Flexible Sensory Representations in Auditory Cortex Driven by Behavioral Relevance

Kato, Gillet, Isaacson · Neuron · 2015 · neuroscience · 10.1016/j.neuron.2015.10.024 · record Kato2015-flexible-sensory-representations-in-auditory
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. method is the weakest facet here: the dominant technique is chronic two-photon calcium imaging across days ('Here, we take advantage of chronic two-photon calcium imaging to investigate how experience and changes in the behavioral relevance of acoustic stimuli alter sensory representations in adult auditory cortex.'), supported by silicon-probe single-unit recording, optogenetic cortical silencing, and a trained head-fixed behavioural task; 'electrophysiology' is quoted from a real experiment in the paper but under-describes the study. The paper also carries a secondary causal claim about A1's contribution to sound detection thresholds via optogenetic silencing, which the single claim type facet cannot hold. 2026-08-13, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.
Other fields define these differently the same word, defined another way in another discipline
behavior 4 fields · anesthesia 2 fields · SEM 2 fields · deconvolution 2 fields · habituation 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 32 concept tags on this paper, 2 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
A1 L2/3 L4 pyramidal SOM PV interneuron habituation excitation inhibition change index anesthesia awake behavioral relevance behavior detection psychometric silencing ipsilateral GCaMP6s unit recording intrinsic signal deconvolution neuropil dF/F TRF tonotopic sustained onset single unit behaving passive Repeated passive exposure raises SOM interneuron activity, and the added SOM-mediated inhibition suppresses layer 2/3 pyramidal responses to the experienced tone. Task engagement suppresses SOM cell firing, releasing pyramidal cells from local inhibition and thereby enlarging the representation of the behaviorally relevant sound. onset response index change index (CI) engagement in the task interneuron subtypes ipsilateral silencing fraction of excited cells fraction of inhibited cells t-test two-tailed t-test Wilcoxon signed-rank test ANOVA one-way ANOVA followed by Tukey’s post hoc test ROC analysis receiver operator characteristic (ROC) analysis correlation correlation coefficient one-way ANOVA SEM electrophysiology

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1016/j.neuron.2015.10.024. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 3 · claim_relations 9 · claim_type 1 · concept_edges 7 · concepts 2 · content_tags 77 · contribution 1 · controls 1 · limitations 9 · mechanisms 8 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 9 · transfers 4

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 7 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studyhow the cortical representation of a sound changes when the sound is repeatedly heard and means nothing, and changes again when the same sound becomes useful
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object_of_studythe paper's words
research_questionwhat happens to auditory cortical representations over days of passive experience, which has been hard to ask because the same cells could not be followed that long
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research_questionthe paper's words
contributionpassive daily exposure suppresses pyramidal responses and recruits inhibition through SOM cells, and task engagement reverses it by suppressing those same SOM cells
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenonexperience-dependent habituation of auditory cortex sound representations
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismshabituation is an active process that recruits inhibition rather than a simple withdrawal of excitation
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mechanisms[2]1.0the tagger's words
mechanismsSOM cells are the source, since their tone-evoked excitation grows with the same experience that suppresses everything else
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mechanisms[3]1.0the tagger's words
mechanismsPV cells cannot be the source because their excitation falls with experience like the pyramidal cells they would have to inhibit
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mechanisms[4]1.0the tagger's words
mechanismsthe enhancement is specific to the sustained part of the response, matching where the suppression of pyramidal activity is strongest
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mechanisms[5]1.0the tagger's words
mechanismssound-guided behavior had the opposite effect on SOM cells compared to L2/3 pyramidal cells, with fewer SOM cells excited by the tone during the behaving block
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mechanisms[6]1.0the tagger's words
mechanismsfiltering sustained sounds while preserving onsets is proposed as the function, since onsets carry the more urgent information
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mechanisms[7]0.7the tagger's words
limitationsSpike inference from calcium signals is sensitivity-limited, so conclusions were re-checked on raw dF/F.
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what this limits: the spike-inference analyses, with the check stated: ALTHOUGH DATA ANALYSES USING SPIKE INFERENCE CAN BE AFFECTED BY SIGNAL-TO-NOISE RATIO, OUR CONCLUSIONS WERE IDENTICAL WHEN DF/F VALUES WERE USED
limitations[0]the tagger's words
limitationsResidual neuropil contamination of cellular signals cannot be excluded.
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what this limits: the single-cell specificity of the signals: WE CANNOT EXCLUDE SOME RESIDUAL CONTAMINATION OF CELLULAR SIGNALS BY NEUROPIL RESPONSES, though the conclusions do not depend on the degree of background subtraction
limitations[1]the tagger's words
limitationsThe use of prolonged tones and a sound-offset detection task may itself explain the divergence from earlier task-engagement studies.
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what this limits: the comparison with the earlier task literature: the use of prolonged tones and a sound-offset detection task may itself explain the divergence
limitations[2]the tagger's words
limitationsOther mechanisms contributing to auditory habituation are not excluded.
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what this limits: the sufficiency of the SOM account: WE DO NOT EXCLUDE THE POSSIBILITY THAT OTHER MECHANISMS COULD CONTRIBUTE TO AUDITORY HABITUATION UNDER DIFFERENT CONDITIONS
limitations[3]the tagger's words
limitationsPV cell excitation after habituation is too sparse for a fine comparison during behaviour
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what this limits: the PV comparison between behaving and passive conditions: THE VERY SPARSE EXCITATION OF PV CELLS FOLLOWING HABITUATION MADE IT DIFFICULT TO PERFORM A FINE COMPARISON
limitations[4]1.0the tagger's words
limitationsthe use of prolonged tones and an offset detection task may itself account for differences from earlier task-engagement studies that used transient sounds
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what this limits: the disagreement with the task-engagement literature: WE CANNOT RULE OUT THE POSSIBILITY THAT THE USE OF PROLONGED TONES AND A SOUND-OFFSET DETECTION TASK MAY ACCOUNT FOR DIFFERENCES BETWEEN OUR FINDINGS AND PREVIOUS STUDIES
limitations[5]1.0the tagger's words
limitationsthe effect of silencing shrank when the same experiment was repeated over days, which is read as compensation downstream
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what this limits: any silencing result, including this one, as a measure of necessity: WHEN THE CONTRALATERAL CORTICAL SILENCING EXPERIMENTS WERE REPEATED OVER SEVERAL DAYS THE SHIFT OF THE PSYCHOMETRIC CURVE BECAME PROGRESSIVELY SMALLER, SUGGESTING COMPENSATORY CHANGES IN SUBCORTICAL CIRCUITS
limitations[6]1.0the tagger's words
limitationsno increase in passive representations appeared after training, contrary to earlier learning studies
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what this limits: the comparison with the learning literature: WE DID NOT OBSERVE AN INCREASE IN SENSORY REPRESENTATIONS IN THE PASSIVE CONDITION AFTER TRAINING, contrary to four cited studies
limitations[7]1.0the tagger's words
limitationsthe whole GABAergic population showed only variable effects, so the result depends on splitting it by subtype
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what this limits: the subtype-specific result, which the population-level data did not show: DAILY TONE EXPERIENCE PRODUCED VARIABLE EFFECTS ACROSS THIS CELL POPULATION ... MODEST EFFECTS AT THE POPULATION LEVEL COULD ARISE IF EXPERIENCE HAD DIFFERENT AND POTENTIALLY OPPOSING ACTIONS ON PARTICULAR SUBTYPES
limitations[8]1.0the tagger's words
transfersCre-dependent expression of a calcium indicator, which is what makes the cell-type split possible at all
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transfers[0]1.0the tagger's words
transfersa macroscopic tonotopic map used to place the cellular imaging field inside the right area
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transfers[1]1.0the tagger's words
transfersdeconvolution of fluorescence into an inferred rate, with the conclusions then rechecked without it
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transfers[2]1.0the tagger's words
transfersa psychometric threshold for tone detection, used as the readout of a cortical silencing experiment
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transfers[3]1.0the tagger's words
controlssounds of three different durations delivered in RANDOMLY INTERLEAVED trials
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eliminates: temporal expectation - a fixed duration lets the animal learn when the sound ends, so a response at offset would be an anticipated event rather than a sensory one · outcome (stated by the tagger, no quotation): held
controls[0]0.95the tagger's words
conceptshabituation
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also in: habituation
concepts[7]the paper's words
conceptsinhibition
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also in: inhibition
concepts[9]the paper's words
sensesA WHOLE RESPONSE CLASS EXISTS ONLY IN THE AWAKE ANIMAL: inhibitory responses were present in about a quarter of cells awake and in NONE under anaesthesia, and prolonged tones evoked only transient onset excitation
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senses[0]1.0the tagger's words
sensesso a literature built on anaesthetised recordings cannot contain the observation this paper is about, whatever it looked for
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senses[1]0.9the tagger's words
sensesTHE DISAGREEMENT WITH PRIOR WORK IS EXPLAINED BY WHAT THE OLDER INSTRUMENT COULD SEE: unit recordings are prone to pick up cells with high firing rates, so earlier experiments may have been sampling the very populations that do not habituate
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senses[2]1.0the tagger's words
sensesand a second explanation is offered beside it, that interneuron activity is attenuated under anaesthesia, with neither chosen
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senses[3]1.0the tagger's words
sensesAVERAGING OVER A POPULATION HID THE EFFECT: the whole GABAergic population gave variable results, and the finding only appeared once the two interneuron subtypes were imaged separately
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senses[4]1.0the tagger's words
sensesTHE DESIGN REMOVES THE CONFOUND RATHER THAN CORRECTING FOR IT: detecting the OFFSET of a tone puts the measurement before the licking and before the reward, so neither can contaminate the sound-evoked response
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senses[5]1.0the tagger's words
sensesAND THE CAUSAL EFFECT SHRINKS WITH REPETITION: the psychometric shift from silencing got progressively smaller over days, so the measured size of a perturbation depends on how many times it has been done
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senses[6]1.0the tagger's words
sensesthe frequency-specificity check is what separates a change in the representation from a change in the animal - the effect appears only at the experienced frequency
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senses[7]1.0the tagger's words
sensesand the conclusion is held against three analysis choices - inferred spikes against raw fluorescence, the amount of neuropil subtracted, and imaging against electrophysiology
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senses[8]1.0the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: chronic two-photon imaging of GCaMP6s in identified pyramidal, layer 4, PV and SOM populations across five days of tone exposure and during alternating behaving and passive blocks, plus optogenetic cortical silencing during a sound-offset detection task
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: habituation of a cortical sensory representation to a repeated, meaningless stimulus, and its reversal when the stimulus becomes behaviourally relevant
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a second reading DIFFERING from the recorded value. Recorded: experience-dependent habituation of auditory cortex sound representations — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationscontradicts → Bao et al. (2001), Kilgard and Merzenich (1998) and Zhang et al. (2001) on adult A1 being refractory to passive experience
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differs in: the state of the animal and the recording: ACUTE RECORDINGS FROM ANESTHETIZED ANIMALS report A1 representations LARGELY REFRACTORY TO EXPERIENCE-DEPENDENT CHANGES IN ADULTHOOD, against chronic imaging in the awake mouse here
claim_relations[0]the tagger's words
claim_relationscontradicts → Noreña et al. (2006) on extensive sound exposure in cat auditory cortex
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differs in: the LEVEL of the pathway at which the change appears: UNLIKE THE RESULTS WE SHOW, THIS EXTENSIVE SOUND EXPOSURE GENERATED A LOSS OF RESPONSIVENESS AT THE LEVEL OF THALAMOCORTICAL INPUT
claim_relations[1]the tagger's words
claim_relationsbuilds-on → Pfeffer et al. (2013) on SOM-to-PV inhibitory connectivity
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claim_relations[2]the tagger's words
claim_relationscontradicts → the view that long-term changes in adult auditory cortex require associative conditioning
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differs in: whether reinforcement is required: long-term changes ARE BELIEVED TO REQUIRE ASSOCIATIVE CONDITIONING - PAIRING TONES OF A PARTICULAR FREQUENCY WITH FOOT SHOCKS OR STIMULATION OF SUBCORTICAL NEUROMODULATORY SYSTEMS - where this paper uses passive exposure alone
claim_relations[3]1.0the tagger's words
claim_relationsreconciles → earlier electrophysiological reports of no adult experience effect, by attributing them to which cells unit recording samples and to anaesthesia
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differs in: which cells were recorded: ONE POSSIBILITY REFLECTS DIFFERENCES IN THE CELL POPULATIONS STUDIED - WE FOUND THAT EXPERIENCE HAD UNIQUE EFFECTS ON SOUND REPRESENTATIONS OF L2/3 PYRAMIDAL CELLS
claim_relations[4]1.0the tagger's words
claim_relationsqualifies → cat studies reporting loss of thalamocortical responsiveness after months of exposure, which differ in where the change sits
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differs in: the exposure duration and the level affected: TONE BURSTS MAINTAINED WITHOUT INTERRUPTION FOR 1.5-5 MONTHS, and the effect was A LOSS OF RESPONSIVENESS AT THE LEVEL OF THALAMOCORTICAL INPUT rather than a cortical change
claim_relations[5]1.0the tagger's words
claim_relationsqualifies → the inconsistent literature on whether auditory cortex is needed for simple sound detection, by measuring a threshold shift rather than an all-or-none loss
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claim_relations[6]1.0the tagger's words
claim_relationssupports → the parallel result in visual cortex, where silencing raises contrast detection threshold by a similar factor
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claim_relations[7]1.0the tagger's words
claim_relationsextends → studies of task engagement in auditory cortex that reached opposite conclusions and did not separate cell types
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claim_relations[8]1.0the tagger's words
concept_edgeshabituation —causes→ inhibition
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direction on the measure: increases · strength of the relation: 1 · note: twenty minutes a day for five days, and the whole effect is carried by a rise in inhibition Audit 2026-09-28: DOUBTFUL - read against its span and kept, but this span describes reduced representations after exposure; the increase in inhibition is stated in a neighbouring sentence.
concept_edges[5]1.0the tagger's words
concept_edgesL4 —distinct-from→ L2/3
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strength of the relation: 1 · note: the thalamorecipient layer barely moves, which is the argument that the change is made in cortex rather than inherited
also in: L4 · L2/3
concept_edges[9]1.0the tagger's words
concept_edgesSOM —contrasted-with→ PV
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strength of the relation: 1 · note: SOM cells are the most excitable population before any experience, at a ratio of 12.5 against 0.34 for PV cells
also in: SOM · PV
concept_edges[11]1.0the tagger's words
concept_edgesbehavior —causes→ SOM
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strength of the relation: 1 · note: AND THE CIRCUIT RUNS BACKWARDS: engagement suppresses SOM responses in 62.3 percent of cells against 1.4 percent the other way Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says behaviour had the opposite effect on SOM cells; 'causes SOM' drops the effect.
also in: behavior · SOM
concept_edges[14]1.0the tagger's words
concept_edgesbehaving —contrasted-with→ passive
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differs in: THE AXIS IS THE PROPORTION OF CELLS FAVOURING EACH STATE, AND NEITHER SIDE IS EMPTY. 'Quotation withheld.' A statement that behaviour enhances responses is true of half the cells and false of a fifth - so the population claim and the cell claim are different claims, and only the percentages distinguish them. · strength of the relation: 1 · note: excited cells rise during the task, and 51.6 percent of them are stronger while behaving against 19.4 percent while passive
also in: behaving · passive
concept_edges[15]1.0the tagger's words
concept_edgessilencing —causes→ psychometric
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strength of the relation: 1 · note: AND THE EFFECT SHRINKS WITH REPETITION: the shift got progressively smaller over days, read as compensation downstream - so the size of a perturbation depends on how often it has been applied Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says contralateral silencing shifted the psychometric curve; 'causes psychometric' is terse.
concept_edges[22]1.0the tagger's words
concept_edgesonset —contrasted-with→ sustained
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strength of the relation: 1 · note: the proposed function: filter out the sustained, keep the onset, because onsets carry the urgent information
also in: onset · sustained
concept_edges[26]1.0the tagger's words
content_tagst-test
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also in: t-test
content_tags.statistics[0]the tagger's words
content_tagsWilcoxon signed-rank test
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content_tags.statistics[1]the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[2]the tagger's words
content_tagsROC analysis
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also in: ROC analysis
content_tags.statistics[3]the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.statistics[4]the tagger's words
content_tagsone-way ANOVA
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also in: one-way ANOVA
content_tags.statistics[5]1.0the tagger's words
content_tagsSEM
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also in: SEM
content_tags.statistics[6]0.8the tagger's words
content_tagsFive days of brief daily passive exposure to the same tone sharply reduced the fraction of layer 2/3 pyramidal cells excited by that tone and roughly doubled the fraction inhibited by it.
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content_tags.findings[0]the tagger's words
content_tagsCortical habituation is an active process that recruits inhibition rather than a passive loss of excitatory drive.
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content_tags.findings[1]the tagger's words
content_tagsLayer 4 thalamorecipient neurons showed only weak, balanced changes with the same exposure, so the habituation in layer 2/3 is generated in cortex rather than inherited from subcortical inputs.
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content_tags.findings[2]the tagger's words
content_tagsThe experience-dependent increase in inhibition of L2/3 pyramidal cells appears to reflect selectively enhanced sound-evoked activity in SOM interneurons.
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content_tags.findings[3]the tagger's words
content_tagsWhen mice performed a sound-offset detection task with the habituated tone, pyramidal cell excitatory representations grew again, partially undoing habituation.
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content_tags.findings[4]the tagger's words
content_tagsPhotoinactivating auditory cortex raised the sound-detection threshold from about 41 to 52 dB.
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content_tags.findings[5]the tagger's words
content_tagsUnder anaesthesia inhibitory responses were entirely absent and tones evoked only transient onset or offset excitation.
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content_tags.findings[6]1.0the tagger's words
content_tagsawake responses to prolonged tones were varied - sustained, ramping, transient, and inhibitory
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content_tags.findings[7]1.0the tagger's words
content_tagsand the same patterns appeared in electrophysiology, so they are not an artefact of imaging
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content_tags.findings[8]1.0the tagger's words
content_tagsthe transient shift was quantified with an onset response index built from the first and last second of the tone
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content_tags.findings[9]1.0the tagger's words
content_tagsfive days of twenty minutes' exposure cut excited cells from 19.9 to 6.1 percent, doubled inhibited cells, and reduced their ratio tenfold
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content_tags.findings[10]1.0the tagger's words
content_tagswhich makes habituation an active recruitment of inhibition rather than a withdrawal of excitation
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content_tags.findings[11]1.0the tagger's words
content_tagsTHE FREQUENCY-SPECIFICITY CHECK separates a change in the representation from a change in the animal - the effect appears only at the experienced frequency
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content_tags.findings[12]1.0the tagger's words
content_tagsand the conclusions held with raw fluorescence instead of inferred spikes and across different amounts of neuropil subtraction
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content_tags.findings[13]1.0the tagger's words
content_tagslayer 4 thalamorecipient cells barely changed, and their excited-to-inhibited ratio not at all
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content_tags.findings[14]1.0the tagger's words
content_tagswhich is the argument that the change is made in cortex rather than inherited from below
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content_tags.findings[15]1.0the tagger's words
content_tagsAVERAGING OVER THE WHOLE INHIBITORY POPULATION HID THE EFFECT, and opposing actions on subtypes was the suspected reason
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content_tags.findings[16]1.0the tagger's words
content_tagsPV cells moved with the pyramidal cells, which rules them out as the source of the new inhibition
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content_tags.findings[17]1.0the tagger's words
content_tagsSOM cells moved the opposite way, with 58 percent showing larger responses on day five against 9.8 percent smaller
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content_tags.findings[18]1.0the tagger's words
content_tagsand the enhancement was strongest in the sustained component, matching where pyramidal suppression was strongest
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content_tags.findings[19]1.0the tagger's words
content_tagsSOM cells were already the most excitable population before any experience, at a ratio of 12.5 against 0.34 for PV cells
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content_tags.findings[20]1.0the tagger's words
content_tagsTHE TASK IS BUILT SO THE CONFOUND CANNOT ARISE: detecting the offset of a tone puts the measurement before the licking and before the reward
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content_tags.findings[21]1.0the tagger's words
content_tagssilencing the contralateral cortex raised the detection threshold by about 10 dB, from 40.7 to 51.9
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content_tags.findings[22]1.0the tagger's words
content_tagsand illuminating the ipsilateral cortex in the same mice did nothing, ruling out the light itself
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content_tags.findings[23]1.0the tagger's words
content_tagsAND THE EFFECT SHRANK WITH REPETITION over days, read as compensation in subcortical circuits
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content_tags.findings[24]1.0the tagger's words
content_tagsso subcortical structures alone suffice for detection while cortex improves sensitivity
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content_tags.findings[25]1.0the tagger's words
content_tagsand the size of the shift matches what silencing visual cortex does to contrast detection
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content_tags.findings[26]1.0the tagger's words
content_tagsno increase in passive representations followed training, contrary to earlier learning studies
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content_tags.findings[27]1.0the tagger's words
content_tagsbut during task engagement excited cells rose and 51.6 percent of them were stronger while behaving against 19.4 percent while passive
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content_tags.findings[28]1.0the tagger's words
content_tagswith block order and baseline fluorescence both checked
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content_tags.findings[29]1.0the tagger's words
content_tagslayer 4 did not move during behaviour either, localising the engagement effect to cortex as well
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content_tags.findings[30]1.0the tagger's words
content_tagsand SOM cells moved the opposite way again, suppressed in 62 percent of cells against 1.4 percent enhanced
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content_tags.findings[31]1.0the tagger's words
content_tagsPV cells could not be compared finely because their excitation was too sparse after habituation
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content_tags.findings[32]1.0the tagger's words
content_tagsTHE DISAGREEMENT WITH EARLIER WORK IS ATTRIBUTED TO WHAT UNIT RECORDING SAMPLES - cells with high firing rates, which may be the very populations that do not habituate
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content_tags.findings[33]1.0the tagger's words
content_tagsand another possibility is the difference in cortical activity between anesthetized and awake animals, since the activity of GABAergic interneurons can be strongly attenuated in the anesthetized state
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content_tags.findings[34]1.0the tagger's words
content_tagscat studies after months of exposure changed the thalamocortical input instead, which is a different location for the effect
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content_tags.findings[35]1.0the tagger's words
content_tagsthe proposed function is filtering sustained sounds while preserving onsets, which carry the more urgent information
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content_tags.findings[36]1.0the tagger's words
content_tagsprior work on task engagement had reached opposite conclusions and had not separated cell types
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content_tags.findings[37]1.0the tagger's words
content_tagsand the prolonged tones and offset task are named as a possible reason for the difference
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content_tags.findings[38]1.0the tagger's words
content_tagsthe standing view had been that adult auditory cortex changes only with associative conditioning
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content_tags.findings[39]1.0the tagger's words
content_tagsdifficulty in monitoring the dynamics of sensory representations in the same animal over long time scales has hampered investigation of the long-term effects of passive sensory experience
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content_tags.findings[40]1.0the tagger's words
content_tagsareas were told apart by tonotopic pattern before any cell was imaged, and all experiments were confined to the 10 to 20 kHz region
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content_tags.findings[41]1.0the tagger's words
content_tagsabout 31 percent of pyramidal cells responded to at least one frequency
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content_tags.findings[42]1.0the tagger's words
content_tagsthe exposure protocol was 200 trials a day of 5 to 9 second tones for five consecutive days
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content_tags.findings[43]1.0the tagger's words
content_tagsonset response index
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content_tags.definitions[1]the tagger's words
content_tagschange index (CI)
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content_tags.definitions[2]the tagger's words
content_tagshabituation
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also in: habituation
content_tags.definitions[3]1.0the tagger's words
content_tagschange index
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: change index
content_tags.definitions[4]0.7the tagger's words
content_tagsdeconvolution
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also in: deconvolution
content_tags.definitions[5]1.0the tagger's words
content_tagsTRF
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also in: TRF
content_tags.definitions[6]0.8the tagger's words
content_tagsengagement in the task
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content_tags.variables[1]the tagger's words
content_tagsinterneuron subtypes
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content_tags.variables[2]the tagger's words
content_tagsipsilateral silencing
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content_tags.variables[5]the tagger's words
content_tagsexcitation
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also in: excitation
content_tags.variables[6]1.0the tagger's words
content_tagsinhibition
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: inhibition
content_tags.variables[7]1.0the tagger's words
content_tagschange index
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: change index
content_tags.variables[8]0.8the tagger's words
content_tagspsychometric
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also in: psychometric
content_tags.variables[9]1.0the tagger's words
content_tagsTRF
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: TRF
content_tags.variables[10]1.0the tagger's words
content_tagsfraction of excited cells
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content_tags.variables[11]the tagger's words
content_tagsfraction of inhibited cells
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content_tags.variables[12]the tagger's words
content_tagsten-fold — reduction in the ratio of excited to inhibited layer 2/3 pyramidal cells after five days of passive tone exposure
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content_tags.quantities[0]the tagger's words
content_tags10 dB — rise in the sound level detection threshold caused by acute optogenetic silencing of contralateral auditory cortex
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content_tags.quantities[1]the tagger's words
content_tags58.0% — proportion of SOM cells whose tone-evoked responses were significantly larger on Day 5 than Day 1 (versus 9.8% showing the opposite)
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content_tags.quantities[2]the tagger's words
content_tags19.9 ± 2.7% / 6.1 ± 1.1% — fraction of layer 2/3 pyramidal cells excited by the exposed tone on Day 1 versus Day 5
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content_tags.quantities[3]the tagger's words
content_tags0% — inhibitory responses under anaesthesia, against about a quarter of cells awake - a response class the anaesthetised preparation cannot produce
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content_tags.quantities[4]1.0the tagger's words
content_tagsten-fold — the drop in the ratio of excited to inhibited cells over five days of passive exposure
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content_tags.quantities[5]1.0the tagger's words
content_tags58.0% — SOM cells with larger responses on day five, against 9.8 percent smaller - the opposite direction to every other population
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content_tags.quantities[6]1.0the tagger's words
content_tags12.5 ± 0.4 — excited-to-inhibited ratio in SOM cells before any experience, against 0.34 in PV cells
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content_tags.quantities[7]1.0the tagger's words
content_tags51.9 ± 4.0 dB — detection threshold with cortex silenced, against 40.7 dB without
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content_tags.quantities[8]1.0the tagger's words
content_tags31.0 ± 4.4% — pyramidal cells responding to at least one frequency, from 1480 cells in 8 mice
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content_tags.quantities[9]1.0the tagger's words

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