Influences of Combined Traffic Noise on the Ability of Learning and Memory in Mice

Di, Qin · Noise & Health · 2018 · medicine · 10.4103/nah.nah_27_17 · record Di2018-influences-of-combined-traffic-noise-on-the
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Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. The design also includes HPLC assays of hippocampal glutamate and GABA, which the method vocabulary cannot express; behavioural-experiment was chosen because the Morris water maze carries the primary claim. The 'replicates' relation is the paper's claim that its mouse result matches earlier human epidemiological findings - a cross-species convergence rather than a formal replication, and the nearest of the four available types. Separate cohorts ('batches') rather than repeated testing of the same animals were used at each exposure duration, which the facets cannot record. 2026-08-12, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
statistical-significance 2 fields · linear regression 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 19 concept tags on this paper, 3 are grounded in a quoted sentence. 16 carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
combined traffic noise hormesis Morris water maze latencies learning rate target quadrant hippocampus Glu GABA synaptic plasticity NMDA excitatory toxic effect overcompensation ICR epidemiological survey day–night equivalent continuous A-weighted sound pressure level short-term exposure long-term exposure ability of learning A low-dose stressor breaks homeostasis and triggers a compensatory response that overshoots the inhibition, producing facilitation early on. With continued exposure the compensatory response is exhausted, so the inhibitory effect of the noise comes to dominate. Glutamate acting on hippocampal NMDA receptors admits calcium and thereby changes synaptic plasticity, which is the substrate of learning and memory. The behavioural swing is mediated by the hippocampal glutamate level, which is raised by short exposure and lowered by long exposure. hidden platform test probe trail test combined traffic noise (CTN) exposure dose of noise percentage of time spent in the target quadrant percentages of time spent in a target quadrant ANOVA analysis of variance with repeated measures t-test independent samples t -test standard error of the mean mean ± SEM (Standard Error of Mean) statistical-significance linear regression linear fitting between latencies and training days behavioural-experiment

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field
unrecordable relationunhoused_relationsa relation the paper asserts that this vocabulary cannot express, with the reason

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.4103/nah.nah_27_17. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 1 · claim_relations 5 · claim_type 1 · concept_edges 8 · concepts 3 · content_tags 44 · controls 1 · limitations 8 · mechanisms 10 · method 1 · object_of_study 1 · phenomenon 1 · senses 6 · transfers 1 · unhoused_relations 1

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 8 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studyMice exposed for six weeks to recorded combined highway and high-speed-railway noise, assessed by water-maze learning and hippocampal neurotransmitters.
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object_of_studythe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenontraffic-noise effects on spatial learning and memory
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phenomenonthe paper's words
methodbehavioural-experiment
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsmechanisms
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mechanisms[3]the tagger's words
mechanismsThe direction of the effect reverses with exposure duration, which the paper identifies as hormesis - excitation at low dose, inhibition at high
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mechanisms[4]the tagger's words
mechanismsDose for noise is not the level but the level multiplied by the duration, which is why the same decibel figure sits on both sides of the curve
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mechanisms[5]the tagger's words
mechanismsThe reversal is attributed to a compensatory response that outruns the insult at first and is then exhausted
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mechanisms[6]the tagger's words
mechanismsThe behavioural reversal is tracked by glutamate, which rises early and falls late while GABA stays flat
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mechanisms[7]the tagger's words
mechanismsGlutamate has its own inverted-U: more release aids learning until excitotoxicity sets in
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mechanisms[8]the tagger's words
mechanismsCombined road and rail noise is not the sum of its parts - the two sources differ in continuity, peak level and low-frequency content
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mechanisms[9]the tagger's words
limitationsThe extrapolation from mice to human cognitive ability is explicitly only a speculation awaiting human testing.
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what this limits: the human relevance of the whole study: THIS SPECULATION NEEDS TO BE VERIFIED BY ADDITIONAL COGNITIVE BEHAVIOR TESTS IN HUMANS EXPOSED TO 70 dB(A) CTN
limitations[0]the tagger's words
limitationsThe compensatory-response account of the biphasic effect is inferred rather than measured.
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what this limits: the mechanistic account of the biphasic effect: IT WAS SPECULATED THAT THE COMPENSATORY RESPONSE WAS GREATER THAN THE INHIBITORY RESPONSE
limitations[1]the tagger's words
limitationsTen mice per group per batch, with the key contrasts significant in only some batches
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what this limits: every group comparison: EACH BATCH (N = 20) CONSISTED OF TWO GROUPS ... THE EXPERIMENTAL GROUP (N = 10) AND THE CONTROL GROUP (N = 10)
limitations[2]the tagger's words
limitationsBatches are separate groups of animals rather than repeated measures, so the time course is between-subjects
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what this limits: the time course specifically: batches are separate groups of animals, so the comparison across durations is between-subjects rather than repeated
limitations[3]the tagger's words
limitationsAll animals were male, so nothing here speaks to sex differences
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what this limits: any claim about the population: A TOTAL OF 80 HEALTHY MALE ICR MICE - all male, so nothing here speaks to sex differences
limitations[4]the tagger's words
limitationsOnly one sound level was tested, so the dose-response curve is traced through duration alone
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what this limits: the dose-response reading: only one sound level was tested, so the curve is traced through EXPOSURE DURATION alone
limitations[5]the tagger's words
limitationsThe mechanism is inferred from a speculation about compensation rather than measured
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duplicate of: limitations[1] · what this limits: the same scope as limitations[1] - the compensation account is speculated, not measured
limitations[6]the tagger's words
limitationsThe human literature the study is motivated by is itself inconsistent, and the paper attributes that to uncontrolled personal and social factors
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what this limits: the human literature this is motivated by: THE RESULTS OF EPIDEMIOLOGICAL SURVEY WERE ALSO INFLUENCED BY THE PERSONAL FACTORS OF PARTICIPANTS (E.G., AGE, EDUCATIONAL LEVEL, AND PHYSICAL CONDITION) - the disagreement it aims to resolve is attributed to confounding
limitations[7]the tagger's words
transfersthe hormesis biphasic dose-response model, with noise dose defined by analogy to an ingested toxicant dose (sound level times duration)
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transfers[0]the tagger's words
controlsa control group of ten mice per batch held at a background level of no more than 35 dB(A), against 70 +/- 1.5 dB(A) for the exposed group, and never given the combined traffic noise
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eliminates: that the auditory and physiological changes follow from handling, captivity or elapsed time rather than from the traffic-noise exposure · outcome (stated by the tagger, no quotation): absent-stated-about-other · would have ruled out, had it been run: handling, caging and the passage of the 42 days as the explanation of the learning and neurotransmitter differences - the control animals live the same 42 days in the same room and differ only in the noise
controls[0]0.9the tagger's words
conceptsshort-term exposure
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concepts[16]the paper's words
conceptslong-term exposure
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concepts[17]the paper's words
conceptsability of learning
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concepts[18]the paper's words
unhoused_relationsMg 2+ → synaptic plasticity
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THE MECHANISM THE SPAN ACTUALLY DESCRIBES, between terms it actually names: magnesium blocked the calcium channel, was removed, and the resulting calcium influx induced the change of synaptic plasticity. A three-step chain, and no edge type carries a chain - each link would have to be asserted separately, losing the ordering that is the content.
unhoused_relations[0]the tagger's words
sensesthe effect of 70 dB(A) noise - after SHORT exposure (6-10 days): learning and memory IMPROVE
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senses[0]1.0the tagger's words
sensesthe effect of 70 dB(A) noise - after LONG exposure (26-40 days): learning and memory DECLINE, at the same sound level
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senses[1]1.0the tagger's words
sensesdose - as sound level: the 70 dB(A) figure, which is what gets reported and compared across studies
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senses[2]1.0the tagger's words
sensesdose - as level times duration: the quantity that actually determines the sign of the effect
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senses[3]1.0the tagger's words
sensesglutamate - below the toxic threshold: more release, better learning
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senses[4]1.0the tagger's words
sensesglutamate - above it: excitotoxic, and learning declines with the same transmitter that improved it
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senses[5]1.0the tagger's words
alternativesphenomenon: traffic-noise effects on spatial learning and memory
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a second reading reaching the same value. Recorded: traffic-noise effects on spatial learning and memory — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsbuilds-on → hormesis, the biphasic low-dose-excitation / high-dose-inhibition dose-effect model in toxicology (refs 22-26)
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claim_relations[0]the tagger's words
claim_relationsreplicates → the epidemiological surveys of Haines (ref 8) and Kempen (ref 9) showing declining cognitive ability in children after long-term aircraft or road traffic noise
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claim_relations[1]the tagger's words
claim_relationsextends → Calabrese's overcompensation account of hormesis
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claim_relations[2]the tagger's words
claim_relationscritiques → previous animal noise studies that used white noise, narrow band noise or pure tones instead of real environmental noise
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claim_relations[3]the tagger's words
claim_relationssupports → Di et al. on combined road-rail noise being more annoying than a single dominant source at the same level
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claim_relations[4]the tagger's words
concept_edgesovercompensation —causes→ hormesis
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strength of the relation: 0.9
concept_edges[1]the tagger's words
concept_edgesGABA —distinct-from→ Glu
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strength of the relation: 1
also in: GABA · Glu
concept_edges[4]the tagger's words
concept_edgesGABA —causes→ NMDA
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strength of the relation: 0.9 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but GABA 'COULD strengthen the blocking effect of Mg2+ on the NMDA receptor'; 'causes NMDA' drops the blocking and is hedged.
also in: GABA · NMDA
concept_edges[5]the tagger's words
concept_edgesGlu —causes→ excitatory toxic effect
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status: the paper's own words: could · strength of the relation: 1 · note: direction corrected 2026-08-20 by the project: the quote puts 'Glu' on the causing side. The edge previously read excitatory toxic effect --causes--> Glu, which is the reverse of its own sentence. Nothing else on the row changed; the quote, weight and anchor are untouched.
concept_edges[7]the tagger's words
concept_edgesMorris water maze —operationalised-as→ latencies
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but latencies are the water-maze measure; operationalised-as is loose.
concept_edges[8]the tagger's words
concept_edgescombined traffic noise —operationalised-as→ day–night equivalent continuous A-weighted sound pressure level
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strength of the relation: 1
concept_edges[10]the tagger's words
concept_edgesshort-term exposure —causes→ ability of learning
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holds when: 6-10 days of exposure to 70 dB(A) combined traffic noise · direction on the measure: increases · strength of the relation: 1 · note: ONE OF A PAIR: the SAME exposure carries the OPPOSITE sign at longer durations. Neither edge is the paper's finding alone - the finding is that the sign flips.
concept_edges[13]the tagger's words
concept_edgeslong-term exposure —causes→ ability of learning
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holds when: 26-30 and 36-40 days of exposure · direction on the measure: reduces · strength of the relation: 1 · note: ONE OF A PAIR: see the short-term edge, which carries the opposite sign on the same measure.
concept_edges[14]the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[0]the tagger's words
content_tagst-test
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also in: t-test
content_tags.statistics[1]the tagger's words
content_tagsstandard error of the mean
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content_tags.statistics[2]the tagger's words
content_tagsstatistical-significance
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content_tags.statistics[3]the tagger's words
content_tagslinear regression
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content_tags.statistics[4]the tagger's words
content_tagsSix to ten days of exposure to 70 dB(A) combined traffic noise improved learning and memory in mice.
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content_tags.findings[0]the tagger's words
content_tagsLonger exposure reversed the effect, degrading learning and memory.
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content_tags.findings[1]the tagger's words
content_tagsLearning rate was significantly higher in exposed mice than in controls in the first batch (6-10 days).
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content_tags.findings[2]the tagger's words
content_tagsTime in the target quadrant was significantly higher in exposed mice than in controls in the first batch (6-10 days).
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content_tags.findings[3]the tagger's words
content_tagsGlutamate rose after short (6-10 day) exposure and fell after long exposure.
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content_tags.findings[4]the tagger's words
content_tagsHippocampal GABA was unchanged by noise exposure at every time point.
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content_tags.findings[5]the tagger's words
content_tagsThe authors rule out excessive glutamate release causing an excitotoxic effect on hippocampal neurons.
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content_tags.findings[6]the tagger's words
content_tagsThe biphasic time course of the noise effect matches the hormesis dose-response pattern.
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content_tags.findings[7]the tagger's words
content_tagsshort exposure to 70 dB(A) combined traffic noise improved water-maze learning and memory
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content_tags.findings[8]the tagger's words
content_tagslong exposure at the same level degraded them
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content_tags.findings[9]the tagger's words
content_tagsin the intermediate batch (16-20 days) learning rate was similar to controls
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content_tags.findings[10]the tagger's words
content_tagsglutamate was higher in exposed mice than in controls in the first batch
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content_tags.findings[11]the tagger's words
content_tagsGABA did not differ between groups in any batch
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content_tags.findings[12]the tagger's words
content_tagsthe human literature already disagrees about noise and cognition, including one study where 71 dB(A) road noise IMPROVED children's episodic memory
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content_tags.findings[13]the tagger's words
content_tagshormesis
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also in: hormesis
content_tags.definitions[0]the tagger's words
content_tagslearning rate
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also in: learning rate
content_tags.definitions[2]the tagger's words
content_tagshidden platform test
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content_tags.definitions[3]the tagger's words
content_tagsprobe trail test
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content_tags.definitions[4]the tagger's words
content_tagscombined traffic noise (CTN)
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content_tags.definitions[5]the tagger's words
content_tagshormesis
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also in: hormesis
content_tags.definitions[6]the tagger's words
content_tagsexposure dose of noise
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content_tags.definitions[7]the tagger's words
content_tagsGABA
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also in: GABA
content_tags.definitions[8]the tagger's words
content_tagsGlu
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also in: Glu
content_tags.definitions[9]the tagger's words
content_tagspercentage of time spent in the target quadrant
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content_tags.variables[3]the tagger's words
content_tagspercentages of time spent in a target quadrant
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content_tags.variables[10]the tagger's words
content_tags70 ± 1.5 dB(A) — day-night equivalent sound pressure level of the combined traffic noise played to the experimental group
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content_tags.quantities[0]the tagger's words
content_tags35 dB(A) — background noise level, i.e. the exposure of the control group
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content_tags.quantities[1]the tagger's words
content_tags80 — total number of male ICR mice used, split into four batches
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content_tags.quantities[2]the tagger's words
content_tagsn = 20 (n = 10 and n = 10) — mice per batch, split evenly into experimental and control groups
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content_tags.quantities[3]the tagger's words
content_tags42 days — duration of continuous noise exposure for the experimental group after a 7-day adaptation
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content_tags.quantities[4]the tagger's words
content_tags5 and 15 μmol/g — normal hippocampal glutamate range against which the measured values were judged non-toxic
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content_tags.quantities[5]the tagger's words
content_tags2092 pcu/h — highway traffic flux used to reconstruct the combined traffic noise stimulus
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content_tags.quantities[6]the tagger's words
content_tags90 s — maximum trial duration in the Morris water maze hidden platform test
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content_tags.quantities[7]the tagger's words
content_tags70 dB(A) — the single exposure level, which produces opposite effects at different durations
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content_tags.quantities[8]the tagger's words
content_tags80 healthy male ICR mice — the whole sample, in four batches of twenty
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content_tags.quantities[9]the tagger's words
content_tags42 days — total exposure period across which the four batches were tested
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content_tags.quantities[10]the tagger's words
content_tags71 dB(A) — the level at which an earlier human study found IMPROVED episodic memory - one decibel above this study's exposure
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content_tags.quantities[11]the tagger's words
content_tags63.5 dB — the level above which combined road-rail noise becomes more annoying than a single dominant source
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[12]the tagger's words
content_tags2092 pcu/h — the highway traffic flux used to reconstruct the combined exposure
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[13]the tagger's words

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