GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis — TEI-tagged view

Zefang Tang, Boxi Kang, Chenwei Li, Tianxiang Chen, Zemin Zhang · 2019 · genetics · doi:10.1093/nar/gkz430 · TEI xml · tagged edition · index · concepts · authors
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Other fields define these differently the same word, defined another way in another discipline
alternative splicing 2 fields · statistical significance 2 fields · TCGA 2 fields · TPM 2 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
signature score isoform usage survival map hazard ratios cancer subtype MSI MSS Quantile-normalization Pfam3 triple-negative breast cancer MAPK6 TPM3 log2(TPM + 1) cancer type breast cancer subtypes GEPIA2 GenomeSpace isoform protein domain structure plots GEPIA (Gene Expression Profiling Interactive Analysis) web server tumor and normal samples TCGA3 GTEx databases updated and enhanced version higher resolution 198 619 isoforms 84 cancer subtypes gene expression quantification gene level transcript level gene signature quantification single-cell sequencing studies customized analysis own RNA-seq data API for batch process easy retrieval of the analysis results data mining2 gene functions Survival analysis gene expression levels2 prognostic outcomes clinical relevance of a given gene differential expression analysis similar gene identification potential biomarkers therapeutic targets alternative splicing5 different isoform usages UCSC Xena recomputed data coding3 non-coding transcripts heterogeneous subtypes with distinct prognosis single-cell sequencing gene signatures2 composition of tumor microenvironment functional status of infiltrating immune content curated list of signatures Expression Analysis Custom Data Analysis eight tabs two tabs Cancer Subtype Classifier Expression Comparison python package2 survival analyses custom cancer types heat map statistical significance69 context-dependent2 prognostic impact users’ custom data public cancer genomic data other two additional normalization strategies uploaded dataset target dataset on the server boxplot gene expression2 TCGA expression data probability of this sample belonging to each subtype two modes more sensitive result cancer with unknown origin isoform symbol Ensembl ID differentially expressed isoforms prognostic isoforms correlation between two isoforms HTML5, JavaScript, and PHP R and Perl scripts uniform pipeline MySQL relational database GEPIA2 python API multiple requests efficiency of users 5 functionalities immune-cell clusters pan-cancer manner Th1-like signature stomach tumors adjacent normal tissues isoform quantification cancer subtype information isoform usage profiling big cancer genomics data system-or-tool-building173
Method, as described: interactive analysis over UCSC Xena recomputed TCGA and GTEx RNA-seq, served from a relational database

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenonprognostic associations that appear only at cancer-subtype resolution— “It is thus desirable to perform prognostic analysis at a higher resolution. Based on the outputs of GEPIA2, we found that MAPK6 showed no association with breast cancer survival while it exhibited significant association with unfavorable prognostic outcome in Lumina A subtype”
claim-typemethod— “GEPIA2 performs survival analyses based on gene or isoform expression levels. Given a list of custom cancer types, GEPIA2 would provide a heat map to show the survival analysis result based on multiple cancer types (Figure 2A).”
method — evidence— “In GEPIA2, we utilized the UCSC Xena recomputed data of TCGA and GTEx for 198,619 coding and a series of other non-coding transcripts, and developed new computational functionalities to explore such events.”
object of study — evidence— “Featuring 198 619 isoforms and 84 cancer subtypes, GEPIA2 has extended gene expression quantification from the gene level to the transcript level, and supports analysis of a specific cancer subtype, and comparison between subtypes.”
research question — evidence— “Featuring 198 619 isoforms and 84 cancer subtypes, GEPIA2 has extended gene expression quantification from the gene level to the transcript level, and supports analysis of a specific cancer subtype, and comparison between subtypes.”
contribution — evidence— “Featuring 198 619 isoforms and 84 cancer subtypes, GEPIA2 has extended gene expression quantification from the gene level to the transcript level, and supports analysis of a specific cancer subtype, and comparison between subtypes.”
transferfrom single-cell sequencing: gene signature quantification, taken from single-cell sequencing practice into bulk TCGA/GTEx analysistransfers[0]
mechanismisoform switching alternative splicing shifts which isoform of a gene predominates, and the shift can be specific to a cancer type
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mechanisms[0]
mechanismcross-dataset normalisation a user's uploaded matrix and the server-side target set are quantile-normalised against each other before any differential test, so the comparison is between normalised distributions rather than raw counts
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mechanisms[1]
extends GEPIA (Tang et al. 2017), the previous version of this server
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claim_relations[0]
qualifies prognostic gene lists identified at the level of a general cancer type
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claim_relations[1]
sensesignature score = mean log2(TPM + 1) across a signature's genes
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senses[0]
sense'Stacked' = pool the selected subtypes, then compare the pool with normal samples
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senses[1]
sense'Separated' = compare each selected subtype with normal samples on its own
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senses[2]
sense'Comparing Across Subtypes' = compare the selected subtypes with each other, not with normal
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senses[3]
senseisoform 'switch' = the isoform carrying most of a gene's expression differs by cancer type
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senses[4]
senseGEPIA2 - enhanced GEPIA with transcript-level, subtype-level, uploaded-data, and batch-API analysis
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senses[5]
senseResolution shift - expression quantification moves from gene level to individual transcripts and cancer subtypes
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senses[6]
senseSurvival analysis - links expression level to prognostic outcome to assess clinical relevance
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senses[7]
senseGene signature - curated gene set used to interrogate tumor-microenvironment composition or infiltrating-immune functional state
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senses[8]
senseSurvival map - context-sensitive gene or isoform prognosis summarized across selected cancer types
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senses[9]
senseUploaded expression comparison - normalize a user matrix with a public target and return differential expression as a boxplot
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senses[10]
senseClassifier modes - known cancer type gives sensitive subtype prediction; unrestricted mode addresses unknown origin
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senses[11]
senseIsoform analysis - profile expression, differential status, prognosis, and pairwise correlation using transcript identifiers
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senses[12]
sensePython API - batch requests and streamlined retrieval for five analysis functions
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senses[13]
controlany accuracy, precision, recall or held-out validation figure for the Cancer-subtype Classifier — absent-declared-unreported
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— rules out a classifier that is confidently wrong - no accuracy, precision, recall or held-out figure is given for a tool the sentence says predicts cancer subtype 'accurately'
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controls[0]
controlthe same MAPK6 survival test run at whole-breast-cancer level alongside the Lumina A subtype level — held
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— rules out a survival signal that exists only in one subtype being reported as a property of the cancer type
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controls[1]
noteGEPIA (Tang et al. 2017), the previous version of this server — the whole paper is a version increment; the extension named first is gene level to transcript level
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claim_relations[0]
weightGEPIA (Tang et al. 2017), the previous version of this server — 0.95
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claim_relations[0]
noteprognostic gene lists identified at the level of a general cancer type — not a contradiction - the paper accepts those lists and argues they are at the wrong resolution
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claim_relations[1]
weightprognostic gene lists identified at the level of a general cancer type — 0.95
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claim_relations[1]
relationsignature score —operationalised-as→ log2(TPM + 1) — the signature score IS DEFINED AS the mean of this transformed value over a signature's genes
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concept_edges[0]
weightsignature score —operationalised-as→ log2(TPM + 1) — 0.95
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concept_edges[0]
differs inMSI —distinct-from→ MSS — response to chemotherapy and immunotherapy
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concept_edges[1]
weightMSI —distinct-from→ MSS — 0.95
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concept_edges[1]
differs intriple-negative breast cancer —distinct-from→ breast cancer subtypes — five-year survival rate, about 15% lower
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concept_edges[2]
weighttriple-negative breast cancer —distinct-from→ breast cancer subtypes — 0.85
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concept_edges[2]
auditcancer subtype —part-of→ cancer type — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span writes 'cancers are often comprised by heterogeneous subtypes', not 'cancer subtype' / 'cancer type'.
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concept_edges[3]
relationcancer subtype —part-of→ cancer type — a cancer is COMPRISED BY its subtypes, so a subtype sits inside a type
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Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[3]
weightcancer subtype —part-of→ cancer type — 0.95
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concept_edges[3]
noteGEPIA2 —contrasted-with→ GenomeSpace — the paper's only named alternative, and it concedes the alternative can do the same analyses
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concept_edges[4]
weightGEPIA2 —contrasted-with→ GenomeSpace — 0.95
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concept_edges[4]
auditPfam —operationalised-as→ isoform protein domain structure plots — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says the plots are BASED ON Pfam predictions; operationalised-as is loose.
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concept_edges[5]
weightPfam —operationalised-as→ isoform protein domain structure plots — 0.85
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concept_edges[5]
notealternative splicing —causes→ different isoform usages — The paper states that alternative splicing results in different isoform usages.
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concept_edges[6]
auditGEPIA (Gene Expression Profiling Interactive Analysis) web server —causes→ potential biomarkers — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span writes 'the GEPIA web server', not 'GEPIA (Gene Expression Profiling Interactive Analysis) web server'.
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concept_edges[7]
noteGEPIA (Gene Expression Profiling Interactive Analysis) web server —causes→ potential biomarkers — GEPIA use led to identification of potential biomarkers.
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concept_edges[7]
auditGEPIA (Gene Expression Profiling Interactive Analysis) web server —causes→ therapeutic targets — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span writes 'the GEPIA web server', not 'GEPIA (Gene Expression Profiling Interactive Analysis) web server'.
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concept_edges[8]
noteGEPIA (Gene Expression Profiling Interactive Analysis) web server —causes→ therapeutic targets — GEPIA use also led to identification of therapeutic targets.
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concept_edges[8]
noteGEPIA2 python API —causes→ efficiency of users — The API boosts efficiency through batch processing and streamlined retrieval.
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concept_edges[9]
auditstomach tumors —distinct-from→ adjacent normal tissues — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says the Th1-like signature is higher in stomach tumors than in adjacent normal tissue; distinct-from is loose.
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concept_edges[10]
notestomach tumors —distinct-from→ adjacent normal tissues — The Th1-like signature is significantly higher in tumors than adjacent normal tissue.
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concept_edges[10]
outcomecontrol — absent-declared-unreported
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controls[0]
outcomecontrol — held
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controls[1]
no type for thisGEPIA2 → GEPIA (Gene Expression Profiling Interactive Analysis) web server — GEPIA2 is the updated and enhanced version of GEPIA. Version-of is absent from the eight edge types.
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unhoused_relations[0]
no type for thisgene signature quantification → single-cell sequencing studies — GEPIA2's signature quantification is inspired by techniques from single-cell sequencing studies. Inspired-by is absent.
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unhoused_relations[1]
no type for thisCancer Subtype Classifier → TCGA expression data — The classifier is trained on TCGA expression data. Trained-on is absent from the governed types.
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unhoused_relations[2]
no type for thisHTML5, JavaScript, and PHP → GEPIA2 — The website's interactive controls are implemented with HTML5, JavaScript and PHP. Implemented-with is absent.
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unhoused_relations[3]
no type for thisR and Perl scripts → GEPIA2 — GEPIA2 accesses and processes server-side data using R and Perl scripts. Implemented-with is absent.
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unhoused_relations[4]
no type for thisGEPIA2 python API → 5 functionalities — The Python package provides access to five named GEPIA2 functions. Provides-access-to is absent from the edge registry.
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unhoused_relations[5]
limitationthe Cancer-subtype Classifier is described as predicting accurately, and the article reports no accuracy, no held-out split and no confusion matrix anywhere
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limitations[0]
limitationthe two classifier modes trade sensitivity against coverage, and the paper states the trade-off without quantifying either side
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limitations[1]
limitationprognostic gene lists in the prior literature were derived at cancer-type level, so a subtype-specific effect is invisible in them
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limitations[2]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingMAPK6 shows no association with breast cancer survival overall, and a significant unfavourable association within the Lumina A subtype
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content_tags.findings[0]
findingthe Th1-like signature score is significantly higher in stomach tumours than in adjacent normal tissue
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content_tags.findings[1]
findinggene survival analyses are context-dependent, which is the stated reason for scanning many cancer types at once
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content_tags.findings[2]
quantity198 619 isoforms —
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content_tags.quantities[0]
quantity84 cancer subtypes —
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content_tags.quantities[1]
quantityabout 15% lower five-year survival in triple-negative breast cancer —
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content_tags.quantities[2]
quantity414 citations of GEPIA by May 2019, per Google Scholar —
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content_tags.quantities[3]
quantityabout 400 000 analysis requests from about 110 000 distinct IP addresses —
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content_tags.quantities[4]
quantity5 functionalities in the python package —
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content_tags.quantities[5]
quantityMySQL version 5.7.17 —
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content_tags.quantities[6]
variableisoform expression level
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content_tags.variables[0]
variablesignature score
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content_tags.variables[1]
variablehazard ratio
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content_tags.variables[2]
definitionsignature score
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content_tags.definitions[0]
definitionisoform usage
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content_tags.definitions[1]
definitionStacked
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content_tags.definitions[2]
definitionSeparated
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content_tags.definitions[3]
definitionComparing Across Subtypes
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content_tags.definitions[4]
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
conceptsignature score — not defined in this paper's own words; the mean of log2(TPM + 1) over the genes of a signature set, in one sample
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concepts[0]
conceptisoform usage — not defined in this paper's own words; the share of a gene's expression carried by each of its isoforms, 0% to 100%
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concepts[1]
conceptsurvival map — not defined in this paper's own words; a heat map of one gene's or isoform's prognostic effect across many cancer types at once
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concepts[2]
concepthazard ratios — not defined in this paper's own words; plotted in logarithmic (log10) scale; red is higher risk, blue lower
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concepts[3]
conceptcancer subtype — not defined in this paper's own words; a division below cancer type, carrying its own prognosis and treatment response
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concepts[4]
conceptMSI — not defined in this paper's own words; microsatellite-instable colorectal cancer, contrasted here with MSS
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[5]
conceptMSS — not defined in this paper's own words; microsatellite-stable colorectal cancer, contrasted here with MSI
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[6]
conceptQuantile-normalization — not defined in this paper's own words; applied to a user's uploaded matrix and the target set before they are compared
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[7]
conceptPfam — not defined in this paper's own words; the domain predictor behind the per-isoform protein structure plots
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[8]
concepttriple-negative breast cancer — not defined in this paper's own words; the subtype the paper uses to argue that subtype prognosis diverges from type prognosis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[9]
conceptMAPK6 — not defined in this paper's own words; the worked example: no association at breast-cancer level, significant within Lumina A
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[10]
conceptTPM — not defined in this paper's own words; transcripts per million; every expression figure in the paper is log2(TPM + 1)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[11]
conceptlog2(TPM + 1) — not defined in this paper's own words; the transform every expression value in the paper is reported on
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[12]
conceptcancer type — not defined in this paper's own words; the level above subtype, and the level the prior prognostic literature worked at
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[13]
conceptbreast cancer subtypes — not defined in this paper's own words; the comparison class for triple-negative breast cancer's survival deficit
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[14]
conceptGEPIA2 — not defined in this paper's own words; the web server this paper announces
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[15]
conceptGenomeSpace — not defined in this paper's own words; the one named alternative platform, conceded to allow similar analyses
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[16]
conceptisoform protein domain structure plots — not defined in this paper's own words; per-isoform domain diagrams, predicted rather than observed
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[17]
conceptGEPIA (Gene Expression Profiling Interactive Analysis) web server — not defined in this paper's own words; original interactive gene-expression analysis server
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[18]
concepttumor and normal samples — not defined in this paper's own words; sample classes drawn from TCGA and GTEx
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[19]
conceptTCGA — not defined in this paper's own words; tumor genomics resource used by GEPIA2
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[20]
conceptGTEx databases — not defined in this paper's own words; normal-tissue expression resource used by GEPIA2
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[21]
conceptupdated and enhanced version — not defined in this paper's own words; status assigned to GEPIA2 relative to GEPIA
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[22]
concepthigher resolution — not defined in this paper's own words; analytical granularity enabled by isoforms and subtypes
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[23]
concept198 619 isoforms — not defined in this paper's own words; transcript coverage advertised for GEPIA2
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[24]
concept84 cancer subtypes — not defined in this paper's own words; subtype coverage advertised for GEPIA2
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[25]
conceptgene expression quantification — not defined in this paper's own words; quantification extended from gene to transcript level
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[26]
conceptgene level — not defined in this paper's own words; coarser expression-analysis level
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[27]
concepttranscript level — not defined in this paper's own words; finer expression-analysis level
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[28]
conceptgene signature quantification — not defined in this paper's own words; analysis technique adapted from single-cell studies
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[29]
conceptsingle-cell sequencing studies — not defined in this paper's own words; source of inspiration for signature quantification
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[30]
conceptcustomized analysis — not defined in this paper's own words; comparison of uploaded RNA-seq data with public samples
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[31]
conceptown RNA-seq data — not defined in this paper's own words; user data accepted by the server
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[32]
conceptAPI for batch process — not defined in this paper's own words; programmatic batch-analysis interface
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[33]
concepteasy retrieval of the analysis results — not defined in this paper's own words; retrieval capability offered by the API
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[34]
conceptdata mining — not defined in this paper's own words; use enabled by public cancer RNA-seq resources
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[35]
conceptgene functions — not defined in this paper's own words; biological target of deeper understanding
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[36]
conceptSurvival analysis — not defined in this paper's own words; method linking expression with prognostic outcomes
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[37]
conceptgene expression levels — not defined in this paper's own words; predictor examined in survival analysis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[38]
conceptprognostic outcomes — not defined in this paper's own words; clinical outcome linked to expression
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[39]
conceptclinical relevance of a given gene — not defined in this paper's own words; interpretive target of survival analysis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[40]
conceptdifferential expression analysis — not defined in this paper's own words; original GEPIA functionality
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[41]
conceptsimilar gene identification — not defined in this paper's own words; original GEPIA functionality
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[42]
conceptpotential biomarkers — not defined in this paper's own words; discovery outcome attributed to GEPIA use
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[43]
concepttherapeutic targets — not defined in this paper's own words; second discovery outcome attributed to GEPIA use
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[44]
conceptalternative splicing — not defined in this paper's own words; process producing different isoform usages
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[45]
conceptdifferent isoform usages — not defined in this paper's own words; cancer-relevant result of alternative splicing
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[46]
conceptUCSC Xena recomputed data — not defined in this paper's own words; uniform transcript-level TCGA/GTEx data used by GEPIA2
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[47]
conceptcoding — not defined in this paper's own words; one class of transcripts included
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[48]
conceptnon-coding transcripts — not defined in this paper's own words; additional transcript class included
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[49]
conceptheterogeneous subtypes with distinct prognosis — not defined in this paper's own words; within-cancer heterogeneity motivating subtype analysis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[50]
conceptsingle-cell sequencing — not defined in this paper's own words; widely available technology motivating signature paradigms
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[51]
conceptgene signatures — not defined in this paper's own words; sets used to interrogate tumor environments and immune content
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[52]
conceptcomposition of tumor microenvironment — not defined in this paper's own words; property interrogated with gene signatures
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[53]
conceptfunctional status of infiltrating immune content — not defined in this paper's own words; second property interrogated with signatures
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[54]
conceptcurated list of signatures — not defined in this paper's own words; efficient signature-analysis resource integrated into GEPIA2
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[55]
conceptExpression Analysis — not defined in this paper's own words; major GEPIA2 feature topic for public data
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[56]
conceptCustom Data Analysis — not defined in this paper's own words; major GEPIA2 feature topic for uploaded data
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[57]
concepteight tabs — not defined in this paper's own words; feature divisions contained in Expression Analysis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[58]
concepttwo tabs — not defined in this paper's own words; feature divisions contained in Custom Data Analysis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[59]
conceptCancer Subtype Classifier — not defined in this paper's own words; custom-data tab predicting type or subtype
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[60]
conceptExpression Comparison — not defined in this paper's own words; custom-data tab comparing uploaded expression
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[61]
conceptpython package — not defined in this paper's own words; command-line access route to GEPIA2 analyses
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[62]
conceptsurvival analyses — not defined in this paper's own words; gene- or isoform-based prognostic analyses
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[63]
conceptcustom cancer types — not defined in this paper's own words; user-selected cancers summarized in a survival map
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[64]
conceptheat map — not defined in this paper's own words; multi-cancer survival-result visualization
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[65]
conceptstatistical significance — not defined in this paper's own words; status marked by dark frames
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[66]
conceptcontext-dependent — not defined in this paper's own words; property of gene survival effects across cancers
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[67]
conceptprognostic impact — not defined in this paper's own words; effect screened across cancer contexts
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[68]
conceptusers’ custom data — not defined in this paper's own words; uploaded expression matrices linked to public genomics
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[69]
conceptpublic cancer genomic data — not defined in this paper's own words; TCGA/GTEx comparison target
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[70]
conceptother two additional normalization strategies — not defined in this paper's own words; alternatives offered alongside quantile normalization
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[71]
conceptuploaded dataset — not defined in this paper's own words; user-side matrix normalized against the target
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[72]
concepttarget dataset on the server — not defined in this paper's own words; public comparison matrix
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[73]
conceptboxplot — not defined in this paper's own words; returned differential-expression visualization
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[74]
conceptgene expression — not defined in this paper's own words; features used to classify an uploaded sample
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[75]
conceptTCGA expression data — not defined in this paper's own words; training data for the subtype classifier
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[76]
conceptprobability of this sample belonging to each subtype — not defined in this paper's own words; per-sample classifier output
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[77]
concepttwo modes — not defined in this paper's own words; conditional and pan-subtype classifier options
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[78]
conceptmore sensitive result — not defined in this paper's own words; advantage of specifying the cancer type first
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[79]
conceptcancer with unknown origin — not defined in this paper's own words; use case for unrestricted subtype prediction
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[80]
conceptisoform symbol — not defined in this paper's own words; one accepted identifier for isoform analysis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[81]
conceptEnsembl ID — not defined in this paper's own words; alternative accepted isoform identifier
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[82]
conceptdifferentially expressed isoforms — not defined in this paper's own words; isoform-level discovery output
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[83]
conceptprognostic isoforms — not defined in this paper's own words; isoform-level survival output
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[84]
conceptcorrelation between two isoforms — not defined in this paper's own words; isoform-level association analysis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[85]
conceptHTML5, JavaScript, and PHP — not defined in this paper's own words; interactive-control implementation technologies
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[86]
conceptR and Perl scripts — not defined in this paper's own words; server-side processing technologies
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[87]
conceptuniform pipeline — not defined in this paper's own words; UCSC Xena recomputation workflow
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[88]
conceptMySQL relational database — not defined in this paper's own words; storage system for expression and subtype datasets
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[89]
conceptGEPIA2 python API — not defined in this paper's own words; programmatic interface for server analyses
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[90]
conceptmultiple requests — not defined in this paper's own words; batch workload targeted by the API
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[91]
conceptefficiency of users — not defined in this paper's own words; property boosted by batch processing and retrieval
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[92]
concept5 functionalities — not defined in this paper's own words; boxplot, similar, correlation, survival and survival-map API scope
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[93]
conceptimmune-cell clusters — not defined in this paper's own words; single-cell-derived populations profiled pan-cancer
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[94]
conceptpan-cancer manner — not defined in this paper's own words; cross-cancer mode of signature profiling
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[95]
conceptTh1-like signature — not defined in this paper's own words; worked immune-cluster signature example
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[96]
conceptstomach tumors — not defined in this paper's own words; tumor context with elevated Th1-like score
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[97]
conceptadjacent normal tissues — not defined in this paper's own words; comparison tissue for the example
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[98]
conceptisoform quantification — not defined in this paper's own words; new data layer pushing analysis resolution
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[99]
conceptcancer subtype information — not defined in this paper's own words; new stratification layer pushing analysis resolution
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[100]
conceptisoform usage profiling — not defined in this paper's own words; new analysis method highlighted in conclusion
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[101]
conceptcustom data analysis — not defined in this paper's own words; uploaded-data method highlighted in conclusion
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[102]
conceptbig cancer genomics data — not defined in this paper's own words; resource domain explored with GEPIA2
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[103]
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
log2(TPM + 1)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[0]
hazard ratio in log10 scale
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[1]
P = 0.022
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[2]
P = 0.15
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[3]
Quantile-normalization
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[4]

When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

Tag layer © the Meta-Tagging Project, CC BY 4.0. The paper text is © its authors/publisher and is linked, not reproduced. Excerpts shown are short quotations for identification and verification. · back to index · concepts · authors · עברית
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