Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and Comparisons with NHANES 1999–2000

Antonia M. Calafat, Lee-Yang Wong, Zsuzsanna Kuklenyik, John A. Reidy, Larry L. Needham · Environmental Health Perspectives · 2007 · environmental-science · 10.1289/ehp.10598 · record calafat2007-polyfluoroalkyl-chemicals-in-the-u
tag layer · index · concepts · authors · עברית
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Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 8 concept tags on this paper, all 8 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
limits of detection geometric mean Biomonitoring serum cotinine split samples PFBuS lipophilic POPs half-life production phase-out reaching human serum differential elimination half-life separate formation pathways childhood carpet contact smokers Race/ethnicity geometric mean of a log-transformed, survey-weighted distribution backward elimination at p < 0.05 with Satterwaite adjusted F statistics detection frequency threshold of 60% for parametric statistics observational-study
Method, as described: isotope-dilution HPLC-tandem mass spectrometry on 2,094 NHANES serum samples, with survey-weighted regression

Legend

relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1289/ehp.10598. The reading view exists for the papers whose licence permits it.

Every tag on this page

claim_relations 2 · claim_type 1 · concepts 8 · content_tags 18 · contribution 1 · controls 8 · limitations 4 · mechanisms 4 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 6 · transfers 1

This record holds no relations between concepts. A layer is empty when the tagger recorded nothing in it — which is not the same as the paper having nothing to record.

facettagfieldconf.whose words
object_of_studyserum concentrations of twelve polyfluoroalkyl chemicals in a representative sample of the U.S. population aged 12 and over
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object_of_studythe paper's words
research_questionwhether U.S. population exposure to PFCs changed after the 2002 discontinuation of PFOS production
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research_questionthe paper's words
contributionthe first nationally representative PFC serum estimates after the manufacturing change, with a method-equivalence check spanning the two survey waves
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contributionthe paper's words
claim_typeexistence
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claim_typethe paper's words
phenomenonpopulation-wide, measurable exposure to persistent fluorinated chemicals, declining for three compounds and rising for one
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phenomenonthe paper's words
methodobservational-study
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methodthe paper's words
mechanismselectrochemical fluorination of PFOS and related compounds stopped in 2002, and three of the four common PFCs show lower geometric means four years later
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mechanisms[0]0.95the tagger's words
mechanismsPFHxS declines least because it clears slowest - 7.3 years against 4.8 for PFOS and 3.5 for PFOA - so the same phase-out shows up later in it
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mechanisms[1]0.95the tagger's words
mechanismsPFOS and PFOA correlate more strongly with each other than either does with PFHxS, which the authors read as a shared source that PFHxS does not have
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mechanisms[2]0.85the tagger's words
mechanismsPFHxS is higher in adolescents than adults, and the proposed reason is contact with carpets treated with it - a route specific to one compound
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mechanisms[3]0.85the tagger's words
limitationsPFNA doubled, and the authors say human exposure data for it are too limited to interpret the rise confidently
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limitations[0]0.95the tagger's words
limitationsfor the two rarest analytes no 95th percentile could be calculated at all
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limitations[1]0.95the tagger's words
limitationsno definite association between PFOS or PFOA exposure and adverse health effects has been established in humans
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limitations[2]0.95the tagger's words
limitationsthe animal effects that motivate concern occur at serum concentrations orders of magnitude above those measured here
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limitations[3]0.95the tagger's words
transfersthe persistent-organic-pollutant framework, carried from chlorinated chemicals to fluorinated ones, including the expectation that concentrations rise with age - which fails here
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transfers[0]0.95the tagger's words
controls124 split samples run through BOTH analytical methods, to test whether the method change between survey waves produced the trend
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eliminates: a fall in serum concentrations that is a change of analytical method between survey waves - the split samples make the two methods comparable on the same serum · outcome: held
controls[0]0.95the tagger's words
controlsthe explicit question of whether the decline is an artefact of changed methodology
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eliminates: the same artefact, asked as a question of the result rather than of the instrument · outcome: held
controls[1]0.95the tagger's words
controlscalibration standards spiked into calf serum to account for matrix effects and the absence of labelled internal standards for most analytes
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eliminates: a systematic bias from the serum matrix, or from the absence of an isotope-labelled internal standard for most analytes, being read as a concentration difference · outcome: held
controls[2]0.95the tagger's words
controlslow- and high-concentration quality-control pools run alongside reagent blank, serum blank and the samples
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eliminates: analytical drift across a run being reported as variation between people · outcome: held
controls[3]0.95the tagger's words
controlsagreement of the declines with independent series - Red Cross blood donors and Arctic ringed seals
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eliminates: a decline confined to this survey's sampling frame - the seals and the blood donors share no methodology and no population with NHANES · outcome: held
controls[4]0.95the tagger's words
controlsconfounding, tested by re-adding each excluded variable and watching the beta coefficients
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eliminates: a coefficient that survives only under the authors' final choice of covariates · outcome: held
controls[5]0.95the tagger's words
controlsthe split-sample comparison for analytes other than PFOA
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eliminates: that the change in concentrations between survey rounds is a change in analytical method - answered for PFOA and left unshown for the other analytes · outcome: partial
controls[6]0.95the tagger's words
controlsemission-reduction efforts for PFNA, the one compound that rose
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eliminates: an emissions explanation for the one compound that ROSE - the reduction efforts that would provide it were looked for and not found, which the paper says · outcome: absent-declared-unreported
controls[7]0.95the tagger's words
conceptslimits of detection
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concepts[0]0.95the paper's words
conceptsgeometric mean
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concepts[1]0.95the paper's words
conceptsBiomonitoring
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also in: Biomonitoring
concepts[2]0.85the paper's words
conceptsserum cotinine
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[3]0.95the paper's words
conceptssplit samples
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: split samples
concepts[4]0.95the paper's words
conceptsPFBuS
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: PFBuS
concepts[5]0.95the paper's words
conceptslipophilic POPs
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[6]0.95the paper's words
conceptshalf-life
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also in: half-life
concepts[7]0.85the paper's words
sensesa NON-DETECT is entered as LOD divided by the square root of 2 - imputed, not measured
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senses[0]0.95the tagger's words
sensesa mean is REPORTABLE only where the analyte was detected in at least 60% of samples
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[1]0.95the tagger's words
sensesa SMOKER is anyone with serum cotinine above 10 ug/L - a biomarker threshold, not self-report
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[2]0.95the tagger's words
sensesRACE/ETHNICITY is three self-reported categories, and everyone else is counted in the total but excluded from every subgroup comparison
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senses[3]0.95the tagger's words
sensesa CONFOUNDER is a variable whose re-addition moves a beta coefficient by 10% or more
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senses[4]0.95the tagger's words
sensesa RETAINED model term is one surviving backward elimination at p < 0.05
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[5]0.95the tagger's words
claim_relationsextends → the NHANES 1999-2000 PFC serum concentrations reported by the same group
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
note: the same survey, the same laboratory, four years later, and the comparison is the paper's point
claim_relations[0]the tagger's words
claim_relationsconfirms → reported reductions in PFOS and PFOA in Red Cross blood donors and in Arctic ringed seals
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note: independent populations and an independent species moving the same way over the same interval
claim_relations[1]the tagger's words
content_tagsApparent reductions in PFOS, PFOA and PFHxS most likely relate to the 2002 end of electrochemical-fluorination production.
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content_tags.findings[0]0.95the tagger's words
content_tagsunlike lipophilic persistent organic pollutants, these PFCs do not accumulate with age
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content_tags.findings[1]0.95the tagger's words
content_tagsPFBuS was detected less often than PFOS, PFOA and PFHxS.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[2]0.95the tagger's words
content_tagsthe two analytical methods agreed on 124 split samples, so the trend is not a method artefact
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content_tags.findings[3]0.95the tagger's words
content_tagslimits of detection
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content_tags.definitions[0]0.95the tagger's words
content_tagssmokers
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also in: smokers
content_tags.definitions[1]0.95the tagger's words
content_tagsRace/ethnicity
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content_tags.definitions[2]0.95the tagger's words
content_tagsPFOS, PFOA, PFHxS and PFNA detected in over 98% of 2,094 samples — None
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value source note: THE VALUE DRAWS ON THE PAPER BEYOND THIS QUOTE: part of it is printed elsewhere in the paper, not in this quote ('of 12 PFCs, including PFOS and PFOA, in 2,094 participants…').
content_tags.quantities[0]0.95the tagger's words
content_tagslimits of detection 0.1 to 1.0 ug/L; accuracy 84 to 135%; precision about 10 to 26% — None
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content_tags.quantities[1]0.95the tagger's words
content_tagsEVIDENCE CORRECTED (RE-GROUNDED - THE POINTER WAS WRONG, NOT THE CLAIM) · geometric means down about 32% for PFOS, 25% for PFOA, 10% for PFHxS; PFNA up 100% — None
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
EVIDENCE CORRECTED: RE-GROUNDED - THE POINTER WAS WRONG, NOT THE CLAIM. The old evidence was verbatim, anchored and correctly cut, and it contained NONE of this claim's numbers (10, 100, 25, 32). The paper states the claim in one sentence elsewhere and the tagger did not use it. the project, 2026-08-23: 'WE HAVE SPENT THE DAY VERIFYING THAT QUOTES ARE REAL AND NONE OF IT ASKS WHETHER THEY ARE RELEVANT.' Confirmed by reading the claim, the old span and the candidate together; the candidate carries every number AND the claim's own content words.
content_tags.quantities[2]0.95the tagger's words
content_tagsserum elimination half-lives: PFHxS 7.3 years, PFOA 3.5, PFOS 4.8 — None
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[3]0.95the tagger's words
content_tagsPFNA ammonium salt production 15-75 tonnes in 2004; PFOA emissions about 15 tonnes, down from 45 in 1999 — None
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content_tags.quantities[4]0.95the tagger's words
content_tagssmoking threshold: serum cotinine above 10 ug/L — None
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content_tags.quantities[5]0.95the tagger's words
content_tagsgeometric mean of a log-transformed, survey-weighted distribution
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content_tags.statistics[0]0.95the tagger's words
content_tagsbackward elimination at p < 0.05 with Satterwaite adjusted F statistics
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content_tags.statistics[1]0.95the tagger's words
content_tagsdetection frequency threshold of 60% for parametric statistics
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content_tags.statistics[2]0.95the tagger's words
content_tagsserum cotinine
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content_tags.variables[0]0.95the tagger's words
content_tagsgeometric mean
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content_tags.variables[1]0.95the tagger's words

Interpretive choices

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