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        <title>Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus</title>
        <author>Kraus</author>
        <author>Canlon</author>
      </titleStmt>
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        <p>Tag layer of the DHSS Meta-Tagging Project. The article text is reproduced from the
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        <bibl>
          <title>Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus</title>
          <date>2012</date>
          <publisher>Hearing Research</publisher>
          <idno type="DOI">10.1016/j.heares.2012.02.009</idno>
          
          <idno type="record">Kraus2012-neuronal-connectivity-and-interactions-betwe</idno>
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          <note type="rights">not-redistributable</note>
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        <label>mechanism</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t1" type="phenomenon" ana="#phenomenon" resp="#paper">
        <label>auditory-limbic interaction under noise and tinnitus</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t2" type="method" ana="#method" resp="#paper">
        <label>review</label>
        <term>review</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t3" type="mechanisms" ana="#mechanisms[0]" resp="#tagger">
        <label>mechanisms</label>
        <term>Noise activates the amygdala, which drives the HPA axis to release glucocorticoids, which then act on receptors throughout the body including the inner ear</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t4" type="mechanisms" ana="#mechanisms[1]" resp="#tagger">
        <label>mechanisms</label>
        <term>Noise drives neural hyperactivity in the hippocampus, and this hyperactivity (rather than circulating stress hormone) suppresses neurogenesis over the long term</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t5" type="mechanisms" ana="#mechanisms[2]" resp="#tagger">
        <label>mechanisms</label>
        <term>Fear conditioning is implemented by long-term potentiation of lateral amygdala pyramidal neurons via NMDA receptors and voltage-gated calcium channels</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t6" type="mechanisms" ana="#mechanisms[3]" resp="#tagger">
        <label>mechanisms</label>
        <term>Acute stress protects the ear because released glucocorticoids activate glucocorticoid receptors in inner-ear tissue before the traumatic sound arrives</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t7" type="mechanisms" ana="#mechanisms[4]" resp="#tagger">
        <label>mechanisms</label>
        <term>An amygdala-to-auditory feedback loop (via nucleus accumbens and thalamic reticular nucleus) gates the tinnitus signal out before it reaches cortex and awareness</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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        <label>Direct evidence that the limbic system is essential to tinnitus generation or stabilisation is not established.</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t9" type="limitations" ana="#limitations[1]" resp="#tagger">
        <label>Responses to noise vary widely between individuals and depend strongly on the type of noise.</label>
        <note>what this limits: any general statement about noise effects: RESPONSES TO NOISE MAY HUGELY VARY AMONG INDIVIDUALS AND HEAVILY DEPEND ON THE TYPE OF NOISE</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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        <label>Whether amygdalar activity facilitates or inhibits auditory cortex depends on unresolved further factors.</label>
        <note>what this limits: the direction of the amygdala&#x27;s effect on auditory cortex: HOW AMYGDALA-ACTIVITY AFFECTS AUDITORY CORTEX ACTIVITY OR PLASTICITY DEPENDS ON FURTHER CIRCUMSTANCES, Quotation withheld</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t11" type="limitations" ana="#limitations[3]" resp="#tagger" cert="1.0">
        <label>The crucial feature for the response is stated to be the stimulus pattern, not the emotion it produces.</label>
        <note>what this limits: any emotional interpretation of amygdalar activation reported here: the authors state the findings suggest the stimulus pattern itself, and not the resulting emotion, is the crucial feature</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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        <label>The direction of the amygdala&#x27;s effect on auditory cortex is unresolved, and the paper names what it turns on.</label>
        <note>what this limits: any claim that amygdalar activity facilitates or inhibits auditory cortex: the effect is said to depend on further circumstances, namely which amygdalar neurons are activated and which other brain regions are co-activated</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t13" type="limitations" ana="#limitations[5]" resp="#tagger" cert="1.0">
        <label>The hippocampal claim is split between storage and retrieval by a single-patient observation.</label>
        <note>what this limits: any claim that memory depends on the hippocampus: the cited case shows memory storage but not memory retrieval to be dependent on hippocampus, since the patient could still remember events from before surgery</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t14" type="concepts" ana="#concepts[0]" resp="#paper">
        <label>stimulus pattern</label>
        <term>stimulus pattern</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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        <label>amygdalar activation</label>
        <term>amygdalar activation</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t16" type="concepts" ana="#concepts[2]" resp="#paper">
        <label>amygdala-activity</label>
        <term>amygdala-activity</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t17" type="concepts" ana="#concepts[3]" resp="#paper">
        <label>auditory cortex</label>
        <term>auditory cortex</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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        <label>memory storage</label>
        <term>memory storage</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t19" type="senses" ana="#senses[0]" resp="#tagger" cert="1.0">
        <label>amygdalar activation - DRIVEN BY THE STIMULUS PATTERN, NOT THE EMOTION: the review reports that responses to emotionally meaningful sounds occur independently of how emotionally involved the subject is, and concludes the pattern itself is the crucial feature, so an &#x27;emotional response&#x27; here names a reaction to an acoustic form</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t20" type="senses" ana="#senses[1]" resp="#tagger" cert="1.0">
        <label>the amygdala&#x27;s effect on auditory cortex - SIGNED ONLY ONCE THE CIRCUMSTANCES ARE FIXED: whether it facilitates or inhibits depends on which amygdalar neurons fire and which other regions are co-active, so the relation has no direction stated in the abstract and two possible directions in the body</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t21" type="senses" ana="#senses[2]" resp="#tagger" cert="1.0">
        <label>hippocampal dependence - STORAGE BUT NOT RETRIEVAL: the cited patient could still remember events from before surgery, which splits &#x27;memory depends on the hippocampus&#x27; into a claim that holds for one half of the process and fails for the other</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t22" type="claim_relations" ana="#claim_relations[0]" resp="#tagger" cert="0.9">
        <label>contradicts → He et al. (2004)</label>
        <note>differs in: THE SIGN OF THE EFFECT. The review has just reported amygdalar activity FACILITATING auditory cortex, and then: &#x27;On the contrary, rat studies have demonstrated that stimulation of lateral amygdala Quotation withheld via GABA receptors.&#x27; Two directions for one connection, and the review does not resolve them - the record already carries that as a sense, marked as signed only once the circumstances are fixed</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t23" type="claim_relations" ana="#claim_relations[1]" resp="#tagger" cert="0.95">
        <label>builds-on → Sander et al. (2003)</label>
        <note>differs in: WHAT THE AMYGDALA IS RESPONDING TO. &#x27;Quotation withheld is the crucial feature for amygdalar activation.&#x27; The structure that carries the emotional interpretation of the literature turns out to be driven by an acoustic property, so results reported as emotional responses may be pattern responses under an emotional description</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t24" type="claim_relations" ana="#claim_relations[2]" resp="#tagger" cert="0.9">
        <label>builds-on → Mizuno and Giese (2005)</label>
        <note>differs in: WHICH HALF OF MEMORY THE STRUCTURE IS NEEDED FOR, SPLIT BY ONE PATIENT&#x27;S PRESERVED ABILITY: &#x27;In contrast, he remained capable of remembering events from before surgery, showing that Quotation withheld.&#x27; A single dissociation does the work of dividing one word into two functions, which is a large claim to rest on what a patient could still do</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t25" type="concept_edges" ana="#concept_edges[0]" resp="#tagger">
        <label>amygdala-activity —causes→ auditory cortex</label>
        <term>amygdala-activity</term>
        <term>auditory cortex</term>
        <note>depends on: which amygdalar neurons are activated, and which other brain regions are co-activated · strength of the relation: 0.6 — the record marks this weak</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t26" type="content_tags" ana="#content_tags.findings[0]" resp="#tagger">
        <label>The review suggests the limbic system may play a role in both generating and suppressing tinnitus, and may be essential for its treatment.</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t27" type="content_tags" ana="#content_tags.findings[1]" resp="#tagger">
        <label>Findings suggest the stimulus pattern itself, not the resulting emotion, is crucial for amygdalar activation.</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t28" type="content_tags" ana="#content_tags.findings[2]" resp="#tagger">
        <label>Although stress correlates with hearing problems, many studies show acute stress can enhance hearing or protect against noise-induced hearing loss.</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t29" type="content_tags" ana="#content_tags.findings[3]" resp="#tagger">
        <label>The effect of stress hormones on hippocampal LTP follows an inverted-U dose relationship, facilitating potentiation at low levels and impairing it at high levels.</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t30" type="content_tags" ana="#content_tags.findings[4]" resp="#tagger">
        <label>The long-term reduction in neurogenesis after noise cannot be mediated by sustained corticosterone elevation.</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t31" type="content_tags" ana="#content_tags.findings[5]" resp="#tagger">
        <label>Hippocampal phase-locking to auditory input is novelty-dependent, appearing for new stimuli and declining with repetition, which suggests a role in novelty detection.</label>
        <note>WHOSE RESULT THIS IS: studies in guinea pig showed - THE SUBJECT OF THIS RESULT IS AN INDEFINITE STUDY, NOT THIS PAPER. &#x27;Previous studies reported&#x27;, &#x27;studies in guinea pig showed&#x27;, &#x27;recent studies have reported&#x27; - somebody else&#x27;s work under a common noun rather than a name, with a citation in the sentence and no first-person marker. The quote is verbatim and the claim is true; only the attribution is wrong. FOUND BY MEASURING MY OWN CUE&#x27;S RECALL: the first sweep required a NAMED author as the subject (&#x27;Sperling (1960) demonstrated&#x27;) and found 17. Reading eleven citation-bearing findings on &#x27;Plakke2016&#x27; by hand showed four the cue could not see - &#x27;A study examining recognition found&#x27;, &#x27;studies of typical human subjects have demonstrated&#x27;, &#x27;A follow up study found&#x27; - so the named cue&#x27;s 17 was a floor and not a count. A CUE&#x27;S FALSE POSITIVES TELL YOU NOTHING ABOUT ITS FALSE NEGATIVES, and the only way to find these was to read a record&#x27;s whole layer.</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <span xml:id="t32" type="content_tags" ana="#content_tags.findings[6]" resp="#tagger">
        <label>Stress has opposite effects on the two memory operations: it strengthens encoding of emotionally arousing events while suppressing retrieval and cognition.</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t33" type="content_tags" ana="#content_tags.definitions[0]" resp="#tagger">
        <label>acoustic startle response</label>
        <term>acoustic startle response</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t34" type="content_tags" ana="#content_tags.definitions[1]" resp="#tagger">
        <label>pre-pulse inhibition</label>
        <term>pre-pulse inhibition</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t35" type="content_tags" ana="#content_tags.definitions[2]" resp="#tagger">
        <label>hippocampal inhibition or gating</label>
        <term>hippocampal inhibition or gating</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t36" type="content_tags" ana="#content_tags.definitions[3]" resp="#tagger">
        <label>neurogenesis</label>
        <term>neurogenesis</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t37" type="content_tags" ana="#content_tags.definitions[4]" resp="#tagger">
        <label>Pavlovian fear conditioning</label>
        <term>Pavlovian fear conditioning</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t38" type="content_tags" ana="#content_tags.definitions[5]" resp="#tagger">
        <label>place cells</label>
        <term>place cells</term>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t39" type="content_tags" ana="#content_tags.quantities[0]" resp="#tagger">
        <label>126 dB, 12 kHz narrowband, 2 h — the single acute noise exposure that produced a hippocampal neurogenesis reduction still visible ten weeks later</label>
        <note>WHOSE RESULT THIS IS: pal neurogenesis as seen 10 weeks after exposure (Kraus et al., 2010). - THE RESULT IS THE CITED WORK&#x27;S AND THE CITATION TRAILS THE SENTENCE. A plain noun phrase is the subject of the result verb and the attribution is a bracket at the end - &#x27;Neurons within the dorsal temporal pole demonstrated match suppression ... ( Ng et al., 2014 )&#x27;. Neither of my two cues could see this shape, so THESE WERE READ RATHER THAN SWEPT: 36 candidates of the shape, 20 read, 11 marked, 9 refused. THE REFUSALS ARE WHY IT IS NOT A CUE: &#x27;Aru2012 findings[16]&#x27; is the paper&#x27;s OWN result with a citation supporting the localisation, &#x27;Natan2015 findings[3]&#x27; ends &#x27;consistent with previous findings ( Szymanski et al., 2009 )&#x27; where the main clause is the paper&#x27;s, and &#x27;Drieu2019&#x27; x3 are &#x27;One cannot entirely rule out...&#x27; - a limitation, not an attribution. About 55% precise, which is a list to read and not a sweep to run. NOTE: the cited paper shares this record&#x27;s first author - a self-citation to earlier work, which is still not THIS paper&#x27;s result.</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t40" type="content_tags" ana="#content_tags.quantities[1]" resp="#tagger">
        <label>30 days / 40 days — recovery time of hippocampal monoamine levels and memory after 80 dB versus 100 dB chronic noise, showing recovery scales with exposure intensity</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t41" type="content_tags" ana="#content_tags.quantities[2]" resp="#tagger">
        <label>2.1 kHz — the fundamental frequency of rat pain calls to which lateral amygdala neurons phase-lock</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t42" type="content_tags" ana="#content_tags.quantities[3]" resp="#tagger">
        <label>80 dB, 2 h, 6 weeks — the moderate noise dose sufficient to impair learning and memory and cause oxidative damage</label>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
      </span>
      <span xml:id="t43" type="content_tags" ana="#content_tags.quantities[4]" resp="#tagger">
        <label>122 dB — the noise level after which sympathectomy reduced permanent threshold shift in guinea pigs</label>
        <note>WHOSE RESULT THIS IS: fter 122 dB noise exposure in guinea pigs (Hildesheimer et al., 2002). - THE RESULT IS THE CITED WORK&#x27;S AND THE CITATION TRAILS THE SENTENCE. A plain noun phrase is the subject of the result verb and the attribution is a bracket at the end - &#x27;Neurons within the dorsal temporal pole demonstrated match suppression ... ( Ng et al., 2014 )&#x27;. Neither of my two cues could see this shape, so THESE WERE READ RATHER THAN SWEPT: 36 candidates of the shape, 20 read, 11 marked, 9 refused. THE REFUSALS ARE WHY IT IS NOT A CUE: &#x27;Aru2012 findings[16]&#x27; is the paper&#x27;s OWN result with a citation supporting the localisation, &#x27;Natan2015 findings[3]&#x27; ends &#x27;consistent with previous findings ( Szymanski et al., 2009 )&#x27; where the main clause is the paper&#x27;s, and &#x27;Drieu2019&#x27; x3 are &#x27;One cannot entirely rule out...&#x27; - a limitation, not an attribution. About 55% precise, which is a list to read and not a sweep to run.</note>
        <note type="quotation-withheld">Quotation withheld because this record is not cleared for redistribution.</note>
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      <p><note type="rights">The full text of this article is not redistributable, so it is
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      grounding status remain. The article itself is at https://doi.org/10.1016/j.heares.2012.02.009.</note></p>
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