Behavioral Strategy Determines Frontal or Posterior Location of Short-Term Memory in Neocortex

Gilad, Gallero-Salas, Groos, Helmchen · Neuron · 2018 · neuroscience · 10.1016/j.neuron.2018.07.029 · record gilad2018-behavioral-strategy-determines-fro
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Where this record's text came from. faceted 2026-08 by reading the locally held text (pdftext); every evidence string verified as an exact substring of that text before merging. method is given as 'calcium-imaging' because none of the listed example values fits - the study is wide-field plus two-photon calcium imaging with optogenetic perturbation, not electrophysiology, fMRI or a purely behavioural experiment; the quoted sentence names the technique explicitly. The Guo et al./Li et al. relation is tagged 'extends' rather than 'contradicts' because the paper qualifies the frontal-maintenance claim (it holds for the active strategy only) rather than denying it. The quoted phenomenon and claim sentences come from the ZORA abstract block reproduced inside the article text, which sits below the ARTICLE TEXT marker; the near-identical SUMMARY section carries mojibake in place of dashes, so the cleaner abstract wording was quoted. 2026-08-13, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
principal component analysis 5 fields · short-term memory 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 7 concept tags on this paper, all 7 are grounded in a quoted sentence.
short-term memory behavioral strategy wide-field activeness quiet trials M2 z-axis drop in focus Posterior parietal area RL, which projects both frontally to M2 and posteriorly to area P, routes the sensory information to one destination or the other according to the animal's behavioural state When information is held frontally in M2, posterior cortex is actively suppressed below baseline, which is why the two memory patterns are mutually exclusive active versus passive trial motor-sensory index (MSI) posterior area P layer 2/3 neuronal activity d-prime body movement Wilcoxon signed-rank test and Mann-Whitney U-test Mann-Whitney U-test ... Wilcoxon signed rank test ANOVA ANOVA and multiple group correction F statistic with 95% confidence interval Kolmogorov-Smirnov test Kolmogorov-Smirnov test on residuals support vector machine with cross-validation label-shuffling permutation test we shuffled between hit and CR labels principal component analysis principal component analysis (PCA) ROC analysis / area under the curve receiver operating characteristics (ROC) curve ... area under the curve (AUC) correlation coefficient Bonferroni correction Bonferroni corrected calcium-imaging
Method, as described: calcium-imaging

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relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1016/j.neuron.2018.07.029. The reading view exists for the papers whose licence permits it.

Every tag on this page

claim_relations 4 · claim_type 1 · concepts 7 · content_tags 33 · controls 5 · limitations 8 · mechanisms 2 · method 1 · phenomenon 1 · senses 4

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facettagfieldconf.whose words
claim_typemechanism
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claim_typethe paper's words
phenomenonshort-term memory localisation in mouse neocortex
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phenomenonthe paper's words
methodcalcium-imaging
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
limitationsWide-field signals are bulk population signals that may be confounded by non-neuronal fluorescence
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what this limits: every signal reported: Quotation withheld (AS WELL AS POTENTIALLY CONFOUNDED BY NON-NEURONAL FLUORESCENCE CHANGES, WHICH NEEDS TO BE CONTROLLED FOR)
limitations[0]the tagger's words
limitationsOnly layer 2/3 was studied; other layers may behave differently
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what this limits: the laminar reach of the conclusions: THIS STUDY FOCUSED ON LAYER 2/3 NEURONS, WHEREAS OTHER LAYERS MAY CONTRIBUTE DIFFERENTLY TO TASK-RELATED PROCESSES
limitations[1]the tagger's words
limitationsThe identity of the posterior activation spot is uncertain and may include neighbouring areas
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what this limits: the anatomical identity of the posterior activation: GIVEN THE VARIABILITY AMONG ANIMALS ... THE OBSERVED ACTIVATION SPOT MAY ALSO ENCOMPASS ADJACENT POSTERIOR AREAS SUCH AS LATEROMEDIAL VISUAL CORTEX OR POSTRHINAL CORTICES
limitations[2]the tagger's words
limitationsThe proposed what/where pathway interpretation is not directly tested here
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what this limits: the what/where pathway interpretation: ADDITIONAL EXPERIMENTS DIRECTLY TESTING EACH PATHWAY WILL BE NEEDED TO SUBSTANTIATE THESE IDEAS
limitations[3]the tagger's words
limitationsThe measurement is a bulk signal, and the authors state they cannot exclude having missed intermingled subpopulations averaged out within it.
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what this limits: the absence of task-relevant activity in an area of these maps: the signal is a bulk population measure and the authors state intermingled subpopulations could be averaged out within it
limitations[4]1.0the tagger's words
limitationsThe grouping variable the entire result rests on is, in some sessions, assigned by a substitute measure whose accuracy is stated as 75%.
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what this limits: the active/passive trial labels in this study: in sessions without usable body-camera images they were predicted from a z-axis focus drop, reported at 75% accuracy against the camera
limitations[5]1.0the tagger's words
limitationsThe independent variable is changed by the manipulation. Strategy is treated as what determines where short-term memory sits, but optogenetic silencing of the site induces strategy switches that persist across days and appear in non-perturbation trials. The paper reports this as a result rather than as a threat, and it is the correct reading - but it means strategy and site are mutually determining, not one prior to the other, and the title states only one direction.
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limitations[6]0.85the tagger's words
limitationsTwo thresholds on the same movement signal do different jobs: one splits trials into active and passive by movement during the sensation period, the other discards trials with movement in the first second of the delay as noisy. The grouping rule and the exclusion rule read the same measure, so which trials survive is not independent of which class they were assigned to.
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limitations[7]0.8the tagger's words
controlsa set of control experiments on the imaging signal itself
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eliminates: autofluorescence and non-calcium-related intrinsic signals as the source of the measured activity · outcome (stated by the tagger, no quotation): held
controls[0]0.9the tagger's words
controlscontrol imaging targeted at the near-midline M2 area, which lies close to the superior sagittal sinus
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eliminates: hemodynamic signal as the source of the activity patterns, in the one location where a blood vessel makes it most likely · outcome (stated by the tagger, no quotation): held
controls[1]0.9the tagger's words
controlstraining two wild-type mice - carrying no GCaMP - on the same task and imaging them awake and performing
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eliminates: autofluorescence, by running the whole experiment in animals that cannot produce the signal of interest · outcome (stated by the tagger, no quotation): held
controls[2]0.95the tagger's words
controlscellular-resolution imaging run alongside the wide-field measurement
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eliminates: the possibility that the bulk population signal is not driven by the layer 2/3 cell bodies it is interpreted as reflecting · outcome (stated by the tagger, no quotation): held
controls[3]0.8the tagger's words
controlsfour experiments on the light delivery, including shining light on cortex not expressing ArchT in the same mice - one record for the set, quoting the sentence that reports the outcome
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eliminates: light disturbance itself as the cause of the behavioural effect, and establishes that the effect requires the right population at the right time · outcome (stated by the tagger, no quotation): held
controls[4]0.95the tagger's words
conceptsshort-term memory
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concepts[0]the paper's words
conceptsbehavioral strategy
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concepts[1]the paper's words
conceptswide-field
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also in: wide-field
concepts[2]the paper's words
conceptsactiveness
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also in: activeness
concepts[3]0.85the paper's words
conceptsquiet trials
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also in: quiet trials
concepts[4]0.95the paper's words
conceptsM2
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also in: M2
concepts[5]0.95the paper's words
conceptsz-axis drop in focus
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concepts[6]0.9the paper's words
senseslocation of short-term memory - NOT A SINGLE SITE: medio-frontal on active trials and lateral posterior on passive ones, so the answer is conditional on the animal's strategy
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senses[0]1.0the tagger's words
sensesbehavioral strategy - an experimental grouping made from the animal's own conduct: engaging the body toward the approaching texture, or passively awaiting the touch
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senses[1]1.0the tagger's words
sensesactive versus passive trial - operationalised by thresholding body movement during the sensation period, so the class is fixed by a cut on a continuous measure
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senses[2]1.0the tagger's words
sensesdelay period - AS ANALYSED, NOT AS RUN: restricted to `quiet trials` in which the mouse did not move for at least the first second, with traces truncated at the first movement thereafter. THIS IS A CONTROL, NOT A CONFOUND - the classes are defined by movement during the SENSATION period, and the delay analysis is made movement-free on purpose so that the persistent activity cannot be motor activity
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senses[3]0.95the tagger's words
claim_relationsreplicates → Chen et al., 2016; Yang et al., 2015 (choice encoding in posterior sensory areas)
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claim_relations[0]the tagger's words
claim_relationsreplicates → Chen et al., 2013, 2016 (timing of hit/CR discrimination)
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claim_relations[1]the tagger's words
claim_relationsextends → Guo et al., 2014; Li et al., 2015 (frontal areas including ALM as the site of short-term memory)
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claim_relations[2]the tagger's words
claim_relationsbuilds-on → Leavitt et al., 2017 (sustained activity encoding working memory is not fully distributed)
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claim_relations[3]the tagger's words
content_tagsWilcoxon signed-rank test and Mann-Whitney U-test
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content_tags.statistics[0]the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[1]the tagger's words
content_tagsF statistic with 95% confidence interval
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content_tags.statistics[2]the tagger's words
content_tagsKolmogorov-Smirnov test
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content_tags.statistics[3]the tagger's words
content_tagssupport vector machine with cross-validation
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content_tags.statistics[4]the tagger's words
content_tagslabel-shuffling permutation test
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content_tags.statistics[5]the tagger's words
content_tagsprincipal component analysis
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content_tags.statistics[6]the tagger's words
content_tagsROC analysis / area under the curve
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content_tags.statistics[7]the tagger's words
content_tagscorrelation coefficient
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content_tags.statistics[8]the tagger's words
content_tagsBonferroni correction
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content_tags.statistics[9]the tagger's words
content_tagsWhich cortical area held the delay-period memory depended on the mouse's behavioural strategy: persistent activity sat medio-frontally (M2) on active trials but in a lateral posterior area on passive trials.
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content_tags.findings[0]the tagger's words
content_tagsThe posterior whisker areas encoded the animal's choice soon after touch under both strategies, so the strategy difference appeared only later, during the delay.
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content_tags.findings[1]the tagger's words
content_tagsOptogenetically silencing M2 or area P lowered task performance only in trials run with the strategy that area supports, and left the other strategy unaffected.
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content_tags.findings[2]the tagger's words
content_tagsSilencing M2 and area P together significantly reduced performance in all four VGAT-ChR2 mice, to levels not significantly different from the expert threshold.
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content_tags.findings[3]the tagger's words
content_tagsOne passive mouse switched its strategy from passive to active in the perturbation sessions.
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content_tags.findings[4]the tagger's words
content_tagsThe two memory sites hold different content: the motor-sensory index was positive in M2 (activity grouped by the upcoming action) and negative in area P (activity grouped by the past texture).
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content_tags.findings[5]the tagger's words
content_tagsOn passive trials a classifier restricted to frontal-cortex pixels was at chance distinguishing hit from correct-rejection trials.
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content_tags.findings[6]the tagger's words
content_tagsDiscrimination performance (d') correlated positively with how actively a mouse used its whiskers (r = 0.6).
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content_tags.findings[7]the tagger's words
content_tagsactiveness
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also in: activeness
content_tags.definitions[0]the tagger's words
content_tagsactive versus passive trial
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content_tags.definitions[1]the tagger's words
content_tagsmotor-sensory index (MSI)
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content_tags.definitions[2]the tagger's words
content_tagsposterior area P
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content_tags.definitions[3]the tagger's words
content_tagslayer 2/3 neuronal activity
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content_tags.variables[2]the tagger's words
content_tagsd-prime
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also in: d-prime
content_tags.variables[3]the tagger's words
content_tagsbody movement
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also in: body movement
content_tags.variables[4]the tagger's words
content_tags16 and 82% — range of activeness (percentage of hit trials with body movement at texture touch) across the eight imaged mice
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content_tags.quantities[0]the tagger's words
content_tags60-88% — accuracy of the classifier separating hit from correct-rejection delay maps, across mice and both strategies
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content_tags.quantities[1]the tagger's words
content_tags48.5 ± 4.2 and 50.4 ± 3.8 — classifier accuracy after shuffling trial labels, i.e. the chance baseline for active and passive trials
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content_tags.quantities[2]the tagger's words
content_tagsr = 0.6 — correlation between a session's activeness and the mouse's d-prime discrimination performance
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content_tags.quantities[3]the tagger's words
content_tags6.9 ± 0.3 weeks — training time needed before imaging, across the eight mice
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content_tags.quantities[4]the tagger's words
content_tags1.2-4.5 s — range of enforced delay durations mice could withhold licking for
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content_tags.quantities[5]the tagger's words
content_tags2.89° ± 0.36° vs. 0.95° ± 0.14° — whisking envelope around texture arrival on active versus passive trials
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content_tags.quantities[6]the tagger's words
content_tags30 — total adult male mice used across imaging, control and optogenetic experiments
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content_tags.quantities[7]the tagger's words

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