A novel visuospatial priming task for rats with relevance to Tourette syndrome and modulation of dopamine levels

Amitai, Weber, Swerdlow, Sharp, Breier, Halberstadt, Young · Neuroscience & Biobehavioral Reviews · 2013 · neuroscience · 10.1016/j.neubiorev.2012.09.007 · record Amitai2013-a-novel-visuospatial-priming-task-for-rats-w
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Replication status is 'replicated' on two grounds, both inside text I read: the paper repeats the short-prime challenge and reports that individual priming values correlated significantly across the two repetitions, and the companion paper Amitai2015, also in this corpus, states in its own words that its findings replicate this report. The article is hybrid — its abstract says it reviews the relevant literature as well as reporting new data — but the contribution being tagged is the new rat paradigm, so method is 'behavioural-experiment'; the review component is not captured by the facets. The third limitation quote is a mid-sentence clause, quoted as an exact substring to avoid the curly quotation marks in the surrounding sentence. 2026-08-18 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 5 concept tags on this paper, all 5 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
negative priming inhibitory information processing Tourette syndrome prime duration amphetamine An inverted-U relation between dopamine transmission and inhibitory processing: amphetamine pushes low-NP animals toward and high-NP animals past an optimum, so the same drug raises or abolishes priming depending on baseline state Brief primes are routed through preconscious, automatic processing, which is the route that generates negative priming; longer primes recruit more controlled processing and weaken it A species difference in speed-accuracy strategy - rats protect response speed and sacrifice accuracy - channels the priming cost into accuracy rather than latency negative priming (NP) accuracy priming value correct response latency priming value high NP and low NP rats convergent validity negative priming trial baseline trial prime stimulus duration AMPH dose trial type response accuracy latency to correct response premature responses priming level body weight interaction effect (factorial analysis) significant interactions between trial type, AMPH dose, and negative priming levels in the drug-free state correlation significantly positively correlated Latin square counterbalanced design a Latin square design behavioural-experiment

Legend

relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1016/j.neubiorev.2012.09.007. The reading view exists for the papers whose licence permits it.

Every tag on this page

claim_relations 1 · claim_type 1 · concept_edges 1 · concepts 5 · content_tags 34 · controls 1 · limitations 3 · mechanisms 3 · method 1 · phenomenon 1 · senses 4 · transfers 1

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 1 relation here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
claim_typemethod
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
claim_typethe paper's words
phenomenonnegative visuospatial priming
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phenomenonthe paper's words
methodbehavioural-experiment
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methodthe paper's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[0]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[1]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[2]the tagger's words
limitationsRats that could not acquire stable performance had to be dropped, reducing the sample.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
limitations[0]the tagger's words
limitationsThe task's whole-body response makes it insensitive to the tens-of-milliseconds latency effects that carry negative priming in humans.
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limitations[1]the tagger's words
limitationsNo animal model, including this one, can capture the full neurobiology of the varied forms of Tourette syndrome.
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limitations[2]the tagger's words
transfersthe Yerkes-Dodson inverted-U law, imported to explain why the same amphetamine dose helps low-NP and harms high-NP rats
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transfers[0]the tagger's words
controlstarget and non-target locations varied pseudorandomly, equal counts per location per session, with location unpredictable
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eliminates: a location bias and an anticipation strategy - the same design as the 2015 sister paper, and the same two-part justification · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
conceptsnegative priming
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[0]0.95the paper's words
conceptsinhibitory information processing
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[1]0.95the paper's words
conceptsTourette syndrome
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[2]0.95the paper's words
conceptsprime duration
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[3]0.95the paper's words
conceptsamphetamine
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: amphetamine
concepts[4]0.95the paper's words
sensesNEGATIVE PRIMING - a priming effect defined as a LOSS, and defined as the NORMAL one: `Quotation withheld` Second record tonight whose priming effect harms performance (after Keane2015's costs), and the first where the harm is the healthy result
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[0]0.95the tagger's words
sensesLESS PRIMING IS THE DEFICIT - the direction that inverts everything. `TS subjects exhibit diminished NP`, so a smaller effect is the pathological finding and a larger one is intact function. Any summary that treats priming magnitude as one quantity with a good direction gets this record backwards, and the corpus contains many records where more priming is the notable result
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[1]0.95the tagger's words
sensesPRIMING AS A PROGNOSTIC INDEX - `their NP levels predict their response to behavioral therapy`. Not a phenomenon under study, not an instrument for probing representations, but a clinical measurement used to forecast treatment outcome. A fourth job for the word in this corpus, alongside phenomenon, instrument and paradigm
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[2]0.95the tagger's words
sensesTHE EFFECT ONLY APPEARS UNDER CHALLENGE, which is a fact about the animal model rather than about the animals: `During the short prime challenge, rats exhibited lower accuracy in NP vs. baseline trials`. A 0.25 s prime was needed to make the phenomenon measurable at all, and the same duration was then carried into the drug study. A translational model whose sensitivity had to be engineered into the timing
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[3]0.95the tagger's words
claim_relationsbuilds-on → the human visuospatial priming task of Tipper (1985) and Swerdlow et al. (1996)
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claim_relations[0]the tagger's words
concept_edgesTourette syndrome —causes→ negative priming
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
direction on the measure: reduces · strength of the relation: 0.9 · note: 'reduces' is correct and reads backwards without the sense rows: the reduction is a reduction OF A REDUCTION. Negative priming is itself a performance loss, and Tourette patients show LESS of it - so less priming is the pathological direction here.
concept_edges[1]0.95the tagger's words
content_tagsinteraction effect (factorial analysis)
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content_tags.statistics[0]the tagger's words
content_tagscorrelation
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: correlation
content_tags.statistics[1]the tagger's words
content_tagsLatin square counterbalanced design
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content_tags.statistics[2]the tagger's words
content_tagsRats trained on the new task showed a robust negative priming effect, performing worse when the target appeared where the distractor had just been.
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content_tags.findings[0]the tagger's words
content_tagsThe authors report this as the first rodent paradigm measuring visuospatial priming.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[1]the tagger's words
content_tagsA shorter prime duration made the negative priming effect stronger.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[2]the tagger's words
content_tagsLengthening the prime from 0.5 s to 1 s weakened negative priming, the mirror image of the short-prime result.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[3]the tagger's words
content_tagsThe degree of negative priming appears to be a stable trait of each animal.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[4]the tagger's words
content_tagsAmphetamine abolished negative priming at every dose in rats that showed strong drug-free priming.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[5]the tagger's words
content_tagsIn rats the negative priming effect was most robust in response accuracy, with lower accuracy on negative-priming trials than on baseline trials.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[6]the tagger's words
content_tagsAmphetamine significantly increased premature responses at all doses.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[7]the tagger's words
content_tagsnegative priming (NP)
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content_tags.definitions[0]the tagger's words
content_tagsinhibitory information processing
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[1]the tagger's words
content_tagsaccuracy priming value
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content_tags.definitions[3]the tagger's words
content_tagscorrect response latency priming value
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content_tags.definitions[4]the tagger's words
content_tagshigh NP and low NP rats
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content_tags.definitions[5]the tagger's words
content_tagsconvergent validity
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content_tags.definitions[6]the tagger's words
content_tagsnegative priming trial
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[7]the tagger's words
content_tagsbaseline trial
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content_tags.definitions[8]the tagger's words
content_tagsprime stimulus duration
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content_tags.variables[0]the tagger's words
content_tagsAMPH dose
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also in: AMPH dose
content_tags.variables[1]the tagger's words
content_tagstrial type
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: trial type
content_tags.variables[2]the tagger's words
content_tagsresponse accuracy
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[3]the tagger's words
content_tagslatency to correct response
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content_tags.variables[4]the tagger's words
content_tagspremature responses
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content_tags.variables[5]the tagger's words
content_tagspriming level
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also in: priming level
content_tags.variables[6]the tagger's words
content_tagsbody weight
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: body weight
content_tags.variables[7]the tagger's words
content_tags13 of 16 — final sample after three rats failed to reach stable task performance and were excluded
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content_tags.quantities[0]the tagger's words
content_tags0, 0.25, 0.5, or 1 mg/kg — d-amphetamine doses given subcutaneously 10 min before testing, in a counterbalanced within-subject design
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content_tags.quantities[1]the tagger's words
content_tags0.5 s to 0.25 s — the reduction in prime stimulus duration that produced the most robust negative priming
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content_tags.quantities[2]the tagger's words
content_tags5 Hz — flicker rate of the non-target distractor light, distinguishing it from the continuous target light
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content_tags.quantities[3]the tagger's words
content_tags0.5 s for seven rats, 0.75 s for three rats, 1 s for one rat, and 1.5 s for two rats — the shortest probe stimulus duration each rat could sustain at criterion performance
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content_tags.quantities[4]the tagger's words
content_tagsaround 15 sessions — average training needed to reach criterion on the visual discrimination stage
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content_tags.quantities[5]the tagger's words
content_tags90% — proportion of free-feeding body weight at which rats were maintained by food restriction throughout testing
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content_tags.quantities[6]the tagger's words

Interpretive choices

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