Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection

McGinley, David, McCormick · Neuron · 2015 · neuroscience · 10.1016/j.neuron.2015.05.038 · record McGinley2015-cortical-membrane-potential-signature-of-opt
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Claim type 'mechanism' rather than 'existence' because the paper offers a synaptic/network account (suppression of slow rhythms then depolarization with hyper-arousal) of an already-classic behavioural relationship; the headline empirical statement is 'Optimal signal detection behavior and sound-evoked responses, at both sub-threshold and spiking levels, occurred at intermediate arousal when pre-decision membrane potentials were stably hyperpolarized.' The Reimer et al. (2014) relation is recorded twice with two types because the paper both aligns itself with that study and reports a specific disagreement with it (layer 2/3 vs deep pyramidal cells). Methods are heavily abbreviated in this source text (Supplemental Methods referenced but not included), so method_evidence comes from the condensed Experimental Procedures section. 2026-08-13, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.
Other fields define these differently the same word, defined another way in another discipline
reliability 5 fields · behavior 4 fields · standard deviation 3 fields · arousal 2 fields · anesthesia 2 fields · latency 2 fields · and 2 more →

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 34 concept tags on this paper, 4 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
arousal pupil ripple eyelid EIS derivative membrane potential Vm variance hyperpolarized depolarization oscillation microdilation walking movement whisking ACtx MG layer evoked spontaneous gain reliability coherence detection hit false alarm latency inverted-U U-shaped state anesthesia sensory behavior rising arousal suppresses low-frequency cortical rhythms, letting cortico-cortical and cortico-subcortical circuits interact more reliably and so producing larger, more precise sensory responses at hyper-arousal the depolarization is carried by task-unrelated synaptic activity that raises membrane variance and thereby disrupts sensory-evoked neuronal interactions the opposing arousal-driven changes in thalamic gain and cortical depolarization combine to generate the U and inverted-U curves relating arousal to neural and behavioural performance the lag between cortical depolarization and pupil dilation arises because pupillary and eyelid muscles respond slowly to sympathetic and parasympathetic drive microdilations eye-indexed state Yerkes-Dodson curve canonical wakeful state target tone level intracellular injection of current spontaneous activity behavioral performance pupil diameter correlation correlation coefficient CC ANOVA ANOVA models with posthoc pairwise comparisons standard deviation standard error of the mean bootstrap confidence interval resampling with replacement signal detection theory measures (d-prime and criterion) standard signal detection theory measures F-test explained variance increase in explained variance cross-correlation average of the correlation coefficient between all pairs of responses cross correlation resampled electrophysiology

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field
unrecordable relationunhoused_relationsa relation the paper asserts that this vocabulary cannot express, with the reason

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1016/j.neuron.2015.05.038. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 3 · claim_relations 8 · claim_type 1 · concept_edges 12 · concepts 4 · content_tags 97 · contribution 1 · controls 1 · limitations 7 · mechanisms 8 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 10 · transfers 4 · unhoused_relations 1

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 12 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studywhat the cortex is doing at the moment an animal is best at detecting a faint sound, and how that state can be measured continuously from outside
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object_of_studythe paper's words
research_questionwhat the synaptic and circuit basis is of the classical inverted-U between arousal and detection performance
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research_questionthe paper's words
contributionarousal read continuously from the pupil predicts membrane potential, sensory response and behaviour, and all three are optimal at an intermediate level where the cortex is stably hyperpolarised
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenonarousal-dependent auditory signal detection
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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status: the paper's own words: We hypothesize that
mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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status: the paper's own words: We propose that
mechanisms[2]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[3]the tagger's words
mechanismsmembrane potential and its variance trace a U-shaped relationship against arousal level as indexed by normalized pupil diameter
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mechanisms[4]1.0the tagger's words
mechanismsso the signal-to-noise ratio of an evoked response is high at that state, from both suppressed background and larger responses
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mechanisms[5]1.0the tagger's words
mechanismsat high arousal the cortex depolarises, which may raise single-neuron responsiveness while degrading the interactions that carry a sensory response
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mechanisms[6]0.7the tagger's words
mechanismsand thalamic responses fall with arousal and fall further with walking, so part of the cortical decline is inherited
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mechanisms[7]1.0the tagger's words
limitationsThe proposed thalamo-cortical account of the U-shaped relationship has not been tested across behavioural contexts.
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what this limits: the thalamo-cortical account of the U-shaped relationship: FURTHER EXAMINATION OF THIS HYPOTHESIS, PARTICULARLY THE INFLUENCE OF BEHAVIORAL CONTEXT, REMAINS TO BE DONE
limitations[0]the tagger's words
limitationsThe paper cannot resolve why locomotion enhances visual but suppresses auditory cortical responses.
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what this limits: the visual-versus-auditory locomotion discrepancy: IT IS CURRENTLY UNCLEAR WHETHER THESE APPARENTLY OPPOSING RESULTS REFLECT VARIATIONS BETWEEN SENSORY SYSTEMS IN CORTICAL OR SUBCORTICAL INFLUENCES OF LOCOMOTION AND/OR AROUSAL
limitations[1]the tagger's words
limitationsThe neuromodulatory pathway linking pupil-indexed arousal to the cortical inhibitory circuitry was not established.
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what this limits: the neuromodulatory account: THE INFLUENCE OF NOREPINEPHRINE, WHICH IS THOUGHT TO CONTROL PUPIL DIAMETER, ON CORTICAL INHIBITORY CIRCUITS REMAINS TO BE DETERMINED
limitations[2]the tagger's words
limitationswhether the opposing visual and auditory results reflect sensory systems, subcortical influences or the arousal level during stillness is stated to be unclear
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what this limits: the generalisation across cortical areas: in visual cortex LOCOMOTION IS ASSOCIATED WITH ENHANCED SENSORY-EVOKED VISUAL RESPONSES, while in auditory cortex the effect runs the other way
limitations[3]1.0the tagger's words
limitationslaminar position and cell type are named as a second possible source of between-study variation, with their layer 5 cells behaving unlike layer 2/3 visual cells
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what this limits: the same scope as limitations[3], with a second candidate source: ANOTHER POSSIBLE SOURCE OF VARIATION BETWEEN STUDIES ... IS THE LAMINAR POSITION AND CELL TYPE OF THE RECORDED NEURONS
limitations[4]1.0the tagger's words
limitationsthe influence of behavioural context on the proposed account remains to be done
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what this limits: the proposed U-shaped account: FURTHER EXAMINATION OF THIS HYPOTHESIS, PART[icularly under behavioural context], remains to be done
limitations[5]1.0the tagger's words
limitationsthe peak of one measure out of thirteen, behavioural discriminability, sits at a significantly smaller pupil diameter than the rest
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what this limits: the claim that the measures share an optimal arousal level: WE DID NOT FIND STATISTICALLY SIGNIFICANT DIFFERENCE BETWEEN 12 OF THE 13 BEHAVIORAL OR PHYSIOLOGICAL measures - so one of thirteen peaks elsewhere, and it is the behavioural one
limitations[6]1.0the tagger's words
transferspupillometry as a continuous index of autonomic state, imported to index cortical membrane potential rather than emotion
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transfers[0]1.0the tagger's words
transferssharp-wave ripple rate as an independent state variable, used to validate the pupil rather than as the object of study
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transfers[1]1.0the tagger's words
transfersresponse latency on hit trials plotted against pupil diameter, showing short latency licks and a large decrease in variability of lick latency at intermediate diameters
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transfers[2]0.9the tagger's words
transfersresponses sorted by state against responses averaged over all states, where no effect would be a diagonal of slope one
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transfers[3]1.0the tagger's words
controlseyelid opening measured IN DARKNESS, alongside the pupil recording
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eliminates: illumination change as the cause of the pupil dilations - an eye movement changes how much light reaches the pupil, so a dilation time-locked to behaviour could be an optical consequence of looking elsewhere · outcome (stated by the tagger, no quotation): held
controls[0]0.95the tagger's words
conceptspupil
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also in: pupil
concepts[1]the paper's words
conceptshyperpolarized
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concepts[9]the paper's words
conceptsevoked
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also in: evoked
concepts[19]the paper's words
conceptshit
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also in: hit
concepts[25]the paper's words
unhoused_relationspupil derivative → pupil diameter
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THE INDEXING / PROXY RELATION - 'from' STANDS IN FOR 'to'. We have no type for it: 'causes' asserts production, and 'operationalised-as' says the authors CHOSE a measure, whereas a proxy claim says THIS STANDS IN FOR WHAT WE ACTUALLY CARE ABOUT AND WE KNOW IT IS NOT THE SAME THING. Measured at 8% of papers. A PROXY FOR ITSELF, DISPLACED IN TIME: 'the explanatory power of the pupil derivative occurs because it serves as a proxy for the pupil diameter approximately 1 second later'. The two endpoints are the same measurement at different lags, which is a substitution no vocabulary of concepts would catch.
unhoused_relations[0]the tagger's words
sensesA LITERATURE'S CONTRADICTIONS ATTRIBUTED TO A VARIABLE NOBODY MEASURED: state fluctuates continuously and in seconds, which produces variability between studies and between moments inside one study, and has not been accounted for
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senses[0]1.0the tagger's words
sensesand one earlier report is named as having recorded across un-anaesthetised states without quantifying the arousal of the animals at all
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senses[1]1.0the tagger's words
sensesA BINARY CATEGORY IS DISSOLVED INTO A CONTINUUM: the same pupil measure had been used to sort trials into aroused and unaroused, and is used here as a graded quantity
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senses[2]1.0the tagger's words
sensesAND A WHOLE LITERATURE'S INDEPENDENT VARIABLE IS RE-IDENTIFIED: the often reported effects of movement may not result from movement per se but from arousal, with one exception named and kept
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senses[3]1.0the tagger's words
sensesTHE SHAPE OF THE EFFECT BREAKS THE SUMMARY STATISTIC: because the relation is U-shaped the correlation is positive over one half of the range and negative over the other, which forced a sliding window rather than one coefficient
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senses[4]1.0the tagger's words
sensesA RIVAL MEASURE IS TESTED AND THEN EXPLAINED AWAY: the derivative of the pupil predicts less than the diameter, and correlates with the diameter a second later, so its explanatory power may be entirely borrowed
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senses[5]1.0the tagger's words
sensesTHE MEASURE IS VALIDATED THROUGH A CHANNEL WHERE THE CONFOUND CANNOT OPERATE: pupil dilation could be a response to light, so eyelid opening was measured in darkness, where dilation is saturated, and moved the same way
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senses[6]1.0the tagger's words
sensesand the recording artefact is ruled out by timing rather than by argument - the depolarisation begins before the behavioural event and returns after it
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senses[7]1.0the tagger's words
sensesTHIRTEEN MEASURES ARE ASKED WHETHER THEY PEAK IN THE SAME PLACE: twelve are statistically indistinguishable and the thirteenth is not, with an interpretation offered for the one
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senses[8]1.0the tagger's words
sensesand the state measure is normalised within session because its maximum drifts between days and animals, so every number here is a fraction of that animal's own range
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senses[9]1.0the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: pupil diameter as a continuous state measure, validated against hippocampal ripple rate and against eyelid opening in darkness, related to membrane potential, evoked responses and trial outcome
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: the inverted-U between arousal and performance, and its cortical signature
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a second reading DIFFERING from the recorded value. Recorded: arousal-dependent auditory signal detection — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsextends → Reimer et al. (2014)
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claim_relations[0]the tagger's words
claim_relationscontradicts → Reimer et al. (2014)
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claim_relations[1]the tagger's words
claim_relationsreplicates → Williamson et al. (2014)
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claim_relations[2]the tagger's words
claim_relationsexplains-away → the rate of change of pupil diameter as the better index of cortical state, which is shown to be a lagged proxy for the diameter itself
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claim_relations[3]1.0the tagger's words
claim_relationsreconciles → the divergent reports of cortical membrane potential in waking animals, by supplying the continuously varying state variable none of them measured
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claim_relations[4]1.0the tagger's words
claim_relationscritiques → studies of the effects of walking and whisking on sensory responses, which most likely involved large uncontrolled changes in arousal
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differs in: THE AXIS IS AROUSAL AS AN UNCONTROLLED VARIABLE. 'Quotation withheld.' A whole literature's independent variable is shown to have carried a second one with it - established by THIS paper's own pupil measurement, which is why nobody could have controlled for it earlier.
claim_relations[5]1.0the tagger's words
claim_relationssupports → the classical Yerkes-Dodson inverted-U between arousal and performance, by giving it a cellular and network basis
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claim_relations[6]1.0the tagger's words
claim_relationsqualifies → the opposing visual and auditory locomotion results, which are left explicitly unresolved
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differs in: THE AXIS IS THE CORTICAL AREA, AND THE SIGN REVERSES ACROSS IT. 'Quotation withheld (over non-locomotion), while in auditory cortex locomot[ion suppresses them].' The paper poses the question, gives the opposite findings, and LEAVES IT UNRESOLVED - so 'locomotion modulates sensory responses' is true with two opposite signs and the area is not optional.
claim_relations[7]1.0the tagger's words
concept_edgesstate —operationalised-as→ arousal
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strength of the relation: 1 · note: A LITERATURE'S CONTRADICTIONS ATTRIBUTED TO A VARIABLE NOBODY MEASURED: it fluctuates continuously and rapidly, producing variability between studies and between moments within one, and has not been accounted for Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span writes 'state (arousal)'; operationalised-as is loose.
also in: state · arousal
concept_edges[0]1.0the tagger's words
concept_edgespupil —operationalised-as→ state
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strength of the relation: 1 · note: chosen for being non-invasive and continuous, and for tracking state changes whether or not they come with overt movement
also in: pupil · state
concept_edges[3]1.0the tagger's words
concept_edgesEIS —operationalised-as→ eyelid
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strength of the relation: 1 · note: and a cheaper proxy is then derived from the light reflected off the eye, so the measure can travel Audit 2026-09-28: DOUBTFUL - read against its span and kept, but reflected infrared light is a proxy for lid opening; operationalised-as is loose.
also in: EIS · eyelid
concept_edges[6]1.0the tagger's words
concept_edgespupil —contrasted-with→ derivative
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differs in: THE AXIS IS WHICH PREDICTOR ADDS ANYTHING, AND THE ANSWER IS THAT ONE DOES NOT. 'Factoring in both the pupil diameter and its derivative explained 40+/-6% of the variance of power in the 2-10 Hz band, which was statistically larger than the amount explained by pupil derivative (p<0.0005), but not pupil diameter alone (p=0.36).' Adding the derivative to diameter does not improve on diameter alone - a null reported in the same sentence as the significant comparison, and the pair is only distinguishable because both tests are given. · strength of the relation: 1 · note: A RIVAL MEASURE TESTED HEAD TO HEAD: the diameter explains 34 percent of the variance in low-frequency power, the derivative about half that, and both together add nothing over the diameter alone Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span compares pupil diameter with its derivative as indicators; contrasted-with is loose.
also in: pupil · derivative
concept_edges[7]1.0the tagger's words
concept_edgesmicrodilation —causes→ membrane potential
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status: ASSOCIATIONAL AND TIME-LOCKED, WHICH IS NOT THE SAME AS CAUSAL: microdilations 'were reliably associated with 5-20 mV time-locked depolarization'. Tight temporal coupling in 16 neurons; nothing was manipulated to establish which leads. · strength of the relation: 1 · note: 5 to 20 mV depolarisations time-locked to them, and leading the pupil by about a second Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says microdilations were ASSOCIATED with depolarization; causes overstates it.
concept_edges[11]1.0the tagger's words
concept_edgesMG —contrasted-with→ ACtx
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strength of the relation: 1 · note: thalamic responses fall steadily with arousal and fall further during walking, so part of the cortical decline is inherited and part is not
also in: MG · ACtx
concept_edges[21]1.0the tagger's words
concept_edgeswalking —is-a→ movement
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strength of the relation: 1 · note: since walking only ever happened at large pupil diameters, previous studies of movement effects most likely involved large changes in arousal
also in: walking · movement
concept_edges[23]1.0the tagger's words
concept_edgeswhisking —distinct-from→ arousal
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strength of the relation: 0.9 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span argues effects may come from arousal rather than movement; distinct-from is loose.
also in: whisking · arousal
concept_edges[25]1.0the tagger's words
concept_edgeshit —contrasted-with→ false alarm
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strength of the relation: 1 · note: with hit and miss trials resampled to equal target level distributions, so loudness cannot be what separates them
also in: hit · false alarm
concept_edges[29]1.0the tagger's words
concept_edgesarousal —causes→ detection
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strength of the relation: 1 · note: the optimum is 40 to 60 percent of full dilation, for the neurons and for the behaviour alike Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says intermediate arousal is optimal for detection; causes is loose and unsigned.
also in: arousal · detection
concept_edges[32]1.0the tagger's words
concept_edgesevoked —distinct-from→ spontaneous
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strength of the relation: 1 · note: and the optimum is a ratio: background suppressed AND response enhanced, not either alone Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span attributes high SNR to suppression of spontaneous activity; distinct-from is loose.
also in: evoked · spontaneous
concept_edges[35]1.0the tagger's words
concept_edgesdepolarization —causes→ reliability
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strength of the relation: 0.7 · note: the proposed cost of the depolarised state - single neurons more responsive, their interactions less so Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span discusses possible detrimental effects of depolarization; causes is loose.
concept_edges[36]0.8the tagger's words
content_tagscoherence
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also in: coherence
content_tags.statistics[0]the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.statistics[1]the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[2]the tagger's words
content_tagsstandard deviation
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content_tags.statistics[3]the tagger's words
content_tagsstandard error of the mean
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content_tags.statistics[4]the tagger's words
content_tagsbootstrap confidence interval
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content_tags.statistics[5]the tagger's words
content_tagsresampling with replacement
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content_tags.statistics[6]the tagger's words
content_tagssignal detection theory measures (d-prime and criterion)
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content_tags.statistics[7]the tagger's words
content_tagsF-test
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also in: F-test
content_tags.statistics[8]the tagger's words
content_tagsexplained variance
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content_tags.statistics[9]the tagger's words
content_tagscross-correlation
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content_tags.statistics[10]the tagger's words
content_tagscoherence
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also in: coherence
content_tags.statistics[11]1.0the tagger's words
content_tagscross correlation
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content_tags.statistics[12]1.0the tagger's words
content_tagsexplained variance
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content_tags.statistics[13]1.0the tagger's words
content_tagsresampled
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also in: resampled
content_tags.statistics[14]0.8the tagger's words
content_tagsPupil diameter showed a strong inverse relationship to the rate of fast ripples, with a peak coherence of about 0.78 at low frequencies.
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content_tags.findings[0]the tagger's words
content_tagsAuditory cortical membrane potential and its variance follow a U-shaped function of arousal, being most hyperpolarized and least variable at intermediate pupil diameter.
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content_tags.findings[1]the tagger's words
content_tagsBrief spontaneous pupil microdilations in still animals are locked to 5-20 mV depolarizations of cortical neurons.
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content_tags.findings[2]the tagger's words
content_tagsThe cortical depolarization leads the pupil dilation by roughly one second, so the membrane potential change comes first.
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content_tags.findings[3]the tagger's words
content_tagsSound-evoked synaptic responses in auditory cortex are largest at intermediate pupil diameter and shrink with either constriction or further dilation.
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content_tags.findings[4]the tagger's words
content_tagsBehavioural hit rate on the tone-in-noise detection task follows an inverted-U in pupil diameter at every tone intensity.
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content_tags.findings[5]the tagger's words
content_tagsJust before correct detections the membrane potential was more hyperpolarized and less variable than before false alarms.
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content_tags.findings[6]the tagger's words
content_tagsPupil diameter predicts trial-to-trial cortical response variability at least as well as walking status and absorbs walking's predictive power.
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content_tags.findings[7]the tagger's words
content_tagsThe optimal arousal band, for both neural coding and behaviour, corresponds to pupils dilated to 40-60% of maximum.
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content_tags.findings[8]the tagger's words
content_tagsThalamic (medial geniculate) sound responses decline steadily as pupil diameter increases and are suppressed further during walking.
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content_tags.findings[9]the tagger's words
content_tagsRaw pupil diameter explains about twice as much of the low-frequency membrane-potential power as the rate of change of pupil diameter does.
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content_tags.findings[10]the tagger's words
content_tagsMice only walked when their pupils were large, so locomotion in this preparation is always accompanied by high arousal.
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content_tags.findings[11]the tagger's words
content_tagsAPPARENTLY DIVERGENT RESULTS ARE ATTRIBUTED TO A VARIABLE NOBODY ACCOUNTED FOR: state fluctuates continuously and rapidly, giving variability between studies and between moments within individual studies
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content_tags.findings[12]1.0the tagger's words
content_tagswith the divergent reports themselves laid out first, across species and sensory systems
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WHOSE RESULT THIS IS: Steriade et al., 2001 ), but recent work in rodent sensory cortical areas has revealed - THE EVIDENCE FOR THIS ROW ATTRIBUTES THE WORK TO SOMEBODY ELSE. The cited name is the subject of a result verb and the sentence carries no first-person marker, so the finding, quantity or definition is the CITED author's rather than this record's. The claim is true and the quote is verbatim - what is wrong is whose result the corpus says it is. Nothing edited, nothing withdrawn: the row is marked so a page can name the source. Where the record is a commentary or review, its claim relations layer usually already names the paper being discussed - the record knows at one layer and forgets at another.
content_tags.findings[13]1.0the tagger's words
content_tagsand one earlier study named as having recorded across un-anaesthetised states without quantifying arousal
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content_tags.findings[14]1.0the tagger's words
content_tagswalking increases visual cortical responses and decreases auditory ones, which is the contradiction in view
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content_tags.findings[15]1.0the tagger's words
content_tagsA BINARY CATEGORY IS DISSOLVED INTO A CONTINUUM: the same pupil measure had been used to sort trials into aroused and unaroused
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content_tags.findings[16]1.0the tagger's words
content_tagspupil diameter tracks hippocampal ripple rate inversely, supporting the view that it may be a useful indicator of brain state
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content_tags.findings[17]1.0the tagger's words
content_tagsTHE LIGHT CONFOUND IS REMOVED BY CHANGING CHANNEL: eyelid opening measured in darkness, where dilation is saturated, moves the same way
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content_tags.findings[18]1.0the tagger's words
content_tagsand a proxy is derived from infrared light reflected from the eye, termed eye-indexed state
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content_tags.findings[19]1.0the tagger's words
content_tagsthe pupil is normalised within session because its maximum drifts between days and animals
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content_tags.findings[20]1.0the tagger's words
content_tagsbrief dilations are time-locked to 5 to 20 mV depolarisations that lead them by about a second
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content_tags.findings[21]1.0the tagger's words
content_tagsmembrane potential and its variance both trace a U against arousal, most hyperpolarised and least variable in the middle
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content_tags.findings[22]1.0the tagger's words
content_tagsTHE SHAPE OF THE EFFECT BREAKS THE SUMMARY STATISTIC: the correlation is positive over one half of the range and negative over the other, forcing a sliding window
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content_tags.findings[23]1.0the tagger's words
content_tagsand layer 5 multi-unit firing shows the same U, lowest at intermediate pupil
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content_tags.findings[24]1.0the tagger's words
content_tagsTHE RECORDING ARTEFACT IS RULED OUT BY TIMING: the depolarisation starts before the behavioural event and returns after it
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content_tags.findings[25]1.0the tagger's words
content_tagsand spike threshold barely tracks the pupil, varying instead with the rate of rise into threshold
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content_tags.findings[26]1.0the tagger's words
content_tagsA RIVAL MEASURE IS TESTED HEAD TO HEAD: raw pupil diameter and the rate of change of pupil diameter are both compared to membrane power at 2-10 Hz, and factoring in both is not statistically better than the diameter alone
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content_tags.findings[27]1.0the tagger's words
content_tagsAND THEN EXPLAINED AWAY: the derivative correlates with the diameter 1.3 s later and not with it at the same moment
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content_tags.findings[28]1.0the tagger's words
content_tagsevoked spikes and synaptic responses are largest at moderate pupil diameters and smaller in both directions
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content_tags.findings[29]1.0the tagger's words
content_tagswith evoked rate, reliability and gain all following the same inverse U
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content_tags.findings[30]1.0the tagger's words
content_tagsand the gain model is built so that no effect is a diagonal of slope one
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content_tags.findings[31]1.0the tagger's words
content_tagsthalamic responses fall steadily as the pupil dilates and are suppressed further during walking
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content_tags.findings[32]1.0the tagger's words
content_tagsTHE PUPIL SUBSUMES THE OLDER VARIABLE: walking status adds 20 percent explained variance, pupil adds 28, and both together (29) are not significantly more than pupil alone
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content_tags.findings[33]1.0the tagger's words
content_tagslick latency is shortest and least variable at intermediate diameters, for hits and false alarms alike
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content_tags.findings[34]1.0the tagger's words
content_tagsmembrane potentials are most hyperpolarised and least variable before hits, with the largest evoked responses
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content_tags.findings[35]1.0the tagger's words
content_tagsand hit and miss trials are resampled to equivalent target tone level distributions
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content_tags.findings[36]1.0the tagger's words
content_tagsTHIRTEEN MEASURES ARE ASKED WHETHER THEY PEAK IN THE SAME PLACE: twelve are indistinguishable and only behavioural discriminability sits lower
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content_tags.findings[37]1.0the tagger's words
content_tagsthe optimum is 40 to 60 percent of full dilation, for the neurons and the behaviour alike
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content_tags.findings[38]1.0the tagger's words
content_tagswhich suggests a cellular and network basis for the classical inverted-U
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content_tags.findings[39]1.0the tagger's words
content_tagsand at the best state the signal-to-noise ratio of evoked cortical responses is high, owing both to the suppression of spontaneous activities and the enhanced amplitude of sensory evoked responses
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content_tags.findings[40]1.0the tagger's words
content_tagsA LITERATURE'S INDEPENDENT VARIABLE IS RE-IDENTIFIED: reported effects of movement may not result from movement per se but from arousal
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content_tags.findings[41]1.0the tagger's words
content_tagswith previous walking studies described as having most likely involved large uncontrolled changes in arousal
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content_tags.findings[42]1.0the tagger's words
content_tagsand one arousal-independent walking effect, on thalamic responses and decision bias, named and kept
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content_tags.findings[43]0.9the tagger's words
content_tagslaminar position and cell type are named as a second source of between-study variation
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content_tags.findings[44]1.0the tagger's words
content_tagsand whether the opposing visual and auditory results reflect systems, subcortical influence or arousal during stillness is left open
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content_tags.findings[45]1.0the tagger's words
content_tagsthe proposed cost is that depolarisation may raise single-neuron responsiveness while harming sensory-evoked neuronal interactions
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content_tags.findings[46]1.0the tagger's words
content_tagsand the influence of behavioural context on the account remains to be done
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content_tags.findings[47]1.0the tagger's words
content_tagsthe classical Yerkes-Dodson curve predicts optimal performance at intermediate arousal
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content_tags.findings[48]1.0the tagger's words
content_tagsmicrodilations
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content_tags.definitions[0]the tagger's words
content_tagseye-indexed state
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content_tags.definitions[1]the tagger's words
content_tagsYerkes-Dodson curve
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content_tags.definitions[2]the tagger's words
content_tagscanonical wakeful state
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content_tags.definitions[3]the tagger's words
content_tagsEIS
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also in: EIS
content_tags.definitions[4]1.0the tagger's words
content_tagsmicrodilation
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also in: microdilation
content_tags.definitions[5]0.8the tagger's words
content_tagsgain
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also in: gain
content_tags.definitions[6]1.0the tagger's words
content_tagsarousal
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also in: arousal
content_tags.definitions[7]0.8the tagger's words
content_tagstarget tone level
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content_tags.variables[0]the tagger's words
content_tagsintracellular injection of current
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content_tags.variables[1]the tagger's words
content_tagsspontaneous activity
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content_tags.variables[2]the tagger's words
content_tagsbehavioral performance
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content_tags.variables[3]the tagger's words
content_tagspupil diameter
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content_tags.variables[4]the tagger's words
content_tagspupil
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: pupil
content_tags.variables[7]1.0the tagger's words
content_tagsmembrane potential
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[8]1.0the tagger's words
content_tagsgain
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: gain
content_tags.variables[9]1.0the tagger's words
content_tagslatency
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: latency
content_tags.variables[10]1.0the tagger's words
content_tagsreliability
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: reliability
content_tags.variables[11]1.0the tagger's words
content_tags0.78 ± 0.07 — peak coherence between pupil diameter and hippocampal fast-ripple rate at low frequencies
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content_tags.quantities[0]the tagger's words
content_tagsR=−0.94 +/− 0.03 — correlation between pupil diameter and hippocampal ripple rate
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content_tags.quantities[1]the tagger's words
content_tags5–20 mV — amplitude of the membrane-potential depolarizations time-locked to pupil microdilations
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content_tags.quantities[2]the tagger's words
content_tags1.1 ± 0.1 s — lead time by which cortical depolarization precedes pupil dilation or eyelid opening
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content_tags.quantities[3]the tagger's words
content_tags34±7% versus 18±4% — variance in 2-10 Hz membrane-potential power explained by pupil diameter versus by its temporal derivative
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content_tags.quantities[4]the tagger's words
content_tags−74 ± 1.2 mV — average membrane potential corresponding to zero change on the arousal heatmap
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content_tags.quantities[5]the tagger's words
content_tags37 ± 17%, 160 ± 120%, and 94 ± 55% — gain in explained variance for d-prime, bias and lick latency when pupil diameter is known in addition to tone intensity
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content_tags.quantities[6]the tagger's words
content_tags~0.15 mm to ~1.8 mm — range over which pupil diameter varied in waking mice under constant low light
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content_tags.quantities[7]the tagger's words
content_tags40–60% — fraction of full dilation that marks the optimal arousal band for neural coding and behaviour
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content_tags.quantities[8]the tagger's words
content_tags40–60% — of full dilation - the optimum, and the same range for the neurons and for the behaviour
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content_tags.quantities[9]1.0the tagger's words
content_tags34±7% — variance in low-frequency membrane power explained by pupil diameter, against about half that for its derivative
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content_tags.quantities[10]1.0the tagger's words
content_tags1.3 ± 0.7 seconds — the lag by which the pupil derivative leads the diameter - which is why it looked like a better predictor
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content_tags.quantities[11]1.0the tagger's words
content_tags1.1 ± 0.1 s — by how much the cortical depolarisation precedes the pupil dilation it is locked to
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content_tags.quantities[12]1.0the tagger's words
content_tags20 ± 8% — explained variance added by knowing walking status, against 28 percent for pupil diameter and nothing for both together
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content_tags.quantities[13]1.0the tagger's words
content_tags12 of the 13 — measures whose optimum could not be distinguished from one another
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content_tags.quantities[14]1.0the tagger's words

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