Neurofunctional topography of the human hippocampus

Neurofunctional topography of the human hippocampus Robinson Barron Kirby Bottenhorn Hill Murphy Katz Salibi

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Neurofunctional topography of the human hippocampus 2015 Human Brain Mapping 10.1002/hbm.22987 Robinson2015-neurofunctional-topography-of-the-human-hipp Robinson2015-neurofunctional-topography-of-the-human-hipp.txt, the project's staged copy 1cc11e27193c3d60ff61b38c4c31e22fc8df43aa not-redistributable neuroscience

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0 spans located by searching the stored text for the quote's exact words, allowing any whitespace between them how the human hippocampus divides into functionally distinct parts along its long axis, derived from what the published literature reports rather than from one paradigm Quotation withheld because this record is not cleared for redistribution. whether a comprehensive data-driven parcellation of the hippocampus can be recovered from the coactivation structure of the published record Quotation withheld because this record is not cleared for redistribution. a three-cluster parcellation of the left hippocampus with emotional, cognitive and perceptual profiles, and an ambiguous right hippocampus for which both a five-cluster and a two-cluster solution are reported and analysed Quotation withheld because this record is not cleared for redistribution. existence Quotation withheld because this record is not cleared for redistribution. long-axis functional topography of the hippocampus Quotation withheld because this record is not cleared for redistribution. meta-analysis meta-analysis Quotation withheld because this record is not cleared for redistribution. mechanisms each hippocampal segment inherits its functional repertoire from the set of regions it is structurally and functionally wired to, so a segment connected to limbic, prefrontal, temporal and parietal cortex can carry out a correspondingly diverse set of cognitive processes Quotation withheld because this record is not cleared for redistribution. mechanisms the parcellation inherits the composition of its input database, and because BrainMap over-represents cognition-based studies the right hippocampus is left without a clean cluster solution Quotation withheld because this record is not cleared for redistribution. the anterior portion is proposed to handle limbic or hot processing and the posterior spatial navigation and learned associations, a division carried over from rodent dorsal and ventral axes Quotation withheld because this record is not cleared for redistribution. the right hippocampus may be functionally heterogeneous, which is offered as the reason its cluster solution is less stable Quotation withheld because this record is not cleared for redistribution. or the right hippocampus may not be organised by behavioural or stimulus features at all, so that its topography is a gradient rather than a set of parts Quotation withheld because this record is not cleared for redistribution. posterior segments connect to the posterior cingulate, a default mode hub, which is read as support for an internal attention account Quotation withheld because this record is not cleared for redistribution. The right hippocampal parcellation is underdetermined and needs more data to settle between the 5- and 2-cluster solutions. what this limits: the right hippocampal segmentation specifically: THE NEED FOR ADDITIONAL DATA TO FULLY PARSE THE SEGMENTATION OF THE RIGHT HIPPOCAMPUS Quotation withheld because this record is not cleared for redistribution. The right-hemisphere behavioural associations did not survive FDR correction. what this limits: the right-hemisphere behavioural associations only: THESE FUNCTIONS DID NOT SURVIVE FDR CORRECTION, THUS THE RIGHT BEHAVIORAL SUBSTRATES ARE INTERPRETED WITH CAUTION Quotation withheld because this record is not cleared for redistribution. The parcellation inherits the BrainMap database's bias toward cognition-based studies. what this limits: the functional coverage of the parcellation: THE DATA ARE RELIANT ON THE BRAINMAP DATABASE, WHICH HEAVILY FAVORS COGNITION-BASED FUNCTIONAL NEUROIMAGING STUDIES Quotation withheld because this record is not cleared for redistribution. The 7 T sample is small and more subjects would strengthen the connectivity results. what this limits: the connectivity results: ADDITIONAL SUBJECTS MAY HELP TO STRENGTHEN OUR UNDERSTANDING OF THE CONNECTIVITY OF THE TOPOGRAPHICAL SEGMENTS Quotation withheld because this record is not cleared for redistribution. The method forces discrete clusters and cannot represent a gradient organisation. what this limits: any claim that the organisation is discrete: THERE IS A GRADIENT COMPONENT TO PROCESSING WITHIN THE HIPPOCAMPUS THAT OUR CURRENT METHOD CANNOT ACCOUNT FOR Quotation withheld because this record is not cleared for redistribution. segmentation is defined in terms of distinct clusters, and a gradient component is called plausible and likely and beyond what the current method can account for what this limits: the same scope as limitations[4] - the segmentation is DEFINED IN TERMS OF DISTINCT CLUSTERS, and a gradient is called PLAUSIBLE, AND LIKELY Quotation withheld because this record is not cleared for redistribution. the right hippocampal behavioural associations did not survive correction and are explicitly interpreted with caution duplicate of: limitations[1] · what this limits: the same scope as limitations[1] - the right behavioural substrates, uncorrected Quotation withheld because this record is not cleared for redistribution. the database heavily favours cognition studies, which is representative of the field but may itself be why no obvious right hippocampal solution emerged what this limits: the same scope as limitations[2], with the paper's own defence: WHILE THIS IS REPRESENTATIVE OF THE FIELD AS A WHOLE, HAVING A MORE BALANCED database would change what can be found Quotation withheld because this record is not cleared for redistribution. uncovering the right hemisphere's ambiguous results is said to need increasing the number of papers in the BrainMap database, and submillimeter fMRI specifically targeting the hippocampus what this limits: the right hemisphere's ambiguous results, and the subiculum finding in particular: TWO AVENUES OF ADDITIONAL WORK ARE NECESSARY TO UNCOVER THE RIGHT HEMISPHERE'S AMBIGUOUS RESULTS, PARTICULARLY IN LIGHT OF THE SUBFIELD (I.E., SUBICULUM) FINDING Quotation withheld because this record is not cleared for redistribution. which of the two right hippocampal solutions is correct is left open until the database grows what this limits: the choice between the two right-hippocampus solutions: WE PRESENTED BOTH A 5-CLUSTER AND A 2-CLUSTER SOLUTION, AS THE 5-CLUSTER SOLUTION WAS DEEMED TO BE MARGINALLY BETTER Quotation withheld because this record is not cleared for redistribution. the imaging validation rests on 23 resting-state and 31 diffusion participants what this limits: the imaging validation: TWENTY-THREE HEALTHY INDIVIDUALS were scanned for resting state, with a separate diffusion sample Quotation withheld because this record is not cleared for redistribution. activation likelihood estimation against a null of random spatial association, used here to characterise each cluster rather than to test a hypothesis Quotation withheld because this record is not cleared for redistribution. behavioral domain, paradigm class and subject population coded alongside the stereotactic coordinates of every archived study Quotation withheld because this record is not cleared for redistribution. clustering that separates the voxels in the ROI into k clusters by minimizing the variance within clusters and maximizing the variance between clusters Quotation withheld because this record is not cleared for redistribution. the dorsal to ventral axis and its hot and cold processing division, mapped onto the human posterior to anterior axis Quotation withheld because this record is not cleared for redistribution. the resting-state and DTI analyses run twice, with and without the left-handed participants eliminates: handedness driving a lateralised functional or structural result · outcome (stated by the tagger, no quotation): held Quotation withheld because this record is not cleared for redistribution. THE NUMBER OF PARTS IS A CHOICE, AND THE CRITERIA DISAGREE: misclassified voxels favour 2 to 4 on the left and 2, 3 or 5 on the right; minimum-to-mean cluster size favours 2 and 3 for both; intercluster distance favours 3 on the left and 2 or 5 on the right Quotation withheld because this record is not cleared for redistribution. and the reported answer is a combination of them - three parts on the left, five on the right - so how many objects the hippocampus contains is a product of how the criteria were weighed Quotation withheld because this record is not cleared for redistribution. TWO PARCELLATIONS OF THE SAME STRUCTURE ARE CARRIED THROUGH THE WHOLE PAPER: the five-cluster right solution is called marginally better than the two-cluster one, and both get their own connectivity analyses Quotation withheld because this record is not cleared for redistribution. THE METHOD CAN ONLY RETURN PARTS: k-means assigns every voxel to one of k non-overlapping clusters, so a structure organised as a gradient would still come back as clusters Quotation withheld because this record is not cleared for redistribution. and the paper says exactly that - segmentation into distinct clusters is a definitional choice, a gradient is plausible and likely, and the method cannot account for it Quotation withheld because this record is not cleared for redistribution. THE OBJECT IS DEFINED BY A THRESHOLD ON A PROBABILITY MAP: the region of interest is an atlas thresholded at 75 percent, chosen to be conservative and to be easy to describe to other researchers Quotation withheld because this record is not cleared for redistribution. THE SAME TAGS ARE READ IN BOTH DIRECTIONS: forward inference asks whether a label is more likely to activate this cluster than the database at large, reverse inference asks which label is most likely given activation here Quotation withheld because this record is not cleared for redistribution. AND THE CORPUS'S SKEW BECOMES THE ANSWER'S SKEW: the database favours cognition studies, which the paper says is representative of the field, and offers that imbalance as a reason the right hippocampus yielded no clean solution Quotation withheld because this record is not cleared for redistribution. THE FOUNDATIONAL RECORD WAS WRONG: half a century of assumptions rest on one patient whose lesion, when finally imaged, did not match the surgical account of it Quotation withheld because this record is not cleared for redistribution. a result that did not survive correction is reported anyway, labelled, and interpreted with caution rather than dropped Quotation withheld because this record is not cleared for redistribution. claim_type: existence a second reading reaching the same value. Recorded: existence — note: a second reading reaching the same value from a different sentence. Not applied - a person decides. Quotation withheld because this record is not cleared for redistribution. method: coactivation-based parcellation of every voxel in the hippocampal region of interest using the BrainMap database, k-means over the coactivation profiles, then activation likelihood estimation, forward and reverse functional decoding, resting-state connectivity and diffusion tractography a second reading DIFFERING from the recorded value. Recorded: meta-analysis — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides. Quotation withheld because this record is not cleared for redistribution. phenomenon: a functional gradient along the long axis of the hippocampus, with limbic processing anteriorly and perceptual or spatial processing posteriorly a second reading DIFFERING from the recorded value. Recorded: long-axis functional topography of the hippocampus — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides. Quotation withheld because this record is not cleared for redistribution. replicates → Fanselow and Dong (2010); King et al. (2008) Quotation withheld because this record is not cleared for redistribution. extends → Moser and Moser (1998) model and the HERNET model Quotation withheld because this record is not cleared for redistribution. extends → Kim (2015) HERNET model Quotation withheld because this record is not cleared for redistribution. extends → Moser and Moser's dorsal to ventral hippocampal gradient, imported from rodent connectivity and behaviour Quotation withheld because this record is not cleared for redistribution. qualifies → that same model, by finding hot and cold processing along the axis but also cold processing anteriorly on the right Quotation withheld because this record is not cleared for redistribution. qualifies → Kim's hippocampal encoding and retrieval network model, supporting its posterior default mode claim and not its anterior dorsal attention claim Quotation withheld because this record is not cleared for redistribution. critiques → the single-paradigm designs that dominate the field, which cannot say whether other neurocognitive processes use the same subregions differs in: THE AXIS IS THE NUMBER OF TASKS PER STUDY. 'these results support the fundamental argument that the hippocampus maintains a neurofunctional topographical organization, but Quotation withheld [task].' The topography is granted and the specificity is not - and no accumulation of single-task studies can supply it, so the missing result is not a matter of more evidence. Quotation withheld because this record is not cleared for redistribution. critiques → the inferential base of the field itself - non-human data, case studies, and narrowly focused cognitive experiments Quotation withheld because this record is not cleared for redistribution. supports → Chase and colleagues' five-cluster parcellation of the subiculum by nearly identical methodology Quotation withheld because this record is not cleared for redistribution. clusters —distinct-from→ gradient clusters gradient strength of the relation: 1 · note: THE OUTPUT TYPE IS A PROPERTY OF THE METHOD: defining the topography as distinct clusters is called a theoretical choice, and a gradient is called plausible and likely and beyond what the method can represent Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but a gradient component is 'plausible, and likely' beside the clusters; distinct-from is loose. Quotation withheld because this record is not cleared for redistribution. behavioral domain —distinct-from→ paradigm class behavioral domain paradigm class strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the two are listed as separate metadata fields; distinct-from is loose. Quotation withheld because this record is not cleared for redistribution. forward inference —operationalised-as→ taxonomic label forward inference taxonomic label strength of the relation: 1 · note: THE SAME TAG READ IN ONE DIRECTION: is activation more probable for this label inside the cluster than across the whole database Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the forward-inference profile is computed from activation probabilities per taxonomic label; operationalised-as is loose. Quotation withheld because this record is not cleared for redistribution. forward inference —operationalised-as→ binomial test forward inference binomial test strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but a binomial test was USED WITHIN the forward-inference approach to judge significance; operationalised-as is loose. Quotation withheld because this record is not cleared for redistribution. reverse inference —operationalised-as→ behavioral domain reverse inference behavioral domain strength of the relation: 1 · note: AND IN THE OTHER: which label is most likely given activation here - the two questions are not the same and both are reported Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the reverse-inference profile identifies the most likely behavioral domain; operationalised-as is loose. Quotation withheld because this record is not cleared for redistribution. seed masks —distinct-from→ target masks seed masks target masks strength of the relation: 1 · note: each cluster against 110 atlas regions, themselves thresholded at 50 percent - a second layer of cuts underneath the first Quotation withheld because this record is not cleared for redistribution. anterior —contrasted-with→ posterior anterior posterior strength of the relation: 1 · note: the hot and cold division, carried across from the rodent ventral and dorsal poles Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the contrast is what earlier authors 'speculated' about ventral and dorsal portions; attributed and hedged. Quotation withheld because this record is not cleared for redistribution. H.M. —is-a→ case study H.M. case study strength of the relation: 1 · note: THE FOUNDATIONAL RECORD WAS WRONG: imaging in the 1990s revealed discrepancies in the neurosurgical account of the lesion, confirmed after death Quotation withheld because this record is not cleared for redistribution. binomial test binomial test Quotation withheld because this record is not cleared for redistribution. chi-squared chi-squared Quotation withheld because this record is not cleared for redistribution. z-score z-score Quotation withheld because this record is not cleared for redistribution. false discovery rate correction false discovery rate correction Quotation withheld because this record is not cleared for redistribution. k-means clustering k-means clustering Quotation withheld because this record is not cleared for redistribution. permutation / null-distribution test permutation / null-distribution test Quotation withheld because this record is not cleared for redistribution. binomial test binomial test Quotation withheld because this record is not cleared for redistribution. χ 2 χ 2 Quotation withheld because this record is not cleared for redistribution. FDR correction FDR correction Quotation withheld because this record is not cleared for redistribution. activation likelihood estimation activation likelihood estimation Quotation withheld because this record is not cleared for redistribution. z ‐scores z ‐scores Quotation withheld because this record is not cleared for redistribution. The left hippocampus divides into three anterior-to-posterior clusters: an emotional cluster tied to amygdala and parahippocampal gyrus, a cognitive cluster tied to anterior cingulate and inferior frontal gyrus, and a posterior perceptual cluster tied to occipital lobe, precuneus and angular gyrus. Quotation withheld because this record is not cleared for redistribution. The right hippocampus does not yield one clear parcellation: both a 2-cluster and a 5-cluster solution remain plausible. Quotation withheld because this record is not cleared for redistribution. The anterior-most left cluster was behaviourally characterised by face monitoring/discrimination, cued explicit recall and encoding. Quotation withheld because this record is not cleared for redistribution. The middle left cluster was characterised by paired associate recall, cued explicit recognition and encoding. Quotation withheld because this record is not cleared for redistribution. The behavioural labels attached to the right-hippocampal clusters failed FDR correction, so they are reported only with caution. Quotation withheld because this record is not cleared for redistribution. Diffusion tractography showed the posterior left cluster connecting to the occipital lobe, specifically lingual gyrus and occipital pole, alongside parahippocampal, posterior cingulate and amygdala connections. Quotation withheld because this record is not cleared for redistribution. Interhemispheric structural connections increase toward the posterior end of both left and right hippocampus. Quotation withheld because this record is not cleared for redistribution. Left and right hippocampus produce different clustering profiles, which the authors read as evidence of hemispheric lateralization. Quotation withheld because this record is not cleared for redistribution. The data support a hot-to-cold anterior-posterior gradient but depart from it in one respect: anterior right-hemisphere portions are also engaged in "cold" processing. Quotation withheld because this record is not cleared for redistribution. the left hippocampus divided into three segments running anterior to posterior, associated with faces and recall, with paired associate recall and recognition, and with perception Quotation withheld because this record is not cleared for redistribution. the right hippocampus divided into five regions, less well defined behaviourally than the left Quotation withheld because this record is not cleared for redistribution. AND THOSE RIGHT-SIDE LABELS DID NOT SURVIVE CORRECTION, which the paper states and then interprets with caution rather than dropping them Quotation withheld because this record is not cleared for redistribution. an alternative to the 5‐cluster model is a 2‐cluster solution, found to be slightly less favorable, with an anterior and a posterior segment Quotation withheld because this record is not cleared for redistribution. BOTH SOLUTIONS ARE PRESENTED: the 5‐cluster solution was deemed marginally better than the 2‐cluster solution, and which is ideal may become clearer as more data is added to the database Quotation withheld because this record is not cleared for redistribution. THE CRITERIA FOR HOW MANY CLUSTERS DISAGREE WITH EACH OTHER: deviant percentage, minimum-to-mean cluster size and intercluster distance each favour a different set of solutions Quotation withheld because this record is not cleared for redistribution. and the reported answer is their combination - three on the left, five on the right Quotation withheld because this record is not cleared for redistribution. the criteria are stated as rules in advance: the percentage of deviants not significantly increased compared with the k − 1 solution, the minimum cluster size more than half of the average cluster size, and no significantly larger increase in intercluster to intracluster distance Quotation withheld because this record is not cleared for redistribution. clustering separates the voxels in the ROI into k non‐overlapping clusters, minimizing the variance within clusters and maximizing the variance between clusters, with centroids chosen at random for each new iteration Quotation withheld because this record is not cleared for redistribution. k values from 2 to 7 were computed for each region before any selection Quotation withheld because this record is not cleared for redistribution. THE METHOD CANNOT REPRESENT A GRADIENT, and the paper says a gradient is plausible and likely Quotation withheld because this record is not cleared for redistribution. and offers the same ambiguity a second reading - the right hippocampus may simply not be organised by behavioural or stimulus features Quotation withheld because this record is not cleared for redistribution. the region of interest is an atlas thresholded at 75 percent, described as conservative and as easy to communicate Quotation withheld because this record is not cleared for redistribution. with mean membership probability of 86 to 88 percent and centroids above 97 percent Quotation withheld because this record is not cleared for redistribution. the database holds 2,630 papers, 12,623 experiments, 100 paradigm classes and 52,289 subjects Quotation withheld because this record is not cleared for redistribution. and stores each paper as significant coordinates plus coded metadata - behavioral domain, paradigm class and subject population Quotation withheld because this record is not cleared for redistribution. only healthy normal-mapping experiments were used, with no restriction by domain or paradigm, to keep the model unconstrained Quotation withheld because this record is not cleared for redistribution. NO SINGLE VOXEL HAS ENOUGH STUDIES, so each borrows the nearest reported activations by Euclidian distance and its profile is a neighbourhood rather than a measurement Quotation withheld because this record is not cleared for redistribution. the number of nearest experiments was swept from 20 to 200 in steps of 5, and stable ranges chosen by fewest deviant voxels Quotation withheld because this record is not cleared for redistribution. FORWARD INFERENCE asks whether a label is more likely to activate inside the cluster than across the database, tested binomially Quotation withheld because this record is not cleared for redistribution. REVERSE INFERENCE asks which label is most likely given activation in the cluster, tested by chi square Quotation withheld because this record is not cleared for redistribution. cluster profiles were built by activation likelihood estimation against a null of random spatial association, corrected family-wise Quotation withheld because this record is not cleared for redistribution. THE DATABASE'S SKEW IS OFFERED AS AN EXPLANATION OF THE RESULT: it heavily favours cognition studies, which is representative of the field, and may be why no obvious right hippocampal solution emerged Quotation withheld because this record is not cleared for redistribution. and the two avenues named are increasing the number of papers in the BrainMap database, and submillimeter fMRI specifically targeting the hippocampus Quotation withheld because this record is not cleared for redistribution. THE FIELD'S FOUNDATIONAL RECORD WAS WRONG: imaging decades later revealed discrepancies in the surgical account of H.M.'s lesion, confirmed after his death Quotation withheld because this record is not cleared for redistribution. and the field's inferences are said to rest on non-human data, case studies, and single-process experiments Quotation withheld because this record is not cleared for redistribution. prior parcellation work used one paradigm at a time, so it could not say whether other processes use the same subregions Quotation withheld because this record is not cleared for redistribution. left anterior clusters connected structurally to the amygdala, thalamus and parahippocampal gyrus, with brainstem connections in most of the sample Quotation withheld because this record is not cleared for redistribution. the posterior left cluster reached the lingual gyrus and occipital pole and lacked the sub-lobar connections of the others Quotation withheld because this record is not cleared for redistribution. the fourth right cluster had the most diverse connectivity of all, which is used to argue for adding studies rather than for a functional claim Quotation withheld because this record is not cleared for redistribution. interhemispheric connections increased toward the posterior end on both sides Quotation withheld because this record is not cleared for redistribution. tracts were kept only where present in more than 15 percent of the sample with connection probability above 10 percent Quotation withheld because this record is not cleared for redistribution. each cluster was scored against 110 atlas target masks thresholded at 50 percent Quotation withheld because this record is not cleared for redistribution. anatomical labels come from the Talairach Demon applied to the coordinates about this quote: This quote ends with the stray word 'For', the first word of the next sentence. It is not trimmed, because the quote without it occurs more than once in the paper's text and could not be tied to one place. The claim is carried by the sentence before 'For'. Quotation withheld because this record is not cleared for redistribution. twenty-three healthy individuals were scanned with a resting-state EPI sequence optimised for the hippocampus Quotation withheld because this record is not cleared for redistribution. partial concordance with the hot and cold model: the axis holds, but anterior right clusters also carry cold processes Quotation withheld because this record is not cleared for redistribution. posterior clusters connect to the posterior cingulate, supporting the default mode half of the encoding-retrieval model and not its anterior half Quotation withheld because this record is not cleared for redistribution. a companion study parcellating only the subiculum with nearly identical methods also found five clusters Quotation withheld because this record is not cleared for redistribution. very few studies address lateralization in this literature, though most have theorized that the right hippocampus is engaged in spatial processing and the left attuned to verbal information Quotation withheld because this record is not cleared for redistribution. coactivation-based parcellation (CBP) coactivation-based parcellation (CBP) Quotation withheld because this record is not cleared for redistribution. meta-analytic connectivity mapping (MACM) meta-analytic connectivity mapping (MACM) Quotation withheld because this record is not cleared for redistribution. forward inference forward inference Quotation withheld because this record is not cleared for redistribution. reverse inference reverse inference Quotation withheld because this record is not cleared for redistribution. clustering clustering Quotation withheld because this record is not cleared for redistribution. BrainMap BrainMap Quotation withheld because this record is not cleared for redistribution. forward inference forward inference Quotation withheld because this record is not cleared for redistribution. reverse inference reverse inference Quotation withheld because this record is not cleared for redistribution. ALE ALE Quotation withheld because this record is not cleared for redistribution. deviants deviants Quotation withheld because this record is not cleared for redistribution. number of experiments number of experiments Quotation withheld because this record is not cleared for redistribution. percentage of misclassified voxels percentage of misclassified voxels Quotation withheld because this record is not cleared for redistribution. anatomical connectivity anatomical connectivity Quotation withheld because this record is not cleared for redistribution. deviants deviants Quotation withheld because this record is not cleared for redistribution. cluster size cluster size Quotation withheld because this record is not cleared for redistribution. probability probability Quotation withheld because this record is not cleared for redistribution. functional connectivity functional connectivity Quotation withheld because this record is not cleared for redistribution. structural connectivity structural connectivity Quotation withheld because this record is not cleared for redistribution. 2,630 papers, 12,623 experiments, 100 paradigm classes, 52,289 subjects — size of the BrainMap database at the time of the analysis Quotation withheld because this record is not cleared for redistribution. 1,880 mm 3 / 2,072 mm 3 — volumes of the left and right hippocampal regions of interest Quotation withheld because this record is not cleared for redistribution. Twenty-three — number of healthy participants scanned for the 7T resting-state fMRI Quotation withheld because this record is not cleared for redistribution. 31 — number of healthy participants scanned for the diffusion tensor imaging Quotation withheld because this record is not cleared for redistribution. 1,000 iterations — number of K-means restarts used to search for the optimal clustering solution Quotation withheld because this record is not cleared for redistribution. 15% / 10% — tractography thresholds: paths present in more than 15% of the sample and tracts with connection probability above 10% Quotation withheld because this record is not cleared for redistribution. 75% — the atlas probability at which the hippocampal region of interest was cut out, which is what fixes the object's boundary Quotation withheld because this record is not cleared for redistribution. 2,630 papers — the database behind every data point here: 12,623 experiments, 100 paradigm classes and 52,289 subjects Quotation withheld because this record is not cleared for redistribution. 20 through 200 — nearest experiments per voxel, swept in steps of 5, with the stable range chosen by fewest deviant voxels Quotation withheld because this record is not cleared for redistribution. 2 through 7 — the cluster counts computed for each region before any criterion was applied Quotation withheld because this record is not cleared for redistribution. 3, and for the right, 5 — the cluster counts finally reported, arrived at by combining criteria that individually favoured different numbers Quotation withheld because this record is not cleared for redistribution. 15% — the share of the sample in which a tract had to be present to be kept, alongside a 10 percent connection probability Quotation withheld because this record is not cleared for redistribution. 110 total masks — atlas targets, themselves thresholded at 50 percent, that the tractography is sorted into Quotation withheld because this record is not cleared for redistribution.

The full text of this article is not redistributable, so it is not included here. The evidence sentences are withheld with it; the tag layer and its grounding status remain. The article itself is at https://doi.org/10.1002/hbm.22987.