Neural underpinnings of the evidence accumulator

Brody, Hanks · Current Opinion in Neurobiology · 2016 · neuroscience · 10.1016/j.conb.2016.01.003 · record Brody2016-neural-underpinnings-of-the-evidence-accumul
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Claim type could arguably be 'null-result' — the pivotal finding it reports is that 'Quotation withheld [ 53 ].' — but as a review its own contribution is the case against PPC as the accumulator, hence 'critique'. Claim relations is deliberately thin: the review's explicit disagreements (e.g. with the 1-to-1 PPC-accumulator proposal, and the retraction of its own serial PPC→FOF model in 'Quotation withheld') are either self-directed or supported only by bare numeric citations, so per the rules they were not recorded as relations. Replication status is 'contested' because the review documents PPC inactivation impairing rodent visual, but not auditory, accumulation tasks. 2026-08-12, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
5 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
This record’s own method is review, and the tags below follow from that. A review’s findings, quantities and statistics are things stated IN this paper, and some of them report results obtained elsewhere. No tag on this page names a different author. Measured across every review in this corpus, 81% of a review’s tags carry no citation at all — most of them are the review speaking. The corpus does not adjudicate the rest: read an unmarked tag as a claim this paper makes, not necessarily one it made first.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 19 concept tags on this paper, 2 are grounded in a quoted sentence. 17 carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
evidence accumulation decision boundary posterior parietal cortex frontal orienting fields lateral intraparietal frontal eye fields random dot motion Poisson clicks tuning curves microstimulation optogenetic inactivation eNpHR3.0 ramping secondary visual cortex causal circuit redundant circuit click-triggered average PPC accumulation of evidence When evidence is weak the accumulator drifts only slowly away from the decision boundary, so it takes longer to establish which side it is on, which is why difficult decisions are slow. FOF acts downstream of accumulation, categorizing the accumulator's value into a choice, which is why its activity is required near the go cue rather than throughout the stimulus. Discrepant PPC inactivation results across rodent visual tasks may arise because the inactivation spreads beyond PPC into neighbouring small secondary visual areas that supply sensory input. tuning curve initial criteria Poisson clicks task review

Legend

second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1016/j.conb.2016.01.003. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 2 · claim_relations 5 · claim_type 1 · concept_edges 10 · concepts 2 · content_tags 25 · limitations 9 · mechanisms 9 · method 1 · object_of_study 1 · phenomenon 1 · senses 6

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; 1 of 10 relations here carries that mark. The rest are the tagger’s reading of the sentence quoted beside them.

This record holds no controls. A layer is empty when the tagger recorded nothing in it — which is not the same as the paper having nothing to record.

facettagfieldconf.whose words
object_of_studyWhich brain regions actually compute the gradual accumulation of evidence, as opposed to merely representing its value.
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object_of_studythe paper's words
claim_typecritique
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claim_typethe paper's words
phenomenongradual accumulation of evidence in perceptual decision-making
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phenomenonthe paper's words
methodreview
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also in: review
methodthe paper's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[0]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[1]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[2]the tagger's words
mechanismsEncoding was inferred from ramping firing rates that rise faster on easy trials than hard ones, exactly as the accumulator model predicts
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mechanisms[3]the tagger's words
mechanismsTuning curves separate two regions that look alike in averages: one reads out the graded value, the other a categorical side of the boundary
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mechanisms[4]the tagger's words
mechanismsA region can be required at a specific moment rather than throughout, which optogenetic timing can test and lesions cannot
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mechanisms[5]the tagger's words
mechanismsMicrostimulation cannot localise its own effect, because it acts largely on axons passing through rather than on the cells at the site
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mechanisms[6]the tagger's words
mechanismsThe proposed test for circuit membership is three conditions at once - inactivation matters, it matters during the accumulation window specifically, and the graded value is encoded there
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mechanisms[7]the tagger's words
mechanismsWhere a label's boundaries are uncertain, an inactivation aimed at one region may be silencing its neighbour, which would reconcile the conflicting results across species
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mechanisms[8]the tagger's words
limitationsThe review restricts itself to two-alternative decisions and excludes human work.
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what this limits: the scope of the review: WE LIMIT OURSELVES TO TWO-ALTERNATIVE DECISIONS ... AND WILL NOT ADDRESS WORK IN HUMANS
limitations[0]the tagger's words
limitationsWhether rats and primates in fact use the same circuits and algorithms for accumulation is inferred from similar ramping responses and is not established.
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what this limits: the rat-to-primate inference: WHETHER THIS IS INDEED THE CASE REMAINS AN OPEN QUESTION
limitations[1]the tagger's words
limitationsBecause the anatomical border of rodent PPC with adjacent small V2 areas is still uncertain, inactivation effects attributed to PPC may reflect spillover into V2.
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what this limits: every inactivation result attributed to rodent PPC: THE PRECISE DEFINITION OF RODENT PPC AND THE LOCATION OF ITS BORDER WITH THESE V2 AREAS [is] STILL HIGHLY UNCERTAIN AND A MATTER OF ACTIVE RESEARCH
limitations[2]the tagger's words
limitationsThe authors report that their own earlier serial model of the two regions was wrong
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what this limits: the authors' own earlier account: AS WE DESCRIBE BELOW, THIS SERIAL MODEL TURNED OUT TO BE WRONG
limitations[3]the tagger's words
limitationsNeither of the two candidate regions satisfies the criteria the authors themselves propose
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what this limits: the two candidate regions against the review's own test: NEITHER THE FOF NOR THE PPC SATISFY ALL THREE CRITERIA
limitations[4]the tagger's words
limitationsA negative inactivation result cannot rule out a redundant circuit in which no single region is required
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what this limits: the negative inactivation results: the PPC COULD, PERHAPS, PLAY A ROLE ... AS PART OF A MUCH LARGER REDUNDANT CIRCUIT, which a null cannot exclude
limitations[5]the tagger's words
limitationsThe region name itself is unsettled, so results labelled PPC may not concern the same tissue across studies
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what this limits: the comparability of PPC results across studies: FURTHER CLARITY ... WILL GREATLY BENEFIT FROM BETTER DEFINITIONS AND KNOWLEDGE ABOUT THE TOPOGRAPHY OF BRAIN REGIONS NEAR THE LOCATION CURRENTLY REFERRED TO AS RODENT PPC
limitations[6]the tagger's words
limitationsSeveral of the supporting results are unpublished data from the authors' own laboratory
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what this limits: several supporting claims: they rest on unpublished data from the authors' own laboratory
limitations[7]the tagger's words
limitationsThe causal evidence in primates rests on three microstimulation studies, all with the confound the authors name
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what this limits: the causal evidence for these areas in primates: ONLY THREE EXISTING PUBLISHED STUDIES, ALL USING ONLY UNILATERAL ELECTRICAL MICROSTIMULATION
limitations[8]the tagger's words
conceptsPPC
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also in: PPC
concepts[17]the paper's words
conceptsaccumulation of evidence
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concepts[18]the paper's words
sensesa region's involvement - ENCODING: the accumulator's graded value can be read out of its firing, which PPC satisfies
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senses[0]1.0the tagger's words
sensesa region's involvement - CAUSAL: silencing it changes behaviour, which PPC does not satisfy despite encoding the value
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senses[1]1.0the tagger's words
sensesnecessity - AT ALL: silencing the region changes performance, criterion one
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senses[2]1.0the tagger's words
sensesnecessity - AT THE RIGHT TIME: silencing during the accumulation window specifically changes performance, criterion two, which separates accumulating from reading out
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senses[3]1.0the tagger's words
sensesPPC - as a name for tissue defined by location, which differs across labs and species
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senses[4]1.0the tagger's words
sensesPPC - as a name the authors propose reserving for tissue defined by function and connectivity, including the very null result at issue
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senses[5]1.0the tagger's words
alternativesclaim_type: critique
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a second reading reaching the same value. Recorded: critique — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesphenomenon: gradual accumulation of evidence in perceptual decision-making
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a second reading reaching the same value. Recorded: gradual accumulation of evidence in perceptual decision-making — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsbuilds-on → Brunton et al. (Poisson clicks rat task)
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claim_relations[0]the tagger's words
claim_relationscritiques → the proposal of a one-to-one relationship between parietal firing rates and the accumulator value
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claim_relations[1]the tagger's words
claim_relationscritiques → microstimulation as a means of localising causal contributions
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claim_relations[2]the tagger's words
claim_relationscritiques → the authors' own earlier serial model in which PPC computes the accumulator and FOF reads it out
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claim_relations[3]the tagger's words
claim_relationsextends → Brunton et al.'s rat Poisson clicks model of accumulation
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claim_relations[4]the tagger's words
concept_edgesposterior parietal cortex —distinct-from→ evidence accumulation
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strength of the relation: 0.9 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the PPC 'MAY play little to no role' in accumulation; distinct-from is hedged.
concept_edges[0]the tagger's words
concept_edgesramping —operationalised-as→ evidence accumulation
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strength of the relation: 0.7 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span proposes a 1-to-1 relation between PPC firing and the accumulator; operationalised-as is loose.
concept_edges[1]the tagger's words
concept_edgesfrontal orienting fields —causes→ decision boundary
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strength of the relation: 0.9 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span 'SUGGESTS' the FOF categorizes the accumulator's value to drive the choice; causes is hedged.
concept_edges[2]the tagger's words
concept_edgeseNpHR3.0 —operationalised-as→ optogenetic inactivation
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but eNpHR3.0 is the TOOL used for optogenetic inactivation; operationalised-as is loose.
concept_edges[5]the tagger's words
concept_edgesRETRACTED (NEITHER ENDPOINT IS IN THE SPAN, AND THE RELATION IS HEDGED THREE TIMES) · frontal orienting fields —same-as→ frontal eye fields
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RETRACTED: NEITHER ENDPOINT IS IN THE SPAN, AND THE RELATION IS HEDGED THREE TIMES. The edge is 'frontal orienting fields --same-as--> frontal eye fields'. The span: 'HAD BEEN SUGGESTED…' The span names 'PPC' and 'FEF'; it does not contain either endpoint name as words at all - the endpoints were supplied from the tagger's vocabulary, THE SAME FAULT AS Gelbard-Sagiv2008's absent 'reactivation'. This edge PREDATES the gate check and could not be written today. On top of that: 'suggested as', 'analogous', and 'perhaps even' are three hedges in eleven words, and 'respectively' means the sentence maps TWO pairs at once, so even the intended relation is half of a two-way mapping. — strength of the relation: 0.7 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the FOF was SUGGESTED as analogous or perhaps homologous to the FEF; same-as is hedged.
concept_edges[7]the tagger's words
concept_edgeslateral intraparietal —part-of→ posterior parietal cortex
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strength of the relation: 1
concept_edges[8]the tagger's words
concept_edgessecondary visual cortex —distinct-from→ posterior parietal cortex
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strength of the relation: 0.9 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but secondary visual cortex lies immediately POSTERIOR TO the PPC; distinct-from is loose.
concept_edges[9]the tagger's words
concept_edgesclick-triggered average —part-of→ Poisson clicks
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the click-triggered average is an analysis OF responses to single clicks; part-of is loose.
concept_edges[11]the tagger's words
concept_edgesdecision boundary —part-of→ evidence accumulation
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but endpoint by anaphora: 'this model' = accumulation of evidence (previous sentence); part-of is loose.
concept_edges[12]the tagger's words
concept_edgesPPC —distinct-from→ accumulation of evidence
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the relation itself is separately evidenced · strength of the relation: 1 · note: RE-GROUNDS the record's 'posterior parietal cortex --distinct-from--> evidence accumulation'. The SPAN was always right; the ENDPOINT NAMES did not match its words. 'normalised' maps the abbreviation and the paper's phrasing onto the existing concepts. · the relation stated: the region ENCODES the accumulator's value yet is dispensable for decisions that use it Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the PPC 'MAY play little to no role' in accumulation; distinct-from is hedged.
concept_edges[13]the tagger's words
content_tagsContrary to expectations, inactivating rat PPC had negligible effects on Poisson Clicks performance.
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content_tags.findings[0]the tagger's words
content_tagsThe authors conclude that PPC is the least likely of the regions examined to be a genuine node of the accumulation circuit.
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content_tags.findings[1]the tagger's words
content_tagsThe serial account in which PPC computes the accumulator and hands it to FOF was falsified by the perturbation results.
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content_tags.findings[2]the tagger's words
content_tagsFrontal orienting fields carry a categorical, step-like read-out of which side of the decision boundary the accumulator is on, rather than its graded value.
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content_tags.findings[3]the tagger's words
content_tagsUnpublished data suggest at least one subcortical region appears to meet all three criteria and may become the first identified node of the causal accumulation circuit.
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content_tags.findings[4]the tagger's words
content_tagsThe authors propose a nomenclature reform, restricting the label 'rodent PPC' to tissue whose physiology and connectivity match primate PPC.
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content_tags.findings[5]the tagger's words
content_tagssilencing parietal cortex had, against expectations, negligible effects on task performance
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content_tags.findings[6]the tagger's words
content_tagsthe same inactivations did affect interspersed free-choice trials, so the manipulation itself worked
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content_tags.findings[7]the tagger's words
content_tagsparietal cortex is the only region whose silencing leaves task behaviour unaffected
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content_tags.findings[8]the tagger's words
content_tagstuning curves were smooth graded functions of accumulator value in PPC but step-like in FOF
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content_tags.findings[9]the tagger's words
content_tagsthe mapping from accumulator value to firing rate stays fixed across the trial even as the value changes
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content_tags.findings[10]the tagger's words
content_tagsneither candidate region satisfies all three of the authors' criteria for causal circuit membership
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content_tags.findings[11]the tagger's words
content_tagsevidence accumulation
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content_tags.definitions[0]the tagger's words
content_tagsdecision boundary
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content_tags.definitions[1]the tagger's words
content_tagstuning curve
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also in: tuning curve
content_tags.definitions[2]the tagger's words
content_tagsinitial criteria
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content_tags.definitions[3]the tagger's words
content_tagsPoisson clicks task
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content_tags.definitions[4]the tagger's words
content_tagssecondary visual cortex
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content_tags.definitions[5]the tagger's words
content_tagstuning curves
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also in: tuning curves
content_tags.definitions[7]the tagger's words
content_tagsthree — number of published causal perturbation studies of accumulation-related areas in the primate random-dot-motion task at the time of writing
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content_tags.quantities[0]the tagger's words
content_tags6 — number of rat brain regions whose silencing had been tested on the Poisson Clicks task, of which only PPC showed no behavioural impact
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content_tags.quantities[1]the tagger's words
content_tags50 — illustrative number of trained subjects needed to deploy a new perturbation technique, used to argue that rodents make perturbation work feasible
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content_tags.quantities[2]the tagger's words
content_tagsthree initial criteria — the proposed test for whether a region belongs to the causal circuit
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content_tags.quantities[3]the tagger's words
content_tags6 different rat regions — how many have been silenced, of which only one showed no effect
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content_tags.quantities[4]the tagger's words
content_tagsonly three existing published studies — the entire causal literature on these primate regions in this task, all by one method
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content_tags.quantities[5]the tagger's words

Interpretive choices

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