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[3]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[4]the tagger's words
limitationsDirect evidence that the limbic system is essential to tinnitus generation or stabilisation is not established.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
limitations[0]the tagger's words
limitationsResponses to noise vary widely between individuals and depend strongly on the type of noise.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: any general statement about noise effects: RESPONSES TO NOISE MAY HUGELY VARY AMONG INDIVIDUALS AND HEAVILY DEPEND ON THE TYPE OF NOISE
limitations[1]the tagger's words
limitationsWhether amygdalar activity facilitates or inhibits auditory cortex depends on unresolved further factors.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: the direction of the amygdala's effect on auditory cortex: HOW AMYGDALA-ACTIVITY AFFECTS AUDITORY CORTEX ACTIVITY OR PLASTICITY DEPENDS ON FURTHER CIRCUMSTANCES, Quotation withheld
limitations[2]the tagger's words
limitationsThe crucial feature for the response is stated to be the stimulus pattern, not the emotion it produces.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: any emotional interpretation of amygdalar activation reported here: the authors state the findings suggest the stimulus pattern itself, and not the resulting emotion, is the crucial feature
limitations[3]1.0the tagger's words
limitationsThe direction of the amygdala's effect on auditory cortex is unresolved, and the paper names what it turns on.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: any claim that amygdalar activity facilitates or inhibits auditory cortex: the effect is said to depend on further circumstances, namely which amygdalar neurons are activated and which other brain regions are co-activated
limitations[4]1.0the tagger's words
limitationsThe hippocampal claim is split between storage and retrieval by a single-patient observation.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: any claim that memory depends on the hippocampus: the cited case shows memory storage but not memory retrieval to be dependent on hippocampus, since the patient could still remember events from before surgery
limitations[5]1.0the tagger's words
conceptsstimulus pattern
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[0]the paper's words
conceptsamygdalar activation
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[1]the paper's words
conceptsamygdala-activity
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[2]the paper's words
conceptsauditory cortex
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[3]the paper's words
conceptsmemory storage
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[4]the paper's words
sensesamygdalar activation - DRIVEN BY THE STIMULUS PATTERN, NOT THE EMOTION: the review reports that responses to emotionally meaningful sounds occur independently of how emotionally involved the subject is, and concludes the pattern itself is the crucial feature, so an 'emotional response' here names a reaction to an acoustic form
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[0]1.0the tagger's words
sensesthe amygdala's effect on auditory cortex - SIGNED ONLY ONCE THE CIRCUMSTANCES ARE FIXED: whether it facilitates or inhibits depends on which amygdalar neurons fire and which other regions are co-active, so the relation has no direction stated in the abstract and two possible directions in the body
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[1]1.0the tagger's words
senseshippocampal dependence - STORAGE BUT NOT RETRIEVAL: the cited patient could still remember events from before surgery, which splits 'memory depends on the hippocampus' into a claim that holds for one half of the process and fails for the other
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[2]1.0the tagger's words
claim_relationscontradicts → He et al. (2004)
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
differs in: THE SIGN OF THE EFFECT. The review has just reported amygdalar activity FACILITATING auditory cortex, and then: 'On the contrary, rat studies have demonstrated that stimulation of lateral amygdala Quotation withheld via GABA receptors.' Two directions for one connection, and the review does not resolve them - the record already carries that as a sense, marked as signed only once the circumstances are fixed
claim_relations[0]0.9the tagger's words
claim_relationsbuilds-on → Sander et al. (2003)
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
differs in: WHAT THE AMYGDALA IS RESPONDING TO. 'Quotation withheld is the crucial feature for amygdalar activation.' The structure that carries the emotional interpretation of the literature turns out to be driven by an acoustic property, so results reported as emotional responses may be pattern responses under an emotional description
claim_relations[1]0.95the tagger's words
claim_relationsbuilds-on → Mizuno and Giese (2005)
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
differs in: WHICH HALF OF MEMORY THE STRUCTURE IS NEEDED FOR, SPLIT BY ONE PATIENT'S PRESERVED ABILITY: 'In contrast, he remained capable of remembering events from before surgery, showing that Quotation withheld.' A single dissociation does the work of dividing one word into two functions, which is a large claim to rest on what a patient could still do
claim_relations[2]0.9the tagger's words
concept_edgesamygdala-activity —causes→ auditory cortex
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
depends on: which amygdalar neurons are activated, and which other brain regions are co-activated · strength of the relation: 0.6 — the record marks this weak
concept_edges[0]the tagger's words
content_tagsThe review suggests the limbic system may play a role in both generating and suppressing tinnitus, and may be essential for its treatment.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[0]the tagger's words
content_tagsFindings suggest the stimulus pattern itself, not the resulting emotion, is crucial for amygdalar activation.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[1]the tagger's words
content_tagsAlthough stress correlates with hearing problems, many studies show acute stress can enhance hearing or protect against noise-induced hearing loss.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[2]the tagger's words
content_tagsThe effect of stress hormones on hippocampal LTP follows an inverted-U dose relationship, facilitating potentiation at low levels and impairing it at high levels.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[3]the tagger's words
content_tagsThe long-term reduction in neurogenesis after noise cannot be mediated by sustained corticosterone elevation.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[4]the tagger's words
content_tagsHippocampal phase-locking to auditory input is novelty-dependent, appearing for new stimuli and declining with repetition, which suggests a role in novelty detection.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
WHOSE RESULT THIS IS: studies in guinea pig showed - THE SUBJECT OF THIS RESULT IS AN INDEFINITE STUDY, NOT THIS PAPER. 'Previous studies reported', 'studies in guinea pig showed', 'recent studies have reported' - somebody else's work under a common noun rather than a name, with a citation in the sentence and no first-person marker. The quote is verbatim and the claim is true; only the attribution is wrong. FOUND BY MEASURING MY OWN CUE'S RECALL: the first sweep required a NAMED author as the subject ('Sperling (1960) demonstrated') and found 17. Reading eleven citation-bearing findings on 'Plakke2016' by hand showed four the cue could not see - 'A study examining recognition found', 'studies of typical human subjects have demonstrated', 'A follow up study found' - so the named cue's 17 was a floor and not a count. A CUE'S FALSE POSITIVES TELL YOU NOTHING ABOUT ITS FALSE NEGATIVES, and the only way to find these was to read a record's whole layer.
content_tags.findings[5]the tagger's words
content_tagsStress has opposite effects on the two memory operations: it strengthens encoding of emotionally arousing events while suppressing retrieval and cognition.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[6]the tagger's words
content_tagsacoustic startle response
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[0]the tagger's words
content_tagspre-pulse inhibition
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[1]the tagger's words
content_tagshippocampal inhibition or gating
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[2]the tagger's words
content_tagsneurogenesis
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: neurogenesis
content_tags.definitions[3]the tagger's words
content_tagsPavlovian fear conditioning
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[4]the tagger's words
content_tagsplace cells
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: place cells
content_tags.definitions[5]the tagger's words
content_tags126 dB, 12 kHz narrowband, 2 h — the single acute noise exposure that produced a hippocampal neurogenesis reduction still visible ten weeks later
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
WHOSE RESULT THIS IS: pal neurogenesis as seen 10 weeks after exposure (Kraus et al., 2010). - THE RESULT IS THE CITED WORK'S AND THE CITATION TRAILS THE SENTENCE. A plain noun phrase is the subject of the result verb and the attribution is a bracket at the end - 'Neurons within the dorsal temporal pole demonstrated match suppression ... ( Ng et al., 2014 )'. Neither of my two cues could see this shape, so THESE WERE READ RATHER THAN SWEPT: 36 candidates of the shape, 20 read, 11 marked, 9 refused. THE REFUSALS ARE WHY IT IS NOT A CUE: 'Aru2012 findings[16]' is the paper's OWN result with a citation supporting the localisation, 'Natan2015 findings[3]' ends 'consistent with previous findings ( Szymanski et al., 2009 )' where the main clause is the paper's, and 'Drieu2019' x3 are 'One cannot entirely rule out...' - a limitation, not an attribution. About 55% precise, which is a list to read and not a sweep to run. NOTE: the cited paper shares this record's first author - a self-citation to earlier work, which is still not THIS paper's result.
content_tags.quantities[0]the tagger's words
content_tags30 days / 40 days — recovery time of hippocampal monoamine levels and memory after 80 dB versus 100 dB chronic noise, showing recovery scales with exposure intensity
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[1]the tagger's words
content_tags2.1 kHz — the fundamental frequency of rat pain calls to which lateral amygdala neurons phase-lock
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[2]the tagger's words
content_tags80 dB, 2 h, 6 weeks — the moderate noise dose sufficient to impair learning and memory and cause oxidative damage
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[3]the tagger's words
content_tags122 dB — the noise level after which sympathectomy reduced permanent threshold shift in guinea pigs
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
WHOSE RESULT THIS IS: fter 122 dB noise exposure in guinea pigs (Hildesheimer et al., 2002). - THE RESULT IS THE CITED WORK'S AND THE CITATION TRAILS THE SENTENCE. A plain noun phrase is the subject of the result verb and the attribution is a bracket at the end - 'Neurons within the dorsal temporal pole demonstrated match suppression ... ( Ng et al., 2014 )'. Neither of my two cues could see this shape, so THESE WERE READ RATHER THAN SWEPT: 36 candidates of the shape, 20 read, 11 marked, 9 refused. THE REFUSALS ARE WHY IT IS NOT A CUE: 'Aru2012 findings[16]' is the paper's OWN result with a citation supporting the localisation, 'Natan2015 findings[3]' ends 'consistent with previous findings ( Szymanski et al., 2009 )' where the main clause is the paper's, and 'Drieu2019' x3 are 'One cannot entirely rule out...' - a limitation, not an attribution. About 55% precise, which is a list to read and not a sweep to run.
content_tags.quantities[4]the tagger's words

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