The FAIR Guiding Principles for scientific data management and stewardship — TEI-tagged view

Mark D. WilkinsonpersName, Michel DumontierpersName, IJsbrand Jan AalbersbergpersName, Gabrielle AppletonpersName, Myles AxtonpersName, Arie BaakpersName, Niklas BlombergpersName, Jan-Willem BoitenpersName, Luiz Bonino da Silva SantospersName, Philip E. BournepersName, Jildau BouwmanpersName, Anthony J. BrookespersName, Tim ClarkpersName, Mercè CrosaspersName, Ingrid DillopersName, Olivier DumonpersName, Scott EdmundspersName, Chris T. EvelopersName, Richard FinkerspersName, Alejandra Gonzalez-BeltranpersName, Alasdair J.G. GraypersName, Paul GrothpersName, Carole GoblepersName, Jeffrey S. GrethepersName, Jaap HeringapersName, Peter A.C ’t HoenpersName, Rob HooftpersName, Tobias KuhnpersName, Ruben KokpersName, Joost KokpersName, Scott J. LusherpersName, Maryann E. MartonepersName, Albert MonspersName, Abel L. PackerpersName, Bengt PerssonpersName, Philippe Rocca-SerrapersName, Marco RoospersName, Rene van SchaikpersName, Susanna-Assunta SansonepersName, Erik SchultespersName, Thierry SengstagpersName, Ted SlaterpersName, George StrawnpersName, Morris A. SwertzpersName, Mark ThompsonpersName, Johan van der LeipersName, Erik van MulligenpersName, Jan VelteroppersName, Andra WaagmeesterpersName, Peter WittenburgpersName, Katherine WolstencroftpersName, Jun ZhaopersName, Barend MonspersName (2016date). “The FAIR Guiding Principles for scientific data management and stewardship.” Scientific Datatitle·j.

Object of study — the FAIR Guiding Principlesterm and machine-actionable stewardship of scholarly digital research objectsterm

Research question — which minimal, domain-independent principles let people and machines find, access, integrate, and reuse scholarly digital objectsterm

Contribution — the first formal publication of the FAIR Principlesterm, their rationale, implementation boundaries, and exemplar community implementations

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The FAIR Guiding Principlesterm for scientific data management and stewardship Abstract There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders—representing academia, industry, funding agencies, and scholarly publishers—have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principlesterm. The intent is that these may act as a guideline for those wishing to enhance the reusabilityterm of their data holdings. Distinct from peer initiativesterm that focus on the human scholar, the FAIR Principlesterm put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals. This Comment is the first formal publication of the FAIR Principlesterm, and includes the rationale behind them, and some exemplar implementations in the community.

Comment Supporting discovery through good data managementterm Good data managementterm is not a goal in itself, but rather is the key conduit leading to knowledge discovery and innovationterm, and to subsequent data and knowledge integration and reuse by the community after the data publication process. Unfortunately, the existing digital ecosystem surrounding scholarly data publication prevents us from extracting maximum benefit from our research investments (e.g., ref. 1 ). Partially in response to this, science funders, publishers and governmental agencies are beginning to require data management and stewardship plans for data generated in publicly funded experiments. Beyond proper collection, annotation, and archival, data stewardshipterm includes the notion of ‘long-term careterm’ of valuable digital assets, with the goal that they should be discovered and re-used for downstream investigations, either alone, or in combination with newly generated data. The outcomes from good data managementterm and stewardship, therefore, are high quality digital publicationsterm that facilitate and simplify this ongoing process of discovery, evaluation, and reuse in downstream studies. What constitutes ‘good data managementterm’ is, however, largely undefined, and is generally left as a decision for the data or repository owner. Therefore, bringing some clarity around the goals and desiderata of good data managementterm and stewardship, and defining simple guideposts to inform those who publish and/or preserve scholarly data, would be of great utility.

This article describes four foundational principles—Findabilityterm, Accessibilityterm, Interoperabilityterm, and Reusabilityterm—that serve to guide data producers and publishersterm as they navigate around these obstacles, thereby helping to maximize the added-value gained by contemporary, formal scholarly digital publishing. Importantly, it is our intent that the principles apply not only to ‘data’ in the conventional sense, but also to the algorithms, tools, and workflowsterm that led to that data. All scholarly digital research objectsterm 2 —from data to analytical pipelines—benefit from application of these principles, since all components of the research process must be available to ensure transparency, reproducibility, and reusabilityterm.

There are numerous and diverse stakeholders who stand to benefit from overcoming these obstacles: researchers wanting to share, get credit, and reuse each other’s data and interpretations; professional data publishers offering their services; software and tool-builders providing data analysis and processing services such as reusable workflows; funding agencies (private and public) increasingly concerned with long-term data stewardshipterm; and a data science community mining, integrating and analysing new and existing data to advance discovery. To facilitate the reading of this manuscript by these diverse stakeholders, we provide definitions for common abbreviations in Box 1 . Humans, however, are not the only critical stakeholders in the milieu of scientific data. Similar problems are encountered by the applications and computational agentsterm that we task to undertake data retrieval and analysis on our behalf. These ‘computational stakeholdersterm’ are increasingly relevant, and demand as much, or more, attention as their importance grows. One of the grand challenges of data-intensive science, therefore, is to improve knowledge discovery through assisting both humans, and their computational agentsterm, in the discovery of, access to, and integration and analysis of, task-appropriate scientific data and other scholarly digital objectsterm.

For certain types of important digital objectsterm, there are well-curated, deeply-integrated, special-purpose repositories such as Genbank 3 , Worldwide Protein Data Bank (wwPDBterm 4 ), and UniProtterm 5 in the life sciences; Space Physics Data Facility (SPDF; http://spdf.gsfc.nasa.gov/ ) and Set of Identifications, Measurements and Bibliography for Astronomical Data (SIMBAD 6 ) in the space sciences. These foundational and critical core resources are continuously curating and capturing high-value reference datasets and fine-tuning them to enhance scholarly output, provide support for both human and mechanical users, and provide extensive tooling to access their content in rich, dynamic ways. However, not all datasets or even data types can be captured by, or submitted to, these repositories. Many important datasets emerging from traditional, low-throughput bench science don’t fit in the data models of these special-purpose repositories, yet these datasets are no less important with respect to integrative research, reproducibility, and reuse in general. Apparently in response to this, we see the emergence of numerous general-purpose data repositoriesterm, at scales ranging from institutional (for example, a single university), to open globally-scoped repositories such as Dataverseterm 7 , FigShare ( http://figshare.com ), Dryad 8 , Mendeley Data ( https://data.mendeley.com/ ), Zenodo ( http://zenodo.org/ ), DataHub ( http://datahub.io ), DANS ( http://www.dans.knaw.nl/ ), and EUDat 9 . Such repositories accept a wide range of data types in a wide variety of formats, generally do not attempt to integrate or harmonize the deposited data, and place few restrictions (or requirements) on the descriptors of the data deposition. The resulting data ecosystem, therefore, appears to be moving away from centralization, is becoming more diverse, and less integrated, thereby exacerbating the discovery and re-usability problemterm for both human and computational stakeholdersterm.

A specific example of these obstacles could be imagined in the domain of gene regulation and expression analysis. Suppose a researcher has generated a dataset of differentially-selected polyadenylation sites in a non-model pathogenic organism grown under a variety of environmental conditions that stimulate its pathogenic state. The researcher is interested in comparing the alternatively-polyadenylated genes in this local dataset, to other examples of alternative-polyadenylation, and the expression levels of these genes—both in this organism and related model organisms—during the infection process. Given that there is no special-purpose archive for differential polyadenylation data, and no model organism database for this pathogen, where does the researcher begin?

We will consider the current approach to this problem from a variety of data discovery and integration perspectives. If the desired datasets existed, where might they have been published, and how would one begin to search for them, using what search tools? The desired search would need to filter based on specific species, specific tissues, specific types of data (Poly-A, microarray, NGS), specific conditions (infection), and specific genes—is that information (‘metadataterm’) captured by the repositories, and if so, what formats is it in, is it searchable, and how? Once the data is discovered, can it be downloaded? In what format(s)? Can that format be easily integrated with private in-house data (the local dataset of alternative polyadenylation sites) as well as other data publications from third-parties and with the community’s core gene/protein data repositories? Can this integration be done automatically to save time and avoid copy/paste errors? Does the researcher have permission to use the data from these third-party researchers, under what license conditions, and who should be cited if a data-point is re-used?

Questions such as these highlight some of the barriers to data discovery and reuse, not only for humans, but even more so for machines; yet it is precisely these kinds of deeply and broadly integrative analyses that constitute the bulk of contemporary e-Science. The reason that we often need several weeks (or months) of specialist technical effort to gather the data necessary to answer such research questions is not the lack of appropriate technology; the reason is, that we do not pay our valuable digital objectsterm the careful attention they deserve when we create and preserve them. Overcoming these barriers, therefore, necessitates that all stakeholders—including researchers, special-purpose, and general-purpose repositories—evolve to meet the emergent challenges described above. The goal is for scholarly digital objectsterm of all kinds to become ‘first class citizensterm’ in the scientific publication ecosystem, where the quality of the publication—and more importantly, the impact of the publication—is a function of its ability to be accurately and appropriately found, re-used, and cited over time, by all stakeholders, both human and mechanical.

With this goal in-mind, a workshop was held in Leiden, Netherlands, in 2014, named ‘Jointly Designing a Data Fairport’. This workshop brought together a wide group of academic and private stakeholders all of whom had an interest in overcoming data discovery and reuse obstacles. From the deliberations at the workshop the notion emerged that, through the definition of, and widespread support for, a minimal set of community-agreed guiding principles and practicesterm, all stakeholders could more easily discover, access, appropriately integrate and re-use, and adequately cite, the vast quantities of information being generated by contemporary data-intensive science. The meeting concluded with a draft formulation of a set of foundational principles that were subsequently elaborated in greater detail—namely, that all research objects should be Findable, Accessible, Interoperable and Reusable (FAIRterm·def) both for machines and for people. These are now referred to as the FAIR Guiding Principlesterm. Subsequently, a dedicated FAIRterm·def working group, established by several members of the FORCE11 community 10 fine-tuned and improved the Principles. The results of these efforts are reported here.

The significance of machines in data-rich research environments The emphasis placed on FAIRnessterm·var being applied to both human-driventerm and machine-driven activitiesterm, is a specific focus of the FAIR Guiding Principlesterm that distinguishes them from many peer initiativesterm (discussed in the subsequent section). Humans and machines often face distinct barriers when attempting to find and process data on the Web. Humans have an intuitive sense of ‘semantics’ (the meaning or intent of a digital objectterm) because we are capable of identifying and interpreting a wide variety of contextual cues, whether those take the form of structural/visual/iconic cues in the layout of a Web page, or the content of narrative notes. As such, we are less likely to make errors in the selection of appropriate data or other digital objectsterm, although humans will face similar difficulties if sufficient contextual metadataterm is lacking. The primary limitation of humans, however, is that we are unable to operate at the scope, scale, and speed necessitated by the scale of contemporary scientific data and complexity of e-Science. It is for this reason that humans increasingly rely on computational agentsterm to undertake discovery and integration tasks on their behalf. This necessitates machines to be capable of autonomously and appropriately acting when faced with the wide range of types, formats, and access-mechanisms/protocols that will be encountered during their self-guided exploration of the global data ecosystem. It also necessitates that the machines keep an exquisite record of provenanceterm·var such that the data they are collecting can be accurately and adequately cited. Assisting these agents, therefore, is a critical consideration for all participants in the data management and stewardship process—from researchers and data producers to data repository hosts.

Throughout this paper, we use the phrase ‘machine actionableterm’ to indicate a continuum of possible states wherein a digital objectterm provides increasingly more detailed information to an autonomously-acting, computational data explorer. This information enables the agent—to a degree dependent on the amount of detail providedterm·var—to have the capacity, when faced with a digital objectterm never encountered before, to: a) identify the type of objectterm·var (with respect to both structure and intent), b) determine if it is useful within the context of the agent’s current task by interrogating metadataterm and/or data elements, c) determine if it is usable, with respect to license, consent, or other accessibility or use constraintsterm·var, and d) take appropriate action, in much the same manner that a human would.

For example, a machine may be capable of determining the data-type of a discovered digital objectterm, but not capable of parsing it due to it being in an unknown format; or it may be capable of processing the contained data, but not capable of determining the licensing requirements related to the retrieval and/or use of that data. The optimal state—where machines fully ‘understand’ and can autonomously and correctly operate-on a digital objectterm—may rarely be achieved. Nevertheless, the FAIR principlesterm provide ‘steps along a path’ toward machine-actionabilityterm; adopting, in whole or in part, the FAIR principlesterm, leads the resource along the continuum towards this optimal state. In addition, the idea of being machine-actionable applies in two contexts—first, when referring to the contextual metadataterm surrounding a digital objectterm (‘what is it?’), and second, when referring to the content of the digital objectterm itself (‘how do I process it/integrate it?’). Either, or both of these may be machine-actionable, and each forms its own continuum of actionability.

Finally, we wish to draw a distinction between data that is machine-actionable as a result of specific investment in software supporting that data-type, for example, bespoke parsersterm that understand life science wwPDBterm files or space science Space Physics Archive Search and Extract (SPASE) files, and data that is machine-actionable exclusively through the utilization of general-purpose, open technologiesterm. To reiterate the earlier point—ultimate machine-actionabilityterm·def occurs when a machine can make a useful decision regarding data that it has not encountered before. This distinction is important when considering both (a) the rapidly growing and evolving data environment, with new technologies and new, more complex data-types continuously being developed, and (b) the growth of general-purpose repositories, where the data-types likely to be encountered by an agent are unpredictable. Creating bespoke parsersterm, in all computer languages, for all data-types and all analytical tools that require those data-types, is not a sustainable activity. As such, the focus on assisting machines in their discovery and exploration of data through application of more generalized interoperability technologies and standardsterm at the data/repository level, becomes a first-priority for good data stewardshipterm.

The FAIR Guiding Principlesterm in detail Representatives of the interested stakeholder-groups, discussed above, coalesced around four core desiderata—the FAIR Guiding Principlesterm—and limited elaboration of these, which have been refined ( Box 2 ) from the meeting’s original draft, available at ( https://www.force11.org/node/6062 ). A separate document that dynamically addresses community discussion relating to clarifications and explanations of the principles, and detailed guidelines for and examples of FAIRterm·def implementations, is currently being constructed ( http://datafairport.org/fair-principles-living-document-menu ). The FAIR Guiding Principlesterm describe distinct considerations for contemporary data publishing environmentsterm with respect to supporting both manual and automated deposition, exploration, sharing, and reuse. While there have been a number of recent, often domain-focused publications advocating for specific improvements in practices relating to data management and archival 1 , 11 , 12 , FAIRterm·def differs in that it describes concise, domain-independent, high-level principles that can be applied to a wide range of scholarly outputs. Throughout the Principles, we use the phrase ‘(meta)data’ in cases where the Principle should be applied to both metadataterm and data.

The elements of the FAIR Principlesterm are related, but independent and separable. The Principles define characteristics that contemporary data resources, tools, vocabularies and infrastructuresterm should exhibit to assist discovery and reuse by third-parties. By minimally defining each guiding principle, the barrier-to-entry for data producers, publishers and stewards who wish to make their data holdings FAIRterm·def is purposely maintained as low as possible. The Principles may be adhered to in any combination and incrementally, as data providers’ publishing environments evolve to increasing degrees of ‘FAIRnessterm·var’. Moreover, the modularity of the Principles, and their distinction between data and metadataterm, explicitly support a wide range of special circumstances. One such example is highly sensitive or personally-identifiable dataterm, where publication of rich metadataterm to facilitate discovery, including clear rules regarding the process for accessing the data, provides a high degree of ‘FAIRnessterm·var’ even in the absence of FAIRterm·def publication of the data itself. A second example involves the publication of non-data research objects. Analytical workflowsterm, for example, are a critical component of the scholarly ecosystem, and their formal publication is necessary to achieve both transparency and scientific reproducibility. The FAIR principlesterm can equally be applied to these non-data assets, which need to be identified, described, discovered, and reused in much the same manner as data.

Specific exemplar efforts that provide varying levels of FAIRnessterm·var are detailed later in this document. Additional issues, however, remain to be addressed. First, when community-endorsed vocabularies or other (meta)data standardsterm do not include the attributes necessary to achieve rich annotation, there are two possible solutions: either publish an extension of an existing, closely related vocabulary, or—in the extreme case—create and explicitly publish a new vocabulary resource, following FAIR principlesterm (‘I2’). Second, to explicitly identify the standardterm chosen when more than one vocabulary or other (meta)data standardterm is available, and given that for instance in the life sciences there are over 600 content standardsterm, the BioSharing registry ( https://biosharing.org/ ) can be of use as it describes the standardsterm in detail, including versions where applicable.

The Principles precede implementation These high-level FAIR Guiding Principlesterm precede implementation choicesterm, and do not suggest any specific technology, standardterm, or implementation-solution; moreover, the Principles are not, themselves, a standardterm or a specificationterm. They act as a guide to data publishers and stewards to assist them in evaluating whether their particular implementation choicesterm are rendering their digital research artefacts Findable, Accessible, Interoperable, and Reusable. We anticipate that these high level principles will enable a broad range of integrative and exploratory behaviours, based on a wide range of technology choices and implementations. Indeed, many repositories are already implementing various aspects of FAIRterm·def using a variety of technology choices and several examples are detailed in the next section; examples include Scientific Data itself and how narrative data articles are anchored to a progressively FAIRterm·def structured metadataterm.

Examples of FAIRnessterm·var, and the resulting value-added Dataverseterm 7 : Dataverseterm is an open-source data repository softwareterm installed in dozens of institutions globally to support public community repositories or institutional research data repositories. Harvard Dataverseterm, with more than 60,000 datasets, is the largest of the current Dataverseterm repositories, and is open to all researchers from all research fields. Dataverseterm generates a formal citation for each depositterm, following the standardterm defined by Altman and King 13 . Dataverseterm makes the Digital Objectterm Identifier (DOI), or other persistent identifiersterm·var (Handles), public when the dataset is published (‘F’). This resolves to a landing page, providing access to metadataterm, data files, dataset terms, waivers or licenses, and version information, all of which is indexed and searchable (‘F’, ‘A’, and ‘R’). Depositsterm include metadataterm, data files, and any complementary files (such as documentation or code) needed to understand the data and analysis (‘R’). Metadataterm is always public, even if the data are restricted or removed for privacy issues (‘F’, ‘A’). This metadataterm is offered at three levels, extensively supporting the ‘I’ and ‘R’ FAIR principlesterm: 1) data citation metadataterm, which maps to DataCite schema or Dublin Core Terms, 2) domain-specific metadataterm, which when possible maps to metadataterm standardsterm used within a scientific domain, and 3) file-level metadataterm, which can be deep and extensive for tabular data files (including column-level metadataterm). Finally, Dataverseterm provides public machine-accessible interfaces to search the data, access the metadataterm and download the data files, using a token to grant access when data files are restricted (‘A’).

FAIRDOMterm ( http://fair-dom.org/about ): integrates the SEEK 14 and openBIS 15 platforms to produce a FAIR data and model management facilityterm for Systems Biology. Individual research assets (or aggregates of data and models) are identified with unique and persistent HTTP URLs, which can be registered with DOIs for publication (‘F’). Assets can be accessed over the Web in a variety of formats appropriate for individuals and/or their computers (RDF, XML) (‘I’). Research assets are annotated with rich metadataterm, using community standardsterm·var, formats and ontologies (‘I’). The metadataterm is stored as RDF to enable interoperabilityterm and assets can be downloaded for reuse (‘R’).

ISAterm 16 : is a community-driven metadata tracking frameworkterm to facilitate standards-compliant collection, curation, management and reuse of life science datasets. ISAterm provides progressively FAIRterm·def structured metadataterm to Nature Scientific Data’s Data Descriptor articles, and many GigaScience data papers, and underpins the EBI MetaboLights database among other data resources. At the heart is a general-purpose, extensible ISAterm model, originally only available as a tabular representation but subsequently enhanced as an RDF-based representation 17 , and JSON serializations to enable the ‘I’ and ‘R’, becoming ‘FAIRterm·def’ when published as linked data ( http://elixir-uk.org/node-events/201cisa-as-a-fair-research-object201d-hack-the-spec-event-1 ) and complementing other research objects 18 .

Open PHACTSterm 19 : Open PHACTSterm is a data integration platformterm for information pertaining to drug discovery. Access to the platform is mediated through a machine-accessible interface 20 which provides multiple representations that are both human (HTML) and machine readable (RDF, JSON, XML, CSV, etc), providing the ‘A’ facet of FAIRnessterm·var. The interface allows multiple URLs to be used to access information about a particular entity through a mappings service (‘F’ and ‘A’). Thus, a user can provide a ChEMBL URL to retrieve information sourced from, for example, Chemspider or DrugBank. Each call provides a canonical URL in its response (‘A’ and ‘I’). All data sources used are described using standardized dataset descriptions, following the global VoID standardterm, with rich provenanceterm·var (‘R’ and ‘I’). All interface features are described using RDF following the Linked Data API specificationterm (‘A’). Finally, a majority of the datasets are described using community agreed upon ontologies (‘I’).

wwPDBterm 4 , 21 : wwPDBterm is a special-purpose, intensively-curated data archiveterm that hosts information about experimentally-determined 3D structures of proteins and nucleic acids. All wwPDBterm entries are stably hosted on an FTP server (‘A’) and represented in machine-readable formats (text and XML); the latter are machine-actionable using the metadataterm provided by the wwPDBterm conforming to the Macromolecular Information Framework (mmCIF 22 ), a data standardterm of the International Union of Crystallography (IUCr) (‘F’,‘I’ for humans, ‘F’,‘I’ for IUCr-aware machines). The wwPDBterm metadataterm contains cross-references to common identifiers such as PubMed and NCBI Taxonomy, and their wwPDBterm metadataterm are described in data dictionaries and schema documents ( http://mmcif.wwpdbterm.org and http://pdbml.wwpdbterm.org ) which conform to the IUCr data standardterm for the chemical and structural biology domains (‘R’). A variety of software tools are available to interpret both wwPDBterm data and meta-data (‘I’,‘R’ for humans, ‘I’,‘R’ for machines with this software). Each entry is represented by a DOI (‘F’, ‘A’ for humans and machines). The DOI resolves to a zipped file which requires special software for further interrogation/interpretation. Other wwPDBterm access points 23–25 provide access to wwPDBterm records through URLs that are likely to be stable in the long-term (‘F’), and all data and metadataterm is searchable through one or more of the wwPDB-affiliated websites (‘F’) UniProtterm 26 : UniProtterm is a comprehensive resourceterm for protein sequence and annotation data. All entries are uniquely identified by a stable URL, that provides access to the record in a variety of formats including a web page, plain-text, and RDF (‘F’ and ‘A’). The record contains rich metadataterm (‘F’) that is both human-readable (HTML) and machine-readable (text and RDF), where the RDF formatted response utilizes shared vocabularies and ontologies such as UniProtterm Core, FALDO, and ECO (‘I’). Interlinking with more than 150 different databases, every UniProtterm record has extensive links into, for example, PubMed, enabling rich citation. These links are machine-actionable in the RDF representation (‘R’). Finally, in the RDF representation, the UniProtterm Core Ontology explicitly types all records, leaving no ambiguity—neither for humans nor machines—about what the data represents (‘R’), enabling fully-automated retrieval of records and cross-referencing information.

In addition to, and in support of, communities and resources that are already pursuing FAIRterm·def objectives, the Data Citation Implementation Groupterm of Force11 has published specific technical recommendations for how to implement many of the principles 27 , with a particular focus on identifiers and their resolution, persistence, and metadataterm accessibilityterm especially related to citation. In addition, the ‘Skunkworks’ group that emerged from the Lorentz Workshop has been creating software supporting infrastructures 28 that are, end-to-end, compatible with FAIR principlesterm, and can be implemented over existing repositories. These code modules have a particular focus on metadataterm publication and searchability, compatibility in cases of strict privacy considerations, and the extremely difficult problem of data and metadataterm interoperabilityterm (manuscript in preparation). Finally, there are several emergent projects, some listed in Box 3 , for which FAIRterm·def is a key objective. These projects may provide valuable advice and guidance for those wishing to become more FAIRterm·def.

FAIRnessterm·var is a prerequisite for proper data management and data stewardshipterm The ideas within the FAIR Guiding Principlesterm reflect, combine, build upon and extend previous work by both the Concept Web Allianceterm ( https://conceptweblog.wordpress.com/ ) partners, who focused on machine-actionabilityterm and harmonization of data structures and semantics, and by the scientific and scholarly organizations that developed the Joint Declaration of Data Citation Principlesterm (JDDCP 29 ), who focused on primary scholarly data being made citable, discoverable and available for reuse, so as to be capable of supporting more rigorous scholarship. An attempt to define the similarities and overlaps between the FAIR Principlesterm and the JDDCP is provided at ( https://www.force11.org/node/6062 ). The FAIR Principlesterm are also complementary to the ‘Data Seal of Approvalterm’ (DSA) ( http://datasealofapproval.org/media/filer_public/2013/09/27/guidelines_2014-2015.pdf ) in that they share the general aim to render data re-usable for users other than those who originally generated them. While the DSA focuses primarily on the responsibilities and conduct of data producers and repositories, FAIRterm·def focuses primarily on the data itself. Clearly, the broader community of stakeholders is coalescing around a set of common, dovetailed visions spanning all facets of the scholarly data publishing ecosystem.

The end result, when implemented, will be more rigorous management and stewardship of these valuable digital resources, to the benefit of the entire academic community. As stated at the outset, good data managementterm and stewardship is not a goal in itself, but rather a pre-condition supporting knowledge discovery and innovationterm. Contemporary e-Science requires data to be Findable, Accessible, Interoperable, and Reusable in the long-term, and these objectives are rapidly becoming expectations of agencies and publishers. We demonstrate, therefore, that the FAIR Data Principlesterm provide a set of mileposts for data producers and publishersterm. They guide the implementation of the most basic levels of good Data Management and Stewardship practiceterm, thus helping researchers adhere to the expectations and requirements of their funding agencies. We call on all data producers and publishersterm to examine and implement these principles, and actively participate with the FAIRterm·def initiative by joining the Force11 working group. By working together towards shared, common goals, the valuable data produced by our community will gradually achieve the critical goals of FAIRnessterm·var.

Additional Information How to cite this article: WilkinsonpersName, M. D. et al. The FAIR Guiding Principlesterm for scientific data management and stewardship. Sci. Data 3:160018 doi: 10.1038/sdata.2016.18 (2016).