The Human Cell Atlas

Aviv Regev, Sarah A Teichmann, Eric S Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew Farmer, Lars Fugger, Berthold Göttgens, Nir Hacohen, Muzlifah Haniffa, Martin Hemberg, Seung Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Emma Lundberg, Joakim Lundeberg, Partha Majumder, John C Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe'er, Anthony Phillipakis, Chris P Ponting, Stephen Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua Sanes, Rahul Satija, Ton N Schumacher, Alex Shalek, Ehud Shapiro, Padmanee Sharma, Jay W Shin, Oliver Stegle, Michael Stratton, Michael J T Stubbington, Fabian J Theis, Matthias Uhlen, Alexander van Oudenaarden, Allon Wagner, Fiona Watt, Jonathan Weissman, Barbara Wold, Ramnik Xavier, Nir Yosef, Human Cell Atlas Meeting Participants · eLife · 2017 · biology · 10.7554/elife.27041 · record regev2017-the-human-cell-atlas
tag layer · index · concepts · authors · עברית
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Other fields define these differently the same word, defined another way in another discipline
scRNA-seq 6 fields · quality control 3 fields · map 3 fields · open data 3 fields · proteins 3 fields · atlas 2 fields · and 1 more →

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 146 concept tags on this paper, all 146 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
cell type cell state Cell-type taxonomies markers Cell Theory scRNA-seq Human Cell Atlas comprehensive reference catalog stable properties transient features locations abundances map relationships fundamental processes system of coordinates human cell defined set of molecular markers expression level 20,000 human protein-coding genes point in ~20,000-dimensional space non-coding genes alternatively spliced forms chromatin state promoter and enhancer post-translationally modified form reduced representations histological and anatomical information temporal information disease status molecular profiles Single-cell multi-omics transcriptomic genomic epigenomic proteomic causal chains genetic variation regulatory mechanisms phenotypic outcome Multiplex in situ analysis spatial techniques nucleic acids proteins hybridization antibody staining sequencing tagging strategies dissociated cells spatial relationships cell-cell communication MERFISH Seq-FISH microscopy-based quantification Imaging Mass Cytometry tissue clearing expansion Histology tissue architecture expression signatures multi-gene signatures cell's molecular profile information about its neighborhood absolute coordinates relative terms machine vision development partly asynchronous branching pathways of development molecular changes gene-expression patterns trajectories in high-dimensional space Waddington's landscape sharp transitions sampling density sorting strategies rare, transient populations relative proportions of cells duration of each phase progenitor cells rate of cell proliferation death true lineage trees common progenitor cell type synthetic circuits molecular barcode lineage barcodes VDJ recombination somatic hypermutation lineage tracing somatic point mutations repeat expansions at microsatellite loci sound statistical sampling biological enrichment purification adaptive, iterative approach initial sparse sampling decisions about further sampling Sky Dive banking fixed or frozen tissues mixed strategy low coverage of the transcriptome deep profiles large-scale uniform sampling stratified sampling specialized sampling atlas cellular branch spatial branch massively parallel transcriptome analysis chromatin genome folding somatic mutations preserved tissue specimens 10 billion cells all tissues, organs, and systems world's diversity rarity of cell types/states spatial resolution coverage of disease and diversity functional assessment model organism atlases engineering animals validation and functional follow-up studies by proxy technically reproducible biological variation measurement noise rigorous protocols, standards, and benchmarks clinical annotations consistent meta-data dissociating samples into single cells fixation freezing validated standard operating procedures computational pipelines benchmarking samples and data sets open data standard models identifiable data platforms efficient aggregation and storage quality control analytical software user-friendly portals intellectually and technologically flexible criteria for 'completion' the Human Cell Atlas granularity similarity metric probability distribution review
Method, as described: single-cell genomic profiling at scale, with unsupervised clustering as an initial framework for discovering types

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relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
unrecordable relationunhoused_relationsa relation the paper asserts that this vocabulary cannot express, with the reason

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.7554/elife.27041. The reading view exists for the papers whose licence permits it.

Every tag on this page

claim_relations 2 · claim_type 1 · concept_edges 6 · concepts 146 · content_tags 15 · contribution 1 · controls 2 · limitations 6 · mechanisms 2 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 16 · unhoused_relations 13

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; 6 of 6 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studythe human cell types themselves - a reference atlas defining them by molecular profile and connecting that to classical description
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object_of_studythe paper's words
research_questionwhether all human cell types can be identified and defined by molecular profile, 150 years after the effort began
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research_questionthe paper's words
contributiona design for a comprehensive cell atlas WHICH DECLINES TO DEFINE ITS OWN CENTRAL TERM: the definition of 'cell type' is deferred to empirical observation on purpose, and the reasons are stated
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contributionthe paper's words
claim_typemethod
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claim_typethe paper's words
phenomenoncells as points in a high-dimensional molecular space, where similar cells are close but never identical
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phenomenonthe paper's words
methodreview
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also in: review
methodthe paper's words
mechanismsa cell TYPE is proposed as a REGION or a PROBABILITY DISTRIBUTION in the full-dimensional molecular space or a projection of it - the category becomes a geometry rather than a list of properties
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mechanisms[0]0.95the tagger's words
mechanismstypes discovered as regions in feature space are then to be DISTILLED into simple molecular and morphological signatures, so that independent laboratories can index and compare cells at all
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mechanisms[1]0.95the tagger's words
limitationsTHE PROJECT DECLINES TO DEFINE ITS CENTRAL TERM AND SAYS SO: `we have not attempted to propose a precise definition of 'cell type'. Rather, the definition should evolve based on empirical observation` - in a paper whose stated aim is to define all human cell types
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limitations[0]0.95the tagger's words
limitationsthe field lacks a rigorous definition of BOTH `cell type` and `cell state`, and the boundary between them is blurred because cells change over time in ways not fully understood
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limitations[1]0.95the tagger's words
limitationsTHE TAXONOMY MAY NOT BE A TAXONOMY: finer distinctions may not obey a strict hierarchy, some distinctions are graded rather than discrete, and IT REMAINS UNCLEAR WHETHER THE MORPHOLOGICAL, MOLECULAR AND PHYSIOLOGICAL AXES AGREE WITH EACH OTHER
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limitations[2]0.95the tagger's words
limitationsthe existing molecular classification is AD HOC - built on markers discovered by accident or chosen for convenience rather than systematically
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limitations[3]0.95the tagger's words
limitationsclustering supplies only a starting framework: the `right` features, the `right` similarity metric and the `right` level of granularity are all open, and the paper puts each of the three in scare quotes
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limitations[4]0.95the tagger's words
limitationsthe full lineage tree from zygote to adult is known for exactly one organism - C. elegans, transparent, with about 1,000 cells
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limitations[5]0.95the tagger's words
controlsthe definition of 'cell type' is deferred to empirical observation rather than fixed in advance, and the deferral is stated as a decision with its reasons
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eliminates: a catalogue whose categories were settled before the data that was supposed to produce them - and the paper's own reasons are that the hierarchy may not hold, the distinctions may be graded, and the axes may not agree · outcome: held
controls[0]0.95the tagger's words
controlstypes found as regions in feature space must be distilled into signatures that independent laboratories can apply
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eliminates: a taxonomy that exists only inside the clustering run that produced it and cannot be used to index, aggregate or compare across labs and individuals · outcome: held
controls[1]0.95the tagger's words
conceptscell type
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also in: cell type
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conceptscell state
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also in: cell state
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conceptsCell-type taxonomies
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concepts[2]0.95the paper's words
conceptsmarkers
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also in: markers
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conceptsCell Theory
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also in: Cell Theory
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conceptsscRNA-seq
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also in: scRNA-seq
concepts[5]0.95the paper's words
conceptsHuman Cell Atlas
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conceptscomprehensive reference catalog
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conceptsstable properties
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conceptstransient features
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conceptslocations
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also in: locations
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conceptsabundances
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also in: abundances
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conceptsmap
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also in: map
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conceptsrelationships
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conceptsfundamental processes
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conceptssystem of coordinates
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conceptshuman cell
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also in: human cell
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conceptsdefined set of molecular markers
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conceptsexpression level
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concepts20,000 human protein-coding genes
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concepts[19]0.95the paper's words
conceptspoint in ~20,000-dimensional space
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conceptsnon-coding genes
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conceptsalternatively spliced forms
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conceptschromatin state
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conceptspromoter and enhancer
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conceptspost-translationally modified form
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conceptsreduced representations
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conceptshistological and anatomical information
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conceptstemporal information
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concepts[28]0.95the paper's words
conceptsdisease status
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conceptsmolecular profiles
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conceptsSingle-cell multi-omics
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conceptstranscriptomic
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conceptsgenomic
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also in: genomic
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conceptsepigenomic
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also in: epigenomic
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conceptsproteomic
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also in: proteomic
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conceptscausal chains
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also in: causal chains
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conceptsgenetic variation
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conceptsregulatory mechanisms
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conceptsphenotypic outcome
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conceptsMultiplex in situ analysis
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conceptsspatial techniques
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conceptsnucleic acids
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conceptsproteins
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also in: proteins
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conceptshybridization
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also in: hybridization
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conceptsantibody staining
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conceptssequencing
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conceptstagging strategies
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conceptsdissociated cells
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conceptsspatial relationships
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conceptscell-cell communication
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conceptsMERFISH
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conceptsSeq-FISH
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conceptsmicroscopy-based quantification
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conceptsImaging Mass Cytometry
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conceptstissue clearing
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conceptsexpansion
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conceptsHistology
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conceptstissue architecture
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conceptsexpression signatures
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conceptsmulti-gene signatures
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conceptscell's molecular profile
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conceptsinformation about its neighborhood
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conceptsabsolute coordinates
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conceptsrelative terms
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conceptsmachine vision
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conceptsdevelopment
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conceptspartly asynchronous branching pathways of development
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conceptsmolecular changes
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conceptsgene-expression patterns
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conceptstrajectories in high-dimensional space
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conceptsWaddington's landscape
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conceptssharp transitions
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conceptssampling density
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conceptssorting strategies
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conceptsrare, transient populations
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conceptsrelative proportions of cells
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conceptsduration of each phase
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conceptsprogenitor cells
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conceptsrate of cell proliferation
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conceptsdeath
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conceptstrue lineage trees
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conceptscommon progenitor cell type
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conceptssynthetic circuits
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conceptsmolecular barcode
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conceptslineage barcodes
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conceptsVDJ recombination
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conceptssomatic hypermutation
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conceptslineage tracing
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conceptssomatic point mutations
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conceptsrepeat expansions at microsatellite loci
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conceptssound statistical sampling
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conceptsbiological enrichment purification
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concepts[92]0.95the paper's words
conceptsadaptive, iterative approach
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[93]0.95the paper's words
conceptsinitial sparse sampling
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concepts[94]0.95the paper's words
conceptsdecisions about further sampling
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concepts[95]0.95the paper's words
conceptsSky Dive
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also in: Sky Dive
concepts[96]0.95the paper's words
conceptsbanking
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also in: banking
concepts[97]0.95the paper's words
conceptsfixed or frozen tissues
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concepts[98]0.95the paper's words
conceptsmixed strategy
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concepts[99]0.95the paper's words
conceptslow coverage of the transcriptome
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concepts[100]0.95the paper's words
conceptsdeep profiles
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also in: deep profiles
concepts[101]0.95the paper's words
conceptslarge-scale uniform sampling
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concepts[102]0.95the paper's words
conceptsstratified sampling
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concepts[103]0.95the paper's words
conceptsspecialized sampling
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concepts[104]0.95the paper's words
conceptsatlas
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also in: atlas
concepts[105]0.95the paper's words
conceptscellular branch
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[106]0.95the paper's words
conceptsspatial branch
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concepts[107]0.95the paper's words
conceptsmassively parallel transcriptome analysis
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concepts[108]0.95the paper's words
conceptschromatin
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also in: chromatin
concepts[109]0.95the paper's words
conceptsgenome folding
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concepts[110]0.95the paper's words
conceptssomatic mutations
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concepts[111]0.95the paper's words
conceptspreserved tissue specimens
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concepts[112]0.95the paper's words
concepts10 billion cells
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concepts[113]0.95the paper's words
conceptsall tissues, organs, and systems
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concepts[114]0.95the paper's words
conceptsworld's diversity
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concepts[115]0.95the paper's words
conceptsrarity of cell types/states
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[116]0.95the paper's words
conceptsspatial resolution
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concepts[117]0.95the paper's words
conceptscoverage of disease and diversity
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concepts[118]0.95the paper's words
conceptsfunctional assessment
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concepts[119]0.95the paper's words
conceptsmodel organism atlases
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concepts[120]0.95the paper's words
conceptsengineering animals
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concepts[121]0.95the paper's words
conceptsvalidation and functional follow-up studies
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concepts[122]0.95the paper's words
conceptsby proxy
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also in: by proxy
concepts[123]0.95the paper's words
conceptstechnically reproducible
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concepts[124]0.95the paper's words
conceptsbiological variation
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concepts[125]0.95the paper's words
conceptsmeasurement noise
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concepts[126]0.95the paper's words
conceptsrigorous protocols, standards, and benchmarks
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concepts[127]0.95the paper's words
conceptsclinical annotations
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concepts[128]0.95the paper's words
conceptsconsistent meta-data
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concepts[129]0.95the paper's words
conceptsdissociating samples into single cells
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concepts[130]0.95the paper's words
conceptsfixation
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also in: fixation
concepts[131]0.95the paper's words
conceptsfreezing
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: freezing
concepts[132]0.95the paper's words
conceptsvalidated standard operating procedures
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concepts[133]0.95the paper's words
conceptscomputational pipelines
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concepts[134]0.95the paper's words
conceptsbenchmarking samples and data sets
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concepts[135]0.95the paper's words
conceptsopen data
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also in: open data
concepts[136]0.95the paper's words
conceptsstandard models
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concepts[137]0.95the paper's words
conceptsidentifiable
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also in: identifiable
concepts[138]0.95the paper's words
conceptsdata platforms
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concepts[139]0.95the paper's words
conceptsefficient aggregation and storage
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concepts[140]0.95the paper's words
conceptsquality control
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concepts[141]0.95the paper's words
conceptsanalytical software
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concepts[142]0.95the paper's words
conceptsuser-friendly portals
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concepts[143]0.95the paper's words
conceptsintellectually and technologically flexible
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concepts[144]0.95the paper's words
conceptscriteria for 'completion'
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concepts[145]0.95the paper's words
unhoused_relationsHuman Cell Atlas → relationships
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The atlas shows relationships among catalogued elements. Shows is absent from the eight governed types.
unhoused_relations[0]0.95the tagger's words
unhoused_relationsduration of each phase → relative proportions of cells
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Relative cell proportions convey information about the duration of each phase. Conveys-information-about is absent from the eight governed types.
unhoused_relations[1]0.95the tagger's words
unhoused_relationsdevelopment → trajectories in high-dimensional space
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
The paper proposes reconstructing development as trajectories in molecular space. Reconstructs-as is absent from the eight governed types.
unhoused_relations[2]0.95the tagger's words
unhoused_relationsSingle-cell multi-omics → causal chains
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Multi-omic measurements could help fill in causal chains. Enables is absent from the eight governed types.
unhoused_relations[3]0.95the tagger's words
unhoused_relationsdissociated cells → tissue samples
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
In-situ results map genomic information from dissociated cells back onto tissue samples. Maps-onto is absent from the eight governed types.
unhoused_relations[4]0.95the tagger's words
unhoused_relationsexpression data → absolute coordinates
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Cell expression data can help map cell position in absolute coordinates. Maps-position is absent from the eight governed types.
unhoused_relations[5]0.95the tagger's words
unhoused_relationslow coverage of the transcriptome → cell types
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Low-coverage transcriptomes can identify many cell types reliably. Identifies is absent from the eight governed types.
unhoused_relations[6]0.95the tagger's words
unhoused_relationsadaptive, iterative approach → Sky Dive
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
The adaptive approach is explicitly termed a Sky Dive. Naming is absent from the eight governed types.
unhoused_relations[7]0.95the tagger's words
unhoused_relationsdeep profiles → low-coverage data
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
A smaller set of deep profiles helps interpret the broad low-coverage data. Helps-interpret is absent from the eight governed types.
unhoused_relations[8]0.95the tagger's words
unhoused_relationspreserved tissue specimens → analyzed later
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Preserved specimens allow collection now and analysis after methods mature. Enables-deferred-analysis is absent from the eight governed types.
unhoused_relations[9]0.95the tagger's words
unhoused_relationsvalidation and functional follow-up studies → conclusions drawn in the human atlas
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Model-organism studies help validate human-atlas conclusions by proxy. Validates-by-proxy is absent from the eight governed types.
unhoused_relations[10]0.95the tagger's words
unhoused_relationsdata platforms → efficient aggregation and storage
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Atlas data platforms must provide aggregation and storage. Provides is absent from the eight governed types.
unhoused_relations[11]0.95the tagger's words
unhoused_relationsstandard models → identifiable
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Mapping sequence data onto standard gene models is proposed to mitigate identifiability. Mitigates is absent from the eight governed types.
unhoused_relations[12]0.95the tagger's words
sensescell type - DELIBERATELY UNDEFINED HERE. Proposed as a region or probability distribution in molecular space, described as intuitively compelling and hard to state precisely, and left to evolve from the data
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[0]0.95the tagger's words
sensescell type against cell state - type implies PERSISTENCE (a hepatic stellate cell), state implies TRANSIENCE (the G1 phase), and the paper says the boundary between the two concepts can be blurred
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[1]0.95the tagger's words
sensesCell-type taxonomies - a hierarchy over morphological, physiological and molecular differences, which the paper says may not be strict and whose three axes may not agree with one another
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[2]0.95the tagger's words
senses`scRNA-seq` - A NAME FOR A CLASS, NOT A PROTOCOL, AND THE PAPER SAYS SO IN ITS DEFINING SENTENCE. `Quotation withheld` Two papers both reporting `scRNA-seq` may share no step of their procedure - the review goes straight on to distinguish methods taking a census of mRNA at the 3' or 5' end from those assessing full transcripts. The term is a citation-level abstraction that is never a method-level one.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[3]0.95the tagger's words
senses`Cell Theory` - A THEORY DEFINED AS THREE CONJOINED CLAIMS, TWO STRUCTURAL AND ONE HISTORICAL. `Quotation withheld.` The first two say what a thing IS MADE OF and what the parts DO; the third is a claim about ORIGIN and is the only one that could have been false without the others failing with it. A citation to `Cell Theory` selects one of the three and the name records which no better than a coin.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[4]0.9the tagger's words
sensesHuman Cell Atlas - a relational map and reference catalog of cell properties, features, locations, and abundances
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[5]0.95the tagger's words
sensesAtlas coordinate system - molecular dimensions plus anatomical, temporal, and disease annotations that can be collapsed into application-specific views
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[6]0.95the tagger's words
sensesSingle-cell multi-omics - two or more molecular data types measured in the same cell to connect variation, regulation, and phenotype
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[7]0.95the tagger's words
sensesMultiplex in-situ analysis - selected RNA or protein targets measured inside tissue so dissociated-cell profiles can be mapped back into spatial context
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[8]0.95the tagger's words
sensesDevelopmental trajectory - branching paths in high-dimensional molecular space reconstructed from cross-sectional single-cell observations
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[9]0.95the tagger's words
sensesLineage tracing - ancestry inferred from engineered or naturally accumulated molecular barcodes
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[10]0.95the tagger's words
sensesSky Dive - adaptive sampling that moves from uniform to stratified to specialized sampling while increasing resolution
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senses[11]0.95the tagger's words
sensesTwo-branch atlas - individual-cell molecular profiling paired with in-situ spatial mapping of tissue organization
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[12]0.95the tagger's words
sensesFull-atlas scope - at least ten billion cells across tissues, organs, systems, health states, and population diversity, with explicit resolution and functional limits
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[13]0.95the tagger's words
sensesAtlas quality - reproducibility through shared protocols, metadata, tissue handling, pipelines, and benchmarking materials
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[14]0.95the tagger's words
sensesOpen-data infrastructure - aggregation, storage, quality control, analysis software, and portals under participant and legal constraints
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senses[15]0.95the tagger's words
claim_relationscritiques → the existing molecular classification of cells, on the ground that it is ad hoc - built on markers discovered by accident or chosen for convenience
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claim_relations[0]0.95the tagger's words
claim_relationsextends → Cell Theory as settled between 1838 and 1855, which named the cell as the unit and left the catalogue of kinds open for 150 years
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
claim_relations[1]0.95the tagger's words
concept_edgescell state —distinct-from→ cell type
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
differs in: persistence against transience - and the paper says the boundary is blurred · the relation itself is separately evidenced · strength of the relation: 0.95 · differs in (stated by the tagger, no quotation): persistence against transience - and the paper says the boundary is blurred · the relation stated: type implies PERSISTENCE and state implies TRANSIENCE - and the paper says in the same passage that the boundary between the two CAN BE BLURRED, so the distinction is asserted and qualified together Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says the boundaries between cell type and cell state CAN BE BLURRED; distinct-from is hedged.
also in: cell state · cell type
concept_edges[0]0.95the tagger's words
concept_edgescomprehensive reference catalog —part-of→ Human Cell Atlas
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
the relation itself is separately evidenced · strength of the relation: 1 · note: The atlas must include the comprehensive reference catalog.
concept_edges[1]0.95the tagger's words
concept_edgeshuman cell —operationalised-as→ point in ~20,000-dimensional space
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
the relation itself is separately evidenced · strength of the relation: 0.7 · note: The paper proposes representing each cell as a point whose dimensions are gene-expression levels. Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says ONE MIGHT describe each cell as such a point; a proposal, hedged.
concept_edges[2]0.95the tagger's words
concept_edgesinitial sparse sampling —causes→ decisions about further sampling
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
direction on the measure: increases · the relation itself is separately evidenced · strength of the relation: 1 · note: The paper says initial sparse sampling drives later sampling decisions. Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says an adaptive approach is LIKELY beneficial, with sparse sampling driving later sampling; hedged.
concept_edges[3]0.95the tagger's words
concept_edgescellular branch —part-of→ atlas
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
the relation itself is separately evidenced · strength of the relation: 1 · note: The atlas must combine a cellular and a spatial branch.
concept_edges[4]0.95the tagger's words
concept_edgesspatial branch —part-of→ atlas
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
the relation itself is separately evidenced · strength of the relation: 1 · note: The atlas must combine a cellular and a spatial branch.
also in: spatial branch · atlas
concept_edges[5]0.95the tagger's words
content_tagsthe project does not propose a precise definition of 'cell type' and lets the definition evolve with empirical observation
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[0]0.95the tagger's words
content_tagsthe cell-type hierarchy may not be strict, some distinctions are GRADED AND NOT DISCRETE, and it is unclear whether the morphological, molecular and physiological axes agree with each other
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[1]0.95the tagger's words
content_tagsmolecular classification of cells has been AD HOC - markers discovered by accident or chosen for convenience rather than systematically
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[2]0.95the tagger's words
content_tagsthe `right` features, the `right` similarity metric and the `right` granularity are all open problems, and the paper scare-quotes each of the three
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[3]0.95the tagger's words
content_tagsthe full lineage tree from zygote to adult is known for one organism only - C. elegans, with about 1,000 cells
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[4]0.95the tagger's words
content_tagsa region or a probability distribution in the full-dimensional molecular space or a projection of it - offered as intuitively compelling and explicitly NOT as a precise definition
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: cell type
content_tags.definitions[0]0.95the tagger's words
content_tagsall organisms are composed of one or more cells; cells are the basic unit of structure and function in life; all cells are derived from pre-existing cells
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: Cell Theory
content_tags.definitions[1]0.95the tagger's words
content_tagsan international effort to define all human cell types by distinctive molecular profile and connect that to classical descriptions such as location and morphology
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content_tags.definitions[2]0.95the tagger's words
content_tagsyears - the age of the effort to identify all human cell types, which this project proposes to complete
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[0]0.95the tagger's words
content_tagscells in C. elegans - the only organism whose full lineage tree from zygote to adult is known
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[1]0.95the tagger's words
content_tagsthe years in which Schleiden, Schwann, Remak and Virchow crystallised Cell Theory
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[2]0.95the tagger's words
content_tagsprobability distribution
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.statistics[0]0.95the tagger's words
content_tagsgranularity
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: granularity
content_tags.variables[0]0.95the tagger's words
content_tagssimilarity metric
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[1]0.95the tagger's words
content_tagsmolecular profiles
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[2]0.95the tagger's words

Interpretive choices

Tags that could not be placed in the text:

What was deliberately not tagged, and why, is recorded per paper by the tagger. Where a paper has no such record, this page says so rather than implying that nothing was declined.

© 2026 Shir Sivroni · ORCID 0009-0000-2597-2824