A novel visuospatial priming task for rats with relevance to Tourette syndrome and modulation of dopamine levels — TEI-tagged view

Amitai, Weber, Swerdlow, Sharp, Breier, Halberstadt, Young · 2013 · neuroscience · doi:10.1016/j.neubiorev.2012.09.007 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Replication status is 'replicated' on two grounds, both inside text I read: the paper repeats the short-prime challenge and reports that individual priming values correlated significantly across the two repetitions, and the companion paper Amitai2015, also in this corpus, states in its own words that its findings replicate this report. The article is hybrid — its abstract says it reviews the relevant literature as well as reporting new data — but the contribution being tagged is the new rat paradigm, so method is 'behavioural-experiment'; the review component is not captured by the facets. The third limitation quote is a mid-sentence clause, quoted as an exact substring to avoid the curly quotation marks in the surrounding sentence. 2026-08-18 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
negative priming4 inhibitory information processing2 Tourette syndrome prime duration5 amphetamine3 behavioural-experiment117

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenonnegative visuospatial priming— “NP is the normal reduction of performance when identifying target stimuli that appears where non-target stimuli appeared previously.”
claim-typemethod— “In summary, we describe a novel visuospatial priming task that detects negative priming in rats.”
method — evidence— “Performance was challenged by shortening prime duration and by administering amphetamine.”
transferfrom classical experimental psychology of arousal and performance: the Yerkes-Dodson inverted-U law, imported to explain why the same amphetamine dose helps low-NP and harms high-NP rats— “This “rate-dependent” effect of AMPH recalls the widely observed pattern described in the Yerkes-Dodson law, which states that performance, especially in difficult tasks, initially increases with physiological or mental arousal, but when levels of arousal become too high, performance is degraded”transfers[0]
mechanismAn inverted-U relation between dopamine transmission and inhibitory processing: amphetamine pushes low-NP animals toward and high-NP animals past an optimum, so the same drug raises or abolishes priming depending on baseline state— “The finding that AMPH improves NP in animals with normally low levels of NP, while reducing NP in animals with high levels of NP, suggests that an optimal level of dopamine transmission might produce maximal amount of negative visuospatial priming, and that levels either above or below that optimal point result in reduced or no negative…mechanisms[0]
mechanismBrief primes are routed through preconscious, automatic processing, which is the route that generates negative priming; longer primes recruit more controlled processing and weaken it— “Conceivably, shorter duration primes may favor processing by preconscious/automatic mechanisms, which may be required for the negative priming effect.”mechanisms[1]
mechanismA species difference in speed-accuracy strategy - rats protect response speed and sacrifice accuracy - channels the priming cost into accuracy rather than latency— “The tendency of rats to maintain speed of responding at the cost of accuracy may therefore explain why the NP effect in our task primarily impacted response accuracy rather than response latencies.”mechanisms[2]
builds-on the human visuospatial priming task of Tipper (1985) and Swerdlow et al. (1996)— “In this study, we aimed to describe the characteristics and heuristic values of a novel rat negative visuospatial priming paradigm ( Figure 1 ), based on a well-established human visuospatial priming task ( Swerdlow et al., 1996 ; Tipper, 1985 ).”claim_relations[0]
senseNEGATIVE PRIMING - a priming effect defined as a LOSS, and defined as the NORMAL one: `NP is the normal reduction of performance when identifying target stimuli that appears where non-target stimuli appeared previously.` Second record tonight whose priming effect harms performance (after Keane2015's costs), and the first where the harm is the healthy result— “NP is the normal reduction of performance when identifying target stimuli that appears where non-target stimuli appeared previously. TS subjects exhibit diminished NP”senses[0]
senseLESS PRIMING IS THE DEFICIT - the direction that inverts everything. `TS subjects exhibit diminished NP`, so a smaller effect is the pathological finding and a larger one is intact function. Any summary that treats priming magnitude as one quantity with a good direction gets this record backwards, and the corpus contains many records where more priming is the notable result— “NP is the normal reduction of performance when identifying target stimuli that appears where non-target stimuli appeared previously. TS subjects exhibit diminished NP”senses[1]
sensePRIMING AS A PROGNOSTIC INDEX - `their NP levels predict their response to behavioral therapy`. Not a phenomenon under study, not an instrument for probing representations, but a clinical measurement used to forecast treatment outcome. A fourth job for the word in this corpus, alongside phenomenon, instrument and paradigm— “Individuals with Tourette syndrome (TS) exhibit deficits in inhibitory information processing which may reflect impaired neural mechanisms underlying symptoms and can be detected using a negative priming (NP) task. NP is the normal reduction of performance when identifying target stimuli that appears where non-target stimuli appeared…senses[2]
senseTHE EFFECT ONLY APPEARS UNDER CHALLENGE, which is a fact about the animal model rather than about the animals: `During the short prime challenge, rats exhibited lower accuracy in NP vs. baseline trials`. A 0.25 s prime was needed to make the phenomenon measurable at all, and the same duration was then carried into the drug study. A translational model whose sensitivity had to be engineered into the timing— “During the short prime challenge, rats exhibited lower accuracy in NP vs. baseline trials, indicative of inhibitory information processing. Modulation by amphetamine administration indicates that this drug had rate-dependent effects”senses[3]
controltarget and non-target locations varied pseudorandomly, equal counts per location per session, with location unpredictable — held — rules out a location bias and an anticipation strategy - the same design as the 2015 sister paper, and the same two-part justification— “The location of the target and non-target stimuli varied pseudorandomly between trials, so that each location contained the stimuli an equal number of times per session, but their location was not predictable on any given trial.”controls[0]
effect directionTourette syndrome —causes→ negative priming — reduces— “Individuals with Tourette syndrome (TS) exhibit deficits in inhibitory information processing which may reflect impaired neural mechanisms underlying symptoms and can be detected using a negative priming (NP) task. NP is the normal reduction of performance when identifying target stimuli that appears where non-target stimuli appeared…concept_edges[1]
noteTourette syndrome —causes→ negative priming — 'reduces' is correct and reads backwards without the sense rows: the reduction is a reduction OF A REDUCTION. Negative priming is itself a performance loss, and Tourette patients show LESS of it - so less priming is the pathological direction here.concept_edges[1]
weightTourette syndrome —causes→ negative priming — 0.9
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concept_edges[1]
outcome (stated by the tagger, no quotation)control — heldcontrols[0]
replicationreplicated
limitationRats that could not acquire stable performance had to be dropped, reducing the sample.
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limitations[0]
limitationThe task's whole-body response makes it insensitive to the tens-of-milliseconds latency effects that carry negative priming in humans.
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limitations[1]
limitationNo animal model, including this one, can capture the full neurobiology of the varied forms of Tourette syndrome.
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limitations[2]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingRats trained on the new task showed a robust negative priming effect, performing worse when the target appeared where the distractor had just been.
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content_tags.findings[0]
findingThe authors report this as the first rodent paradigm measuring visuospatial priming.
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content_tags.findings[1]
findingA shorter prime duration made the negative priming effect stronger.
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content_tags.findings[2]
findingLengthening the prime from 0.5 s to 1 s weakened negative priming, the mirror image of the short-prime result.
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content_tags.findings[3]
findingThe degree of negative priming appears to be a stable trait of each animal.
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content_tags.findings[4]
findingAmphetamine abolished negative priming at every dose in rats that showed strong drug-free priming.
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content_tags.findings[5]
findingIn rats the negative priming effect was most robust in response accuracy, with lower accuracy on negative-priming trials than on baseline trials.
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content_tags.findings[6]
findingAmphetamine significantly increased premature responses at all doses.
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content_tags.findings[7]
quantity13 of 16 — final sample after three rats failed to reach stable task performance and were excluded
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content_tags.quantities[0]
quantity0, 0.25, 0.5, or 1 mg/kg — d-amphetamine doses given subcutaneously 10 min before testing, in a counterbalanced within-subject design
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content_tags.quantities[1]
quantity0.5 s to 0.25 s — the reduction in prime stimulus duration that produced the most robust negative priming
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content_tags.quantities[2]
quantity5 Hz — flicker rate of the non-target distractor light, distinguishing it from the continuous target light
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content_tags.quantities[3]
quantity0.5 s for seven rats, 0.75 s for three rats, 1 s for one rat, and 1.5 s for two rats — the shortest probe stimulus duration each rat could sustain at criterion performance
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content_tags.quantities[4]
quantityaround 15 sessions — average training needed to reach criterion on the visual discrimination stage
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content_tags.quantities[5]
quantity90% — proportion of free-feeding body weight at which rats were maintained by food restriction throughout testing
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content_tags.quantities[6]
variableprime stimulus duration (independent)
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content_tags.variables[0]
variableAMPH dose (independent)
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content_tags.variables[1]
variabletrial type (independent)
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content_tags.variables[2]
variableresponse accuracy (dependent)
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content_tags.variables[3]
variablelatency to correct response (dependent)
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content_tags.variables[4]
variablepremature responses (dependent)
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content_tags.variables[5]
variablepriming level (moderator)
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content_tags.variables[6]
variablebody weight (control)
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content_tags.variables[7]
definitionnegative priming (NP)
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content_tags.definitions[0]
definitioninhibitory information processing
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content_tags.definitions[1]
definitionaccuracy priming value
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content_tags.definitions[3]
definitioncorrect response latency priming value
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content_tags.definitions[4]
definitionhigh NP and low NP rats
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content_tags.definitions[5]
definitionconvergent validity
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content_tags.definitions[6]
definitionnegative priming trial
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content_tags.definitions[7]
definitionbaseline trial
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content_tags.definitions[8]
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
conceptnegative priming — not defined in this paper's own words; a priming effect whose NORMAL value is a loss - slower or less accurate identification of a target appearing where a distractor was. And in this literature LESS of it is the deficit, which inverts the usual reading of effect size
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concepts[0]
conceptinhibitory information processing — not defined in this paper's own words; what the reduction is taken to index: the target is harder to identify BECAUSE the location was actively suppressed a moment earlier, so the loss is evidence of a working mechanism rather than of a failing one
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concepts[1]
conceptTourette syndrome — not defined in this paper's own words; the clinical anchor, and the reason the effect is measured at all here - patients show DIMINISHED negative priming, and how much they show predicts how they respond to behavioural therapy
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concepts[2]
conceptprime duration — not defined in this paper's own words; the challenge variable that makes the effect appear at all in rats - 0.25 s produced the most robust negative priming, so the model's sensitivity is a property of the timing rather than of the animals
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concepts[3]
conceptamphetamine — not defined in this paper's own words; the pharmacological challenge, and the result is reported with its own qualifier - 'rate-dependent effects', meaning the drug's direction depended on the baseline rather than being uniform
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concepts[4]
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
interaction effect (factorial analysis) as written: significant interactions between trial type, AMPH dose, and negative priming levels in the drug-free state
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content_tags.statistics[0]
correlation as written: significantly positively correlated
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content_tags.statistics[1]
Latin square counterbalanced design as written: a Latin square design
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content_tags.statistics[2]

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