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        <title>Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender</title>
        <author>Selçuk Özdin</author>
        <author>Selçuk Özdin</author>
        <author>Şükriye Bayrak Özdin</author>
        <author>Şükriye Bayrak Özdin</author>
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          <title>Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender</title>
          <date>2020</date>
          <publisher>International Journal of Social Psychiatry</publisher>
          <idno type="DOI">10.1177/0020764020927051</idno>
          
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      <span xml:id="t0" from="#a3" to="#a4" type="research_question" ana="#research_question" resp="#paper">Aims: The purpose of this study was to evaluate the levels of depression, anxiety and health anxiety in Turkish society during the COVID-19 pandemic, and to examine the factors affecting these.</span>
      <span xml:id="t1" from="#a7" to="#a8" type="claim_type" ana="#claim_type" resp="#paper">existence</span>
      <span xml:id="t2" from="#a3" to="#a4" type="phenomenon" ana="#phenomenon" resp="#paper">Levels and predictors of anxiety, depression and health anxiety during COVID-19 pandemic in Turkish society: The importance of gender</span>
      <span xml:id="t3" from="#a5" to="#a6" type="method" ana="#method" resp="#paper">survey<term>survey</term></span>
      <span xml:id="t4" from="#a54" to="#a55" type="mechanisms" ana="#mechanisms[0]" resp="#tagger" cert="0.8">mechanisms<term>A low level of health anxiety in pandemics may result in situations that adversely affect people’s lives from numerous perspectives, due to failure to comply with protective measures.</term></span>
      <span xml:id="t5" from="#a13" to="#a15" type="mechanisms" ana="#mechanisms[1]" resp="#tagger" cert="0.8">mechanisms<term>Background A novel Coronavirus type (2019-nCoV) was identified as an etiological agent in cases of pneumonia of indefinite cause seen in the Chinese city of Wuhan on 31 December 2019 ( Zhu et al., 2020 ).</term></span>
      <span xml:id="t6" from="#a26" to="#a27" type="mechanisms" ana="#mechanisms[2]" resp="#tagger" cert="0.8">mechanisms<term>Health anxiety is a crucial issue, and both increases and decreases can result in problems ( GjG, 2004 ).</term></span>
      <span xml:id="t7" from="#a28" to="#a29" type="mechanisms" ana="#mechanisms[3]" resp="#tagger" cert="0.8">mechanisms<term>Some individuals with high health anxiety during the pandemic may cause crowding in the health system by presenting to physicians and hospitals on a frequent basis.</term></span>
      <span xml:id="t8" from="#a62" to="#a63" type="limitations" ana="#limitations[0]" resp="#tagger" cert="0.85">One of the principal limitations of this study is that due to the cross-sectional nature of the research, it is difficult to draw any conclusions regarding its long-term effect.</span>
      <span xml:id="t9" from="#a60" to="#a61" type="controls" ana="#controls[0]" resp="#tagger" cert="0.8">However, we found no statistically significant difference in terms of depression, anxiety and health anxiety levels between individuals living with another person aged above 60 and the control group.<note>eliminates: However, we found no statistically significant difference in terms of depression, anxiety and health anxiety levels between individuals living with another person aged above 60 and the control group.</note></span>
      <span xml:id="t10" from="#a3" to="#a4" type="concepts" ana="#concepts[0]" resp="#paper" cert="0.85">health anxiety<term>health anxiety</term></span>
      <span xml:id="t11" from="#a3" to="#a4" type="concepts" ana="#concepts[1]" resp="#paper" cert="0.85">depression<term>depression</term></span>
      <span xml:id="t12" from="#a3" to="#a4" type="concepts" ana="#concepts[2]" resp="#paper" cert="0.85">anxiety<term>anxiety</term></span>
      <span xml:id="t13" from="#a1" to="#a2" type="concepts" ana="#concepts[3]" resp="#paper" cert="0.85">COVID-19<term>COVID-19</term></span>
      <span xml:id="t14" from="#a14" to="#a17" type="senses" ana="#senses[0]" resp="#tagger" cert="0.98">COVID-19 — the pandemic caused by the rapidly spreading 2019-nCoV</span>
      <span xml:id="t15" from="#a24" to="#a25" type="senses" ana="#senses[1]" resp="#tagger" cert="0.99">health anxiety — distressing emotions, arousal, bodily sensations, danger-related thoughts and images, avoidance, and other defensive behaviours</span>
      <span xml:id="t16" from="#a56" to="#a59" type="claim_relations" ana="#claim_relations[0]" resp="#tagger" cert="0.96">supports → previous studies by Alexander et al. (2007), Liu et al. (2020), and Y. Wang et al. (2020) linking female gender with greater anxiety, depression, or post-pandemic stress symptoms</span>
      <span xml:id="t17" from="#a57" to="#a58" type="concept_edges" ana="#concept_edges[0]" resp="#tagger" cert="0.95">health anxiety —causes→ anxiety<note>strength of the relation: 0.6 — the record marks this weak · note: The sentence uses ‘may’ and ‘vulnerable to’, explicitly presenting a possible rather than deterministic pathway, setting the weight at 0.60.
Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says high health anxiety MAY leave the individual vulnerable to anxiety; hedged.</note><term>health anxiety</term><term>anxiety</term></span>
      <span xml:id="t18" from="#a57" to="#a58" type="concept_edges" ana="#concept_edges[1]" resp="#tagger" cert="0.95">health anxiety —causes→ depression<note>strength of the relation: 0.6 — the record marks this weak · note: The sentence uses ‘may’ and ‘vulnerable to’, explicitly presenting a possible rather than deterministic pathway, setting the weight at 0.60.
Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says high health anxiety MAY leave the individual vulnerable to depression; hedged.</note><term>health anxiety</term><term>depression</term></span>
      <span xml:id="t19" from="#a7" to="#a8" type="content_tags" ana="#content_tags.findings[0]" resp="#tagger" cert="0.85">Results: In terms of HADS cut-off points, 23.6% ( n = 81) of the population scored above the depression cut-off point, and 45.1% ( n = 155) scored above the cut-off point for anxiety.</span>
      <span xml:id="t20" from="#a9" to="#a10" type="content_tags" ana="#content_tags.findings[1]" resp="#tagger" cert="0.85">In regression analysis, female gender, living in urban areas and previous psychiatric illness history were found as risk factors for anxiety; living in urban areas was found as risk factor for depression; and female gender, accompanying chronic disease and previous psychiatric history were found as risk factors for health anxiety.</span>
      <span xml:id="t21" from="#a11" to="#a12" type="content_tags" ana="#content_tags.findings[2]" resp="#tagger" cert="0.85">Conclusion: The results of this cross-sectional study suggest that the groups most psychologically affected by the COVID-19 pandemic are women, individuals with previous psychiatric illness, individuals living in urban areas and those with an accompanying chronic disease.</span>
      <span xml:id="t22" from="#a18" to="#a19" type="content_tags" ana="#content_tags.findings[3]" resp="#tagger" cert="0.85">Various precautions began being adopted as the number of cases increased, and a wide range of measures are still in place.</span>
      <span xml:id="t23" from="#a20" to="#a21" type="content_tags" ana="#content_tags.findings[4]" resp="#tagger" cert="0.85">Questions related to the pandemic with no definite answers, such as when it will come to an end and methods of treatment; constant exposure to a flow of information about the pandemic and its effects; decreased social relations due to the pandemic; and recommendations/prohibitions such as remaining at home as much as possible all can adversely affect individuals’ mental health.</span>
      <span xml:id="t24" from="#a34" to="#a35" type="content_tags" ana="#content_tags.findings[5]" resp="#tagger" cert="0.85">Higher scores indicate increased severity of anxiety or depression.</span>
      <span xml:id="t25" from="#a38" to="#a39" type="content_tags" ana="#content_tags.findings[6]" resp="#tagger" cert="0.85">Multiple linear regression analysis was used to identify the factors associated with health anxiety.</span>
      <span xml:id="t26" from="#a40" to="#a41" type="content_tags" ana="#content_tags.findings[7]" resp="#tagger" cert="0.85">Values of p less than .05 were regarded as significant for all tests.</span>
      <span xml:id="t27" from="#a44" to="#a45" type="content_tags" ana="#content_tags.findings[8]" resp="#tagger" cert="0.85">Depression scores were significantly higher among women, individuals living in an urban area, individuals with COVID+ patients among friends or relatives, individuals with current or previous psychiatric illness history and individuals with chronic disease.</span>
      <span xml:id="t28" from="#a46" to="#a47" type="content_tags" ana="#content_tags.findings[9]" resp="#tagger" cert="0.85">Anxiety scores were significantly higher among women, individuals with a COVID+ patient among friends and relatives and individuals with a current psychiatric disease.</span>
      <span xml:id="t29" from="#a16" to="#a17" type="content_tags" ana="#content_tags.definitions[0]" resp="#tagger" cert="0.85">COVID-19<term>COVID-19</term></span>
      <span xml:id="t30" from="#a32" to="#a33" type="content_tags" ana="#content_tags.quantities[0]" resp="#tagger" cert="0.85">318 — reported sample, observation, or event count</span>
      <span xml:id="t31" from="#a22" to="#a23" type="content_tags" ana="#content_tags.quantities[1]" resp="#tagger" cert="0.85">253 individuals; 7% incidence of post-traumatic stress symptoms 1 month after the outbreak — reported percentage, rate, or performance value</span>
      <span xml:id="t32" from="#a30" to="#a31" type="content_tags" ana="#content_tags.quantities[2]" resp="#tagger" cert="0.85">age above 60s (a more severe course) — reported measured value with units</span>
      <span xml:id="t33" from="#a42" to="#a43" type="content_tags" ana="#content_tags.quantities[3]" resp="#tagger" cert="0.85">250 (72.8%) working before the pandemic, 89 of whom stopped; 35 (10.2%) with friends or relatives with COVID-19; 54 (15.7%) with a chronic disease; 62 (42.5%) of 162 smokers quit or cut down — reported sample, observation, or event count</span>
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        <p><anchor xml:id="a0"/> Abstract. Background: <anchor xml:id="a1"/>The COVID-19 pandemic is having negative effects on societies’ mental health.<anchor xml:id="a2"/> Both the pandemic and the measures taken to combat it can affect individuals’ mental health. Aims: <anchor xml:id="a3"/>The purpose of this study was to evaluate the levels of depression, anxiety and health anxiety in Turkish society during the COVID-19 pandemic, and to examine the factors affecting these.<anchor xml:id="a4"/> Method: <anchor xml:id="a5"/>The study was performed using an online questionnaire.<anchor xml:id="a6"/> Participants were asked to complete a sociodemographic data form, the Hospital Anxiety and Depression Scale (HADS) and the Health Anxiety Inventory (HAI). The effects on depression, anxiety and health anxiety levels of factors such as age, sex, marital status, living with an individual aged above 60, the presence of a new Coronavirus+ patient among friends or relatives, previous and current psychiatric illness and presence of accompanying chronic disease were then investigated. <anchor xml:id="a7"/>Results: In terms of HADS cut-off points, 23.6% ( n = 81) of the population scored above the depression cut-off point, and 45.1% ( n = 155) scored above the cut-off point for anxiety.<anchor xml:id="a8"/> <anchor xml:id="a9"/>In regression analysis, female gender, living in urban areas and previous psychiatric illness history were found as risk factors for anxiety; living in urban areas was found as risk factor for depression; and female gender, accompanying chronic disease and previous psychiatric history were found as risk factors for health anxiety.<anchor xml:id="a10"/> Conclusion: <anchor xml:id="a11"/>The results of this cross-sectional study suggest that the groups most psychologically affected by the COVID-19 pandemic are women, individuals with previous psychiatric illness, individuals living in urban areas and those with an accompanying chronic disease.<anchor xml:id="a12"/> Priority might therefore be attached to these in future psychiatric planning. <anchor xml:id="a13"/>Background <anchor xml:id="a14"/>A novel Coronavirus type (2019-nCoV) was identified as an etiological agent in cases of pneumonia of indefinite cause seen in the Chinese city of Wuhan on 31 December 2019 ( Zhu et al., 2020 ).<anchor xml:id="a15"/> <anchor xml:id="a16"/>The virus subsequently spread rapidly across the world and led to the pandemic known as COVID-19.<anchor xml:id="a17"/> Although the virus was first seen in China, countries in the European and American continents are the most affected. The first case in Turkey was reported on 11 March 2020. <anchor xml:id="a18"/>Various precautions began being adopted as the number of cases increased, and a wide range of measures are still in place.<anchor xml:id="a19"/> As of 20 April 2020, the total number of reported cases in Turkey was 90,980, with 2,140 deaths ( Republic of Turkey Ministry of Health, 2020 ). Traumatic events can reduce people’s feeling of security, remind them of the fact of death and have adverse effects on their mental health. <anchor xml:id="a20"/>Questions related to the pandemic with no definite answers, such as when it will come to an end and methods of treatment; constant exposure to a flow of information about the pandemic and its effects; decreased social relations due to the pandemic; and recommendations/prohibitions such as remaining at home as much as possible all can adversely affect individuals’ mental health.<anchor xml:id="a21"/> Symptoms such as anxiety, depression, fear, stress and sleep problems are being seen more frequently during the COVID-19 pandemic ( Torales et al., 2020 ). An incidence of depression, anxiety and post-traumatic stress disorder symptoms between 10% and 18% was reported during and after the Severe Acute Respiratory Syndrome (SARS) epidemic ( Wu et al., 2005 ). <anchor xml:id="a22"/>One study of 253 individuals from one of the regions most affected by the COVID-19 pandemic in China reported a 7% incidence of post-traumatic stress symptoms 1 month after the outbreak of the pandemic ( Liu et al., 2020 ).<anchor xml:id="a23"/> Another study from China observed that 53% of people experienced feelings of terror ( Zhang &amp; Ma, 2020 ). One extensive study determined that 0.9% of university students exhibited severe symptoms of anxiety, 2.7% moderate symptoms and 21.3% mild symptoms. Family income stability and living together with parents were found to exhibit a protective effect against anxiety symptoms ( Cao et al., 2020 ). Variables such as occupation, education and gender have been found to affect symptoms of anxiety and depression developing during the pandemic ( Y. Wang et al., 2020 ). <anchor xml:id="a24"/>Health anxiety is a multifaceted phenomenon, consisting of distressing emotions, physiological arousal and associated bodily sensations, thoughts and images of danger and avoidance and other defensive behaviors.<anchor xml:id="a25"/> The phenomenon is experienced on an occasional basis by many people in daily life. <anchor xml:id="a26"/>Health anxiety is a crucial issue, and both increases and decreases can result in problems ( GjG, 2004 ).<anchor xml:id="a27"/> Considering heath anxiety as a broad spectrum, individuals’ health anxiety can be classified as high or low ( Taylor, 2019 ). <anchor xml:id="a28"/>Some individuals with high health anxiety during the pandemic may cause crowding in the health system by presenting to physicians and hospitals on a frequent basis.<anchor xml:id="a29"/> Others with high anxiety may be reluctant to seek medical assistance out of concerns that hospitals are sources of transmission. In contrast, individuals with low health anxiety may be reluctant to comply with warnings regarding bringing the pandemic under control, and may behave in a highly relaxed manner ( Asmundson &amp; Taylor, 2020 ). One study investigating the number of visits to 18 emergency departments in the United States following the H1N1 pandemic showed that the emergency department visits in the week before the pandemic reached the country was as high as the number in the week when the pandemic was most intense. The number of presentations was also 7% higher than in normal times ( McDonnell et al., 2012 ). The ability to bring pandemics under control depends on compliance with warnings. One psychological factor capable of affecting adherence to warnings is health anxiety. The current COVID-19 pandemic and the measures adopted against it are as follows: The psychological effects on the Turkish public may vary depending on variables such as gender, place of residence, age, accompanying chronic disease, previous or current psychiatric illness and presence of a COVID+ relative. Since anxiety and depressive disorders are more prevalent in women ( Alexander et al., 2007 ), women are also estimated to be more affected during pandemics ( Kim et al., 2014 ). Crowded areas involve a greater risk for droplet-transmitted 2019-nCoV. Individuals living in urban areas may therefore also be expected to be more affected. As is known from previous epidemics, individuals with a history of current or previous psychiatric illness are significantly affected ( Page et al., 2011 ). <anchor xml:id="a30"/>2019-nCoV is known to exhibit a particularly severe course in the above 60s and individuals with accompanying chronic disease ( Zhou et al., 2020 ).<anchor xml:id="a31"/> This group and individuals living with someone above 60 may therefore be expected to be more severely affected. To the best of our knowledge, no previous studies have investigated health anxiety during the COVID-19 pandemic. This research investigated the levels of depression, anxiety and health anxiety in Turkish society during the COVID-19 pandemic. This study also investigated the effect on these variables of potentially affecting factors such as age, gender, place of residence, accompanying chronic disease, a COVID+ friend or relative, living with someone aged above 60 and a current or previous history of psychiatric disease. Method The research population in this descriptive population consisted of individuals aged above 18 living in various provinces of Turkey. Minitab 19.0 software was used to determine the sample size. The sample size was calculated based on an expected prevalence of 6.3% ( Y. Wang et al., 2020 ), Type 1 error of 5% and study power of 95% based on a similar previous study. The calculation showed that at least 159 individuals would need to be enrolled. <anchor xml:id="a32"/>However, to be able to perform subgroup comparisons within the main study group, we planned to enroll 318 participants.<anchor xml:id="a33"/> Data were collected through an online questionnaire between 14 and 16 April 2020, using SurveyMonkey software (SurveyMonkey, San Mateo, CA, USA). Individuals agreeing to participate were asked to complete the questionnaire through social media (WhatsApp, Twitter and Facebook). The 54-item questionnaire consisted of a sociodemographic data form, the Hospital Anxiety and Depression Scale (HADS) and the Health Anxiety Inventory (HAI). HADS is a self-report scale developed by Zigmond and Snaith (1983) which is used to determine anxiety and depression levels. It consists of 14 questions, each of which is scored 0–3. Anxiety and depression are evaluated with seven questions each. The lowest possible scores for depression and anxiety are 0, and the highest possible scores are 21. <anchor xml:id="a34"/>Higher scores indicate increased severity of anxiety or depression.<anchor xml:id="a35"/> The reliability and validity of the Turkish language version were examined by Aydemir et al. Cut-off scores for Turkish society have been determined as 7 for anxiety and 10 for depression ( Aydemir et al., 1997 ). HAI is a self-report scale developed by Salkovskis et al. (2002) and contains 18 questions. The first 14 questions consist of four options from which individuals select the one that best describes their mental state. The last four questions are intended to measure mental state in the event of severe disease. All questions are scored 0–3, with higher scores indicating greater health anxiety. The total score ranges from 0 to 54. The validity and reliability were studied by Aydemir et al. (2013) . Statistical analyses were performed on SPSS 15.0 software. <anchor xml:id="a36"/>Results were expressed as mean ± standard deviation or number (%).<anchor xml:id="a37"/> The Kolmogorov–Smirnov test was used to assess normal distribution of quantitative data. The use of nonparametric tests at data analysis was found to be appropriate. The Mann–Whitney U -test was applied in two-way group comparisons, and the chi-square test for quantitative data. Participants were grouped as individuals with anxiety and depression based on HADS cut-off scores, and binary logistic regression was used to identify factors associated with anxiety and depression. <anchor xml:id="a38"/>Multiple linear regression analysis was used to identify the factors associated with health anxiety.<anchor xml:id="a39"/> Due to the absence of sufficient individuals aged above 60 ( n = 9), a cut-off point of 50 was determined. <anchor xml:id="a40"/>Values of p less than .05 were regarded as significant for all tests.<anchor xml:id="a41"/> Approval for the study was granted by the Ondokuz Mayıs University Clinical Research Ethical Committee (no. 2020/147). Results A total of 343 individuals completed the questionnaire online, 278 of whom lived in an urban area and 71 (20.9%) of whom lived with another person aged above 60. Participants shared their homes with a mean 3.51 people (±1.27). <anchor xml:id="a42"/>Overall, 250 (72.8%) participants were working before the pandemic, of whom 89 stopped or suspended working after it; 35 participants (10.2%) had friends or relatives with COVID-19; 54 (15.7%) participants had a chronic disease; and 62 (42.5%) of the 162 individuals who smoked before the pandemic reported quitting or cutting down after it.<anchor xml:id="a43"/> The number of participants who had gone outside in the previous week was 282 (82.2%), the most common reasons cited being to buy food ( n = 224) and for work ( n = 118). And 15 (4.3%) participants did not follow news stories or developments about COVID-19. Participants’ mean HADS anxiety and depression scores were 6.8 ± 4.2 and 6.7 ± 4.2, respectively. HAI total score was 15.1 ± 7.0 ( Table 1 ). Table 1. Sociodemographic and clinical features of the participants. Variables Age (years), M ± SD 37.16 ± 10.31 Gender, n (%) Male 174 (50.7) Female 169 (49.2) Marital status, n (%) Married 218 (63.5) Single a 125 (36.4) Place of residence, n (%) Urban 278 (81.0) Rural 65 (18.9) Education time, M ± SD 14.85 ± 3.95 Working before pandemic, n (%) Yes 250 (72.8) Working after pandemic Yes 161 (64.4) No 89 (35.6) No 93 (27.1) No. of people living together, M ± SD 3.51 ± 1.27 Living with an individual aged above 60, n (%) Yes 72 (20.9) No 271 (79.0) Friends or relatives with COVID, n (%) Yes 35 (10.2) No 308 (89.8) Accompanying chronic disease, n (%) Yes 54 (15.7) No 289 (84.3) Smoking, n (%) No 181 (52.7) Yes, with the same frequency 79 ( 23.0) Yes, reduced 69 (20.1) Yes, increased 14 (4.0) Previous or current psychiatric illness, n (%) Yes 75 (21.8) No 268 (78.2) History of going out in the past week, n (%) Yes 282 (82.2) No 61 (17.7) Reason for going out in the previous week, n Work 118 Food supply 224 Health 68 Financial transactions 60 Others 46 Following new stories about COVID-19, n (%) Yes 324 (95.7) No 15 (4.3) HADS, M ± SD Anxiety subscale 6.8 ± 4.2 Depression subscale 6.7 ± 4.2 HAI, M ± SD Total 15.1 ± 7.0 HADS: Hospital Anxiety and Depression Scale; HAI: Health Anxiety Inventory. a Divorced and widowed people are grouped together with singles because there are few. <anchor xml:id="a44"/>Depression scores were significantly higher among women, individuals living in an urban area, individuals with COVID+ patients among friends or relatives, individuals with current or previous psychiatric illness history and individuals with chronic disease.<anchor xml:id="a45"/> <anchor xml:id="a46"/>Anxiety scores were significantly higher among women, individuals with a COVID+ patient among friends and relatives and individuals with a current psychiatric disease.<anchor xml:id="a47"/> Total HAI score was significantly higher among women, individuals with current or previous psychiatric illness and individuals with chronic disease ( Table 2 ). In terms of HADS cut-off points, 23.6% ( n = 81) of the population scored above the depression cut-off point, and 45.1% ( n = 155) scored above the cut-off point for anxiety. Table 2. Comparison of the participants divided into groups in terms of HADS and HAI. Variables HADS HAI M ± SD Depression M ± SD Anxiety M ± SD Gender Male 6.2 ± 3.8 5.9 ± 3.6 14.2 ± 6.2 Female 7.2 ± 4.4 7.7 ± 4.5 15.9 ± 7.6 p -value .047 * .000 * .030 Age groups 18–49 6.8 ± 4.1 6.8 ± 4.1 15.1 ± 6.8 ⩾50 6.14 ± 4.9 6.3 ± 4.7 14.7 ± 8.0 p -value .171 .310 .458 Marital status Married 6.4 ± 4.0 6.6 ± 4.0 14.5 ± 6.4 Single a 7.2 ± 4.4 7.0 ± 4.4 16.1 ± 7.8 p -value .091 .664 .144 Place of residence Urban 6.9 ± 4.2 6.9 ± 4.3 15.2 ± 7.1 Rural 5.8 ± 4.1 6.2 ± 3.3 14.4 ± 6.3 p -value .029 * .373 .550 Working after pandemic Yes 7.0 ± 4.2 6.9 ± 4.3 14.8 ± 6.7 No 6.3 ± 3.8 6.2 ± 3.7 14.1 ± 6.3 p -value .340 .308 .542 Living with an individual aged above 60 Yes 7.7 ± 4.3 6.7 ± 4.1 14.6 ± 7.7 No 6.6 ± 4.1 6.8 ± 4.2 15.2 ± 6.8 p -value .433 .952 .403 Friends or relatives with COVID Yes 9.0 ± 4.6 8.4 ± 4.4 16.8 ± 7.7 No 6.4 ± 4.0 6.6 ± 4.1 14.9 ± 6.9 p -value .001 * .014 * .144 Previous psychiatric illness Yes 8.3 ± 4.8 7.8 ± 4.7 18.3 ± 7.2 No 6.5 ± 4.1 6.7 ± 4.1 14.8 ± 6.9 p -value .036 * .206 .011 * Current psychiatric illness Yes 7.9 ± 4.6 8.5 ± 4.8 18.0 ± 8.2 No 6.4 ± 4.0 6.3 ± 3.9 14.3 ± 6.4 p -value .020 * .000 * .000 * History of going out in the previous week Yes 6.8 ± 4.2 6.9 ± 4.2 15.0 ± 7.0 No 6.1 ± 4.0 6.2 ± 4.0 15.5 ± 6.8 p -value .247 .369 .342 Accompanying chronic disease Yes 7.8 ± 4.5 7.7 ± 4.3 17.9 ± 7.6 No 6.5 ± 4.1 6.6 ± 4.1 14.6 ± 6.7 p -value .050 * .061 .001 * HADS: Hospital Anxiety and Depression Scale, HAI: Health Anxiety Inventory. a Divorced and widowed people are grouped together with singles because there are few. * p &lt; .05. <anchor xml:id="a48"/>According to the results of multiple binary logistic regression analysis evaluating the risk factors for depression and anxiety, living in urban areas (OR = 0.534, 95% CI = (0.297, 0.960)) was found to be a risk factor for depression, while female gender (OR = 2.478, 95% CI = (1.439, 4.267)), living in urban areas (OR = 0.362, 95% CI = (0.159, 0.823)) and previous psychiatric illness (OR = 0.363, 95% CI = (0.196, 0.675)) were identified as risk factors for anxiety ( Table 3 ).<anchor xml:id="a49"/> <anchor xml:id="a50"/>According to the results of multiple linear regression analysis evaluating risk factors for health anxiety, female gender (β = .105, p = .047), accompanying chronic disease (β = .160, p = .003) and previous psychiatric illness (β = .176, p = .001) were found to predict health anxiety ( Table 4 ).<anchor xml:id="a51"/> Table 3. <anchor xml:id="a52"/>Results of logistic regression analysis on factors significantly associated with depression and anxiety.<anchor xml:id="a53"/> According to HADS anxiety vs non anxiety According to HADS depression vs non-depression OR (95% CI) p -value OR (95% CI) p -value Gender (female vs male) 2.478 (1.439, 4.267) .001 * 1.298 (0.833, 2.022) .249 Place of residence (urban vs rural) 0.362 (0.159, 0.823) .015 * 0.534 (0.297, 0.960) .036 * Friends or relatives with COVID (yes vs no) 0.650 (0.297, 1.423) .281 0.485 (0.232, 1.012) .054 Accompanying chronic disease (yes vs no) 0.601 (0.302, 1.197) .148 0.587 (0.317, 1.087) .090 Current psychiatric illness (yes vs no) 0.981 (0.388, 2.484) .968 1.002 (0.429, 2.340) .996 Previous psychiatric illness (yes vs no) 0.363 (0.196, 0.675) .001 * 0.573 (0.323, 1.019) .058 HADS: Hospital Anxiety and Depression Scale; OR: odds ratio; CI: confidence interval. * p &lt; .05. Table 4. Results of multiple linear regression analysis a of clinical variables for predicting HAI subscales. HAI B β 95% CI for B p -value Gender (female vs male) 1.475 .105 (0.022, 2.928) .047 * Place of residence (urban vs rural) 0.560 .031 (−1.291, 2.411) .552 Friends or relatives with COVID (yes vs no) 1.476 .064 (−0.906, 3.858) .224 Accompanying chronic disease (yes vs no) 3.133 .160 (1.098, 5.168) .003 * Current psychiatric illness (yes vs no) 1.375 .054 (−1.403, 4.154) .331 Previous psychiatric illness (yes vs no) 3.088 .176 (1.195, 4.982) .001 * HAI: Health Anxiety Inventory; CI: confidence interval. a Forced entry model was applied. * p &lt; .05. Discussion This study investigated the levels of depression, anxiety and health anxiety in Turkish society during the COVID-19 pandemic and found that women, and individuals living in urban areas, with a COVID+ patient among friends or relatives, previously or currently in receipt of psychiatric treatment and with at least one accompanying chronic disease, were more severely affected. Various measures are being taken during the pandemic to reduce the spread of the virus such as social distancing, lockdowns and self-isolation. At the same time, the number of patients contracting the disease and death rates continue to grow rapidly. Based on the number of reported cases, Turkey had the seventh highest number of reported cases as of 20 April 2020 (World Health Organization, 2020). All these factors can have adverse effects on the mental health of the society. The relatively high depression and anxiety levels and rates (23.6% and 45.1%, respectively) are therefore expected findings in terms of pandemic psychological effects. One extensive study from China reported that approximately 35% of people were psychologically affected by the pandemic ( Qiu et al., 2020 ). The high incidence of depression and anxiety in individuals with previous histories of psychiatric illness may be a finding associated with recurrence of psychiatric diseases before and after the pandemic, as shown in previous such studies ( Lee et al., 2007 ). People are being asked not to leave their homes during the pandemic. In addition, individuals with psychiatric symptoms experience difficulties in obtaining medical assistance for reasons such as some hospitals being converted into pandemic hospitals, psychiatric clinics being unable to provide active health services or number of patients examined being reduced for safety reasons, and hospital environments constituting a risk in terms of viral load. Individuals experience varying levels of psychological distress during pandemics. <anchor xml:id="a54"/>A low level of health anxiety in pandemics may result in situations that adversely affect people’s lives from numerous perspectives, due to failure to comply with protective measures.<anchor xml:id="a55"/> It is therefore important for everyone to exhibit the same awareness and responsibility at times when collective awareness needs to be high, such as pandemics. This study shows that women, individuals with past or present psychiatric illnesses and individuals with chronic disease have greater sensitivity to and awareness of sensations in their own bodies. Health anxiety may be higher in women and individuals with a history of psychiatric disease ( Bobevski et al., 2016 ). The increase in health anxiety in individuals with chronic disease linked to an increased risk may also reflect the psychological distress that people feel during the COVID-19 pandemic. As far as is known, the level of health anxiety was studied for the first time in the COVID-19 pandemic. It was found that female gender, accompanying chronic disease, and previous psychiatric illness history predict sensitivity to physical sensations. <anchor xml:id="a56"/>In this study, depression, anxiety and health anxiety levels were higher in women, showing that the psychiatric impact during the COVID-19 pandemic may be greater on women. Several previous studies have shown that anxiety disorders and depressive disorders are more frequent in women ( Alexander et al., 2007 ). Female gender has been identified as the most potent predictor of post-traumatic stress disorder symptoms after pandemics ( Liu et al., 2020 ). In a study from China, although women were better informed about the disease than men during the COVID-19 pandemic and complied more with advice, such as wearing masks and avoiding public spaces, they also reported not knowing whether the pandemic could be brought under control or the probability of such control being established ( Zhong et al., 2020 ). Anxiety disorder has been seen at three-fold higher levels in women than in men during the COVID-19 pandemic ( Y. Wang et al., 2020 ). <anchor xml:id="a57"/>High health anxiety may result in the individual misinterpreting his or her own sensations, and may leave the individual vulnerable to negative affective states such as anxiety and depression.<anchor xml:id="a58"/> In light of our present knowledge, the higher levels of anxiety, depression and health anxiety in women in this study is not an unexpected finding.<anchor xml:id="a59"/> 2019-nCoV is a viral agent mainly transmitted through droplets or direct contact. Such viruses can be transmitted more, and more easily, in urban and central areas with denser human populations ( Taylor, 2019 ). Psychological impact may therefore be greater in individuals in urban areas ( Chen et al., 2020 ). Individuals living in urban areas may also have a greater probability of access to communication and information. The majority of COVID-19 cases in Turkey are known to be in urban areas. The higher levels of depression among people living in urban areas, where the probabilities of encountering the virus are also higher, is therefore also an expected finding. Advanced age and comorbid chronic diseases have been identified as the most important risk factors for mortality due to 2019-nCoV ( Zhou et al., 2020 ). In addition, the elderly and individuals with chronic disease have an increased risk of contracting the disease ( B. Wang et al., 2020 ). Parallel to all these findings, increased levels of health anxiety, depression and anxiety were also observed in individuals with chronic disease. <anchor xml:id="a60"/>However, we found no statistically significant difference in terms of depression, anxiety and health anxiety levels between individuals living with another person aged above 60 and the control group.<anchor xml:id="a61"/> Although this is a difficult finding to account for, participants’ relatively high educational level (14.85 ± 3.95) may have a protective effect against negative emotions ( Y. Wang et al., 2020 ). Individuals with high educational levels have higher levels of information about and better attitudes toward COVID-19 ( Zhong et al., 2020 ). At the same time, there was no significant difference in variables between the 18–49 and above-50 age groups. The 60-and-above age group is generally reported to be the group in which the course of disease is most severe; 80% of mortality is in this age group ( CDC COVID-19 Response Team, 2020 ). To show the difference, the age cut-off value in this study (50 years) may have remained low. Another reason may be the protective role against life events of crystallized intelligence with increasing experience, as suggested by Cattell (1963) . Not following new stories about COVID-19 ( n = 15, 4.3%) may be regarded as avoidance behavior. Many Turkish television channels are presenting news broadcasts and programs about the pandemic. At the same time, there is more content about the pandemic on the social media. Other factors in the social-psychological field of pandemic psychology are rumors and observational learning ( Taylor, 2019 ). These also frequently occur during the COVID-19 pandemic. Avoidance is a defense mechanism that can be used as a means of coping with anxiety. The prevalence of avoidance behavior during the swine flu epidemic in the United Kingdom in 2009 was reported as 4.9% ( Rubin et al., 2009 ). Avoidance has been identified as one of the behavioral coping methods employed during outbreaks ( Chew et al., 2020 ). The rate of avoidance in this study is therefore unsurprising. One particular advantage of this study is that it measured the public psychological state during the pandemic. Depression, anxiety and health anxiety levels were evaluated in a cross-sectional manner in the pandemic. <anchor xml:id="a62"/>One of the principal limitations of this study is that due to the cross-sectional nature of the research, it is difficult to draw any conclusions regarding its long-term effect.<anchor xml:id="a63"/> It is difficult to apply sampling methods at this time because of the pandemic. In addition, there is also the possibility of selection bias since the study was performed with an online questionnaire. Individuals without Internet and unable or unwilling to use smartphones or email could not be included in the study. Conclusion In conclusion, our findings suggest that the pandemic may have a greater effect on women, individuals with a past or present psychiatric disease, individuals living in urban areas and individuals with a comorbid chronic disease. Priority might therefore perhaps be attached to psychological support measures for members of these groups.<anchor xml:id="a64"/></p>
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