Consciousness and Anesthesia

Alkire, Hudetz, Tononi · Science (New York, N.Y.) · 2008 · neuroscience · 10.1126/science.1149213 · record Alkire2008-consciousness-and-anesthesia
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Claim relations is deliberately empty. The review cites everything by number, so no prior work is named in the article text; and its one explicit self-positioning against rival theories ("Other frameworks for consciousness, emphasizing access to a global workspace ( 65 , 66 ), or the formation of large coalitions of neurons ( 43 ), are also consistent with many of the findings described here") asserts compatibility, which is none of builds-on / extends / contradicts / replicates. method is 'review' by inference from the synthesising voice of the text; the paper never labels itself a review in words, so the method_evidence quote is the clearest sentence showing it reasons over an assembled evidence base rather than reporting new data. 2026-08-12, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
8 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
This record’s own method is review, and the tags below follow from that. A review’s findings, quantities and statistics are things stated IN this paper, and some of them report results obtained elsewhere. No tag on this page names a different author. Measured across every review in this corpus, 81% of a review’s tags carry no citation at all — most of them are the review speaking. The corpus does not adjudicate the rest: read an unmarked tag as a claim this paper makes, not necessarily one it made first.
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Other fields define these differently the same word, defined another way in another discipline
consciousness 10 fields · information 4 fields · integration 3 fields · anesthesia 2 fields · functional connectivity 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 34 concept tags on this paper, 3 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
unconsciousness unresponsiveness amnesia consciousness integration information integrated information phi corticothalamic system thalamus consciousness switch burst-suppression up-state down-state bispectral index isolated forearm technique intraoperative awareness transfer entropy small-world transcranial magnetic stimulation hyperkinetic mutism akinetic mutism vegetative state ketamine propofol thiopental cerebellum global workspace default network connectional core slow wave sleep anesthesia mesial cortical areas depth of anesthesia Anesthetics abolish consciousness by blocking the corticothalamic system's capacity to integrate information, not simply by silencing neurons Because the corticothalamic system is a small-world network, cutting only a few long-range connections fragments it into functionally disconnected components Deep anesthesia collapses the response repertoire into a stereotypic two-state burst-suppression regime, so activity carries almost no information even while remaining globally integrated general anesthetics REM sleep sevoflurane nitrous oxide precuneus posterior cingulate cortex inferior parietal electroencephalogram functional connectivity ion channels large-scale integration small-world networks burst-suppression pattern electroencephalogram (EEG) flat EEG thalamic metabolism EEG coherence anesthetic dose repertoire of discriminable states field potentials phi (Φ) bits current density review

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1126/science.1149213. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 3 · claim_relations 6 · claim_type 1 · concept_edges 14 · concepts 3 · content_tags 77 · contribution 1 · limitations 9 · mechanisms 14 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 10 · transfers 5

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; 1 of 14 relations here carries that mark. The rest are the tagger’s reading of the sentence quoted beside them.

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facettagfieldconf.whose words
object_of_studyhow general anesthetics abolish consciousness, and whether the states they produce are unconsciousness or only unresponsiveness and amnesia
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object_of_studythe paper's words
research_questionwhen we are anesthetized, does consciousness always vanish — and what neural change is the one that actually removes it
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research_questionthe paper's words
contributionargues that anesthetics remove consciousness when they block the integration of information — either by disconnecting the posterior corticothalamic complex or by collapsing its repertoire of states — and that the field's behavioural test cannot tell unconsciousness from unresponsiveness
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenonanesthetic-induced unconsciousness
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phenomenonthe paper's words
methodreview
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also in: review
methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismstwo independent routes to unconsciousness are proposed, so that a brain can fail either by disconnecting or by running out of things to say
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mechanisms[3]0.95the tagger's words
mechanismsburst-suppression is the crucial counterexample to activity-based accounts: the system is active, hyperexcitable and globally integrated, and still unconscious, because its repertoire has fallen to two states
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mechanisms[4]0.95the tagger's words
mechanismsa causal role for the thalamus is demoted to a readout by a timing argument: cortical EEG changes at the instant of loss of consciousness, thalamic EEG only ten minutes later
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mechanisms[5]0.9the tagger's words
mechanismsunresponsiveness is separated from unconsciousness by existence proofs rather than by measurement: dreaming and pharmacological paralysis are states with experience and without response
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mechanisms[6]0.95the tagger's words
mechanismsamnesia is separated from unconsciousness the same way: the isolated forearm technique buys a channel of report that survives paralysis, and patients use it and then deny having been awake
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mechanisms[7]0.95the tagger's words
mechanismsTMS is used as a perturbation probe: push the cortex and measure how far and how specifically the response travels, which turns integration into something measurable rather than inferred from correlation
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mechanisms[8]0.9the tagger's words
mechanismsconvergence across two unrelated ways of losing consciousness — anesthesia and slow-wave sleep — is what carries the argument, since neither alone would isolate the common factor
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mechanisms[9]0.95the tagger's words
mechanismsnetwork topology explains the disproportion between a small pharmacological insult and a total loss of consciousness: in a small-world graph a few long-range edges hold the whole thing together
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mechanisms[10]0.9the tagger's words
mechanismslesion data and anesthesia data are used as mutual corroboration, on the argument that a drug and a knife reaching the same region should produce the same deficit
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mechanisms[11]0.9the tagger's words
mechanismsa theory is used to license a negative rule of inference, forbidding both directions of the usual behavioural reading
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mechanisms[12]0.95the tagger's words
mechanismsthe die metaphor is doing real theoretical work, not decoration: it makes 'integration' and 'information' visibly separable — a die that disintegrates versus a die that is flattened
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mechanisms[13]0.85the tagger's words
limitationsThe integrated-information measure the paper's framework rests on cannot at present be computed for real brains, only for small simulated systems.
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what this limits: every quantitative use of the integrated-information framework: IN PRACTICE, PHI CAN ONLY BE MEASURED RIGOROUSLY FOR SMALL, SIMULATED SYSTEMS - not for the brains the theory is about
limitations[0]the tagger's words
limitationsThe paper cannot settle which component of the posterior complex matters most, nor the role of anterior cortex.
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what this limits: any anatomical localisation drawn from the review: WHETHER THE MEDIAL OR LATERAL COMPONENT IS MORE IMPORTANT, AND WHETHER ANTERIOR CORTICAL REGIONS ARE CRITICAL ... RE[mains open]
limitations[1]the tagger's words
limitationsthe measure the theory rests on cannot be computed for a brain
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duplicate of: limitations[0] · what this limits: the same scope as limitations[0] - the measure the framework rests on cannot be computed for a brain
limitations[2]1.0the tagger's words
limitationsthe paper opens by conceding that the thing it is explaining the loss of is itself unexplained
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what this limits: everything the review explains: HOW CONSCIOUSNESS ARISES IN THE BRAIN REMAINS UNKNOWN, so the loss is described without the thing being lost being understood
limitations[3]0.95the tagger's words
limitationswhich part of the posterior complex matters is left open
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what this limits: the same scope as limitations[1] - which part of the posterior complex matters is left open
limitations[4]0.95the tagger's words
limitationsthe existing monitors fail exactly where they are needed, at the transition
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what this limits: the clinical monitors: THEY REMAIN LIMITED AT DIRECTLY INDICATING THE PRESENCE OR ABSENCE OF CONSCIOUSNESS, ESPECIALLY AROUND THE TRANSITION POINT - which is where they are needed
limitations[5]0.95the tagger's words
limitationsa disjunction the paper cannot resolve: the signal may be wrong, or the interpretation may be
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what this limits: any EEG-based correlate: EITHER THE EEG IS NOT SENSITIVE ENOUGH TO THE NEURAL PROCESSES UNDERLYING CONSCIOUSNESS, OR WE STILL DO NOT YET FULLY UNDERSTAND WHAT TO LOOK FOR
limitations[6]0.95the tagger's words
limitationsthe candidate region is deactivated in REM sleep, when experience is vivid — the paper states the counterexample to its own anatomy without resolving it
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what this limits: the deactivation-equals-unconsciousness account: MESIAL CORTICAL AREAS ARE DEACTIVATED IN REM SLEEP, WHEN SUBJECTS EXPERIENCE VIVID DREAMS
limitations[7]0.95the tagger's words
limitationsselective deactivation of the candidate posterior region produces altered experience, not absent experience
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what this limits: the same scope as limitations[7], from the clinical side: WHEN THESE AREAS START TO TURN OFF, SUBJECTS REPORT DREAMLIKE FEELINGS WITH DEPERSONALIZATION AND OUT OF BODY EXPERIENCES, RATHER THAN UNCONSCIOUSNESS
limitations[8]0.9the tagger's words
transfersthe classical measurement of information as reduction of uncertainty in bits, applied to brain states and conscious experience
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transfers[0]the tagger's words
transfersthe bit and the reduction of uncertainty among alternatives, imported wholesale as the measure of how much experience a brain state constitutes
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transfers[1]0.95the tagger's words
transferssmall-world topology, used to explain why a small pharmacological insult to a few long-range connections can fragment the whole system
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transfers[2]0.95the tagger's words
transferstransfer entropy, borrowed as a directional measure so that feedforward and feedback interactions can be scored separately
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transfers[3]0.9the tagger's words
transfersthe die as a model of a state repertoire, extended so that losing integration shatters it into many dice and losing information flattens it to two faces
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transfers[4]0.9the tagger's words
conceptsintegration
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also in: integration
concepts[4]0.85the paper's words
conceptsinformation
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also in: information
concepts[5]the paper's words
conceptsburst-suppression
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concepts[11]the paper's words
sensesunconsciousness — behavioural sense: failing to move on command, the 160-year-old clinical criterion
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senses[0]0.95the tagger's words
sensesunconsciousness — experiential sense: absence of experience, which the behavioural criterion does not track
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senses[1]0.95the tagger's words
sensesinformation — classical sense: reduction of uncertainty among alternatives, measured in bits
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senses[2]0.95the tagger's words
sensesinformation — the paper's working sense: the number of discriminable activity patterns a neural system can produce
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senses[3]0.95the tagger's words
sensesintegration — the ability of different cortical regions to interact effectively, explicitly flagged as a loose definition
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senses[4]0.95the tagger's words
sensesconsciousness — graded, increasing with the repertoire of discriminable states, not all-or-none
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senses[5]0.95the tagger's words
sensesthalamus — as a switch that gates consciousness, versus as a readout of cortical state; the paper names both and argues for the second
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senses[6]0.9the tagger's words
sensesdown-state — local, induced under one TMS site, versus global, induced across the connectional core; the same term at two scales in one paragraph
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senses[7]0.85the tagger's words
sensesanesthetics — two classes by clinical role: intravenous agents to induce, volatile agents to maintain
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senses[8]0.95the tagger's words
sensesloss of consciousness — as an abrupt threshold crossing, versus as a shrinking or dimming; the paper says the evidence shows both
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senses[9]0.9the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: narrative review — pharmacological, neuroimaging, lesion, EEG and TMS evidence read together and against a theory, with no new data
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a second reading DIFFERING from the recorded value. Recorded: review — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: loss of consciousness under general anesthesia
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a second reading DIFFERING from the recorded value. Recorded: anesthetic-induced unconsciousness — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationscritiques → the behavioural definition of unconsciousness that anesthesia has used since its introduction
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claim_relations[0]0.95the tagger's words
claim_relationscritiques → the thalamic switch hypothesis (ref 2), that the thalamus gates consciousness
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differs in: READOUT AGAINST SWITCH - the axis is what role the thalamus plays, not whether it is involved. 'the effects of anesthetics on the thalamus effect Quotation withheld, and thalamic activity may not be a sufficient basis for consciousness.' The thalamic-switch hypothesis is not denied its data; it is denied its causal direction.
claim_relations[1]0.95the tagger's words
claim_relationssupports → the integrated information theory of consciousness (ref 52)
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claim_relations[2]0.95the tagger's words
claim_relationscontradicts → the clinical inference from absent motor response to absent consciousness
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claim_relations[3]0.95the tagger's words
claim_relationsextends → existing depth-of-anesthesia monitoring, by proposing monitors that measure integration and information separately
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claim_relations[4]0.9the tagger's words
claim_relationssupports → rival frameworks — global workspace and coalitions of neurons — which the paper declines to argue against
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claim_relations[5]0.85the tagger's words
concept_edgesunresponsiveness —distinct-from→ unconsciousness
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strength of the relation: 0.95
concept_edges[0]the tagger's words
concept_edgesEVIDENCE CORRECTED (RE-GROUNDED) · amnesia —distinct-from→ unconsciousness
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EVIDENCE CORRECTED: RE-GROUNDED. The old span named only unconsciousness. This sentence names both and distinguishes them ON THE EVIDENCE AVAILABLE FOR EACH - anaesthesia 'undoubtedly induces ... amnesia' while the extent to which it causes unconsciousness 'is harder to establish'. — strength of the relation: 0.95 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says anesthesia induces amnesia while its extent of causing unconsciousness is harder to establish; distinct-from is implied, not stated.
concept_edges[1]the tagger's words
concept_edgesintegrated information —operationalised-as→ phi
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strength of the relation: 0.95
concept_edges[3]the tagger's words
concept_edgesintegration —operationalised-as→ transfer entropy
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strength of the relation: 0.85 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span names transfer entropy as a measure of directional interactions; operationalising integration is a loose reading.
concept_edges[4]the tagger's words
concept_edgesthalamus —distinct-from→ consciousness switch
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differs in: THE AXIS IS CAUSAL DIRECTION. 'the effects of anesthetics on the thalamus effect Quotation withheld, and thalamic activity may not be a sufficient basis for consciousness.' The thalamic data are not disputed; what is disputed is whether the thalamus DRIVES the state or REPORTS it. · strength of the relation: 0.75 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the thalamic effect 'MAY represent' a readout rather than a consciousness switch; distinct-from is hedged.
concept_edges[5]the tagger's words
concept_edgesburst-suppression —causes→ information
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direction on the measure: reduces · the relation itself is separately evidenced · strength of the relation: 0.8 · the relation stated: the collapse to burst-suppression carries a LOSS OF information - two states where there were many Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span is a fragment ('with a corresponding loss of information'); the cause is not in it.
concept_edges[6]the tagger's words
concept_edgesup-state —distinct-from→ down-state
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strength of the relation: 0.95
also in: up-state · down-state
concept_edges[7]the tagger's words
concept_edgescorticothalamic system —is-a→ small-world
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strength of the relation: 0.85
concept_edges[8]the tagger's words
concept_edgescerebellum —contrasted-with→ corticothalamic system
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strength of the relation: 0.9 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but endpoint by anaphora: 'By contrast' = the corticothalamic complex (previous sentence).
concept_edges[9]the tagger's words
concept_edgesdepth of anesthesia —operationalised-as→ bispectral index
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strength of the relation: 0.85
concept_edges[10]the tagger's words
concept_edgesglobal workspace —distinct-from→ integrated information
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strength of the relation: 0.7 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says other frameworks such as the global workspace are ALSO CONSISTENT with the findings; distinct-from is loose.
concept_edges[11]the tagger's words
concept_edgespropofol —contrasted-with→ thiopental
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strength of the relation: 0.8
also in: propofol · thiopental
concept_edges[12]the tagger's words
concept_edgesslow wave sleep —contrasted-with→ anesthesia
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strength of the relation: 0.8 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says anesthesia is not the same as natural sleep; the endpoint 'slow wave sleep' is narrower.
concept_edges[13]the tagger's words
concept_edgesmesial cortical areas —part-of→ default network
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strength of the relation: 0.75
concept_edges[14]the tagger's words
content_tagsMost anesthetic agents appear to cause unconsciousness by acting, directly or indirectly, on a posterior lateral corticothalamic complex around the inferior parietal lobe, and perhaps a medial cortical core.
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content_tags.findings[0]the tagger's words
content_tagsThe thalamic effects of anesthetics may be a readout of global cortical activity rather than a consciousness switch.
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content_tags.findings[1]the tagger's words
content_tagsBehavioural unresponsiveness under anesthesia does not reliably indicate that the patient is unconscious.
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content_tags.findings[2]the tagger's words
content_tagsPost-operative amnesia is likewise not evidence that the patient was unconscious during surgery.
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content_tags.findings[3]the tagger's words
content_tagsEvidence from both anesthesia and sleep converges on two routes to unconsciousness: loss of cortical integration or collapse of the repertoire of cortical activity patterns.
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content_tags.findings[4]the tagger's words
content_tagsOn the integrated-information account, consciousness is graded rather than all-or-none, scaling with the size of a system's repertoire of discriminable states.
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content_tags.findings[5]the tagger's words
content_tagsintraoperative awareness occurs about once in every 1000–2000 operations
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content_tags.findings[6]1.0the tagger's words
content_tagssevoflurane sedation cuts relative thalamic metabolism by 23% while subjects are still awake and responsive
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content_tags.findings[7]1.0the tagger's words
content_tagscortical EEG changed at the instant of loss of consciousness while thalamic EEG did not change for another ten minutes
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content_tags.findings[8]1.0the tagger's words
content_tagsin REM sleep the two dissociate the other way: cortical EEG activated as if awake, thalamic EEG showing slow waves as if asleep
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content_tags.findings[9]1.0the tagger's words
content_tagsafter thalamic ablation the cortex still produces an activated EEG
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content_tags.findings[10]1.0the tagger's words
content_tagsthe thalamic effects of anesthetics in animals disappear when the cortex is removed
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content_tags.findings[11]1.0the tagger's words
content_tagsketamine raises global metabolism, especially in the thalamus
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content_tags.findings[12]1.0the tagger's words
content_tagsat equivalent hypnotic doses propofol and thiopental both deactivate posterior areas, but only propofol deactivates frontal cortex
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content_tags.findings[13]1.0the tagger's words
content_tagslarge frontal lesions do not by themselves produce unconsciousness
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content_tags.findings[14]1.0the tagger's words
content_tagsa clinically unresponsive woman with large frontal lesions produced cortical activation patterns indistinguishable from healthy subjects when asked to imagine playing tennis
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content_tags.findings[15]1.0the tagger's words
content_tagsas consciousness fades, EEG coherence in the gamma range drops between the two frontal cortices and between frontal and occipital regions
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content_tags.findings[16]1.0the tagger's words
content_tagsthe coherence loss is far stronger for long-range than for local connections
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content_tags.findings[17]1.0the tagger's words
content_tagsin rats losing responsiveness, information transfer falls in the feedback direction first
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content_tags.findings[18]1.0the tagger's words
content_tagsanesthesia suppresses the late component of visual responses but not the early feedforward one, and abolishes contextual and attentional modulation
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content_tags.findings[19]1.0the tagger's words
content_tagsin early non-REM sleep a TMS pulse produces only a short (<150 ms) local response, suggesting a loss of integration
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content_tags.findings[20]1.0the tagger's words
content_tagsTMS to mesial parietal cortex, over the main connectional hub, triggers a stereotypic high-amplitude slow wave closely resembling a spontaneous one
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content_tags.findings[21]1.0the tagger's words
content_tagsnitrous oxide at intermediate doses selectively deactivates posterior mesial cortex, yet subjects report dreamlike experience rather than none
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content_tags.findings[22]1.0the tagger's words
content_tagsgeneralized convulsive seizures abolish consciousness even though neural activity is high and hypersynchronous, because that activity is stereotypic
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content_tags.findings[23]1.0the tagger's words
content_tagsGABA agonists injected into the intralaminar nuclei make rats fall asleep, and a nicotine injection there awakens rats under sevoflurane
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content_tags.findings[24]1.0the tagger's words
content_tagscomputer simulations show a rapid state transition at a critical anesthetic dose, consistent with a breakdown of network integration
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content_tags.findings[25]1.0the tagger's words
content_tagspatients can be aware and responsive during surgery while the bispectral index says otherwise
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content_tags.findings[26]1.0the tagger's words
content_tagsintegrated information
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content_tags.definitions[0]the tagger's words
content_tagslarge-scale integration
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content_tags.definitions[2]the tagger's words
content_tagshyperkinetic mutism
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content_tags.definitions[3]the tagger's words
content_tagssmall-world networks
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content_tags.definitions[4]the tagger's words
content_tagsburst-suppression pattern
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content_tags.definitions[5]the tagger's words
content_tagsintegration
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also in: integration
content_tags.definitions[6]1.0the tagger's words
content_tagsinformation
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also in: information
content_tags.definitions[7]1.0the tagger's words
content_tagsphi
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also in: phi
content_tags.definitions[8]1.0the tagger's words
content_tagsburst-suppression
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content_tags.definitions[9]1.0the tagger's words
content_tagsSmall-world networks
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content_tags.definitions[10]1.0the tagger's words
content_tagstransfer entropy
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content_tags.definitions[11]1.0the tagger's words
content_tagsisolated forearm technique
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content_tags.definitions[12]1.0the tagger's words
content_tagshyperkinetic mutism
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content_tags.definitions[13]1.0the tagger's words
content_tagselectroencephalogram (EEG)
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content_tags.definitions[14]1.0the tagger's words
content_tagsdown-state
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also in: down-state
content_tags.definitions[15]1.0the tagger's words
content_tagsflat EEG
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also in: flat EEG
content_tags.definitions[16]1.0the tagger's words
content_tagsinformation
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also in: information
content_tags.definitions[17]1.0the tagger's words
content_tagsonce in every 1000–2000 operations — rate at which a surgical patient regains or retains consciousness under general anesthesia (intraoperative awareness)
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content_tags.quantities[0]the tagger's words
content_tags23% — reduction of relative thalamic metabolism under sevoflurane sedation in subjects who are still awake and responsive, showing thalamic suppression is not sufficient for unconsciousness
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content_tags.quantities[1]the tagger's words
content_tagsonce in every 1000–2000 operations — rate of intraoperative awareness
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content_tags.quantities[2]1.0the tagger's words
content_tagsover 160 years — age of the behavioural definition of unconsciousness
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content_tags.quantities[3]1.0the tagger's words
content_tags23% — reduction of relative thalamic metabolism under sevoflurane sedation in awake responsive subjects
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content_tags.quantities[4]1.0the tagger's words
content_tags10 minutes — lag between the cortical EEG change at loss of consciousness and any thalamic change
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content_tags.quantities[5]1.0the tagger's words
content_tags20 to 80 Hz — gamma range in which coherence drops as consciousness fades
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content_tags.quantities[6]1.0the tagger's words
content_tags20 to 60 Hz — gamma range of the flash-evoked response in rat occipital cortex
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content_tags.quantities[7]1.0the tagger's words
content_tags300 ms — duration of the sequential TMS-evoked response during wakefulness
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content_tags.quantities[8]1.0the tagger's words
content_tags<150 ms — duration of the local TMS-evoked response in early non-REM sleep
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content_tags.quantities[9]1.0the tagger's words
content_tags>100 ms — the late visual response component that anesthesia suppresses
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content_tags.quantities[10]1.0the tagger's words
content_tags1 Hz or less — frequency of the slow oscillation between up- and down-states in slow wave sleep
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content_tags.quantities[11]1.0the tagger's words
content_tagsroughly once a second — rate of up/down oscillation at intermediate anesthetic concentrations
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content_tags.quantities[12]1.0the tagger's words
content_tagsa tenth of a second or more — duration of the synaptic silence in the down-state
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content_tags.quantities[13]1.0the tagger's words
content_tags1.1% isoflurane — anesthetic concentration in the rat flash-response experiment
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content_tags.quantities[14]1.0the tagger's words
content_tags0.2 Hz — rate of the flashing light stimulus
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content_tags.quantities[15]1.0the tagger's words
content_tags1 bit — information from a two-sided outcome, the coin and the flattened die
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content_tags.quantities[16]1.0the tagger's words
content_tags~2.6 bits — information from a six-faced die
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content_tags.quantities[17]1.0the tagger's words
content_tagsa trillion faces — the scale of the experiential repertoire in the paper's metaphor
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content_tags.quantities[18]1.0the tagger's words
content_tagstransfer entropy
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content_tags.statistics[0]1.0the tagger's words
content_tagsphi (Φ)
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also in: phi (Φ)
content_tags.statistics[1]1.0the tagger's words
content_tagsEEG coherence
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also in: EEG coherence
content_tags.statistics[2]1.0the tagger's words
content_tagsbits
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also in: bits
content_tags.statistics[3]0.85the tagger's words
content_tagscurrent density
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content_tags.statistics[4]0.95the tagger's words
content_tagsbispectral index
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content_tags.statistics[5]0.85the tagger's words
content_tagsthalamic metabolism
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content_tags.variables[0]1.0the tagger's words
content_tagsEEG coherence
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also in: EEG coherence
content_tags.variables[1]1.0the tagger's words
content_tagstransfer entropy
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content_tags.variables[2]1.0the tagger's words
content_tagsdepth of anesthesia
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content_tags.variables[3]1.0the tagger's words
content_tagsanesthetic dose
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content_tags.variables[4]1.0the tagger's words
content_tagsrepertoire of discriminable states
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content_tags.variables[5]1.0the tagger's words
content_tagsfield potentials
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content_tags.variables[6]1.0the tagger's words
content_tagsfunctional connectivity
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content_tags.variables[7]1.0the tagger's words

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