Behavioral origin of sound-evoked activity in mouse visual cortex

Bimbard, Sit, Lebedeva, Reddy, Harris, Carandini · Nature Neuroscience · 2023 · neuroscience · 10.1038/s41593-022-01227-x · record Bimbard2023-behavioral-origin-of-sound-evoked-activity-i
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Claim type 'mechanism' captures the paper's positive explanation (movement/internal state produces the activity); the paper also carries a strong null-result component (transectomy did not reduce sound-evoked activity in V1) and a critique of the multisensory interpretation of prior work, neither of which the single-valued facet can hold. Method is 'electrophysiology' (Neuropixels in V1 and hippocampal formation) but the design also includes videography/facemap movement tracking, encoding-model fitting, and anatomical transectomy with Allen Connectivity Atlas fibre reconstruction. Replication status is 'contested' because the paper itself reports that its central result conflicts with the previously published transectomy study while agreeing only partially with a layer-1 whisking study. Prior work is cited numerically, so claim_relation targets are described rather than named by author. 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
61 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.
Other fields define these differently the same word, defined another way in another discipline
control 43 fields · bias 38 fields · prediction 24 fields · accuracy 9 fields · reliability 5 fields · model 4 fields · and 5 more →

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 45 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
multisensory sound video V1 visual cortex auditory cortex hippocampal formation projection fiber transectomy cut movement whisker behavior internal state pupil spontaneous dimension low-dimensional high-dimensional PC1 variance cvPCA interaction decoding accuracy correlation stereotyped model auditory model behavioral model full model prediction subspace trial neuron layer two-photon threshold fraction control bias ISI reliability stimulus Sounds change the animal's internal state, which simultaneously drives uninstructed body movements and a widespread low-dimensional modulation of cortical (and hippocampal) activity; the apparent multisensory response is that state signal, not an auditory input. Sound-evoked V1 activity is generated by sound-triggered changes in internal and behavioral state rather than by auditory-cortical projections. intracellular extracellular auditory PC1 dimensionality behavioral subspace body motion variables binned firing rate body movements decoding accuracy Wilcoxon signed-rank test Wilcoxon right-tailed signed rank test principal component analysis (cross-validated) ridge regression reduced-rank regression cross-validation threefold cross-validation ANOVA repeated-measures ANOVA permutation/shuffling test a shuffling method Pearson correlation coefficient Fisher z-transformation Fisher’s Z-transforming F-test F-statistic versus constant model cross-validated Principal Component Analysis shuffling method electrophysiology

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field
unrecordable relationunhoused_relationsa relation the paper asserts that this vocabulary cannot express, with the reason

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1038/s41593-022-01227-x. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 3 · claim_relations 9 · claim_type 1 · concept_edges 13 · content_tags 91 · contribution 1 · controls 1 · limitations 9 · mechanisms 6 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 15 · transfers 4 · unhoused_relations 4

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 13 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studywhether the activity that sounds evoke in visual cortex is an auditory signal at all, or a low-dimensional signal of internal state and movement
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object_of_studythe paper's words
research_questionwhether that activity has the attributes of a behavioral signal - low dimension, a footprint beyond the cortex, independence from auditory input, and predictability from movement
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research_questionthe paper's words
contributionthe sound-evoked activity is one-dimensional, identical in the hippocampal formation, unchanged by cutting the auditory-to-visual fibers, and fully predicted by the small movements the sounds elicit
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenonsound-evoked activity in visual cortex
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[0]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[1]the tagger's words
mechanismssounds elicit small uninstructed movements, mainly whisker twitches, which are stereotyped across trials and mice and different for each sound
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mechanisms[2]1.0the tagger's words
mechanismsand the movement precedes the neural activity by a few tens of milliseconds, even with no stimulus present
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mechanisms[3]1.0the tagger's words
mechanismsthe subspace of activity predictable from movement during spontaneous behavior overlaps the sound-related subspace far more than the video-related one
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mechanisms[4]1.0the tagger's words
mechanismsand the paper stops short of a direct cause - cortical activity and body movements may both arise from changes in the internal state instead
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mechanisms[5]0.8the tagger's words
limitationsThe results do not rule out genuine auditory signals reaching visual cortex from auditory cortex.
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what this limits: the negative conclusion about auditory input: OUR FINDINGS DO NOT EXCLUDE THE POSSIBILITY OF GENUINE AUDITORY SIGNALS INHERITED BY VISUAL CORTEX FROM AUDITORY CORTEX
limitations[0]the tagger's words
limitationsRecordings sampled mainly deep layers, not layer 2/3 where earlier conflicting results were obtained.
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what this limits: any comparison with the earlier conflicting layer 2/3 results: OUR V1 RECORDINGS WERE BIASED TOWARD LAYERS 4-6
limitations[1]the tagger's words
limitationsAuditory projections might affect only a small or low-firing subset of V1 neurons that these recordings missed.
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what this limits: the same negative conclusion, from the sampling side: IT IS ALSO POSSIBLE THAT AUDITORY PROJECTIONS AFFECT ONLY A MINOR FRACTION OF V1 NEURONS, OR THAT THEY AFFECT NEURONS THAT DO NOT FIRE AT HIGH RATES, AND THAT WE MISSED THESE NEURONS IN OUR RECORDINGS
limitations[2]the tagger's words
limitationsOnly facial movements were measured and only with linear analyses; other body parts or richer models could predict the neural activity better.
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what this limits: the claim that facial movement predicts the activity well: IT IS POSSIBLE THAT MOVEMENTS OF OTHER BODY PARTS, OR MORE COMPLEX ANALYSES, WOULD PROVIDE EVEN BETTER PREDICTIONS OF THE NEURAL ACTIVITY ELICITED BY SOUNDS
limitations[3]the tagger's words
limitationsThe behavioral-origin conclusion is scoped to these experiments.
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what this limits: the behavioural-origin conclusion, bounded by the paper itself: THESE RESULTS SUGGEST THAT, AT LEAST IN OUR EXPERIMENTS, THE SOUND-EVOKED ACTIVITY HAD A BEHAVIORAL ORIGIN
limitations[4]the tagger's words
limitationsgenuine auditory signals are not excluded - the projections exist and may carry them for other stimuli or contexts, or affect neurons the recordings missed
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what this limits: the same scope as limitations[0], with the anatomy: PROJECTIONS FROM AUDITORY TO VISUAL CORTEX EXIST AND MAY CARRY AUDITORY SIGNALS FOR OTHER stimuli or contexts
limitations[5]1.0the tagger's words
limitationsonly facial movements were measured and the analyses are linear, so other body parts or better analyses could predict even more
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what this limits: the prediction result: ALL THE MOVEMENTS WE MEASURED ARE IN THE FACE, AND OUR ANALYSES ARE LINEAR
limitations[6]1.0the tagger's words
limitationsthe disagreement with the study that introduced the same cut cannot be settled here, and three method differences are offered instead
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what this limits: the disagreement with the transectomy study: THE PREVIOUS STUDY WAS CONDUCTED INTRACELLULARLY AND MOSTLY IN LAYERS 2/3, against extracellular recording in layers 4-6 here
limitations[7]1.0the tagger's words
limitationsand the disagreement with the whisking study is likewise attributed to recording method, layer, and an analysis that used a hard threshold where this one estimated a fraction
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what this limits: the comparison with the whisking study, which agrees in part: IN AGREEMENT WITH OUR RESULTS, THIS STUDY FOUND THAT WHISKING EXPLAINS A FRACTION OF THOSE NEURONS' SOUND-EVOKED ACTIVITY
limitations[8]1.0the tagger's words
transfersthe low dimension and brain-wide footprint of behavioral signals, used here as a diagnostic signature
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transfers[0]1.0the tagger's words
transfersthe marginalisation that separates video-related from sound-related components
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transfers[1]1.0the tagger's words
transferscross-validated principal component analysis, and the contrast with a high-dimensional image code
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transfers[2]0.9the tagger's words
transfersa published fiber atlas, used to estimate what fraction of the projection the cut actually removed
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transfers[3]1.0the tagger's words
controlsa ridge regression of the auditory PC1 on the motion PCs, run alongside the cross-correlogram
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eliminates: the AUTOCORRELATION of the two signals as the source of an apparently large cross-correlation - two slow signals correlate at long lags whether or not they are related · outcome (stated by the tagger, no quotation): held
controls[0]0.9the tagger's words
unhoused_relationsmovement → neural activity
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CORRELATION WITH A STATED LEAD-LAG, and no type for it. Auditory PC1 activity correlated with movement during spontaneous behaviour (r = 0.29 +/- 0.03 s.e.), and movement PRECEDED neural activity by a few tens of milliseconds. Recording this as 'causes' in either direction overstates it; recording it as nothing loses a measured result with its direction. Replaces the retracted concept_edges[32], which pointed the other way.
unhoused_relations[0]the tagger's words
unhoused_relationsinternal state → behavior
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CO-ORDINATE, NOT CAUSAL. The paper names them as a pair every time - 'low-dimensional changes in internal state and behavior', 'behavioral and state signals have profound effects on sensory areas', 'these behavioral and state signals are low-dimensional and largely orthogonal'. Both are offered as joint explanations of the multisensory signals, and movement is an instance of the behavioural half. No edge type can record that two things occupy the same role.
unhoused_relations[1]the tagger's words
unhoused_relationsbody movements → multisensory
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THE PAPER'S ACTUAL CLAIM, WHICH THE RETRACTED EDGE INVERTED: stereotyped body movements are elicited by sounds, images and odours, and those movements EXPLAIN neural activity previously interpreted as multisensory. In their own experiments video-evoked responses in hippocampal formation 'could be largely explained by video-evoked body movements'.
unhoused_relations[2]the tagger's words
unhoused_relationssound-evoked activity → hippocampal formation
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THE ACTIVITY RESEMBLES, NOT THE REGIONS: sound-evoked activity in V1 is stereotyped across neurons and mice, independent of auditory-cortex projections, and Quotation withheld - which receives little direct auditory input. The paper's account is that both reflect small stereotyped body movements, so the resemblance is evidence of a COMMON CAUSE and not of any identity between V1 and the hippocampal formation.
unhoused_relations[3]the tagger's words
sensesAN APPARENTLY MULTISENSORY SIGNAL EXPLAINED AWAY BY behavior: neural activity that is apparently multisensory MAY SIMPLY ARISE from low-dimensional signals associated with internal state and behavior
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senses[0]1.0the tagger's words
sensesand the account being replaced is stated first, with its evidence - suppression by inhibiting auditory cortex, mimicry by stimulating auditory fibers
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senses[1]1.0the tagger's words
sensesTHE HYPOTHESIS IS TURNED INTO FOUR ADVANCE PREDICTIONS: low dimension, a broad footprint beyond the cortex, independence from auditory input, and predictability from behavior
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senses[2]1.0the tagger's words
sensesTHREE MODELS, AND THE RANKING IS THE FINDING: one from sound identity alone, one from movement alone, one from both - and the behavioral model performs JUST AS WELL as the full model
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senses[3]1.0the tagger's words
senseswith the auditory model's built-in advantage disclosed - it is equivalent to a test-retest prediction and would fit perfectly with infinite trials, so it performs well REGARDLESS of the origin of the activity
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senses[4]1.0the tagger's words
sensesTHE MANIPULATION WAS CHOSEN FOR WHAT IT DOES NOT DISTURB: silencing or stimulating auditory cortex would interfere with auditory processing and could affect the sound-evoked behavior, so the fibres were cut instead
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senses[5]1.0the tagger's words
sensesand the control is INSIDE the animal - bilateral recording, the uncut side, the same mouse and the same behavior
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senses[6]1.0the tagger's words
sensesTHREE METHOD DIFFERENCES ENUMERATED WHERE THE RESULT CONTRADICTS THE STUDY THAT INTRODUCED THE SAME CUT: intracellular in layers 2/3 against extracellular in layers 4-6, hours against days after surgery, and anesthetized against awake
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senses[7]1.0the tagger's words
sensesAND A THRESHOLD AGAINST A FRACTION: the earlier whisking study used a hard threshold to call a response auditory or movement-related, where this one estimated the fraction explained
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senses[8]1.0the tagger's words
sensesTHE DIMENSIONALITY OF THE RESPONSE IS USED TO CLASSIFY WHAT KIND OF SIGNAL IT IS: four significant components for sounds against seventy-nine for videos, and zero for their interaction
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senses[9]1.0the tagger's words
senseswith a between-animal correlation reported against its own within-animal ceiling - 0.34 across mice against a test-retest of 0.44 within them
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senses[10]1.0the tagger's words
sensesA SELECTION STEP CHECKED AGAINST THE RESULT IT COULD HAVE PRODUCED: the reliability of auditory responses did not correlate with the spike-contamination score, and if anything went the other way
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senses[11]1.0the tagger's words
sensesA WHOLE LITERATURE'S CONTROLS DECLARED INADEQUATE: distinguishing auditory signals from state and behavior requires careful and systematic controls, WHICH ARE RARELY PERFORMED in passively listening mice
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senses[12]1.0the tagger's words
sensesand the correlation is not claimed as causation - cortical activity and body movements may BOTH arise from changes in the internal state
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senses[13]1.0the tagger's words
senseswith the same suspicion extended outward - stereotyped movements are elicited by images and odors too, so other multisensory findings may have the same origin
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senses[14]1.0the tagger's words
alternativesclaim_type: critique
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a second reading DIFFERING from the recorded value. Recorded: mechanism — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: three encoding models fitted to the same responses - one from sound identity alone, one from measured movement alone, one from both - with the ranking of their predictions as the result
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: activity evoked by sounds in visual cortex, previously read as multisensory integration
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a second reading DIFFERING from the recorded value. Recorded: sound-evoked activity in visual cortex — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationscontradicts → studies ascribing sound-evoked V1 activity to direct input from auditory cortex
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claim_relations[0]the tagger's words
claim_relationscontradicts → the original study that introduced the auditory-to-visual transectomy
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claim_relations[1]the tagger's words
claim_relationsreplicates → the study of whisking contributions to sound-evoked activity in layer 1 V1 neurons
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claim_relations[2]the tagger's words
claim_relationsreinterprets → sound-evoked activity in visual cortex, as a signal of movement and internal state rather than an auditory input
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claim_relations[3]1.0the tagger's words
claim_relationscontradicts → the study that introduced the transectomy and found the activity abolished, with three method differences named
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differs in: the recording mode and the layer: THE PREVIOUS STUDY WAS CONDUCTED INTRACELLULARLY AND MOSTLY IN LAYERS 2/3 (WHERE SOUNDS HYPERPOLARIZED CELLS, UNLIKE IN OTHER LAYERS WHERE SOUNDS INCREASED SPIKING), WHEREAS WE RECORDED EXTRACELLULARLY MAINLY IN LAYERS 4-6
claim_relations[4]1.0the tagger's words
claim_relationsqualifies → an earlier report that whisking explains only a fraction of sound-evoked activity, by pointing at its hard threshold
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differs in: the recording technique: THIS DISCREPANCY COULD BE DUE TO DIFFERENCES IN RECORDING METHODS (TWO-PHOTON IMAGING VERSUS ELECTROPHYSIOLOGY), on a point where the two studies otherwise agree
claim_relations[5]1.0the tagger's words
claim_relationsconfirms → the reported low dimension and brain-wide footprint of movement-related activity
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claim_relations[6]1.0the tagger's words
claim_relationsgeneralises → the behavioural explanation to other multisensory findings, since images and odors also elicit stereotyped movements
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claim_relations[7]0.7the tagger's words
claim_relationscritiques → the controls used in passively listening mice, as rarely systematic enough to separate auditory from behavioral signals
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differs in: which movements were controlled for: SOME STUDIES HAVE CONTROLLED FOR EYE MOVEMENTS OR FOR OVERT BEHAVIORS SUCH AS LICKING. HOWEVER, EVEN THESE STUDIES MAY HAVE OVERLOOKED THE TYPES OF MOVEMENT THAT WE OBSERVED
claim_relations[8]1.0the tagger's words
concept_edgesmultisensory —distinct-from→ internal state
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strength of the relation: 1 · note: AN APPARENTLY MULTISENSORY SIGNAL EXPLAINED AWAY: it MAY SIMPLY ARISE from low-dimensional signals associated with internal state and behavior Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span offers internal state as an alternative explanation of multisensory signals; distinct-from is loose.
concept_edges[0]1.0the tagger's words
concept_edgessound —causes→ V1
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says V1 is influenced by sounds; causes 'V1' names a region, not an effect.
also in: sound · V1
concept_edges[1]1.0the tagger's words
concept_edgeslow-dimensional —contrasted-with→ high-dimensional
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strength of the relation: 1
concept_edges[3]1.0the tagger's words
concept_edgesbehavior —causes→ multisensory
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strength of the relation: 1 · note: the alternative offered explicitly as an alternative EXPLANATION, before any of its own data Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span offers behaviour as an alternative explanation; causes is loose.
concept_edges[6]1.0the tagger's words
concept_edgesvideo —contrasted-with→ sound
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strength of the relation: 1 · note: separated by a marginalisation borrowed from factorial analysis of variance, each averaged over the other and referred to the grand mean Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span decomposes responses into visual and auditory components; contrasted-with is loose.
also in: video · sound
concept_edges[11]1.0the tagger's words
concept_edgescvPCA —operationalised-as→ PC1
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but PC1 is the first component FOUND BY cvPCA; operationalised-as is loose.
also in: cvPCA · PC1
concept_edges[14]1.0the tagger's words
concept_edgesintracellular —contrasted-with→ extracellular
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span notes the earlier study was intracellular; the contrast is implied.
concept_edges[27]1.0the tagger's words
concept_edgeswhisker —is-a→ movement
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strength of the relation: 1 · note: subtle whisker twitches, quantified as the first component of facial motion energy Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span images whisker and body movements; is-a is loose.
also in: whisker · movement
concept_edges[28]1.0the tagger's words
concept_edgesauditory model —contrasted-with→ behavioral model
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differs in: THE AXIS IS WHETHER THE MODEL CAN DISCRIMINATE THE ORIGIN OF THE ACTIVITY. 'THE FIRST WAS A purely auditory model where the time course of neural activity depends only on sound identity. This model is EQUIVALENT TO A TEST-RETEST PREDICTION, so it will perform well regardless of the origin of sound-evoked activity.' A model that cannot fail is not evidence, and the authors say so about their own first model before using the others. Same shape as a row of Desimone1996 in this same batch. · strength of the relation: 1 · note: AND THE AUDITORY MODEL'S BUILT-IN ADVANTAGE IS DISCLOSED: it is equivalent to a test-retest prediction and would fit perfectly with infinite trials, so it performs well REGARDLESS of the origin of the activity
concept_edges[34]1.0the tagger's words
concept_edgespupil —part-of→ behavioral model
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but pupil is one input to the behavioural model; part-of is loose.
concept_edges[36]1.0the tagger's words
concept_edgessound —distinct-from→ behavior
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differs in: THE AXIS IS NECESSITY VERSUS SUFFICIENCY FOR PREDICTING THE ACTIVITY. 'Quotation withheld' The two are separated not by what they are but by their standing in one prediction, and the paper's title claim rests entirely on that asymmetry. · strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says the sounds were unnecessary and the movements sufficient to predict V1 activity; distinct-from is loose.
also in: sound · behavior
concept_edges[38]1.0the tagger's words
concept_edgesmovement —distinct-from→ internal state
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strength of the relation: 0.8 · note: THE CORRELATION IS NOT CLAIMED AS CAUSATION: cortical activity and body movements may BOTH arise from changes in internal state, which also covers the anesthetized case where movement is impossible Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says movement and cortical activity may both arise from internal state; distinct-from is loose.
concept_edges[46]0.8the tagger's words
concept_edgesV1 —same-as→ visual cortex
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strength of the relation: 1 · note: used interchangeably throughout, with the recording sites pooled under the second name
also in: V1 · visual cortex
concept_edges[55]1.0the tagger's words
content_tagsWilcoxon signed-rank test
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content_tags.statistics[0]the tagger's words
content_tagsprincipal component analysis (cross-validated)
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content_tags.statistics[1]the tagger's words
content_tagsridge regression
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content_tags.statistics[2]the tagger's words
content_tagsreduced-rank regression
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content_tags.statistics[3]the tagger's words
content_tagscross-validation
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content_tags.statistics[4]the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[5]the tagger's words
content_tagspermutation/shuffling test
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content_tags.statistics[6]the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.statistics[7]the tagger's words
content_tagsFisher z-transformation
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content_tags.statistics[8]the tagger's words
content_tagsF-test
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also in: F-test
content_tags.statistics[9]the tagger's words
content_tagsWilcoxon right-tailed signed rank test
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content_tags.statistics[10]1.0the tagger's words
content_tagsreduced-rank regression
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content_tags.statistics[11]1.0the tagger's words
content_tagscross-validated Principal Component Analysis
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content_tags.statistics[12]1.0the tagger's words
content_tagsshuffling method
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content_tags.statistics[13]1.0the tagger's words
content_tagsThe population activity that sounds evoke in mouse V1 is so stereotyped across neurons that it is essentially one-dimensional.
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content_tags.findings[0]the tagger's words
content_tagsSound-evoked activity in the hippocampal formation is remarkably similar to that in visual cortex.
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content_tags.findings[1]the tagger's words
content_tagsThe sound-evoked activity in visual cortex in these experiments cannot be explained by direct inputs from auditory cortex.
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content_tags.findings[2]the tagger's words
content_tagsA model using only sound-elicited body movements predicted sound-evoked V1 activity as well as a model that also had access to sound identity.
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content_tags.findings[3]the tagger's words
content_tagsThe sound-elicited movements lead the neural activity in time, consistent with movement (or the state driving it) preceding the cortical signal.
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content_tags.findings[4]the tagger's words
content_tagsSounds evoked small but highly reproducible uninstructed body movements that differed between sounds.
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content_tags.findings[5]the tagger's words
content_tagsThe population response showed no significant components for interactions between videos and sounds.
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content_tags.findings[6]the tagger's words
content_tagsAN APPARENTLY MULTISENSORY SIGNAL EXPLAINED AWAY BY behavior: it MAY SIMPLY ARISE from low-dimensional signals of internal state and behavior
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content_tags.findings[7]1.0the tagger's words
content_tagswith the account being replaced stated first, including its evidence from silencing and from stimulating auditory fibers
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content_tags.findings[8]1.0the tagger's words
content_tagsthe alternative is offered explicitly as an alternative explanation, before any of the paper's own data
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content_tags.findings[9]1.0the tagger's words
content_tagsTHE HYPOTHESIS IS TURNED INTO FOUR ADVANCE PREDICTIONS: low dimension, a footprint beyond cortex, independence from auditory input, predictability from behavior
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content_tags.findings[10]1.0the tagger's words
content_tagsand all four are then reported as met, in the order they were stated
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content_tags.findings[11]1.0the tagger's words
content_tagsvideo and sound components are separated by a marginalisation borrowed from factorial analysis of variance
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content_tags.findings[12]1.0the tagger's words
content_tagssound identity is decodable from single trials at 18% against a chance of one in twelve, and video identity at 95%
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content_tags.findings[13]1.0the tagger's words
content_tagsthe sound-evoked activity is essentially ONE-DIMENSIONAL, one component carrying 55% of the sound-related variance
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content_tags.findings[14]1.0the tagger's words
content_tagsA BETWEEN-ANIMAL CORRELATION REPORTED AGAINST ITS OWN WITHIN-ANIMAL CEILING: 0.34 across mice against a test-retest of 0.44 within them
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content_tags.findings[15]1.0the tagger's words
content_tagswhile the video-evoked activity is larger and much higher dimensional
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content_tags.findings[16]1.0the tagger's words
content_tagsthe same probe reached the hippocampal formation, which receives little input from auditory cortex or thalamus
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content_tags.findings[17]1.0the tagger's words
content_tagsand the sound-evoked activity there is hardly distinguishable from the one in visual cortex, r = 0.82
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content_tags.findings[18]1.0the tagger's words
content_tagswith the prediction stated before the result - IF the activity comes from auditory cortex it SHOULD BE DRASTICALLY REDUCED on the cut side
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content_tags.findings[19]1.0the tagger's words
content_tagsTHE CENTRAL NULL: identical to the opposite hemisphere at r = 0.9 and to intact controls, with cross-correlation peaking at zero delay
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content_tags.findings[20]1.0the tagger's words
content_tagsTHE MANIPULATION WAS CHOSEN FOR WHAT IT DOES NOT DISTURB: silencing or stimulating would interfere with auditory processing and could change the behavior
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content_tags.findings[21]1.0the tagger's words
content_tagsTHREE METHOD DIFFERENCES against the study that introduced the transectomy: the previous study was conducted intracellularly and mostly in layers 2/3 where sounds hyperpolarized cells, performed recordings hours after the transectomy, and anesthetized the mice
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content_tags.findings[22]1.0the tagger's words
content_tagssounds evoke small uninstructed movements, mainly whisker twitches, stereotyped across trials and mice
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content_tags.findings[23]1.0the tagger's words
content_tagsand sound identity decodes from the face at 16%, not significantly different from the 18% from the neurons
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content_tags.findings[24]1.0the tagger's words
content_tagsthe two time courses correlate at r = 0.75, and the mice that moved more consistently carried more sound information in V1
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content_tags.findings[25]1.0the tagger's words
content_tagsthe coupling survives with no stimulus at all, and the MOVEMENT PRECEDES the activity by a few tens of milliseconds
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content_tags.findings[26]1.0the tagger's words
content_tagsthe movement subspace, defined during the no-stimulus period, explains 75% of the sound-related variance and only 35% of the video-related
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content_tags.findings[27]1.0the tagger's words
content_tagsAND THE AUDITORY MODEL'S BUILT-IN ADVANTAGE IS DISCLOSED: it is a test-retest prediction and would fit perfectly with infinite trials
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content_tags.findings[28]1.0the tagger's words
content_tagsTHREE MODELS AND THE RANKING IS THE FINDING: the behavioral model performs just as well as the full model, so the sounds themselves were unnecessary
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content_tags.findings[29]1.0the tagger's words
content_tagsTHE CONTROL THAT MAKES THE CLAIM SPECIFIC: a purely visual model explains the video-evoked activity where the behavioral one does not
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content_tags.findings[30]1.0the tagger's words
content_tagsand the trial-to-trial variation is captured too, which the auditory model cannot do BY DEFINITION
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content_tags.findings[31]1.0the tagger's words
content_tagsthe conclusion is stated with its scope - AT LEAST IN OUR EXPERIMENTS, the activity had a behavioral origin
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content_tags.findings[32]1.0the tagger's words
content_tagsAND THE NULL IS BOUNDED THREE WAYS: other stimuli, other contexts, or low-firing neurons the recordings missed
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content_tags.findings[33]1.0the tagger's words
content_tagsA WHOLE LITERATURE'S CONTROLS DECLARED INADEQUATE: the necessary controls ARE RARELY PERFORMED in passively listening mice
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content_tags.findings[34]1.0the tagger's words
content_tagsA THRESHOLD AGAINST A FRACTION: the earlier whisking study used a hard threshold where this one estimated the fraction explained
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content_tags.findings[35]1.0the tagger's words
content_tagsTHE CORRELATION IS NOT CLAIMED AS CAUSATION: activity and movement may BOTH arise from changes in internal state
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content_tags.findings[36]1.0the tagger's words
content_tagsand the suspicion is extended outward - images and odors elicit stereotyped movements too
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content_tags.findings[37]1.0the tagger's words
content_tagswith the limitation running in the direction that would STRENGTHEN the claim - only facial movements, only linear analyses
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content_tags.findings[38]1.0the tagger's words
content_tagsA SELECTION STEP CHECKED AGAINST THE RESULT IT COULD HAVE PRODUCED: the contamination score did not correlate with response reliability, and if anything went the other way
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content_tags.findings[39]1.0the tagger's words
content_tagsTHE DIMENSIONALITY CLASSIFIES THE SIGNAL: 79 significant components for videos, 4 for sounds, ZERO for their interaction
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content_tags.findings[40]1.0the tagger's words
content_tagswith components found on one half of the data and their reliability measured on the other
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content_tags.findings[41]1.0the tagger's words
content_tagsthe extent of the cut was estimated by overlaying tractography from the Allen connectivity atlas on the reconstructed cut
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content_tags.findings[42]1.0the tagger's words
content_tagsand the mice were habituated to the rig but NOT to the specific stimuli before the experiment
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content_tags.findings[43]1.0the tagger's words
content_tagswith the recording areas pooled under one name after checking that the exact location did not affect the results
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content_tags.findings[44]1.0the tagger's words
content_tagsauditory PC1
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also in: auditory PC1
content_tags.definitions[0]the tagger's words
content_tagsdimensionality
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content_tags.definitions[1]the tagger's words
content_tagsbehavioral subspace
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content_tags.definitions[2]the tagger's words
content_tagsbody motion variables
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content_tags.definitions[3]the tagger's words
content_tagscvPCA
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also in: cvPCA
content_tags.definitions[4]1.0the tagger's words
content_tagssubspace
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also in: subspace
content_tags.definitions[5]1.0the tagger's words
content_tagsauditory model
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content_tags.definitions[6]1.0the tagger's words
content_tagsbehavioral model
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content_tags.definitions[7]1.0the tagger's words
content_tagsdimension
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also in: dimension
content_tags.definitions[8]1.0the tagger's words
content_tagstransectomy
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also in: transectomy
content_tags.variables[2]the tagger's words
content_tagsbinned firing rate
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content_tags.variables[3]the tagger's words
content_tagsbody movements
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content_tags.variables[4]the tagger's words
content_tagsdecoding accuracy
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content_tags.variables[5]the tagger's words
content_tagsdimension
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also in: dimension
content_tags.variables[7]1.0the tagger's words
content_tagsvariance
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also in: variance
content_tags.variables[8]1.0the tagger's words
content_tagsaccuracy
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also in: accuracy
content_tags.variables[9]1.0the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.variables[10]1.0the tagger's words
content_tags55% — share of the cross-validated sound-related variance in V1 explained by the first principal component of sound-related activity
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content_tags.quantities[0]the tagger's words
content_tags18 ± 2% — single-trial accuracy of decoding which sound was played from marginalized V1 population activity (chance = 1/12)
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content_tags.quantities[1]the tagger's words
content_tags16 ± 2% — accuracy of decoding sound identity from facial motion components alone, statistically indistinguishable from decoding it from V1 activity
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content_tags.quantities[2]the tagger's words
content_tagsr = 0.82 — correlation between the auditory PC1 time courses measured in visual cortex and in the hippocampal formation
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content_tags.quantities[3]the tagger's words
content_tags75 ± 3% — fraction of sound-related variance explained by the first four components of the movement-related subspace defined during stimulus-free periods
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content_tags.quantities[4]the tagger's words
content_tags79 — average number of significant cvPCA components for video-related activity, versus four for sound-related activity
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content_tags.quantities[5]the tagger's words
content_tagsfour — average number of significant cvPCA dimensions carrying sound-related variance in V1
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content_tags.quantities[6]the tagger's words
content_tags>3.6 — estimated factor by which the transectomy reduced auditory-cortical input to the visual areas on the cut side relative to the intact side
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content_tags.quantities[7]the tagger's words
content_tags640 — number of single cells recorded in primary visual cortex across eight mice (plus 233 in hippocampal formation)
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content_tags.quantities[8]the tagger's words
content_tags0.39 — correlation between trial-by-trial fluctuations of V1 auditory PC1 and their cross-validated prediction from movement
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content_tags.quantities[9]the tagger's words
content_tags0.34 — the correlation of the sound-evoked component across different mice, reported against its own within-mouse test-retest ceiling of 0.44
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content_tags.quantities[10]1.0the tagger's words
content_tags18 ± 2% — sound decoding accuracy from V1 neurons against a chance of one in twelve, and against 16% from the face alone
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content_tags.quantities[11]1.0the tagger's words
content_tagsr = 0.82 — the correlation between the sound-evoked components of visual cortex and hippocampal formation - two regions with very different auditory input
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content_tags.quantities[12]1.0the tagger's words
content_tags75 ± 3% — the sound-related variance explained by a subspace defined entirely from movement during the no-stimulus period, against 35% of the video-related variance
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content_tags.quantities[13]1.0the tagger's words
content_tagszero significant components — the audiovisual interaction term - a reported null that removes the simplest form of multisensory integration
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content_tags.quantities[14]1.0the tagger's words

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© 2026 Shir Sivroni · ORCID 0009-0000-2597-2824