Influences of Combined Traffic Noise on the Ability of Learning and Memory in Mice — TEI-tagged view

Di, Qin · 2018 · medicine · doi:10.4103/nah.nah_27_17 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. The design also includes HPLC assays of hippocampal glutamate and GABA, which the method vocabulary cannot express; behavioural-experiment was chosen because the Morris water maze carries the primary claim. The 'replicates' relation is the paper's claim that its mouse result matches earlier human epidemiological findings - a cross-species convergence rather than a formal replication, and the nearest of the four available types. Separate cohorts ('batches') rather than repeated testing of the same animals were used at each exposure duration, which the facets cannot record. 2026-08-12, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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statistical-significance 2 fields · linear regression 2 fields
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combined traffic noise hormesis Morris water maze latencies learning rate7 target quadrant hippocampus29 Glu GABA8 synaptic plasticity NMDA4 excitatory toxic effect overcompensation ICR epidemiological survey day–night equivalent continuous A-weighted sound pressure level short-term exposure long-term exposure ability of learning behavioural-experiment117

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenontraffic-noise effects on spatial learning and memory— “The present study aimed to evaluate the influences of combined traffic noise (CTN) on the ability of learning and memory in mice.”
claim-typemechanism— “Furthermore, those effects were regulated and controlled by the level of glutamate in the hippocampus.”
method — evidence— “On the basis of behavioral reactions in Morris water maze (MWM) and the concentrations of amino acid neurotransmitters in the hippocampus, the impacts of CTN on learning and memory in mice were examined.”
object of study — evidence— “The present study aimed to evaluate the influences of combined traffic noise (CTN) on the ability of learning and memory in mice.”
transferfrom toxicology: the hormesis biphasic dose-response model, with noise dose defined by analogy to an ingested toxicant dose (sound level times duration)— “Corresponding to the dose of toxicity that was ingested by organisms, the exposure dose of noise for organisms was the value of exposure sound level times exposure duration.”transfers[0]
mechanismA low-dose stressor breaks homeostasis and triggers a compensatory response that overshoots the inhibition, producing facilitation early on.— “Under the condition of low-dose stimulation, the compensatory response produced by organisms could be greater than the inhibitory response of stimuli, which resulted in the excitatory effect of stimuli.”mechanisms[0]
mechanismWith continued exposure the compensatory response is exhausted, so the inhibitory effect of the noise comes to dominate.— “It could be caused by a gradual exhaustion of compensatory response.”mechanisms[1]
mechanismGlutamate acting on hippocampal NMDA receptors admits calcium and thereby changes synaptic plasticity, which is the substrate of learning and memory.— “Subsequently, Mg 2+ , which blocked the channel of Ca 2+ , was removed, and the Ca 2+ flowed into the cell, which induced the change of synaptic plasticity.”mechanisms[2]
mechanismThe behavioural swing is mediated by the hippocampal glutamate level, which is raised by short exposure and lowered by long exposure.— “Thus, it could be speculated that the effects of CTN on the ability of learning and memory in mice were regulated and controlled by the level of Glu in the hippocampus.”mechanisms[3]
mechanismThe direction of the effect reverses with exposure duration, which the paper identifies as hormesis - excitation at low dose, inhibition at high— “Hormesis was the common biphasic dose-effect model in toxicology and was characterized by low-dose excitement and high-dose inhibition.[ 22 ]”mechanisms[4]
mechanismDose for noise is not the level but the level multiplied by the duration, which is why the same decibel figure sits on both sides of the curve— “Corresponding to the dose of toxicity that was ingested by organisms, the exposure dose of noise for organisms was the value of exposure sound level times exposure duration.[ 25 ]”mechanisms[5]
mechanismThe reversal is attributed to a compensatory response that outruns the insult at first and is then exhausted— “Under the condition of low-dose stimulation, the compensatory response produced by organisms could be greater than the inhibitory response of stimuli, which resulted in the excitatory effect of stimuli.”mechanisms[6]
mechanismThe behavioural reversal is tracked by glutamate, which rises early and falls late while GABA stays flat— “Obviously, the level of Glu in mice rose after short-term exposure (6–10 days) to 70 dB(A) CTN, but the long-term exposure (26–30 days, 36–40 days) led to a decrease in the Glu level in mice.”mechanisms[7]
mechanismGlutamate has its own inverted-U: more release aids learning until excitotoxicity sets in— “Nonetheless, too much release of Glu could cause an excitatory toxic effect on the neurons, which resulted in a decline in the learning and memory ability.”mechanisms[8]
mechanismCombined road and rail noise is not the sum of its parts - the two sources differ in continuity, peak level and low-frequency content— “Highway traffic noise is relatively continuous. However, high-speed railway produces intermittent noise, which is characterized by shorter duration, higher-peak…mechanisms[9]
builds-on hormesis, the biphasic low-dose-excitation / high-dose-inhibition dose-effect model in toxicology (refs 22-26)claim_relations[0]
replicates the epidemiological surveys of Haines (ref 8) and Kempen (ref 9) showing declining cognitive ability in children after long-term aircraft or road traffic noiseclaim_relations[1]
extends Calabrese's overcompensation account of hormesis
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claim_relations[2]
critiques previous animal noise studies that used white noise, narrow band noise or pure tones instead of real environmental noise
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claim_relations[3]
supports Di et al. on combined road-rail noise being more annoying than a single dominant source at the same level
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claim_relations[4]
sensethe effect of 70 dB(A) noise - after SHORT exposure (6-10 days): learning and memory IMPROVE
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senses[0]
sensethe effect of 70 dB(A) noise - after LONG exposure (26-40 days): learning and memory DECLINE, at the same sound level
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senses[1]
sensedose - as sound level: the 70 dB(A) figure, which is what gets reported and compared across studies
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senses[2]
sensedose - as level times duration: the quantity that actually determines the sign of the effect
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senses[3]
senseglutamate - below the toxic threshold: more release, better learning
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senses[4]
senseglutamate - above it: excitotoxic, and learning declines with the same transmitter that improved it
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senses[5]
controla control group of ten mice per batch held at a background level of no more than 35 dB(A), against 70 +/- 1.5 dB(A) for the exposed group, and never given the combined traffic noise — absent-stated-about-other — rules out that the auditory and physiological changes follow from handling, captivity or elapsed time rather than from the traffic-noise exposure
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controls[0]
weightovercompensation —causes→ hormesis — 0.9
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concept_edges[1]
edgeGABA —distinct-from→ Glu
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concept_edges[4]
auditGABA —causes→ NMDA — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but GABA 'COULD strengthen the blocking effect of Mg2+ on the NMDA receptor'; 'causes NMDA' drops the blocking and is hedged.
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concept_edges[5]
weightGABA —causes→ NMDA — 0.9
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concept_edges[5]
evidential statusGlu —causes→ excitatory toxic effect — the paper's own words: could
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concept_edges[7]
noteGlu —causes→ excitatory toxic effect — direction corrected 2026-08-20 by the project: the quote puts 'Glu' on the causing side. The edge previously read excitatory toxic effect --causes--> Glu, which is the reverse of its own sentence. Nothing else on the row changed; the quote, weight and anchor are untouched.
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concept_edges[7]
auditMorris water maze —operationalised-as→ latencies — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but latencies are the water-maze measure; operationalised-as is loose.
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concept_edges[8]
edgecombined traffic noise —operationalised-as→ day–night equivalent continuous A-weighted sound pressure level
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concept_edges[10]
effect directionshort-term exposure —causes→ ability of learning — increases
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concept_edges[13]
holds whenshort-term exposure —causes→ ability of learning — 6-10 days of exposure to 70 dB(A) combined traffic noise
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concept_edges[13]
noteshort-term exposure —causes→ ability of learning — ONE OF A PAIR: the SAME exposure carries the OPPOSITE sign at longer durations. Neither edge is the paper's finding alone - the finding is that the sign flips.
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concept_edges[13]
effect directionlong-term exposure —causes→ ability of learning — reduces
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concept_edges[14]
holds whenlong-term exposure —causes→ ability of learning — 26-30 and 36-40 days of exposure
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concept_edges[14]
notelong-term exposure —causes→ ability of learning — ONE OF A PAIR: see the short-term edge, which carries the opposite sign on the same measure.
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concept_edges[14]
outcome (stated by the tagger, no quotation)control — absent-stated-about-othercontrols[0]
for which uselimitation — the human relevance of the whole study: THIS SPECULATION NEEDS TO BE VERIFIED BY ADDITIONAL COGNITIVE BEHAVIOR TESTS IN HUMANS EXPOSED TO 70 dB(A) CTN
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limitations[0]
for which uselimitation — the mechanistic account of the biphasic effect: IT WAS SPECULATED THAT THE COMPENSATORY RESPONSE WAS GREATER THAN THE INHIBITORY RESPONSE
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limitations[1]
for which uselimitation — every group comparison: EACH BATCH (N = 20) CONSISTED OF TWO GROUPS ... THE EXPERIMENTAL GROUP (N = 10) AND THE CONTROL GROUP (N = 10)
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limitations[2]
for which uselimitation — the time course specifically: batches are separate groups of animals, so the comparison across durations is between-subjects rather than repeated
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limitations[3]
for which uselimitation — any claim about the population: A TOTAL OF 80 HEALTHY MALE ICR MICE - all male, so nothing here speaks to sex differences
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limitations[4]
for which uselimitation — the dose-response reading: only one sound level was tested, so the curve is traced through EXPOSURE DURATION alone
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limitations[5]
duplicate oflimitation — limitations[1]
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limitations[6]
for which uselimitation — the same scope as limitations[1] - the compensation account is speculated, not measured
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limitations[6]
for which uselimitation — the human literature this is motivated by: THE RESULTS OF EPIDEMIOLOGICAL SURVEY WERE ALSO INFLUENCED BY THE PERSONAL FACTORS OF PARTICIPANTS (E.G., AGE, EDUCATIONAL LEVEL, AND PHYSICAL CONDITION) - the disagreement it aims to resolve is attributed to confounding
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limitations[7]
replicationuntested
no type for thisMg 2+ → synaptic plasticity — THE MECHANISM THE SPAN ACTUALLY DESCRIBES, between terms it actually names: magnesium blocked the calcium channel, was removed, and the resulting calcium influx induced the change of synaptic plasticity. A three-step chain, and no edge type carries a chain - each link would have to be asserted separately, losing the ordering that is the content.
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unhoused_relations[0]
limitationThe extrapolation from mice to human cognitive ability is explicitly only a speculation awaiting human testing.
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limitations[0]
limitationThe compensatory-response account of the biphasic effect is inferred rather than measured.
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limitations[1]
limitationTen mice per group per batch, with the key contrasts significant in only some batches
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limitations[2]
limitationBatches are separate groups of animals rather than repeated measures, so the time course is between-subjects
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limitations[3]
limitationAll animals were male, so nothing here speaks to sex differences
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limitations[4]
limitationOnly one sound level was tested, so the dose-response curve is traced through duration alone
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limitations[5]
limitationThe mechanism is inferred from a speculation about compensation rather than measured
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limitations[6]
limitationThe human literature the study is motivated by is itself inconsistent, and the paper attributes that to uncontrolled personal and social factors
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limitations[7]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingSix to ten days of exposure to 70 dB(A) combined traffic noise improved learning and memory in mice.
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content_tags.findings[0]
findingLonger exposure reversed the effect, degrading learning and memory.
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content_tags.findings[1]
findingLearning rate was significantly higher in exposed mice than in controls in the first batch (6-10 days).
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content_tags.findings[2]
findingTime in the target quadrant was significantly higher in exposed mice than in controls in the first batch (6-10 days).
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content_tags.findings[3]
findingGlutamate rose after short (6-10 day) exposure and fell after long exposure.
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content_tags.findings[4]
findingHippocampal GABA was unchanged by noise exposure at every time point.
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content_tags.findings[5]
findingThe authors rule out excessive glutamate release causing an excitotoxic effect on hippocampal neurons.
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content_tags.findings[6]
findingThe biphasic time course of the noise effect matches the hormesis dose-response pattern.
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content_tags.findings[7]
findingshort exposure to 70 dB(A) combined traffic noise improved water-maze learning and memory
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content_tags.findings[8]
findinglong exposure at the same level degraded them
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content_tags.findings[9]
findingin the intermediate batch (16-20 days) learning rate was similar to controls
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content_tags.findings[10]
findingglutamate was higher in exposed mice than in controls in the first batch
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content_tags.findings[11]
findingGABA did not differ between groups in any batch
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content_tags.findings[12]
findingthe human literature already disagrees about noise and cognition, including one study where 71 dB(A) road noise IMPROVED children's episodic memory
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content_tags.findings[13]
quantity70 ± 1.5 dB(A) — day-night equivalent sound pressure level of the combined traffic noise played to the experimental group
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content_tags.quantities[0]
quantity35 dB(A) — background noise level, i.e. the exposure of the control group
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content_tags.quantities[1]
quantity80 — total number of male ICR mice used, split into four batches
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content_tags.quantities[2]
quantityn = 20 (n = 10 and n = 10) — mice per batch, split evenly into experimental and control groups
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content_tags.quantities[3]
quantity42 days — duration of continuous noise exposure for the experimental group after a 7-day adaptation
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content_tags.quantities[4]
quantity5 and 15 μmol/g — normal hippocampal glutamate range against which the measured values were judged non-toxic
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content_tags.quantities[5]
quantity2092 pcu/h — highway traffic flux used to reconstruct the combined traffic noise stimulus
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content_tags.quantities[6]
quantity90 s — maximum trial duration in the Morris water maze hidden platform test
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content_tags.quantities[7]
quantity70 dB(A) — the single exposure level, which produces opposite effects at different durations
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content_tags.quantities[8]
quantity80 healthy male ICR mice — the whole sample, in four batches of twenty
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content_tags.quantities[9]
quantity42 days — total exposure period across which the four batches were tested
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content_tags.quantities[10]
quantity71 dB(A) — the level at which an earlier human study found IMPROVED episodic memory - one decibel above this study's exposure
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content_tags.quantities[11]
quantity63.5 dB — the level above which combined road-rail noise becomes more annoying than a single dominant source
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content_tags.quantities[12]
quantity2092 pcu/h — the highway traffic flux used to reconstruct the combined exposure
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content_tags.quantities[13]
variablepercentage of time spent in the target quadrant (dependent)
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content_tags.variables[3]
variablepercentages of time spent in a target quadrant (dependent)
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content_tags.variables[10]
definitionhormesis
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content_tags.definitions[0]
definitionlearning rate
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content_tags.definitions[2]
definitionhidden platform test
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content_tags.definitions[3]
definitionprobe trail test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[4]
definitioncombined traffic noise (CTN)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[5]
definitionhormesis
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content_tags.definitions[6]
definitionexposure dose of noise
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[7]
definitionGABA
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[8]
definitionGlu
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[9]
key-termscombined traffic noise, hormesis, Morris water maze, latencies, learning rate, target quadrant, hippocampus, Glu, GABA, synaptic plasticity, NMDA, excitatory toxic effect, overcompensation, epidemiological survey
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
conceptshort-term exposure
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[16]
conceptlong-term exposure
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[17]
conceptability of learning
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[18]
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
ANOVA as written: analysis of variance with repeated measures
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[0]
t-test t as written: independent samples t -test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[1]
standard error of the mean SEM as written: mean ± SEM (Standard Error of Mean)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[2]
statistical-significance as written: Significance was accepted at the level of P < 0.05
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[3]
linear regression as written: linear fitting between latencies and training days
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[4]
Second readings
a facet read a second time, independently, from its own sentence — and whether the two readings agree
phenomenontraffic-noise effects on spatial learning and memory — a second reading reaching the same value; recorded: traffic-noise effects on spatial learning and memory
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.phenomenon

When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

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