Repetition priming of motor activity mediated by a central pattern generator: the importance of extrinsic vs. intrinsic program initiators

Siniscalchi, Cropper, Jing, Weiss · Journal of Neurophysiology · 2016 · invertebrate-neurophysiology · 10.1152/jn.00365.2016 · record Siniscalchi2016-repetition-priming-of-motor-activity-mediate
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Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. The paper contains a genuine null result nested inside the mechanism claim — repeated B63 stimulation produces no articulation at all ('Repetition priming is not observed when motor programs are triggered by B63, a neuron within the feeding CPG') — but claim type is single-valued and the paper frames that null as the premise for its positive mechanistic account, so I tagged mechanism. The discussion also builds an explanation of asymmetric task-switching costs (negative biasing egestive-to-ingestive, positive biasing ingestive-to-egestive) and connects it to the human task-switching literature; that cross-species extension is a real part of the contribution that no facet field captures. The 'replicates' relation is one the authors state about their own control condition rather than the paper's headline claim. 2026-08-17 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
repetition priming 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 9 concept tags on this paper, all 9 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
repetition priming central pattern generator B63 CBI-2 B40 B20 chemical coding task switching negative biasing Priming requires modulatory peptides released by extrinsic CPG inputs; stimulating a core CPG neuron does not release them, so no priming accumulates FCAP/CP-2 released from CBI-2 raise the excitability of the ingestive interneuron B40, which is then recruited into later programs and imposes an ingestive B8 firing pattern Priming is stored as persistent modulator-induced changes in the pattern-generating interneurons B20 and B40 inside the feeding network rather than presynaptically in the input terminals Carry-over between behaviours occurs only when the interneuron modified by the first behaviour is also part of the circuit recruited by the second, which is why switch costs are asymmetric ingestion egestion protraction chemical coding model exogenous peptide application B8 firing frequency B40 excitability latency to spike initiation interstimulus interval injected current high-divalent cation solution paired t-test paired t -tests ANOVA an appropriate ANOVA repeated-measures ANOVA Bonferroni correction for multiple comparisons t -tests with Bonferroni corrections correlation standard error of the mean means ± SE electrophysiology

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relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it
unrecordable relationunhoused_relationsa relation the paper asserts that this vocabulary cannot express, with the reason

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1152/jn.00365.2016. The reading view exists for the papers whose licence permits it.

Every tag on this page

claim_relations 2 · claim_type 1 · concept_edges 6 · concepts 9 · content_tags 38 · controls 1 · limitations 2 · mechanisms 4 · method 1 · phenomenon 1 · senses 4 · unhoused_relations 1

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 6 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
claim_typemechanism
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claim_typethe paper's words
phenomenonrepetition priming of motor programs
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsmechanisms
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mechanisms[3]the tagger's words
limitationsSomatic recordings used to rule out indirect recruitment of the CPG inputs may not reflect activity at those inputs' terminals.
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limitations[0]the tagger's words
limitationsAn additional contribution from modulation of the motor neuron B8 itself is not excluded.
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limitations[1]the tagger's words
controlssix to ten control measurements taken first, then B40 current injections interleaved with the CBI-2 stimulation trains
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eliminates: drift in the preparation over the course of a long intracellular recording - the baseline is established first and the two conditions then alternate rather than running in sequence · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
conceptsrepetition priming
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concepts[0]0.95the paper's words
conceptscentral pattern generator
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concepts[1]0.95the paper's words
conceptsB63
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also in: B63
concepts[2]0.95the paper's words
conceptsCBI-2
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also in: CBI-2
concepts[3]0.95the paper's words
conceptsB40
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also in: B40
concepts[4]0.95the paper's words
conceptsB20
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also in: B20
concepts[5]0.95the paper's words
conceptschemical coding
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concepts[6]0.95the paper's words
conceptstask switching
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concepts[7]0.95the paper's words
conceptsnegative biasing
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concepts[8]0.95the paper's words
unhoused_relationsrepetition priming as defined here - increased performance as a behaviour is repeated, measured in a dissected Aplysia ganglion, with no reference to memory, awareness or a subject → media priming as defined in Hoewe2020 (in this corpus), which REQUIRES that the person be unable to mentally trace the source of the influence, and is restricted to System 1
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THE SAME WORD AT BOTH ENDS OF ITS POSSIBLE EXTENSION, IN ONE CORPUS. One paper applies 'priming' to a preparation with no subject at all - a buccal ganglion on a dish, where the criterion is that a motor pattern becomes better articulated on repetition. Another makes the ABSENCE OF A SUBJECT'S AWARENESS the defining criterion, and proposes an operational test built entirely on asking the person what they noticed. A definition requiring unawareness and a definition with nobody to be unaware cannot be the same definition, yet neither paper marks the word as belonging to another field. Both are ordinary uses in their own literatures. This is not a disagreement and not an error by either: it is the extension of a term stretched past the point where one definition can cover it, which is the object this project was assembled to document. The schema has no relation type for 'these records use one term at incompatible scopes'; 'renamed-across-fields' is the closest and it is wrong, because the name did not change - only what it can be true of., and for the missing types.
unhoused_relations[0]0.95the tagger's words
sensesrepetition priming, in an invertebrate preparation - INCREASED PERFORMANCE AS A BEHAVIOUR IS REPEATED, and nothing else. No memory, no awareness, no subject. Set beside Hoewe2020, where the same word requires that a person be unable to trace an influence, this is the widest extension of the term in the corpus
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senses[0]0.95the tagger's words
senseshow priming MANIFESTS here - not faster or stronger but better ARTICULATED: the first cycle of a program is neither ingestive nor egestive, and repetition makes it become one. The measured quantity is the definiteness of a pattern, not the size of a response
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senses[1]0.95the tagger's words
senses`prime` in the authors' own scare quotes - used for the derived case, where a program triggered from inside the CPG shows priming only because extrinsic inputs were stimulated first. They mark the word when the thing does not meet their own paradigm case
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senses[2]0.95the tagger's words
sensesthe negative result read carefully - the authors decline the strong reading of their own null: nothing PRECLUDES priming of B63-induced programs, the modulators are simply not released when only B63 is stimulated. An absence of an effect is read as an absence of a cause, not as an impossibility
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senses[3]0.95the tagger's words
claim_relationsbuilds-on → the chemical coding model of repetition priming developed from the radula opener circuitry (Friedman et al. 2015; Friedman and Weiss 2010)
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claim_relations[0]the tagger's words
claim_relationsreplicates → previous demonstrations that unprimed CBI-2- and EN-induced buccal motor programs have intermediate rather than ingestive or egestive characteristics (Dacks et al. 2012; Friedman et al. 2009; Proekt et al. 2004)
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claim_relations[1]the tagger's words
concept_edgesB63 —causes→ repetition priming
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direction on the measure: no-change · strength of the relation: 0.1 — the record marks this weak · note: THE LOAD-BEARING NEGATIVE. Repetition alone does not prime; the priming belongs to the extrinsic inputs. The paper predicted this before testing it - 'if priming is…' - which is what makes the null a result rather than a gap.
concept_edges[0]0.95the tagger's words
concept_edgesCBI-2 —causes→ repetition priming
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direction on the measure: increases · strength of the relation: 0.9 · note: And the KIND of priming follows the input, not the repetition - which is the chemical coding model's whole content.
concept_edges[1]0.95the tagger's words
concept_edgesCBI-2 —causes→ B40
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direction on the measure: increases · strength of the relation: 0.9 · note: THE LOCALISATION, and the reason it is convincing: the same effect is produced by stimulating the input OR by applying its peptides directly, so the route is chemical rather than synaptic.
also in: CBI-2 · B40
concept_edges[2]0.95the tagger's words
concept_edgesrepetition priming —causes→ negative biasing
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strength of the relation: 0.8 · note: The consequence for task switching, and it follows from persistence: B20 is left more excitable by egestive priming and is active during ingestive programs too, so the modification carries into the next behaviour. Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but negative biasing is 'observed when' CBI-2 follows repetition priming; causes is loose.
concept_edges[3]0.95the tagger's words
concept_edgeschemical coding —causes→ repetition priming
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strength of the relation: 0.85 · note: Stated as what the data SUGGEST rather than as established here - the supporting work is cited to Friedman et al. - and weighted for that. The content is that WHICH modulator is released decides which kind of priming occurs, so the identity of the input is the identity of the effect. Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the data 'suggest' chemical coding 'plays a role in the context of' repetition priming; hedged.
concept_edges[4]0.95the tagger's words
concept_edgesB20 —causes→ negative biasing
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strength of the relation: 0.75 · note: Hedged by the authors - 'likely to be at least partially responsible' - and weighted for it. The mechanism is specific even where the claim is cautious: B20 receives input during BOTH program types, so a modification made during egestive priming is still in place when an ingestive program is triggered. Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the B20 modifications 'are likely to be at least partially responsible'; hedged.
also in: B20 · negative biasing
concept_edges[5]0.95the tagger's words
content_tagspaired t-test
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also in: paired t-test
content_tags.statistics[0]the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[1]the tagger's words
content_tagsrepeated-measures ANOVA
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content_tags.statistics[2]the tagger's words
content_tagsBonferroni correction for multiple comparisons
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content_tags.statistics[3]the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.statistics[4]the tagger's words
content_tagsstandard error of the mean
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content_tags.statistics[5]the tagger's words
content_tagsStimulating the CPG interneuron B63 to trigger feeding programs produced no significant improvement in response articulation.
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content_tags.findings[0]the tagger's words
content_tagsRepetition priming did occur when programs were induced through the esophageal nerve or CBI-2.
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content_tags.findings[1]the tagger's words
content_tagsUnprimed programs were mostly intermediate: 80% of those induced by CBI-2 and 75% of those induced by the esophageal nerve.
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content_tags.findings[2]the tagger's words
content_tagsCBI-2-induced repetition priming appears to modify properties of the core feeding network postsynaptic to CBI-2.
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content_tags.findings[3]the tagger's words
content_tagsRepeated esophageal-nerve stimulation also appears to induce priming by modifying properties of the core feeding network.
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content_tags.findings[4]the tagger's words
content_tagsBath application of the CBI-2 peptides FCAP and CP-2 partially mimicked CBI-2 stimulation, raising retraction-phase B8 firing to over 250% of baseline.
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content_tags.findings[5]the tagger's words
content_tagsBath application of the esophageal-nerve peptide SCPb reproduced the egestive signature, raising protraction-phase B8 firing to over 250% of baseline.
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content_tags.findings[6]the tagger's words
content_tagsIngestive priming increased the excitability of the interneuron B40 and its firing frequency during B63-induced programs.
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content_tags.findings[7]the tagger's words
content_tagsEgestive priming instead recruited the egestive interneuron B20, whose protraction firing frequency more than doubled after esophageal-nerve stimulation.
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content_tags.findings[8]the tagger's words
content_tagsThe authors suggest this partly accounts for the asymmetry of task switching in the feeding network: negative biasing egestive-to-ingestive, positive biasing ingestive-to-egestive.
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content_tags.findings[9]the tagger's words
content_tagsrepetition priming
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content_tags.definitions[0]the tagger's words
content_tagsingestion
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also in: ingestion
content_tags.definitions[1]the tagger's words
content_tagsegestion
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also in: egestion
content_tags.definitions[2]the tagger's words
content_tagsprotraction
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also in: protraction
content_tags.definitions[4]the tagger's words
content_tagschemical coding model
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content_tags.definitions[5]the tagger's words
content_tagsnegative biasing
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content_tags.definitions[6]the tagger's words
content_tagstask switching
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content_tags.definitions[7]the tagger's words
content_tagsexogenous peptide application
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content_tags.variables[1]the tagger's words
content_tagsB8 firing frequency
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content_tags.variables[2]the tagger's words
content_tagsB40 excitability
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content_tags.variables[3]the tagger's words
content_tagslatency to spike initiation
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content_tags.variables[4]the tagger's words
content_tagsinterstimulus interval
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content_tags.variables[5]the tagger's words
content_tagsinjected current
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content_tags.variables[6]the tagger's words
content_tagshigh-divalent cation solution
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content_tags.variables[7]the tagger's words
content_tags94% — Share of unprimed buccal motor programs triggered from inside the CPG (B63) that were classified as intermediate
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content_tags.quantities[0]the tagger's words
content_tags1.2 ± 0.4 Hz to 6.1 ± 0.8 Hz — Fivefold increase in B8 retraction-phase firing in B63-triggered programs caused by prior CBI-2 (ingestive) priming
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content_tags.quantities[1]the tagger's words
content_tags1.0 ± 0.2 Hz to 3.1 ± 0.5 Hz — Threefold increase in B8 protraction-phase firing in B63-triggered programs caused by prior esophageal-nerve (egestive) priming, recovering within 15 min
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content_tags.quantities[2]the tagger's words
content_tags9.8 ± 5.7% to 87.5 ± 4.2% — Fraction of the protraction phase during which B40 was active, before versus after CBI-2-induced priming
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content_tags.quantities[3]the tagger's words
content_tags8.7 ± 0.9 to 19.2 ± 2.3 spikes — Spikes evoked in B40 by a fixed 3-s current pulse before and after three trains of CBI-2 stimulation, i.e. the excitability increase
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content_tags.quantities[4]the tagger's words
content_tagsr = 0.7665, P < 0.0001, n = 103 BMPs — Correlation between B40 firing and B8 retraction-phase activity pooled across time points and preparations
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content_tags.quantities[5]the tagger's words
content_tagsr = 0.8296, P < 0.0001, n = 56 BMPs — Correlation between B20 firing and B8 firing during protraction
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content_tags.quantities[6]the tagger's words
content_tags1.0 ± 0.2 Hz vs 1.4 ± 0.2 Hz, P = 0.18 — B8 protraction and retraction firing in unprimed B63-triggered programs, statistically indistinguishable between phases
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content_tags.quantities[7]the tagger's words

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