Flexible Sensory Representations in Auditory Cortex Driven by Behavioral Relevance — TEI-tagged view

Kato, Gillet, Isaacson · 2015 · neuroscience · doi:10.1016/j.neuron.2015.10.024 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. method is the weakest facet here: the dominant technique is chronic two-photon calcium imaging across days ('Here, we take advantage of chronic two-photon calcium imaging to investigate how experience and changes in the behavioral relevance of acoustic stimuli alter sensory representations in adult auditory cortex.'), supported by silicon-probe single-unit recording, optogenetic cortical silencing, and a trained head-fixed behavioural task; 'electrophysiology' is quoted from a real experiment in the paper but under-describes the study. The paper also carries a secondary causal claim about A1's contribution to sound detection thresholds via optogenetic silencing, which the single claim type facet cannot hold. 2026-08-13, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
Other fields define these differently the same word, defined another way in another discipline
behavior 4 fields · anesthesia 2 fields · SEM 2 fields · deconvolution 2 fields · habituation 2 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
A112 L2/32 L42 pyramidal16 SOM12 PV22 interneuron24 habituation4 excitation7 inhibition17 change index anesthesia14 awake7 behavioral relevance2 behavior19 detection8 psychometric3 silencing4 ipsilateral6 GCaMP6s5 unit recording intrinsic signal deconvolution5 neuropil3 dF/F TRF2 tonotopic9 sustained4 onset6 single unit3 behaving passive7 electrophysiology110

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenonexperience-dependent habituation of auditory cortex sound representations— “Here we show in mouse primary auditory cortex (A1) that daily passive sound exposure causes a long-lasting reduction in representations of the experienced sound by layer 2/3 pyramidal cells.”
claim-typemechanism— “This habituation arises locally in A1 and involves an enhancement in inhibition and selective upregulation in the activity of somatostatin-expressing inhibitory neurons (SOM cells).”
method — evidence— “Indeed, electrophysiological recordings of single unit activity revealed a similar shift to tone-evoked inhibition after daily sound experience ( Figure S1 ).”
object of study — evidence— “Here we show in mouse primary auditory cortex (A1) that daily passive sound exposure causes a long-lasting reduction in representations of the experienced sound by layer 2/3 pyramidal cells. This habituation arises locally in A1 and involves an enhancement in inhibition and selective upregulation in the activity of somatostatin-expressing…
research question — evidence— “However, difficulty in monitoring the dynamics of sensory representations in the same animal over long time scales has hampered investigation of the long-term effects of passive sensory experience on cortical auditory coding.”
contribution — evidence— “Taken together, our results demonstrate the bidirectional modulation of A1 sensory representations by passive experience and engagement in sound-guided behavior and point to SOM cells as a regulator of this flexibility”
transferfrom genetically targeted imaging: Cre-dependent expression of a calcium indicator, which is what makes the cell-type split possible at all— “We used adeno-associated virus (AAV) vectors to express the calcium indicator GCaMP6s ( Chen et al., 2013 ) in auditory cortex neurons of transgenic mice containing the activity independent reporter tdTomato in GABAergic neurons ( GAD2-IRES-Cre × Rosa-LSL-tdTomato ). This allowed us to optically distinguish glutamatergic pyramidal cells…transfers[0]
transferfrom intrinsic signal mapping: a macroscopic tonotopic map used to place the cellular imaging field inside the right area— “Two to three weeks following virus injection and the implantation of a glass window over auditory cortex, we performed intrinsic signal imaging to map the precise position of A1. Responses to pure tones of three frequencies (3, 10 and 30 kHz) routinely revealed three cortical regions that displayed tonotopic organization ( Figure 1B 1 ).…transfers[1]
transferfrom spike inference: deconvolution of fluorescence into an inferred rate, with the conclusions then rechecked without it— “To better estimate the time course of evoked activity, we calculated inferred spike rate from changes in fluorescence using deconvolution ( Vogelstein et al., 2010 ) and we used a single frequency based on the tone that activated the most cells during TRF mapping of each field.”transfers[2]
transferfrom psychophysics: a psychometric threshold for tone detection, used as the readout of a cortical silencing experiment— “Cortical photoinactivation shifted the psychometric curve to the right (n = 5 mice, Figures 5C and 5D ) indicating an increase in threshold (63% success rate) for sound detection (LED on : 51.9 ± 4.0 dB; LED off : 40.7 ± 2.6 dB; p = 0.03).”transfers[3]
mechanismRepeated passive exposure raises SOM interneuron activity, and the added SOM-mediated inhibition suppresses layer 2/3 pyramidal responses to the experienced tone.— “Habituation increases SOM cell activity, which leads to decreased sound representations in L2/3 pyramidal cells.”mechanisms[0]
mechanismTask engagement suppresses SOM cell firing, releasing pyramidal cells from local inhibition and thereby enlarging the representation of the behaviorally relevant sound.— “In contrast, engagement in sound-guided behavior suppresses SOM cell activity, leading to the enhancement of sound representations in L2/3 pyramidal cells.”mechanisms[1]
mechanismhabituation is an active process that recruits inhibition rather than a simple withdrawal of excitation— “Furthermore, habituation in A1 is not just a simple withdrawal of excitation; rather it also reflects a pronounced increase in inhibitory responses to the experienced stimulus. This sensory habituation provides a way for the cortex to filter out information lacking behavioral relevance.”mechanisms[2]
mechanismSOM cells are the source, since their tone-evoked excitation grows with the same experience that suppresses everything else— “Intriguingly, daily sound experience had a dramatically different action on the responses of SOM cells compared to PV and pyramidal cells: passive tone exposure increased the strength of tone-evoked SOM cell excitation ( Figure 4F, H ; CI = 0.39 ± 0.04; p < 0.001). Indeed, 58.0% of all SOM cells showed significantly larger responses on Day…mechanisms[3]
mechanismPV cells cannot be the source because their excitation falls with experience like the pyramidal cells they would have to inhibit— “Together, these results indicate that the effects of experience on PV cells mirror those of L2/3 pyramidal cells. Importantly, the strong experience-dependent reduction in PV cell activity suggests they are not the source of the enhanced pyramidal cell inhibition during habituation.”mechanisms[4]
mechanismthe enhancement is specific to the sustained part of the response, matching where the suppression of pyramidal activity is strongest— “Furthermore, the experience-induced enhancement of SOM cell evoked activity was most prominent during the sustained component of responses, consistent with the pronounced suppression of sustained activity we observed in L2/3 pyramidal cells”mechanisms[5]
mechanismsound-guided behavior had the opposite effect on SOM cells compared to L2/3 pyramidal cells, with fewer SOM cells excited by the tone during the behaving block— “Intriguingly, sound-guided behavior had the opposite effect on SOM cells compared to L2/3 pyramidal cells ( Figure 7D , n = 4 mice, 109 cells): the fraction of cells excited by the tone during the behaving block was significantly smaller ( Figure 7E , passive: 63.0 ± 8.1%; behaving: 43.8 ± 8.6%, p = 0.01) and the fraction of inhibited cells…mechanisms[6]
mechanismfiltering sustained sounds while preserving onsets is proposed as the function, since onsets carry the more urgent information— “Sound onsets are likely to signal more critical information (e.g. approach of a predator) than sustained sound features. Thus the mechanisms we describe may provide animals with the ability to selectively filter out sustained sounds (which are of limited behavioral relevance) while preserving the ability to detect sound onsets. While we do…mechanisms[7]
contradicts Bao et al. (2001), Kilgard and Merzenich (1998) and Zhang et al. (2001) on adult A1 being refractory to passive experience— “In contrast, acute recordings from anesthetized animals after long-term sound exposure report that A1 sensory representations are largely refractory to experience-dependent changes in adulthood ( Bao et al., 2001 ; Kilgard and Merzenich, 1998 ; Zhang et al., 2001 , but see Noreña et al., 2006 ).”claim_relations[0]
contradicts Noreña et al. (2006) on extensive sound exposure in cat auditory cortex— “However, unlike the results we show, this extensive sound exposure generated a loss of responsiveness at the level of thalamocortical input.”claim_relations[1]
builds-on Pfeffer et al. (2013) on SOM-to-PV inhibitory connectivity— “The fact that PV cells receive strong inhibitory input from SOM cells ( Pfeffer et al., 2013 ) may explain our finding that habituation leads to reduced tone-evoked excitation and increased inhibition of PV cells.”claim_relations[2]
contradicts the view that long-term changes in adult auditory cortex require associative conditioning— “In adults, however, long-term changes in auditory cortex circuits are believed to require associative conditioning. For instance, pairing tones of a particular frequency with foot shocks or stimulation of subcortical neuromodulatory systems shifts the frequency tuning of individual neurons in A1 towards the frequency of the conditioned…claim_relations[3]
reconciles earlier electrophysiological reports of no adult experience effect, by attributing them to which cells unit recording samples and to anaesthesia— “What accounts for the difference between the lack of effect in previous electrophysiological studies and…claim_relations[4]
qualifies cat studies reporting loss of thalamocortical responsiveness after months of exposure, which differ in where the change sitsclaim_relations[5]
qualifies the inconsistent literature on whether auditory cortex is needed for simple sound detection, by measuring a threshold shift rather than an all-or-none loss
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claim_relations[6]
supports the parallel result in visual cortex, where silencing raises contrast detection threshold by a similar factor
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claim_relations[7]
extends studies of task engagement in auditory cortex that reached opposite conclusions and did not separate cell types
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claim_relations[8]
senseA WHOLE RESPONSE CLASS EXISTS ONLY IN THE AWAKE ANIMAL: inhibitory responses were present in about a quarter of cells awake and in NONE under anaesthesia, and prolonged tones evoked only transient onset excitation
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senses[0]
senseso a literature built on anaesthetised recordings cannot contain the observation this paper is about, whatever it looked for
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senses[1]
senseTHE DISAGREEMENT WITH PRIOR WORK IS EXPLAINED BY WHAT THE OLDER INSTRUMENT COULD SEE: unit recordings are prone to pick up cells with high firing rates, so earlier experiments may have been sampling the very populations that do not habituate
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senses[2]
senseand a second explanation is offered beside it, that interneuron activity is attenuated under anaesthesia, with neither chosen
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senses[3]
senseAVERAGING OVER A POPULATION HID THE EFFECT: the whole GABAergic population gave variable results, and the finding only appeared once the two interneuron subtypes were imaged separately
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senses[4]
senseTHE DESIGN REMOVES THE CONFOUND RATHER THAN CORRECTING FOR IT: detecting the OFFSET of a tone puts the measurement before the licking and before the reward, so neither can contaminate the sound-evoked response
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senses[5]
senseAND THE CAUSAL EFFECT SHRINKS WITH REPETITION: the psychometric shift from silencing got progressively smaller over days, so the measured size of a perturbation depends on how many times it has been done
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senses[6]
sensethe frequency-specificity check is what separates a change in the representation from a change in the animal - the effect appears only at the experienced frequency
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senses[7]
senseand the conclusion is held against three analysis choices - inferred spikes against raw fluorescence, the amount of neuropil subtracted, and imaging against electrophysiology
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senses[8]
controlsounds of three different durations delivered in RANDOMLY INTERLEAVED trials — held — rules out temporal expectation - a fixed duration lets the animal learn when the sound ends, so a response at offset would be an anticipated event rather than a sensory one
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controls[0]
differs inBao et al. (2001), Kilgard and Merzenich (1998) and Zhang et al. (2001) on adult A1 being refractory to passive experience — the state of the animal and the recording: ACUTE RECORDINGS FROM ANESTHETIZED ANIMALS report A1 representations LARGELY REFRACTORY TO EXPERIENCE-DEPENDENT CHANGES IN ADULTHOOD, against chronic imaging in the awake mouse here
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claim_relations[0]
differs inNoreña et al. (2006) on extensive sound exposure in cat auditory cortex — the LEVEL of the pathway at which the change appears: UNLIKE THE RESULTS WE SHOW, THIS EXTENSIVE SOUND EXPOSURE GENERATED A LOSS OF RESPONSIVENESS AT THE LEVEL OF THALAMOCORTICAL INPUT
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claim_relations[1]
differs inthe view that long-term changes in adult auditory cortex require associative conditioning — whether reinforcement is required: long-term changes ARE BELIEVED TO REQUIRE ASSOCIATIVE CONDITIONING - PAIRING TONES OF A PARTICULAR FREQUENCY WITH FOOT SHOCKS OR STIMULATION OF SUBCORTICAL NEUROMODULATORY SYSTEMS - where this paper uses passive exposure alone
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claim_relations[3]
differs inearlier electrophysiological reports of no adult experience effect, by attributing them to which cells unit recording samples and to anaesthesia — which cells were recorded: ONE POSSIBILITY REFLECTS DIFFERENCES IN THE CELL POPULATIONS STUDIED - WE FOUND THAT EXPERIENCE HAD UNIQUE EFFECTS ON SOUND REPRESENTATIONS OF L2/3 PYRAMIDAL CELLS
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claim_relations[4]
differs incat studies reporting loss of thalamocortical responsiveness after months of exposure, which differ in where the change sits — the exposure duration and the level affected: TONE BURSTS MAINTAINED WITHOUT INTERRUPTION FOR 1.5-5 MONTHS, and the effect was A LOSS OF RESPONSIVENESS AT THE LEVEL OF THALAMOCORTICAL INPUT rather than a cortical change
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claim_relations[5]
audithabituation —causes→ inhibition — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but this span describes reduced representations after exposure; the increase in inhibition is stated in a neighbouring sentence.
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concept_edges[5]
effect directionhabituation —causes→ inhibition — increases
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concept_edges[5]
notehabituation —causes→ inhibition — twenty minutes a day for five days, and the whole effect is carried by a rise in inhibition
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concept_edges[5]
noteL4 —distinct-from→ L2/3 — the thalamorecipient layer barely moves, which is the argument that the change is made in cortex rather than inherited
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concept_edges[9]
noteSOM —contrasted-with→ PV — SOM cells are the most excitable population before any experience, at a ratio of 12.5 against 0.34 for PV cells
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concept_edges[11]
auditbehavior —causes→ SOM — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says behaviour had the opposite effect on SOM cells; 'causes SOM' drops the effect.
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concept_edges[14]
notebehavior —causes→ SOM — AND THE CIRCUIT RUNS BACKWARDS: engagement suppresses SOM responses in 62.3 percent of cells against 1.4 percent the other way
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concept_edges[14]
differs inbehaving —contrasted-with→ passive — THE AXIS IS THE PROPORTION OF CELLS FAVOURING EACH STATE, AND NEITHER SIDE IS EMPTY. '51.6% of excited cells showed significantly stronger net activity during the behaving block, whereas only 19.4% showed more activity in the passive condition.' A statement that behaviour enhances responses is true of half the cells and false of a fifth - so the population claim and the cell claim are different claims, and only the percentages distinguish them.
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concept_edges[15]
notebehaving —contrasted-with→ passive — excited cells rise during the task, and 51.6 percent of them are stronger while behaving against 19.4 percent while passive
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concept_edges[15]
auditsilencing —causes→ psychometric — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says contralateral silencing shifted the psychometric curve; 'causes psychometric' is terse.
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concept_edges[22]
notesilencing —causes→ psychometric — AND THE EFFECT SHRINKS WITH REPETITION: the shift got progressively smaller over days, read as compensation downstream - so the size of a perturbation depends on how often it has been applied
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concept_edges[22]
noteonset —contrasted-with→ sustained — the proposed function: filter out the sustained, keep the onset, because onsets carry the urgent information
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concept_edges[26]
outcome (stated by the tagger, no quotation)control — heldcontrols[0]
for which uselimitation — the spike-inference analyses, with the check stated: ALTHOUGH DATA ANALYSES USING SPIKE INFERENCE CAN BE AFFECTED BY SIGNAL-TO-NOISE RATIO, OUR CONCLUSIONS WERE IDENTICAL WHEN DF/F VALUES WERE USED
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limitations[0]
for which uselimitation — the single-cell specificity of the signals: WE CANNOT EXCLUDE SOME RESIDUAL CONTAMINATION OF CELLULAR SIGNALS BY NEUROPIL RESPONSES, though the conclusions do not depend on the degree of background subtraction
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limitations[1]
for which uselimitation — the comparison with the earlier task literature: the use of prolonged tones and a sound-offset detection task may itself explain the divergence
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limitations[2]
for which uselimitation — the sufficiency of the SOM account: WE DO NOT EXCLUDE THE POSSIBILITY THAT OTHER MECHANISMS COULD CONTRIBUTE TO AUDITORY HABITUATION UNDER DIFFERENT CONDITIONS
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limitations[3]
for which uselimitation — the PV comparison between behaving and passive conditions: THE VERY SPARSE EXCITATION OF PV CELLS FOLLOWING HABITUATION MADE IT DIFFICULT TO PERFORM A FINE COMPARISON
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limitations[4]
for which uselimitation — the disagreement with the task-engagement literature: WE CANNOT RULE OUT THE POSSIBILITY THAT THE USE OF PROLONGED TONES AND A SOUND-OFFSET DETECTION TASK MAY ACCOUNT FOR DIFFERENCES BETWEEN OUR FINDINGS AND PREVIOUS STUDIES
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limitations[5]
for which uselimitation — any silencing result, including this one, as a measure of necessity: WHEN THE CONTRALATERAL CORTICAL SILENCING EXPERIMENTS WERE REPEATED OVER SEVERAL DAYS THE SHIFT OF THE PSYCHOMETRIC CURVE BECAME PROGRESSIVELY SMALLER, SUGGESTING COMPENSATORY CHANGES IN SUBCORTICAL CIRCUITS
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limitations[6]
for which uselimitation — the comparison with the learning literature: WE DID NOT OBSERVE AN INCREASE IN SENSORY REPRESENTATIONS IN THE PASSIVE CONDITION AFTER TRAINING, contrary to four cited studies
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limitations[7]
for which uselimitation — the subtype-specific result, which the population-level data did not show: DAILY TONE EXPERIENCE PRODUCED VARIABLE EFFECTS ACROSS THIS CELL POPULATION ... MODEST EFFECTS AT THE POPULATION LEVEL COULD ARISE IF EXPERIENCE HAD DIFFERENT AND POTENTIALLY OPPOSING ACTIONS ON PARTICULAR SUBTYPES
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limitations[8]
replicationuntested
limitationSpike inference from calcium signals is sensitivity-limited, so conclusions were re-checked on raw dF/F.
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limitations[0]
limitationResidual neuropil contamination of cellular signals cannot be excluded.
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limitations[1]
limitationThe use of prolonged tones and a sound-offset detection task may itself explain the divergence from earlier task-engagement studies.
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limitations[2]
limitationOther mechanisms contributing to auditory habituation are not excluded.
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limitations[3]
limitationPV cell excitation after habituation is too sparse for a fine comparison during behaviour
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limitations[4]
limitationthe use of prolonged tones and an offset detection task may itself account for differences from earlier task-engagement studies that used transient sounds
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limitations[5]
limitationthe effect of silencing shrank when the same experiment was repeated over days, which is read as compensation downstream
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limitations[6]
limitationno increase in passive representations appeared after training, contrary to earlier learning studies
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limitations[7]
limitationthe whole GABAergic population showed only variable effects, so the result depends on splitting it by subtype
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limitations[8]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingFive days of brief daily passive exposure to the same tone sharply reduced the fraction of layer 2/3 pyramidal cells excited by that tone and roughly doubled the fraction inhibited by it.
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content_tags.findings[0]
findingCortical habituation is an active process that recruits inhibition rather than a passive loss of excitatory drive.
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content_tags.findings[1]
findingLayer 4 thalamorecipient neurons showed only weak, balanced changes with the same exposure, so the habituation in layer 2/3 is generated in cortex rather than inherited from subcortical inputs.
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content_tags.findings[2]
findingThe experience-dependent increase in inhibition of L2/3 pyramidal cells appears to reflect selectively enhanced sound-evoked activity in SOM interneurons.
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content_tags.findings[3]
findingWhen mice performed a sound-offset detection task with the habituated tone, pyramidal cell excitatory representations grew again, partially undoing habituation.
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content_tags.findings[4]
findingPhotoinactivating auditory cortex raised the sound-detection threshold from about 41 to 52 dB.
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content_tags.findings[5]
findingUnder anaesthesia inhibitory responses were entirely absent and tones evoked only transient onset or offset excitation.
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content_tags.findings[6]
findingawake responses to prolonged tones were varied - sustained, ramping, transient, and inhibitory
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content_tags.findings[7]
findingand the same patterns appeared in electrophysiology, so they are not an artefact of imaging
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content_tags.findings[8]
findingthe transient shift was quantified with an onset response index built from the first and last second of the tone
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content_tags.findings[9]
findingfive days of twenty minutes' exposure cut excited cells from 19.9 to 6.1 percent, doubled inhibited cells, and reduced their ratio tenfold
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content_tags.findings[10]
findingwhich makes habituation an active recruitment of inhibition rather than a withdrawal of excitation
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content_tags.findings[11]
findingTHE FREQUENCY-SPECIFICITY CHECK separates a change in the representation from a change in the animal - the effect appears only at the experienced frequency
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content_tags.findings[12]
findingand the conclusions held with raw fluorescence instead of inferred spikes and across different amounts of neuropil subtraction
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content_tags.findings[13]
findinglayer 4 thalamorecipient cells barely changed, and their excited-to-inhibited ratio not at all
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content_tags.findings[14]
findingwhich is the argument that the change is made in cortex rather than inherited from below
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content_tags.findings[15]
findingAVERAGING OVER THE WHOLE INHIBITORY POPULATION HID THE EFFECT, and opposing actions on subtypes was the suspected reason
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content_tags.findings[16]
findingPV cells moved with the pyramidal cells, which rules them out as the source of the new inhibition
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content_tags.findings[17]
findingSOM cells moved the opposite way, with 58 percent showing larger responses on day five against 9.8 percent smaller
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content_tags.findings[18]
findingand the enhancement was strongest in the sustained component, matching where pyramidal suppression was strongest
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content_tags.findings[19]
findingSOM cells were already the most excitable population before any experience, at a ratio of 12.5 against 0.34 for PV cells
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content_tags.findings[20]
findingTHE TASK IS BUILT SO THE CONFOUND CANNOT ARISE: detecting the offset of a tone puts the measurement before the licking and before the reward
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content_tags.findings[21]
findingsilencing the contralateral cortex raised the detection threshold by about 10 dB, from 40.7 to 51.9
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content_tags.findings[22]
findingand illuminating the ipsilateral cortex in the same mice did nothing, ruling out the light itself
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content_tags.findings[23]
findingAND THE EFFECT SHRANK WITH REPETITION over days, read as compensation in subcortical circuits
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content_tags.findings[24]
findingso subcortical structures alone suffice for detection while cortex improves sensitivity
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content_tags.findings[25]
findingand the size of the shift matches what silencing visual cortex does to contrast detection
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content_tags.findings[26]
findingno increase in passive representations followed training, contrary to earlier learning studies
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content_tags.findings[27]
findingbut during task engagement excited cells rose and 51.6 percent of them were stronger while behaving against 19.4 percent while passive
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content_tags.findings[28]
findingwith block order and baseline fluorescence both checked
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content_tags.findings[29]
findinglayer 4 did not move during behaviour either, localising the engagement effect to cortex as well
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content_tags.findings[30]
findingand SOM cells moved the opposite way again, suppressed in 62 percent of cells against 1.4 percent enhanced
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content_tags.findings[31]
findingPV cells could not be compared finely because their excitation was too sparse after habituation
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content_tags.findings[32]
findingTHE DISAGREEMENT WITH EARLIER WORK IS ATTRIBUTED TO WHAT UNIT RECORDING SAMPLES - cells with high firing rates, which may be the very populations that do not habituate
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content_tags.findings[33]
findingand another possibility is the difference in cortical activity between anesthetized and awake animals, since the activity of GABAergic interneurons can be strongly attenuated in the anesthetized state
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content_tags.findings[34]
findingcat studies after months of exposure changed the thalamocortical input instead, which is a different location for the effect
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content_tags.findings[35]
findingthe proposed function is filtering sustained sounds while preserving onsets, which carry the more urgent information
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content_tags.findings[36]
findingprior work on task engagement had reached opposite conclusions and had not separated cell types
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content_tags.findings[37]
findingand the prolonged tones and offset task are named as a possible reason for the difference
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content_tags.findings[38]
findingthe standing view had been that adult auditory cortex changes only with associative conditioning
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content_tags.findings[39]
findingdifficulty in monitoring the dynamics of sensory representations in the same animal over long time scales has hampered investigation of the long-term effects of passive sensory experience
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content_tags.findings[40]
findingareas were told apart by tonotopic pattern before any cell was imaged, and all experiments were confined to the 10 to 20 kHz region
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content_tags.findings[41]
findingabout 31 percent of pyramidal cells responded to at least one frequency
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content_tags.findings[42]
findingthe exposure protocol was 200 trials a day of 5 to 9 second tones for five consecutive days
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content_tags.findings[43]
quantityten-fold — reduction in the ratio of excited to inhibited layer 2/3 pyramidal cells after five days of passive tone exposure
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content_tags.quantities[0]
quantity10 dB — rise in the sound level detection threshold caused by acute optogenetic silencing of contralateral auditory cortex
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content_tags.quantities[1]
quantity58.0% — proportion of SOM cells whose tone-evoked responses were significantly larger on Day 5 than Day 1 (versus 9.8% showing the opposite)
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content_tags.quantities[2]
quantity19.9 ± 2.7% / 6.1 ± 1.1% — fraction of layer 2/3 pyramidal cells excited by the exposed tone on Day 1 versus Day 5
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content_tags.quantities[3]
quantity0% — inhibitory responses under anaesthesia, against about a quarter of cells awake - a response class the anaesthetised preparation cannot produce
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content_tags.quantities[4]
quantityten-fold — the drop in the ratio of excited to inhibited cells over five days of passive exposure
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content_tags.quantities[5]
quantity58.0% — SOM cells with larger responses on day five, against 9.8 percent smaller - the opposite direction to every other population
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content_tags.quantities[6]
quantity12.5 ± 0.4 — excited-to-inhibited ratio in SOM cells before any experience, against 0.34 in PV cells
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content_tags.quantities[7]
quantity51.9 ± 4.0 dB — detection threshold with cortex silenced, against 40.7 dB without
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content_tags.quantities[8]
quantity31.0 ± 4.4% — pyramidal cells responding to at least one frequency, from 1480 cells in 8 mice
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[9]
variableengagement in the task (independent)
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content_tags.variables[1]
variableinterneuron subtypes (independent)
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content_tags.variables[2]
variableipsilateral silencing (control)
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content_tags.variables[5]
variableexcitation
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content_tags.variables[6]
variableinhibition
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content_tags.variables[7]
variablechange index
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content_tags.variables[8]
variablepsychometric
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content_tags.variables[9]
variableTRF
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content_tags.variables[10]
variablefraction of excited cells (dependent)
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content_tags.variables[11]
variablefraction of inhibited cells (dependent)
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content_tags.variables[12]
definitiononset response index
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content_tags.definitions[1]
definitionchange index (CI)
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content_tags.definitions[2]
definitionhabituation
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content_tags.definitions[3]
definitionchange index
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content_tags.definitions[4]
definitiondeconvolution
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content_tags.definitions[5]
definitionTRF
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content_tags.definitions[6]
key-termsA1, L2/3, L4, pyramidal, SOM, PV, interneuron, habituation, excitation, inhibition, change index, awake, behavioral relevance, behavior, detection, psychometric, silencing, ipsilateral, GCaMP6s, unit recording, intrinsic signal, deconvolution, neuropil, dF/F, TRF, tonotopic, sustained, onset, single unit, passive, behaving
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
concepthabituation — not defined in this paper's own words; the progressive loss of representation for a repeated meaningless tone
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[7]
conceptinhibition — not defined in this paper's own words; the other half, which rises - and which does not exist at all under anaesthesia
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concepts[9]
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
t-test p as written: two-tailed t-test
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content_tags.statistics[0]
Wilcoxon signed-rank test
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content_tags.statistics[1]
ANOVA p as written: one-way ANOVA followed by Tukey’s post hoc test
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content_tags.statistics[2]
ROC analysis as written: receiver operator characteristic (ROC) analysis
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content_tags.statistics[3]
correlation as written: correlation coefficient
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content_tags.statistics[4]
one-way ANOVA
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content_tags.statistics[5]
SEM
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content_tags.statistics[6]
Second readings
a facet read a second time, independently, from its own sentence — and whether the two readings agree
claim typemechanism — a second reading reaching the same value; recorded: mechanism
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alternatives.claim_type
methodchronic two-photon imaging of GCaMP6s in identified pyramidal, layer 4, PV and SOM populations across five days of tone exposure and during alternating behaving and passive blocks, plus optogenetic cortical silencing during a sound-offset detection task — a second reading DIFFERING from the recorded value; recorded: electrophysiology
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alternatives.method
phenomenonhabituation of a cortical sensory representation to a repeated, meaningless stimulus, and its reversal when the stimulus becomes behaviourally relevant — a second reading DIFFERING from the recorded value; recorded: experience-dependent habituation of auditory cortex sound representations
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alternatives.phenomenon

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