GENETICS OF NATURAL POPULATIONS. XIX. ORIGIN OF HETEROSIS THROUGH NATURAL SELECTION IN POPULATIONS OF DROSOPHILA PSEUDOOBSCURA

Theodosius Dobzhansky · Genetics · 1950 · population-genetics · 10.1093/genetics/35.3.288 · record dobzhansky1950-genetics-of-natural-populations-xi
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Where this record's text came from. faceted 2026-08 by reading the locally held text (pdftext); every evidence string verified as an exact substring of that text before merging. Extraction is readable but hyphenation across line breaks splits many words ('chro mosomes', 'popula tions'); all quotes were picked from clean runs and substring-verified. The discussion also relates the work to Crow (1948) on maize, Wallace (1948) on the sex-ratio X chromosome, Shull (1948) on the term heterosis and da Cunha (1949), but the sentences naming those works are broken by extraction artefacts or state a parallel rather than a relation of this paper's own claim, so they were left out. A secondary claim - that adaptive value is not proportional to survival at all stages - would also qualify as a null-result/critique, but the single claim type slot records the coadaptation mechanism. 2026-08-14, 2026-08-15 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 6 concept tags on this paper, all 6 are grounded in a quoted sentence.
heterosis euheterosis luxuriance adaptive value polygene complexes population cages Natural selection coadapts polygene complexes only within a population, so chromosomes brought together from populations that never interbreed have not been mutually adjusted and their heterozygotes lack heterosis. Heterosis arises from interaction between polygene complexes carried by differently arranged chromosomes, which the inversions protect from being broken up by crossing over in the heterozygote. A second, distinct kind of heterosis arises when deleterious recessive mutants accumulated in the population are sheltered by their normal dominant alleles in the heterozygote. Viability and adaptive value diverge because larval survival is only one of several components (adult longevity, fecundity, sexual activity) that jointly determine net fitness. coadaptation viability quotient chi-squared computing chi-squares degrees of freedom one degree of freedom significance level the conventional level of statistical significance experiment
Method, as described: laboratory-experiment

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relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it

The paper

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Every tag on this page

claim_relations 1 · claim_type 1 · concept_edges 3 · concepts 6 · content_tags 19 · controls 1 · limitations 5 · mechanisms 4 · method 1 · phenomenon 1 · senses 3

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 3 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
claim_typemechanism
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claim_typethe paper's words
phenomenonheterosis in chromosomal inversion heterozygotes
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phenomenonthe paper's words
methodexperiment
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also in: experiment
methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsmechanisms
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mechanisms[3]the tagger's words
limitationsThe cages were not run long enough for the inferior chromosome type to be eliminated, so the predicted outcome was not observed to completion.
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what this limits: the elimination prediction specifically: THE CH CHROMOSOMES WERE RARE IN CAGES NOS. 48 AND 49, BUT MUCH LONGER OBSERVATION WOULD BE NEEDED TO SEE THEM ELIMINATED COMPLETELY
limitations[0]the tagger's words
limitationsIn the California-Mexico cage No. 55 the viability differences among genotypes did not reach conventional significance.
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what this limits: the viability comparison in cage No. 55: THE DIFFERENCES ARE, HOWEVER, MOSTLY BELOW THE CONVENTIONAL LEVEL OF STATISTICAL SIGNIFICANCE
limitations[1]the tagger's words
limitationsThe paper opens its discussion by saying the term names several scarcely related phenomena that the field treats as one.
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what this limits: any result reported as heterosis or hybrid vigor: the paper states these terms Quotation withheld, so two such results need not be about the same thing
limitations[2]1.0the tagger's words
limitationsFitness measured at one developmental stage can point the opposite way from fitness overall, and the paper gives its own case.
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what this limits: a fitness or survival figure from a single developmental stage: adaptive value is stated not to be proportional to survival value at all stages, and here some types with higher egg-to-adult mortality were nevertheless adaptively superior
limitations[3]1.0the tagger's words
limitationsThe effect is a property of chromosomes that evolved together, so the same gene-arrangement label does not carry the same behaviour between localities.
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what this limits: a heterosis result carried from one population to another: polygene complexes from geographically distant localities have not undergone coadaptation, so the same chromosomal type does not behave the same way in a different population
limitations[4]1.0the tagger's words
controlsinversion heterozygotes compared against inversion homozygotes, with the paper noting that the heterozygotes were also heterozygous for geographical gene complexes
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eliminates: very little on its own - and the paper says so, which is why this is worth recording: it names the confound its own comparison does not remove · outcome (stated by the tagger, no quotation): partial
controls[0]0.85the tagger's words
conceptsheterosis
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also in: heterosis
concepts[0]the paper's words
conceptseuheterosis
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also in: euheterosis
concepts[1]the paper's words
conceptsluxuriance
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also in: luxuriance
concepts[2]the paper's words
conceptsadaptive value
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concepts[3]the paper's words
conceptspolygene complexes
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concepts[4]the paper's words
conceptspopulation cages
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concepts[5]the paper's words
sensesheterosis - KIND ONE, AN ACCIDENT OF MUTATION: superiority arising because deleterious recessive mutants are hidden by their dominant alleles, which is a by-product of the mutation process
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senses[0]1.0the tagger's words
sensesheterosis - KIND TWO, A PRODUCT OF SELECTION: specific interaction effects from complexes of linked polygenes, called overdominance, engendered by natural selection as adaptation
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senses[1]1.0the tagger's words
sensesadaptive value - AS FREQUENCY CHANGE IN A CAGE: not a physiological measurement but the observed change in the relative frequencies of two types over time in a population cage
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senses[2]1.0the tagger's words
claim_relationsbuilds-on → Wright and Dobzhansky (1946) and Dobzhansky (1947a, b) population-cage results on within-population heterosis
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claim_relations[0]the tagger's words
concept_edgespolygene complexes —causes→ heterosis
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strength of the relation: 1
concept_edges[0]the tagger's words
concept_edgeseuheterosis —distinct-from→ luxuriance
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strength of the relation: 1
concept_edges[1]the tagger's words
concept_edgesEVIDENCE CORRECTED (RE-GROUNDED) · adaptive value —operationalised-as→ population cages
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EVIDENCE CORRECTED: RE-GROUNDED. Same sentence, CARRIED TO ITS END. The old span stopped at 'observing the…' and lost the apparatus; the full sentence finishes '…breeding in POPULATION CAGES…', which is the operationalisation the edge records. The broken word 'popula tions' is the staged text's own and is quoted as it stands. — strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but adaptive values are DETERMINED by observing frequencies in population cages; operationalised-as is loose.
concept_edges[2]the tagger's words
content_tagschi-squared
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also in: chi-squared
content_tags.statistics[0]the tagger's words
content_tagsdegrees of freedom
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content_tags.statistics[1]the tagger's words
content_tagssignificance level
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content_tags.statistics[2]the tagger's words
content_tagsInversion heterozygotes built from two third chromosomes of the same population show heterosis, but heterozygotes built from chromosomes of geographically remote populations generally do not.
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content_tags.findings[0]the tagger's words
content_tagsIn every experiment one homozygote was sharply less viable than the heterozygote (quotients 0.17 to 0.76).
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content_tags.findings[1]the tagger's words
content_tagsHeterozygosity for same-population ST and AR third chromosomes raises viability even on a geographically mixed background of the other chromosomes.
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content_tags.findings[2]the tagger's words
content_tagsIn both cages the adaptive values were ST/AR > ST/ST > AR/AR, the reverse of the viability relations in cage 46.
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content_tags.findings[3]the tagger's words
content_tagsBy March 1948 Arrowhead had risen to 91 percent and Chiricahua had fallen to 9 percent.
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content_tags.findings[4]the tagger's words
content_tagsIn cage 56 the Pinon Arrowhead homozygote was significantly more viable than the heterozygote, and the Mexican Chiricahua homozygote equally or slightly more viable.
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content_tags.findings[5]the tagger's words
content_tagsA type's adaptive value (net fitness) is not necessarily proportional to its survival at every developmental stage.
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content_tags.findings[6]the tagger's words
content_tagscoadaptation
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also in: coadaptation
content_tags.definitions[1]the tagger's words
content_tagsviability quotient
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content_tags.definitions[2]the tagger's words
content_tags0.17 to 0.76 — Range of viability quotients of the inferior homozygote relative to the heterozygote across the five geographically mixed cages
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content_tags.quantities[0]the tagger's words
content_tagschi-squares 6.63 to 16.05 — Range of chi-squared values testing the inferiority of the poorly viable homozygote against the heterozygote, on the pooled sexes
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content_tags.quantities[1]the tagger's words
content_tags91 percent ... 9 percent — Frequencies of Mather Arrowhead and Pinon Chiricahua chromosomes in cage 45 by March 1948, from an equal start in February 1947
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content_tags.quantities[2]the tagger's words
content_tags79 percent ... 53 percent — Equilibrium frequency of Arrowhead reached in pure Pinon Flats and in pure Mather populations, against which the runaway hybrid cages are compared
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content_tags.quantities[3]the tagger's words
content_tags1,217 — Number of AR/CH heterozygote flies introduced into population cage No. 45 at the start of the experiment
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content_tags.quantities[4]the tagger's words
content_tags300 miles — Distance between the two Californian source localities, Mather and Pinon Flats
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content_tags.quantities[5]the tagger's words
content_tags31:32 — Probability that both chromosomal types of a heterozygous parent are detected when six larvae are examined, implying one thirty-second of heterozygotes are misclassified as homozygotes
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content_tags.quantities[6]the tagger's words

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