Electrical Stimulation of the Midbrain for Hearing Restoration: Insight into the Functional Organization of the Human Central Auditory System

Lim, Lenarz, Joseph, Battmer, Samii, Samii, Patrick, Lenarz · Journal of Neuroscience · 2007 · neuroscience · 10.1523/jneurosci.3123-07.2007 · record Lim2007-electrical-stimulation-of-the-midbrain-for-h
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Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. method is tagged system-or-tool-building because the paper's substance is the design, implantation and evaluation of a device; a large part of the reported data is nonetheless human psychophysics (threshold/comfort levels, pitch ranking and scaling, loudness growth, sound localisation, speech tests), so a behavioural-experiment tag would be equally true of the measurements but not of the contribution. The paper is unusual in that its headline finding is partly a negative one — the tonotopic pitch ordering predicted from animal work did not appear — but this is reported as an open question rather than framed as a null result, so claim type stays method. Array placement differed across the three patients by surgical accident rather than design, which the authors treat as a fortunate source of comparison; no explicit statement frames this as a limitation, so it is not listed. 2026-08-13 and 2026-08-14 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
ICC 4 fields · standard deviation 3 fields · threshold 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 45 concept tags on this paper, 4 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
auditory midbrain implant auditory brainstem implant cochlear implant inferior colliculus ICC lateral lemniscus cochlear nucleus midbrain medial superior olive auditory nerve electrode array sites array placement tonotopic isofrequency pitch loudness threshold dynamic range compliance voltage current level pulse rate temporal resolution sound localization contralateral ipsilateral binaural monaural percept side effects paresthesia tinnitus NF2 deaf plastic speech perception lip reading vowel environmental sounds animal models speech tracking guinea pig MRI stimulation safety Sustained stimulation rates and patterns overdrive adaptation-prone neurons in the dorsal IC, raising the current needed over time Neurons higher in the auditory pathway lose the ability to phase-lock, and that loss of temporal synchronization is traded for a spatial, spike-rate-based code of temporal features, which is why the midbrain follows lower rates than the fibre pathway below it Ipsilaterally and contralaterally driven brainstem projections stay segregated as they ascend into the IC, so which region the array sits in determines the perceived direction of the sound The ipsilaterally excited fibre population is dominated by low-frequency-tuned neurons, so stimulating it yields low-pitch percepts An array lying outside the IC acts as a surface electrode, so current must travel further to reach neurons and activation levels rise animal studies lip-reading enhancement T level comfortable (C) level auditory brainstem implant (ABI) cochlear implant (CI) perceived pitch azimuth mean standard deviation averaging of repeated measurements randomly repeated three times and averaged for each site mean ± SD chance level system-or-tool-building

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1523/jneurosci.3123-07.2007. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 3 · claim_relations 7 · claim_type 1 · concept_edges 9 · concepts 4 · content_tags 98 · contribution 1 · controls 1 · limitations 10 · mechanisms 12 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 10 · transfers 4

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 9 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studywhether a penetrating electrode array in the inferior colliculus can restore useful hearing, and what stimulating different midbrain regions reveals about how the human auditory system is organised
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object_of_studythe paper's words
research_questionwhether stimulating along the tonotopic gradient of the human central nucleus produces ordered pitch percepts, as it does along the cochlea
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research_questionthe paper's words
contributionthe implant is safe and gives loudness, temporal and directional percepts and speech benefit comparable with the brainstem implant, but the ordered pitch the whole rationale predicted did not appear
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contributionthe paper's words
claim_typemethod
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claim_typethe paper's words
phenomenonauditory midbrain implant for hearing restoration
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phenomenonthe paper's words
methodsystem-or-tool-building
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsmechanisms
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mechanisms[3]the tagger's words
mechanismsmechanisms
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mechanisms[4]the tagger's words
mechanismsthe central nucleus is chosen because it receives almost all ascending brainstem pathways, so it should give access to a more complete set of inputs than the cochlea or cochlear nucleus
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mechanisms[5]1.0the tagger's words
mechanismsthe limited performance of tumour patients with the brainstem implant is attributed to tumour damage in the cochlear nucleus, which is the argument for moving upstream
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mechanisms[6]1.0the tagger's words
mechanismssegregated monaural and binaural pathways ascending into the midbrain are proposed to explain why each patient perceived only one direction
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mechanisms[7]0.9the tagger's words
mechanismsipsilaterally driven pathways carry mostly low frequencies, which is offered as the reason one patient heard only low pitches
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mechanisms[8]0.8the tagger's words
mechanismstemporal synchrony degrades at successive stages of the pathway, so a site below the colliculus should follow faster rates - which is what happened
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mechanisms[9]0.8the tagger's words
mechanismslong shallow loudness tails are read as a non-homogeneous mix of excitatory and inhibitory neurons along the isofrequency dimension
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mechanisms[10]0.6the tagger's words
mechanismsrising activation levels in one patient are hypothesised to be neurons in the dorsal region being overdriven by the stimulation pattern
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status: the paper's own words: is not clear
mechanisms[11]0.5the tagger's words
limitationsPitch data exist for only one patient whose array lay along the intended tonotopic gradient, so no definitive claim about human midbrain tonotopy can be made
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what this limits: any tonotopy claim about the human midbrain: BECAUSE WE ONLY HAVE PITCH DATA FOR ONE PATIENT WHOSE ARRAY IS SUPPOSEDLY ALIGNED ALONG THE TONOTOPIC GRADIENT OF THE ICC, WE CANNOT MAKE ANY DEFINITIVE CLAIMS
limitations[0]the tagger's words
limitationsThe standard temporal-resolution measures could not be run because of software limits, so a substitute continuity-rate judgement was used instead
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what this limits: the temporal-resolution results: THE COMMON TESTS ... ARE AMPLITUDE MODULATION DETECTION AND GAP DETECTION, WE COULD NOT PERFORM THESE TESTS WITH OUR SOFTWARE
limitations[1]the tagger's words
limitationsOne of the three patients produced no usable pitch-ordering data at all
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what this limits: the pitch-ordering data: NO RELIABLE PITCH ORDERING RESULTS WERE OBTAINED FOR AMI-1 WHO HAD DIFFICULTIES PERFORMING THESE TESTS - one of three patients
limitations[2]the tagger's words
limitationspitch data exist for only one patient whose array is aligned along the intended gradient, so no definitive claim about human midbrain tonotopy is made
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duplicate of: limitations[0] · what this limits: the same scope as limitations[0] - one aligned array, no definitive tonotopy claim
limitations[3]1.0the tagger's words
limitationsthe standard tests for temporal resolution could not be run because the software would not do them, so a different measure was substituted
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what this limits: the same scope as limitations[1], with the substitute: INSTEAD, WE STIMULATED A GIVEN SITE WITH CONtinuous trains
limitations[4]1.0the tagger's words
limitationsloudness balancing across the different sites and pulse rates was difficult because of limitations in the testing software, and performance on this test was argued to depend on whether the patient could clearly hear the sound rather than on slight variations in loudness
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what this limits: every across-site and across-rate comparison: LOUDNESS BALANCING WAS DIFFICULT TO PERFORM ACROSS THE DIFFERENT SITES AND PULSE RATES ATTRIBUTABLE TO LIMITATIONS IN OUR TESTING SOFTWARE
limitations[5]1.0the tagger's words
limitationsimaging after implantation was impossible because the array distorts the scan, so location comes from a fused reconstruction
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what this limits: every anatomical claim about electrode position: ACCURATE MRI IMAGES OF THE MIDBRAIN COULD NOT BE OBTAINED AFTER AMI IMPLANTATION BECAUSE OF THE DISTORTION CAUSED BY THE ELECTRODE ARRAY
limitations[6]1.0the tagger's words
limitationsall three patients had tinnitus throughout and were asked to ignore it while judging the stimulus
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what this limits: every percept the patients reported: ALL PATIENTS HAVE TINNITUS, WHICH WAS PRESENT BEFORE AND AFTER SURGERY, and AMI STIMULATION COULD ALTER THEIR TINNITUS
limitations[7]1.0the tagger's words
limitationsone patient's activation levels rose until they reached the compliance voltage of the stimulator and the device had to be switched off for 48 days
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what this limits: the stimulation levels reported for that patient: they rose until they reached THE COMPLIANCE VOLTAGE OF THE STIMULATOR and the device could no longer deliver more
limitations[8]1.0the tagger's words
limitationsthe work was supported by the company that makes the device, and one author is employed there
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what this limits: the independence of the evaluation, not its methods: THIS WORK WAS SUPPORTED BY COCHLEAR LIMITED, the manufacturer of the device under test
limitations[9]1.0the tagger's words
transfersthe tonotopic laminar organisation of the central nucleus, imported as the design principle for a human electrode array
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transfers[0]1.0the tagger's words
transferspulse rates and pulse widths fixed at the point where greater total charge stopped lowering thresholds and shorter pulse widths and slower pulse rates raised them
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transfers[1]0.9the tagger's words
transfersfixed and stained midbrain sections, used as the reference against which each patient's fused scan is read
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transfers[2]1.0the tagger's words
transfersthe patient scales the perceived pitch of each stimulated site on an environmental scale, selecting the environmental sound that most resembles it
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transfers[3]1.0the tagger's words
controlsthe CT scans taken AT LEAST SIX WEEKS after implantation rather than immediately
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eliminates: post-surgical distortion of the brain as the apparent electrode position - imaging a freshly operated brain measures the swelling as much as the anatomy · outcome (stated by the tagger, no quotation): held
controls[0]0.9the tagger's words
conceptslateral lemniscus
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concepts[5]the paper's words
conceptsloudness
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also in: loudness
concepts[16]the paper's words
conceptscurrent level
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also in: current level
concepts[20]the paper's words
conceptstemporal resolution
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concepts[22]the paper's words
sensesTHE PREDICTION THAT JUSTIFIED THE WHOLE TARGET FAILED, AND THE PAPER SAYS SO IN ONE LINE: ordered pitch along the tonotopic gradient was hypothesised from the animal work, and 'However, this has not yet been the case.'
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senses[0]1.0the tagger's words
sensesand the failure is not noise - stimulation of all sites in all three patients gave low pitches, and rates up to 2400 pulses per second produced no obvious rise over 250
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senses[1]1.0the tagger's words
sensesthe paper then lists four rival explanations as open questions - the stimulus form, plastic loss of high frequency representation after six years of deafness, position along the isofrequency dimension or passing fibres, and species differences - and chooses none
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senses[2]1.0the tagger's words
sensesAND REFUSES TO GENERALISE FROM ITS ONE INFORMATIVE PATIENT: with pitch data from a single correctly aligned array, no definitive claim about human midbrain tonotopy is made at all
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senses[3]1.0the tagger's words
sensesTHE ACCIDENT IS THE INDEPENDENT VARIABLE: the three arrays landed in three different places, and that unintended variation is what turns a safety trial into a map of the human auditory midbrain
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senses[4]1.0the tagger's words
sensesthe intended placement is stated separately from what happened, so the record contains both the plan and the deviation
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senses[5]1.0the tagger's words
sensesTHE ADVERSE EVENTS ARE MEASUREMENTS: dizziness and chest sensations, paresthesia in the face and upper body, paresthesia in the thigh and leg - each one locates the deep sites in a different non-auditory structure
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senses[6]1.0the tagger's words
sensesand every percept here is a patient's spoken report, obtained while they were asked to ignore a tinnitus that all three had before and after surgery
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senses[7]1.0the tagger's words
sensesTHE SAME RESULT SUPPORTS TWO INCOMPATIBLE READINGS AND BOTH ARE KEPT: faster rate following in the patient implanted below the colliculus fits the degradation-along-the-pathway account, or the other two sites simply sit in regions of poor temporal resolution
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senses[8]1.0the tagger's words
sensesTHE COMPARISON GROUP IS MATCHED ON THE RATER, NOT JUST THE PROTOCOL: eleven brainstem implant patients tested in the same clinic under the same protocols, by the same speech therapist who tested these three
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senses[9]1.0the tagger's words
alternativesclaim_type: method
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a second reading reaching the same value. Recorded: method — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: three patients implanted during tumour removal, array location reconstructed from fused imaging against fixed anatomical sections, then psychophysics per site - threshold, comfortable level, loudness growth, pitch ranking and scaling, rate discrimination, perceived direction - plus speech tests at six months
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a second reading DIFFERING from the recorded value. Recorded: system-or-tool-building — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: electrically evoked hearing: percepts of loudness, pitch, rate and direction produced by stimulating single sites in the human midbrain
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a second reading DIFFERING from the recorded value. Recorded: auditory midbrain implant for hearing restoration — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsbuilds-on → Lim and Anderson (2003, 2006); Lenarz et al. (2006a) animal studies of inferior colliculus stimulation
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claim_relations[0]the tagger's words
claim_relationsbuilds-on → the authors' own guinea pig work showing lower thresholds and more frequency-specific cortical activation from central nucleus stimulation than from the cochlea
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claim_relations[1]1.0the tagger's words
claim_relationscontradicts → the animal-derived prediction that stimulating along the tonotopic gradient would produce ordered pitch percepts
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claim_relations[2]1.0the tagger's words
claim_relationsqualifies → its own animal-derived expectation of lower thresholds, since the measured thresholds and dynamic ranges match the cochlear implant rather than beating it
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differs in: THE AXIS IS THE COMPARISON THE PREDICTION IS MEASURED AGAINST. 'AMI sites are in direct contact with surrounding neurons, UNLIKE CI SITES; thus, thresholds should be lower as shown in animal studies. However, AMI thresholds ... are 6-12 nC ..., and dynamic ranges are 7-9 dB, which are similar to those of the CI.' The animal-derived expectation is not refuted in animals; it fails to transfer to the human implant.
claim_relations[3]1.0the tagger's words
claim_relationssupports → the animal-derived account of segregated monaural and binaural pathways in the central auditory system
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claim_relations[4]1.0the tagger's words
claim_relationssupports → the hypothesis that temporal synchronisation degrades at successive stations and is traded for a spatial rate code
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claim_relations[5]0.9the tagger's words
claim_relationsextends → the observation that non-tumour brainstem implant patients do far better, which located the problem in tumour damage rather than in the site
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differs in: THE AXIS IS WHETHER THE PATIENT HAD A TUMOUR. 'Recently, the ABI has been implanted in nontumor patients who would not benefit from CIs. Surprisingly, some of these patients achieve performance levels comparable with CI patients, suggesting that the limited per[formance] [in tumour patients has another cause].' The poor outcomes of the original population are reattributed to the tumour rather than to the implant site - so a device evaluated only in tumour patients was being judged on a confound.
claim_relations[6]1.0the tagger's words
concept_edgespulse rate —distinct-from→ pitch
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strength of the relation: 1 · note: and the obvious escape route is closed in a parenthesis - rates to 2400 per second gave no obvious rise in pitch over 250 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span asks what stimuli elicit higher pitch than pulse rate alone; distinct-from is loose.
also in: pulse rate · pitch
concept_edges[1]1.0the tagger's words
concept_edgesdeaf —causes→ plastic
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strength of the relation: 0.6 — the record marks this weak · note: one of four rival explanations offered as open questions and none of them chosen Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span is a question about plastic reorganization after deafness.
also in: deaf · plastic
concept_edges[5]0.6the tagger's words
concept_edgescontralateral —distinct-from→ ipsilateral
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strength of the relation: 1 · note: and the percept does not vary across the 1.7 to 1.9 mm the active sites span, which is the argument for segregated ascending pathways Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span reports one directional percept per patient; distinct-from is loose.
concept_edges[15]1.0the tagger's words
concept_edgesmonaural —distinct-from→ binaural
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strength of the relation: 1
also in: monaural · binaural
concept_edges[16]1.0the tagger's words
concept_edgesipsilateral —causes→ pitch
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strength of the relation: 0.7 · note: and the same anatomy is then used to explain that patient's low pitches, so one placement accounts for two separate anomalies Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span explains low pitches by ipsilateral low-frequency pathways; causes 'pitch' is terse.
also in: ipsilateral · pitch
concept_edges[18]0.8the tagger's words
concept_edgestemporal resolution —operationalised-as→ pulse rate
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strength of the relation: 1 · note: THE MEASURE IS A SUBSTITUTE: modulation and gap detection could not be run because the software would not do them, so the rate at which pulses fuse into a continuous sound is used instead
concept_edges[19]1.0the tagger's words
concept_edgesthreshold —operationalised-as→ current level
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strength of the relation: 1 · note: found by raising the current until a sound is heard and lowering it until it is not, repeated until the patient is consistent Audit 2026-09-28: DOUBTFUL - read against its span and kept, but thresholds were measured in current level; operationalised-as is loose.
concept_edges[23]1.0the tagger's words
concept_edgesinferior colliculus —contrasted-with→ cochlear nucleus
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strength of the relation: 1 · note: the target is chosen because nearly all ascending pathways converge there, so it should give access to a more complete set of inputs
concept_edges[29]1.0the tagger's words
concept_edgesmidbrain —contrasted-with→ cochlear nucleus
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strength of the relation: 1 · note: the new target against the existing one - the whole clinical claim is a comparison with the alternative these patients would otherwise receive Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span contrasts the midbrain implant with the brainstem implant only by implication.
concept_edges[33]1.0the tagger's words
content_tagsmean
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also in: mean
content_tags.statistics[0]the tagger's words
content_tagsstandard deviation
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content_tags.statistics[1]the tagger's words
content_tagsaveraging of repeated measurements
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content_tags.statistics[2]the tagger's words
content_tagsmean ± SD
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also in: mean ± SD
content_tags.statistics[3]1.0the tagger's words
content_tagschance level
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also in: chance level
content_tags.statistics[4]0.9the tagger's words
content_tagsThree NF2 patients were implanted with a penetrating auditory midbrain implant and the device proved safe, with the array showing minimal movement over time.
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content_tags.findings[0]the tagger's words
content_tagsMidbrain stimulation delivered usable loudness, pitch, temporal and directional percepts.
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content_tags.findings[1]the tagger's words
content_tagsAll three patients gained lip-reading enhancement and environmental sound awareness, with speech perception on a par with NF2 auditory brainstem implant patients.
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content_tags.findings[2]the tagger's words
content_tagsContrary to the animal-derived prediction, stimulating successive depths along the ICC tonotopic gradient did not produce an ordered pitch shift, and every site in every patient sounded predominantly low-pitched.
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content_tags.findings[3]the tagger's words
content_tagsWith IC stimulation, patients perceived a continuous stimulus above 80 pps, mostly around 50 pps, a resolution of about 20 ms.
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content_tags.findings[4]the tagger's words
content_tagsThe patient implanted at the lateral lemniscus rather than in the IC still heard buzzing up to 220 pps, about three times the rate the IC-implanted patients could follow.
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content_tags.findings[5]the tagger's words
content_tagsPerceived sound direction was fixed within each patient but differed by implant location: ipsilateral for the lateral-lemniscus placement and contralateral for the dorsomedial ICC placement.
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content_tags.findings[6]the tagger's words
content_tagsDespite electrodes sitting directly among midbrain neurons, thresholds (6-12 nC) and dynamic ranges (7-9 dB) were no better than those of a cochlear implant.
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content_tags.findings[7]the tagger's words
content_tagsLoudness grew monotonically with current level in all three patients, so level cues can be coded systematically from the midbrain.
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content_tags.findings[8]the tagger's words
content_tagsIn the patient implanted in the dorsal IC, threshold and comfortable levels drifted upward until they hit the stimulator's compliance voltage.
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content_tags.findings[9]the tagger's words
content_tagsWith the implant alone, two patients identified 23% and 40% of vowels against a 10% chance level.
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content_tags.findings[10]the tagger's words
content_tagsPatients detected all instruments but could identify only the low-frequency ones.
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content_tags.findings[11]the tagger's words
content_tagsTHE FOUNDING PREDICTION FAILED: ordered pitch along the tonotopic gradient was hypothesised from animal work, and did not appear
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content_tags.findings[12]1.0the tagger's words
content_tagsstimulation of nearly all sites in all three patients gave low pitch percepts, below a man's voice
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content_tags.findings[13]1.0the tagger's words
content_tagsand pulse rates up to 2400 per second produced no obvious rise in pitch over 250
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content_tags.findings[14]1.0the tagger's words
content_tagspitch scores varied across days and even across different times on the same day, variability much greater than what is typically observed for CI patients
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content_tags.findings[15]1.0the tagger's words
content_tagsfor the one correctly aligned array the deviation from the predicted order is left unexplained
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content_tags.findings[16]1.0the tagger's words
content_tagsFOUR RIVAL EXPLANATIONS ARE LISTED AS OPEN QUESTIONS and none is chosen: stimulus form, plastic loss of high frequency representation after six years of deafness, position along the isofrequency dimension or passing fibres, and species differences
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content_tags.findings[17]1.0the tagger's words
content_tagsAND NO DEFINITIVE CLAIM IS MADE about human midbrain tonotopy, because only one patient's array was aligned along the gradient
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content_tags.findings[18]1.0the tagger's words
content_tagsAMI thresholds and dynamic ranges are similar to those of the CI, though the sites are in direct contact with surrounding neurons and thresholds should be lower
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content_tags.findings[19]1.0the tagger's words
content_tagsand the animal explanation offered for that is questioned in the same paragraph
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content_tags.findings[20]1.0the tagger's words
content_tagsall patients gave monotonically increasing loudness with current, so level cues are transmissible
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content_tags.findings[21]1.0the tagger's words
content_tagsone patient showed long shallow loudness tails, read as a non-homogeneous mix of excitatory and inhibitory neurons along the lamina
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content_tags.findings[22]1.0the tagger's words
content_tagsONE DIRECTION PER PATIENT: binaural throughout for the dorsal placement, ipsilateral throughout for the lemniscal one, contralateral throughout for the central nucleus one
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content_tags.findings[23]1.0the tagger's words
content_tagsand the direction did not change across the 1.7 to 1.9 mm the active sites span
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content_tags.findings[24]1.0the tagger's words
content_tagswhich is taken as human support for segregated monaural and binaural pathways derived from animal work
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content_tags.findings[25]1.0the tagger's words
content_tagsthe ipsilateral percepts are attributed to medial superior olive fibres, using the enlarged medial and reduced lateral olive of humans
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content_tags.findings[26]1.0the tagger's words
content_tagsand the same placement is used to explain that patient's low pitches, since ipsilaterally driven pathways carry mostly low frequencies
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content_tags.findings[27]1.0the tagger's words
content_tagspulses fused into a continuous sound above 80 per second and usually near 50, a resolution of about 20 ms, against 250 to 300 for cochlear stimulation
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content_tags.findings[28]1.0the tagger's words
content_tagsthe patient implanted below the colliculus followed about three times the rate of the other two
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content_tags.findings[29]1.0the tagger's words
content_tagsTWO INCOMPATIBLE READINGS OF THAT ARE BOTH KEPT: synchrony degrading up the pathway, or the other two arrays simply sitting in regions of poor temporal resolution
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content_tags.findings[30]1.0the tagger's words
content_tagsTHE ACCIDENT IS THE INDEPENDENT VARIABLE: three arrays landed in three different places, and that variation is what makes the trial a map of the auditory midbrain
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content_tags.findings[31]1.0the tagger's words
content_tagsthe intention was to insert the array 45 degrees off the sagittal plane and into the ICC to position the sites within different anatomical layers, which supposedly correspond to different frequency laminas
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content_tags.findings[32]1.0the tagger's words
content_tagsdeep sites in the first patient caused dizziness and chest and facial sensations and were switched off
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content_tags.findings[33]1.0the tagger's words
content_tagsthe second array sat below the colliculus near the lateral lemniscus and every site mixed auditory with cold and paresthetic sensations
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content_tags.findings[34]1.0the tagger's words
content_tagsthe third array reached the intended central nucleus, with deep sites producing paresthesia in the contralateral thigh, leg and foot
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content_tags.findings[35]1.0the tagger's words
content_tagsno pain or adverse functional effect resulted, and uncomfortable percepts were removed by switching sites off
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content_tags.findings[36]1.0the tagger's words
content_tagsthe auditory sensations and side effects associated with each site have generally remained stable, indicating minimal movement of the implant over time
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content_tags.findings[37]1.0the tagger's words
content_tagsbut the levels for AMI-1 continued to rise, reaching the compliance voltage of the stimulator, so the processor was turned off for 48 d, after which the activation levels decreased dramatically but not completely to the initial values
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content_tags.findings[38]1.0the tagger's words
content_tagsspeech benefit at six months was comparable with eleven brainstem implant patients tested in the same clinic by the same speech therapist
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content_tags.findings[39]1.0the tagger's words
content_tagsand the brainstem group's own scores span a wide range, with six of eleven getting no consonant benefit at all
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[40]1.0the tagger's words
content_tagstwo patients scored above chance on vowels with the implant alone
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[41]1.0the tagger's words
content_tagsboth tested patients detected every instrument but could identify only the low frequency ones
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[42]1.0the tagger's words
content_tagsand the reported gains are in everyday awareness - traffic, birds, doors, the telephone - and in one patient's control of her own voice
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content_tags.findings[43]1.0the tagger's words
content_tagsTHE MEASURE IS A SUBSTITUTE: modulation and gap detection could not be run because the software would not do them
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content_tags.findings[44]1.0the tagger's words
content_tagsand loudness could not be balanced for that test either, which is argued not to matter for what it measures
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content_tags.findings[45]1.0the tagger's words
content_tagsbefore the pitch and direction tests every site was adjusted until the patient said they were equally loud
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content_tags.findings[46]1.0the tagger's words
content_tagswith no reference tone available, absolute pitch was scaled against familiar imagined environmental sounds
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content_tags.findings[47]1.0the tagger's words
content_tagsthe stimulus parameters were chosen at the point where more charge stopped lowering thresholds and less charge raised them sharply
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content_tags.findings[48]1.0the tagger's words
content_tagsaccurate MRI images of the midbrain could not be obtained after AMI implantation because of the distortion caused by the electrode array, so CT images were obtained at least 6 weeks after implantation
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content_tags.findings[49]1.0the tagger's words
content_tagsand those slices are read against fixed and stained human midbrain sections from an anatomical collection
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content_tags.findings[50]1.0the tagger's words
content_tagsall three patients had tinnitus before and after surgery and were instructed to ignore it during testing
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content_tags.findings[51]1.0the tagger's words
content_tagsthe surgical method for placing the array was improved across these three patients
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content_tags.findings[52]1.0the tagger's words
content_tagsa three-dimensional array spanning the colliculus is proposed as the next design
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[53]1.0the tagger's words
content_tagsthe stated advantage over the brainstem implant is surgical - direct visual exposure, no tumour distortion, less risk to brainstem structures
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content_tags.findings[54]1.0the tagger's words
content_tagsthe work was supported by the company that makes the device
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content_tags.findings[55]1.0the tagger's words
content_tagslip-reading enhancement
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content_tags.definitions[0]the tagger's words
content_tagsT level
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also in: T level
content_tags.definitions[1]the tagger's words
content_tagscomfortable (C) level
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[2]the tagger's words
content_tagsauditory brainstem implant (ABI)
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[3]the tagger's words
content_tagscochlear implant (CI)
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content_tags.definitions[4]the tagger's words
content_tagsauditory brainstem implant
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content_tags.definitions[5]1.0the tagger's words
content_tagscochlear implant
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[6]1.0the tagger's words
content_tagstemporal resolution
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[7]1.0the tagger's words
content_tagslip reading
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: lip reading
content_tags.definitions[8]0.8the tagger's words
content_tagselectrode array
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[9]1.0the tagger's words
content_tagscurrent level
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: current level
content_tags.variables[1]the tagger's words
content_tagspulse rate
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: pulse rate
content_tags.variables[2]the tagger's words
content_tagsperceived pitch
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[3]the tagger's words
content_tagsazimuth
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: azimuth
content_tags.variables[4]the tagger's words
content_tagsthreshold
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: threshold
content_tags.variables[8]1.0the tagger's words
content_tagspitch
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: pitch
content_tags.variables[9]1.0the tagger's words
content_tagsloudness
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: loudness
content_tags.variables[10]1.0the tagger's words
content_tagstemporal resolution
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[11]1.0the tagger's words
content_tagssound localization
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[12]0.85the tagger's words
content_tagsThree — number of patients implanted with the auditory midbrain implant
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content_tags.quantities[0]the tagger's words
content_tags6.2 mm long with a diameter of 0.4 mm — dimensions of the penetrating AMI electrode array
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content_tags.quantities[1]the tagger's words
content_tags20 platinum ring electrodes linearly spaced at an interval of 200 μm — electrode count and spacing on the array
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content_tags.quantities[2]the tagger's words
content_tags6–12 nC ... 7–9 dB — AMI threshold charge and dynamic range in the patient implanted in the ICC
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[3]the tagger's words
content_tags42 ± 7 and 65 ± 8 pps — pulse rate at which buzzing fused into a continuous percept for the two IC-implanted patients
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content_tags.quantities[4]the tagger's words
content_tags220 pps (mean ± SD, 180 ± 17) — temporal fusion rate for the patient implanted at the lateral lemniscus
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[5]the tagger's words
content_tags23 and 40% correct (10% chance level) — vowel identification with AMI stimulation alone for AMI-2 and AMI-3 at 6 months
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content_tags.quantities[6]the tagger's words
content_tags12.5 and 10% — consonant and number test scores achieved above chance by AMI-3 with the implant alone
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[7]the tagger's words
content_tags∼2–11 words per minute — lip-reading enhancement in speech tracking obtained by adding the AMI to lip reading
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content_tags.quantities[8]the tagger's words
content_tags∼85–100 words per minute — speech tracking rate of normal-hearing subjects in the same clinic, as a reference
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content_tags.quantities[9]the tagger's words
content_tagsonly four — number out of 11 ABI NF2 patients who beat AMI-3's 11 words-per-minute lip-reading enhancement
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content_tags.quantities[10]the tagger's words
content_tags2400 pps — pulse rates swept this high without any obvious increase in pitch over 250, which closes the most obvious escape from the failed prediction
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content_tags.quantities[11]1.0the tagger's words
content_tags7–9 dB — dynamic range in the correctly placed patient, similar to the cochlear implant rather than better as animal work predicted
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content_tags.quantities[12]1.0the tagger's words
content_tags∼20 ms — the temporal resolution implied by fusion near 50 pulses per second, against a few milliseconds for cochlear stimulation
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content_tags.quantities[13]1.0the tagger's words
content_tags1.7–1.9 mm — the span of active sites across which the perceived direction never changed
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content_tags.quantities[14]1.0the tagger's words
content_tags48 d — how long the device was switched off after one patient's levels reached the stimulator's compliance voltage
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content_tags.quantities[15]1.0the tagger's words
content_tags6.2 mm — array length, carrying 20 sites at 200 micrometre spacing
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content_tags.quantities[16]1.0the tagger's words
content_tags11 ABI NF2 patients — the comparison group, tested in the same clinic under the same protocols by the same speech therapist
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content_tags.quantities[17]1.0the tagger's words

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