Recognition of social health: A conceptual framework in the context of dementia research. — TEI-tagged view

Myrra Vernooij-DassenpersName, Eline VerspoorpersName, Suraj SamtanipersName, Perminder S. SachdevpersName, M. Arfan IkrampersName, Meike W. VernooijpersName, Claudia HuberspersName, Rabih ChattatpersName, Marta Lenart-BuglapersName, Joanna RymaszewskapersName, Dorota SzczesniakpersName, Henry BrodatypersName, Anna-Karin WelmerpersName, Jane MaddockpersName, Isabelle F. van der VelpenpersName, Henrik WiegelmannpersName, Anna MarsegliapersName, Marcus RichardspersName, Rene MelispersName, Marjolein de VugtpersName, Esme Moniz-CookpersName, Yun-Hee JeonpersName, Marieke PerrypersName, Karin Wolf-OstermannpersName (2022date). “Recognition of social health: A conceptual framework in the context of dementia research..” Frontiers in Psychiatrytitle·j.

Object of study — social healthterm·dom as a concept in dementia research

Research question — what social healthterm·dom consists of, at the level of the individual and of the social environment

Contribution — a conceptual frameworkterm·key for social healthterm·dom with domains at the individual and the social-environment level

Full text — tagged

Recognition of social healthterm·dom: A conceptual frameworkterm·key in the context of dementia research.

Abstract The recognition of dementia as a multifactorial disorder encourages the exploration of new pathways to understand its origins. Social healthterm·dom might play a role in cognitive decline and dementia, but conceptual clarity is lacking and this hinders investigation of associations and mechanisms. The objective is to develop a conceptual frameworkterm·key for social healthterm·dom to advance conceptual clarity in future studies.

We use the following steps: underpinning for concept advancement, concept advancement by the development of a conceptual model, and exploration of its potential feasibility. An iterative consensus-based process was used within the international multidisciplinary SHARED project.

Underpinning of the concept drew from a synthesis of theoretical, conceptual and epidemiological work, and resulted in a definition of social healthterm·dom as wellbeing that relies on capacities both of the individual and the social environment. Consequently, domains in the conceptual frameworkterm·key are on both the individual (e.g., social participationterm·key) and the social environmental levels (e.g., social networkterm·key). We hypothesize that social healthterm·dom acts as a driver for use of cognitive reserveterm·dom which can then slow cognitive impairment or maintain cognitive functioning. The feasibility of the conceptual frameworkterm·key is demonstrated in its practical use in identifying and structuring of social healthterm·dom markers within the SHARED project.

The conceptual frameworkterm·key provides guidance for future research and facilitates identification of modifiable risk and protective factors, which may in turn shape new avenues for preventive interventions. We highlight the paradigm of social healthterm·dom in dementia as a priority for dementia research.

Keywords: social healthterm·dom, conceptual frameworkterm·key, dementia preventionterm·key, epidemiology, cognitive reserveterm·dom, concept advancement Introduction Dementia is an urgent problem affecting 57.4 million people in 2019 worldwide ( 1 ). Most of the dementias are associated with neurodegenerative processes for which mechanisms are unclear. There is currently no cure for dementia. Our current understanding of dementia risks is primarily focused on the most common cause, namely Alzheimer’s Disease, and driven by biological factors such as the amyloid cascade hypothesis for Alzheimer’s Disease ( 2 ). While medications to manage brain amyloid exist, few effects on sustained clinical outcomes have been reported ( 3 ). Also the acknowledgment that dementia is not “normal aging” nor is it an acceleration of aging ( 4 ), suggests that these hypotheses do not tell the complete developmental story. Moreover, new findings note that age-specific incidence rates are declining in North America and Europe ( 5 ). The exploration of new pathways and hypotheses is encouraged by the recognition of neurodegenerative dementias, including Alzheimer’s disease, as multifactorial disorders that may be determined by the interplay of genetic susceptibility and environmental factors across the life course ( 6 ).

We aim to explore the role of social healthterm·dom in cognitive decline and the onset of dementia. Social healthterm·dom has been defined by the World Health Organization in 1946 as the social domain of health, alongside mental and physical health ( 7 ). Our hypothesis is that social healthterm·dom is a driver for the use of cognitive reserveterm·dom through active facilitation and utilization of social resources of individuals and that poor social healthterm·dom has a substantial influence on cognitive decline and the onset of dementia.

Associations between social characteristics or markers and cognitive decline and dementia are well-documented ( 8 – 18 ). Markers of poor social healthterm·dom, such as poor social engagement and social isolation, are associated with incident dementia ( 9 – 12 , 18 , 19 ). Although associations of lonelinessterm·key with dementia risk remain inconsistent ( 11 , 12 ), social markers such as frequency of contacts, social engagement, social networkterm·key and (social) leisure activities are associated with better cognitive functioning which may contribute to cognitive reserveterm·dom and maintenance of cognitive functionterm·dom in old age ( 10 , 14 , 18 , 20 ).

Since social healthterm·dom is an umbrella concept, combinations of social healthterm·dom markers might provide added value to knowledge of the development of dementia. Several studies show that a combination of social healthterm·dom markers including social isolation, living alone, inability to help (feelings of not being able to help others), limited social participationterm·key and not talking to others every day, is associated with both the development of dementia and reduced cognitive functioning ( 21 – 23 ). A combination of social healthterm·dom markers including participation in social, mental and physical leisure activities and demographic factors such as having high occupational complexity appear protective against cognitive decline ( 24 , 25 ). Interestingly, a broad spectrum of leisure activities may also be more beneficial than engagement in just one activity ( 26 ). These protective “lifestyle factors” are also seen in studies of the development of dementia ( 27 , 28 ). The combination of four social healthterm·dom markers and one demographic marker is associated with a lower likelihood of developing incident dementia e.g., being married, having support from family members, having contact with friends, participating in community groups and the demographic marker of engaging in paid work ( 29 ). Combined scores were linearly associated with incident dementia where those with the highest scores were 46% less likely to develop dementia compared with those in the lowest category ( 29 ).

The current associations only address a limited scope of potentially relevant social healthterm·dom markers, underscoring the lack of clarity of the concept of social healthterm·dom. Social healthterm·dom requires a clear definition to advance research into its associations and mechanisms. Currently, many terms are used interchangeably, including social networkterm·key ( 30 ), social integration ( 30 ), social engagement ( 31 ), social functioning ( 32 ), social capital ( 33 ), and social contact ( 18 ).

Conceptual advancement is needed. This requires a strategic concept–driven effort, that incrementally builds from a conceptual meaning to a more precisely defined unit of meaning ( 34 ). In that way we develop a conceptual frameworkterm·key which provides a system to organize thinking about this complex phenomenon ( 35 ).

A conceptual frameworkterm·key with an overarching definition of social healthterm·dom, that covers the spectrum of social healthterm·dom domains and potential markers can advance the definition of social healthterm·dom to facilitate the identification of modifiable risk and protective factors, which may in turn shape new avenues for preventive interventions.

Our aim is to develop a conceptual frameworkterm·key for social healthterm·dom to aid conceptual clarity and more comprehensive assessment of social healthterm·dom in future studies.

Development of conceptual frameworkterm·key Study context The INTERDEM network (pan-European multidisciplinary network of dementia researchers) 1 profiled social healthterm·dom in the context of dementia ( 36 – 40 ) and initiated the “Social Healthterm·dom And Reserve in the Dementia patient journey (SHARED)” project, funded by the European Union’s Joint Program Neurodegenerative Diseases (JPND 733051082) 2 . SHARED involves several studies with the aim to unravel the interplay between social healthterm·dom and biological and psychological factors. Studies include the development of a conceptual frameworkterm·key for social healthterm·dom, epidemiological studies ( 41 , 42 ), a systematic review on factors influencing cognitive health ( 17 ), a Group Model Buildingterm (GMBterm) study ( 43 ), a current study to identify social healthterm·dom measures and an ongoing qualitative study. The conceptual frameworkterm·key was iteratively developed by the interdisciplinary Social Healthterm·dom Stream of SHARED, consisting of a team of 11 experts, and discussed with the whole consortium. The consortium consisted of experts from The Netherlands ( n = 5), Poland ( n = 5), Germany ( n = 4), Australia ( n = 2), UK ( n = 1), and Italy ( n = 1), that were from the disciplines of: psychology ( n = 5), public health/health services and nursing research ( n = 4), medicine: geriatrics, psychiatry, neuropsychiatry, and family practice ( n = 4), epidemiology ( n = 3), and sociology ( n = 2).

Process Our effort to profile social healthterm·dom started with the conceptualization of HuberpersName et al. ( 44 ) focusing on the active role of the individual. This was applied to dementia ( 36 , 39 ) and to the hypothesis of the SHARED research proposal. In response to questions about the individual focus, we explored underpinnings of the conceptual frameworkterm·key using the following steps: underpinning for concept advancement; concept advancement; and exploration of feasibility of the conceptual frameworkterm·key. Concept advancement used a synthesis of the underpinning studies and an iterative process in which final consensus on the conceptual frameworkterm·key was achieved at the consortium.

Underpinning for concept advancement We synthesize theoretical models, conceptualizations, and epidemiological evidence.

The theoretical models that constitute our knowledge of how associations between social healthterm·dom and cognitive functioning and dementia might work through social activity and brain mechanisms are the Social Network Modelterm ( 31 ) and the Cognitive Reserve Hypothesisterm ( 45 ). The Social Network Modelterm rests on the assumption that the social structureterm·dom of the network itself shapes the flow of resources which determines access to opportunities and constraints on behavior ( 30 ). It suggests pathways by which networks might influence health status, but does not include cognitive health status as an outcome ( 30 ). Additional to social engagement of the individual, this model focuses on the specific characteristics and functioning of the social environment.

The Cognitive Reserve Hypothesisterm suggests that the brain actively attempts to cope with age-related pathological changes by using preexisting neurobiological capital (e.g., neurons/synapses) to enhance brain network efficiency and flexibility, thus enabling the individual to cope with neuropathological changes ( 46 ). This results in maintenance of the level of cognitive functionterm·dom, thus postponing the clinical manifestation of dementia ( 47 ). Cognitive reserveterm·dom reflects the adaptability of the brain in maintaining cognitive abilities or day-to-day functionterm·dom, despite brain aging, pathology, or injury ( 46 , 48 ). Fundamentally the cognitive reserveterm·dom concept is one of effect modification: for a given level of neuropathology, this is less clinically expressed (including, but not limited to, cognitive functionterm·dom) in those with higher “reserve” ( 49 ). Previous studies have used different approaches to measure cognitive reserveterm·dom. The most common approach is proxy-based, where education (years or attained level) has been the most commonly studied ( 46 ). Other proxies included psychosocial and lifestyle factors such as occupational complexity and engaging in physical and cognitive activities ( 50 ).

For the conceptualization, we build on the basic sociological description of the term “social” ( 51 ), the WHO definition of health as “a state of complete physical, mental and social wellbeing” ( 7 ) and the response to the WHO definition by HuberpersName et al. ( 44 ) stating that health might not be a state of complete wellbeing, but the ability to adapt to health challenges and to self-manage. This is especially but not exclusively relevant for advancing age ( 44 ).

The key sociological definition refers to social phenomena as a consequence of human interactions, and the influence of one person on another ( 51 ). HuberpersName et al. ( 44 ) define social healthterm·dom as the influence of social conditions in achieving a balance between capacities and limitations.

Epidemiological evidence reveals markers that refer to the social environment and to the participation of the individual in social life ( 8 – 17 ).

From the social network modelterm, the conceptualizations and the epidemiological evidence we learn that both the individual and the social environment have an active role. Therefore, our conceptualization includes both individual and social environmental levels.

Social healthterm·dom is essentially a relational concept in which wellbeing is defined on the one hand, as the impact that an individual has on others (social environment), and on the other hand as the impact that the social environment (others) has, in turn, on the individual.

These underpinnings have consequences for our past work on social healthterm·dom and we therefore refine our hypothesis as follows: Social healthterm·dom acts as a driver for stimulating the development and the use of cognitive reserveterm·dom through active facilitation and utilization of the individual’s capacities and those of their social environment. This slows cognitive impairment or maintains cognitive functioning in old age.

Concept advancement: A conceptual frameworkterm·key for social healthterm·dom The underpinnings outlined provide us with a concept that is built on theoretical, conceptual and empirical work. Yet, conceptual advancement is needed since the concept remains abstract and hard to operationalize. Therefore, we developed a conceptual frameworkterm·key where meaning is elaborated into more precisely defined domains. The first step is the distinction between the levels of the individual and the social environment. Second, to further facilitate operationalization, we also distinguish domains at both levels. This now allows use of the conceptual frameworkterm·key to identify social healthterm·dom markers and instruments to measure these markers.

Individual level The individual level represents the competences of the individual to act in social life. For the elaboration on this level, we use the domain-related definition of HuberpersName et al. ( 44 ). They describe social healthterm·dom as a dynamic balance between capacities and limitations, determined by the individual’s ability to adapt and self-manage to (social) challenges ( 44 ). They distinguish the following domains: - The capacity to fulfill one’s potential (according to one’s abilities and talents) and obligations (i.e., social demands). This refers to compliance with social norms ( 38 ). Epidemiological studies related to cognitive functioning and dementia did not identify any markers reflecting this domain ( 8 – 18 ).

-The ability to manage life with some degree of independence (i.e., preserving autonomyterm·dom and solving problems in daily life). Autonomyterm·dom refers to acting according to one’s own free will, following own norms and habits to some degree ( 52 ). Epidemiological studies related to cognitive functioning and dementia did not identify any markers reflecting this domain ( 8 – 18 ).

- The ability to actively participate in social activities refers to joining activities with others and there is both theoretical and epidemiological evidence for markers in this domain ( 4 , 8 , 18 ).

Social environmental level The immediate social environment has structural and functional domains that are well-established in social networkterm·key research. As shown below, we added the domain of appraisalterm·dom of the quality of relationships, as our consortium discussions concluded that appraisalterm·dom can differ from what can be actually observed. We distinguish the following domains: -Structure refers to the social ties between persons in networks (e.g., social networkterm·key size and composition) ( 14 ).

-Function refers to actual exchanges between network members, e.g., emotional support and instrumental aid ( 30 , 53 ). A marker identified in epidemiological research is having support from family members ( 29 ).

-Appraisal of the quality of the relationship and interaction refers to perceptions and interpretations. These might differ from actual interactions. An example of its markers is lonelinessterm·key ( 10 ). Social contacts can be perceived as positive or negative, and can be challenging ( 54 ).

Important novelty value of this conceptual frameworkterm·key is its emphasis on the fact that in the case of dementia an individual’s functioning depends not only on their own capacities. The behavior of their social environment which may support but also hinder them using their capacities may be equally important. This effort now provides a framework for identifying social healthterm·dom markers. Future research could study the inter-relationships within the framework. See Figure 1 Conceptual frameworkterm·key for social healthterm·dom.

Conceptual frameworkterm·key for social healthterm·dom.

Exploration of potential feasibility of the conceptual frameworkterm·key The conceptual frameworkterm·key was developed as an aid to identify social healthterm·dom markers in the SHARED project. But does it work like that? We explore the feasibility, meaning the applicability, of the conceptual frameworkterm·key through its use in the following studies of the SHARED project: the review of epidemiological studies ( 17 ), the epidemiological associations between social healthterm·dom and cognitive functioning in the SHARED data bases ( 41 , 42 ) and a Group Model Buildingterm (GMBterm) ( 43 ).

The review of reviews includes 314 studies with social factors constituting 10% of all identified factors ( 17 ). The epidemiological studies use data bases of five ( 41 ) and 13 longitudinal cohort studies ( 42 ). These studies are scrutinized to identify social healthterm·dom markers using the conceptual frameworkterm·key. At the individual level, markers are only identified for the domain of social participationterm·key, but at the level of the social environment social healthterm·dom markers are identified for all domains.

Since epidemiological research only provides information on what is available in databases, we applied other methodologies to get information on the broad spectrum of social healthterm·dom markers.

In the Group Model Buildingterm (GMBterm) study, a participatory method for involving experts in developing models, we used the systematic review and SHARED’s experts consensus ( 55 ). The new GMBterm information included markers at the level of the individual: the capacity to fulfill norms and obligations (e.g., reciprocity) and independence (e.g., autonomyterm·dom) ( 43 ). These two GMBterm markers are added to the conceptual frameworkterm·key as domain examples, the other domain marker examples are derived from epidemiological studies. See Figure 1 Conceptual frameworkterm·key for social healthterm·dom.

The conceptual frameworkterm·key is currently being used to classify measures ( 56 ) and in the ongoing qualitative study to probe additional relevant social markers.

In sum, the conceptual frameworkterm·key facilitated identification of domain related markers in the SHARED project, thus showing its potential feasibility. Without this framework it would have been hard to systematically identify social healthterm·dom markers or gaps in social healthterm·dom data in current epidemiological research.

Discussion We developed a conceptual frameworkterm·key for social healthterm·dom and fine-tuned our hypothesis. The synthesis of theoretical, conceptual and epidemiological resources, led to the recognition of social healthterm·dom relying on the impact of capacities of both the individual and the social environment. This is reflected in the conceptual frameworkterm·key with domains at the individual level referring to aspects of functioning of the individual in social life e.g., being able to fulfill social obligations, while preserving a certain amount of independence and actual participation in social life. The domains at the social environmental level refer to its structureterm·dom, to social ties that are in place; its functionsterm·dom (what people do), and to the appraisalterm·dom of the social environment (perception of the quality of social life). These domains resonate with recent work which outlines three similar social environmental life course domains ( 57 ).

Our hypothesis linking neuropsychiatric and social sciences extends thinking beyond a predominantly biological concept and touches upon the complexity of dementia etiology.

The proof of the pudding is in the eating. Feasibility exploration demonstrates proof of concept through practical use of the framework in identification of social healthterm·dom markers in the SHARED project’s studies. Our exploration broadened the scope of social heath in the context of cognitive decline from focus on the capacities of the individual ( 44 ) to a concept including the capacities of the social environment. Our work expands the 2020 Lancet Commission Report ( 18 ), by providing a conceptual frameworkterm·key for identification of social healthterm·dom markers, and thereby potential social risk and protective factors. The conceptual frameworkterm·key remains flexible for novel ideas that can fit under the umbrella concept. Thus, there is scope for the organic growth of new knowledge in this area.

New knowledge is required regarding the interrelationship between the constituent domains at each level and between the individual and the social environmental levels. For now, social healthterm·dom acts as the sum of constituent domains. However, there may be compensation within and between the levels. At the individual level balancing between adaptation to norms, self-management and independency are aspects that require study. We hypothesize that at the environmental level the structural and functional domains are interrelated because they depend on each other. The social structureterm·dom provides the base for social interaction and social functioning maintains the social structureterm·dom. Appraisalterm·dom, personal perception, provides the linking pin between the two levels. The perception of the quality of social environment by the individual offers a key target for intervention research into the interplay between cognitive and social healthterm·dom.

Interventions The ultimate goal is to address modifiable social healthterm·dom risks and protective factors in preventive interventions. Interventions can take place at a clinical level and should adopt an individually tailored approach ( 45 ), since “one size does not fit all.’ Interventions at a public health level can raise awareness of the importance of social participationterm·key for brain health. The results of the first large dementia preventionterm·key trial showing a benefit on cognition, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), indicated that multi-domain lifestyle-based intervention including diet, exercise, blood pressure monitoring and stimulation of social interaction through activities could contribute to the prevention of cognitive and functional decline amongst at-risk older people ( 58 , 59 ).

Delineations Our conceptual frameworkterm·key describes what constitutes social healthterm·dom; it does not suggest pathways to social healthterm·dom. We see social healthterm·dom from the perspective of the immediate social circle. We consider socioeconomic and cultural characteristics as factors influencing social healthterm·dom. Likewise personal characteristics (e.g., introversion) are considered as internal psychological factors that influence social healthterm·dom but are not a constituent part of social healthterm·dom. While our focus is on the onset of dementia, we acknowledge the important role of social healthterm·dom in living with dementia ( 60 ).

Limitations The epidemiological studies included in the development of our conceptual frameworkterm·key used associations, so causality cannot be imputed. The study of possible causal mechanisms will be a major challenge. The databases of the epidemiological studies do not include the full spectrum of social healthterm·dom domains, as only social participationterm·key is noted at the individual level. Additionally, studies do not always use validated measures (e.g., for lonelinessterm·key). A broader spectrum of social healthterm·dom markers should be included in epidemiological databases and valid tools for measuring domain-related aspects are needed. Another limitation is that this conceptual frameworkterm·key is a based on western studies. A more diverse perspective is needed for future work ( 61 ).

Conclusion This conceptual frameworkterm·key has scope for identifying and structuring social healthterm·dom markers relevant in the context of cognitive decline and dementia. Our SHARED project demonstrates its potential feasibility and highlights gaps for relevant future epidemiological research. This is an important first step toward the identification of modifiable risks and factors, which may in turn shape new avenues for preventive interventions.

We therefore suggest that social healthterm·dom is recognized and included in future (epidemiological) studies as one of the factors influencing cognitive functioning and dementia. It is now time to highlight the paradigm of social healthterm·dom in dementia as a priority for dementia research.

Author contributions MV-D, MP, and KW-O designed the study. MV-D coordinated the study and drafted the manuscript. SS, ML-B, DS, A-KW, JM, IV, HW, and AM applied the conceptual frameworkterm·key. All authors contributed to the manuscript and agreed with the submitted version.

Footnotes Funding This project was supported through funding organizations under the aegis of JPND 733051082: Netherlands, ZonMw grant number 733050831; Sweden, Res. C. Health, Working Life, Welf FORTE grant number 2018-01888; Australia, NHMRC RG181672 United Kingdom, Alz Society UK grant number 469; Germany, BMBF 01ED1905; and Poland, NCBiR (National Center for Research and Development in Poland, project number JPND/06/2020).

Conflict of interest PS was on the Expert Advisory Committee of Biogen Australia. HB was or had been an expert advisory committee member for Nutricia, Roche and Skin2Neuron, a consultant to Biogen, and a member of the Clinical Advisory Committee for Cranbrook Care and Montefiore Homes. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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