Parvalbumin-Expressing Inhibitory Interneurons in Auditory Cortex Are Well-Tuned for Frequency

Moore, Wehr · Journal of Neuroscience · 2013 · neuroscience · 10.1523/jneurosci.0663-13.2013 · record Moore2013-parvalbumin-expressing-inhibitory-interneuro
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. Replication status is 'contested' because the paper itself documents that the same question answered with waveform-based (FS/RS) classification gives the opposite result in cat and rat A1, and its gain finding is explicitly inconsistent with Wu et al. (2008); the paper reconciles this by arguing that FS and PV+ are overlapping but non-identical populations. Note the tuning-width comparison is formally a non-significant difference (p = 0.06, KS p = 0.08), so the headline 'well tuned' claim rests on an accepted null plus the positive observation that PV+ best frequencies matched the local population; claim type is recorded as existence rather than null-result because that is how the paper frames its contribution. 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
standard deviation 3 fields · latency 2 fields · response latency 2 fields · white noise 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 23 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
PV+ PV− ChR2 tuning width spike width waveform intensity tuning best frequency endslope FS untuned local pooling cotuning lateral inhibition tonotopically monotonicity index rate-level function latency characteristic frequency auditory cortex visual cortex basket cells white noise PV+ interneurons pool densely and without bias from excitatory neurons in a small local radius, so their tuning inherits the feature organization of that local patch - homogeneous in a columnar or tonotopic area, heterogeneous in a salt-and-pepper one Greater monotonicity keeps PV+ firing rates rising over a wider span of sound levels, which stretches the level dynamic range and thereby flattens the slope of the rate-level function Faster membrane time constants combined with strong thalamocortical synaptic drive make PV+ cells fire early, placing them in a feedforward inhibitory loop that sharpens the timing of pyramidal responses monotonicity index (MI) response gain frequency tuning width response latency sound-evoked firing rate maximal evoked firing rate depth distributions Wilcoxon rank-sum test Wilcoxon rank sum test standard deviation mean ± SD Kolmogorov-Smirnov test two-sample Kolmogorov–Smirnov test Fisher's exact test ANOVA one-way ANOVA curve fitting (Gaussian) σ of a Gaussian fit to the tuning curve goodness of fit / coefficient of determination correlation resampling (random subsampling of trials) parametric model fitting six-parameter, two-tailed split Gaussian electrophysiology

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

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Every tag on this page

alternatives 3 · claim_relations 8 · claim_type 1 · concept_edges 6 · content_tags 81 · contribution 1 · controls 1 · limitations 8 · mechanisms 8 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 5 · transfers 2

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facettagfieldconf.whose words
object_of_studywhat the receptive fields of a genetically defined inhibitory cell class actually look like, as opposed to what is inferred from blocking inhibition wholesale
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object_of_studythe paper's words
research_questionwhether and how the response properties of PV+ neurons differ from those of PV- neurons in auditory cortex
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research_questionthe paper's words
contributionauditory cortical PV+ neurons are well tuned for frequency, unlike their visual cortical counterparts, which is what the local-pooling account predicts given tonotopy
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contributionthe paper's words
claim_typeexistence
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claim_typethe paper's words
phenomenonfrequency tuning of parvalbumin-positive interneurons in auditory cortex
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsPV+ cells densely sample a small radius, so their tuning should mirror how the local network is organised - broad where tuning is salt-and-pepper, narrow where it is columnar
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mechanisms[3]1.0the tagger's words
mechanismscotuned inhibition sharpens spike tuning through a thresholding or iceberg mechanism rather than by suppressing non-preferred stimuli
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mechanisms[4]1.0the tagger's words
mechanismsvery short PV+ latencies suggest a feedforward inhibitory network driven rapidly by thalamocortical excitation
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mechanisms[5]1.0the tagger's words
mechanismsmonotonic PV+ rate-level functions support local inhibition shaping intensity tuning in auditory cortex
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mechanisms[6]1.0the tagger's words
mechanismsthe pooling and feedforward roles could be performed in sequence, or simultaneously for continuous sounds
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mechanisms[7]0.7the tagger's words
limitationsNot every stimulus set could be run on every cell, so the sub-samples for tuning curves, rate-level functions and latency differ.
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what this limits: any comparison between the tuning-curve, rate-level and other sub-samples: DUE TO THE CONSTRAINTS OF RECORDING DURATION, WE WERE NOT ABLE TO PRESENT ALL STIMULUS ARRAYS FOR ALL CELLS
limitations[0]the tagger's words
limitationsThe PV− comparison group is only presumed to be excitatory; a small fraction could be non-PV inhibitory interneurons.
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what this limits: the comparison group in every PV+ versus PV- result: PRESUMABLY, THESE PV- CELLS WERE ALMOST EXCLUSIVELY EXCITATORY PYRAMIDAL CELLS, ALTHOUGH A SMALL FRACTION (<12%) COULD HAVE BEEN PV- INHIBITORY INTERNEURONS
limitations[1]the tagger's words
limitationsThe observed heterogeneity of PV+ response properties may partly reflect limited specificity of the PV promoter rather than true biological diversity.
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what this limits: the reported heterogeneity of PV+ responses: it is LIKELY DUE AT LEAST IN PART TO THE DEGREE OF SPECIFICITY OF THE PV PROMOTER, WHICH EXPRESSES IN MORE THAN ONE CELL TYPE
limitations[2]the tagger's words
limitationswell tuned PV+ cells are also consistent with selective connectivity rather than unbiased pooling, though that would be a different rule from other cortical areas
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what this limits: the unbiased-pooling interpretation: WELL TUNED PV+ NEURONS ARE ALSO CONSISTENT WITH SELECTIVE CONNECTIVITY RATHER THAN UNBIASED POOLING, BECAUSE NARROW TUNING COULD FOLLOW FROM EITHER SCHEME
limitations[3]1.0the tagger's words
limitationslateral inhibition could still operate here, either through a different network configuration or through other inhibitory cell types
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what this limits: the negative conclusion about lateral inhibition: LATERAL INHIBITION COULD STILL BE IMPLEMENTED IN AUDITORY CORTEX IN AT LEAST TWO WAYS
limitations[4]1.0the tagger's words
limitationsa small fraction of the PV- sample could have been non-PV inhibitory interneurons rather than pyramidal cells
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duplicate of: limitations[1] · what this limits: the same scope as limitations[1] - the PV- sample is defined by absence of a label, with a bound of under 12% on the contamination
limitations[5]1.0the tagger's words
limitationsrecording duration prevented presenting every stimulus array to every cell, so the two samples are only approximately matched
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what this limits: the same scope as limitations[0] - stimuli PRESENTED TO OUR PV- SAMPLE WERE APPROXIMATELY MATCHED TO THE PV+ SAMPLE, not identically matched
limitations[6]1.0the tagger's words
limitationsdeep-layer neurons were slightly underrepresented relative to the anatomical distribution
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what this limits: the laminar generality of the PV+ results: NEURONS IN DEEP LAYERS WERE SLIGHTLY UNDERREPRESENTED IN OUR SAMPLE, though the depth distributions DID NOT DIFFER SIGNIFICANTLY
limitations[7]1.0the tagger's words
transfersthe unbiased local pooling principle, carried across modalities as a prediction that reverses because auditory cortex is columnar where mouse V1 is not
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transfers[0]1.0the tagger's words
transfersthe monotonicity index and rate-level function decomposition, used to give intensity tuning a single number
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transfers[1]0.8the tagger's words
controlsrate-level functions NORMALISED before comparison
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eliminates: the higher baseline firing rate of PV+ neurons as the source of the difference - without it, a cell type that simply fires more would appear to have a different rate-level relationship · outcome (stated by the tagger, no quotation): held
controls[0]0.95the tagger's words
sensesPV+ here means a cell that responded to blue light with a reliable short-latency burst, in a mouse where over 97 percent of PV-immunopositive cells carry the opsin - identity by manipulation, validated against a stain in two separate reporter lines
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senses[0]1.0the tagger's words
sensesthe FS/RS spike-width cutoff of 0.8 ms was set from THIS dataset, halfway between the two group means, and the paper states there is no consensus value in the literature because it may depend on the recording technology
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senses[1]1.0the tagger's words
sensesUNTUNED is a category created because the measure does not apply: a sound-responsive cell with disordered frequency-intensity structure has no meaningful tuning width, so it is labelled rather than fitted
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senses[2]1.0the tagger's words
sensesmonotonicity index is a ratio of the response at the loudest tested level to the maximum response, so 1 means no intensity tuning and near zero means strong tuning - the measure carries its own null
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senses[3]1.0the tagger's words
sensesthe 80 ms response window was chosen to exclude non-evoked spikes BECAUSE PV+ cells have high spontaneous rates - an analysis choice driven by one of the very differences under study
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senses[4]1.0the tagger's words
alternativesclaim_type: existence
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a second reading reaching the same value. Recorded: existence — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: extracellular single-unit recording with optogenetic identification by light response, Gaussian fits to iso-intensity tuning curves and split-Gaussian fits to rate-level functions
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: frequency tuning widths of PV+ and PV- neurons that do not differ, with very tightly tuned PV+ cells uncommon
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a second reading DIFFERING from the recorded value. Recorded: frequency tuning of parvalbumin-positive interneurons in auditory cortex — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationscontradicts → Wu et al. (2008), FS cells in rat A1
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claim_relations[0]the tagger's words
claim_relationsbuilds-on → local-pooling account of PV+ tuning (Kerlin et al., 2010; Hofer et al., 2011)
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claim_relations[1]the tagger's words
claim_relationsreplicates → Atencio and Schreiner (2008), FS cells in auditory cortex
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claim_relations[2]the tagger's words
claim_relationscontradicts → lateral inhibition models in which sharpening comes from inhibitory neurons more broadly tuned than excitatory ones
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claim_relations[3]1.0the tagger's words
claim_relationssupports → the cotuning model in which excitation and inhibition share frequency tuning and inhibition sharpens by thresholding
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claim_relations[4]1.0the tagger's words
claim_relationsextends → the local unbiased pooling account of PV+ tuning developed in mouse visual cortex
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claim_relations[5]1.0the tagger's words
claim_relationscritiques → the use of extracellular spike waveform as a marker for PV+ interneurons in vivo
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claim_relations[6]1.0the tagger's words
claim_relationsqualifies → pharmacological and voltage-clamp studies that lump all sources of synaptic inhibition together
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claim_relations[7]1.0the tagger's words
concept_edgesPV+ —contrasted-with→ visual cortex
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strength of the relation: 1 · note: the same cell class gives OPPOSITE tuning answers in two modalities, and that is the result rather than a discrepancy Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but auditory PV+ neurons are contrasted WITH PV+ neurons IN visual cortex; 'visual cortex' as the endpoint drops the cell type.
also in: PV+ · visual cortex
concept_edges[1]1.0the tagger's words
concept_edgeslocal pooling —causes→ tuning width
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strength of the relation: 1 · note: MECHANISM: dense sampling of a small radius means the cell inherits whatever tuning organisation that radius has - so a tonotopic area predicts well-tuned inhibitory cells Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the local pooling HYPOTHESIS PREDICTS similar tuning, and the data were consistent; causes is hedged.
concept_edges[2]1.0the tagger's words
concept_edgeswaveform —distinct-from→ PV+
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strength of the relation: 1 · note: THE PROXY MEASURED AGAINST A GENETIC GROUND TRUTH AND FOUND WANTING: up to 40 percent misclassification from any single waveform measure
also in: waveform · PV+
concept_edges[5]1.0the tagger's words
concept_edgesFS —distinct-from→ PV+
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strength of the relation: 1 · note: the two are heterogeneous populations that OVERLAP BUT ARE NOT IDENTICAL - so results reported for one do not transfer to the other
also in: FS · PV+
concept_edges[6]1.0the tagger's words
concept_edgesPV+ —part-of→ basket cells
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strength of the relation: 0.5 — the record marks this weak · note: and only approximately half of basket cells express PV, which is the second reason the waveform proxy cannot work Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but PV is expressed in only about half of basket cells; part-of is loose and runs the other way.
also in: PV+ · basket cells
concept_edges[8]1.0the tagger's words
concept_edgesuntuned —distinct-from→ tuning width
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strength of the relation: 1 · note: THE MEASURE HAS A DOMAIN: a sound-responsive cell with disordered structure gets a label rather than a number
also in: untuned · tuning width
concept_edges[10]1.0the tagger's words
content_tagsWilcoxon rank-sum test
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content_tags.statistics[0]the tagger's words
content_tagsstandard deviation
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content_tags.statistics[1]the tagger's words
content_tagsKolmogorov-Smirnov test
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content_tags.statistics[2]the tagger's words
content_tagsFisher's exact test
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content_tags.statistics[3]the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[4]the tagger's words
content_tagscurve fitting (Gaussian)
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content_tags.statistics[5]the tagger's words
content_tagsgoodness of fit / coefficient of determination
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content_tags.statistics[6]the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.statistics[7]the tagger's words
content_tagsresampling (random subsampling of trials)
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content_tags.statistics[8]the tagger's words
content_tagsparametric model fitting
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content_tags.statistics[9]the tagger's words
content_tagsWilcoxon rank sum test
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content_tags.statistics[10]0.8the tagger's words
content_tagstwo-sample Kolmogorov–Smirnov test
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content_tags.statistics[11]1.0the tagger's words
content_tagsFrequency tuning width did not differ significantly between optogenetically identified PV+ interneurons and PV- neurons in mouse auditory cortex (0.84 vs 0.62 octaves).
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content_tags.findings[0]the tagger's words
content_tagsVery tightly tuned cells (below 0.5 octaves) were about half as common among PV+ cells (29%) as among PV- cells (58%), even though the two distributions largely overlapped.
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content_tags.findings[1]the tagger's words
content_tagsThe best frequency of every tuned PV+ neuron was within half an octave of its recording site's best frequency, so PV+ tuning matched the local population.
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content_tags.findings[2]the tagger's words
content_tagsPV+ cells responded to best-frequency tones roughly 11 ms earlier than PV- cells (17.9 vs 29.1 ms).
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content_tags.findings[3]the tagger's words
content_tagsThe latency advantage was stimulus-specific: for white noise, PV+ and PV- latencies did not differ significantly.
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content_tags.findings[4]the tagger's words
content_tagsPV+ cells had twofold higher spontaneous firing rates than PV- cells (5.5 vs 2.0 Hz), and higher evoked rates.
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content_tags.findings[5]the tagger's words
content_tagsAfter normalizing for their higher firing rates, PV+ cells had shallower response gain to characteristic-frequency tones than PV- cells (0.04 vs 0.15).
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content_tags.findings[6]the tagger's words
content_tagsPV+ cells were markedly less intensity-tuned than PV- cells for tones at characteristic frequency: only 14% of PV+ cells were nonmonotonic compared with 55% of PV- cells.
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content_tags.findings[7]the tagger's words
content_tagsFor white noise, PV+ and PV- neurons did not differ significantly in monotonicity.
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content_tags.findings[8]the tagger's words
content_tagsClassifying cells by extracellular spike waveform instead of by PV expression would misclassify as many as 40% of them, so waveform is an unreliable marker of PV+ identity.
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content_tags.findings[9]the tagger's words
content_tagsThe classification method changes the scientific conclusion: sorting the same cells by spike width rather than PV expression made narrow-spike cells come out significantly more broadly tuned than broad-spike cells (0.87 vs 0.60 octaves).
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content_tags.findings[10]the tagger's words
content_tagsThe PV+/PV- differences reported across all layers held within each laminar group as well.
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content_tags.findings[11]the tagger's words
content_tagsfrequency tuning widths of PV+ and PV- cells were not significantly different, as the local pooling account predicts for a tonotopic area
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content_tags.findings[12]1.0the tagger's words
content_tagsvery tightly tuned PV+ cells were comparatively rare, which fits pooling over locally diverse tuning
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content_tags.findings[13]1.0the tagger's words
content_tagsTHE PREDICTION WAS DERIVED BEFORE THE TEST: if unbiased pooling generalises across modalities, PV+ cells should be well tuned here because auditory cortex has frequency columns
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content_tags.findings[14]1.0the tagger's words
content_tagsand the same principle explains why PV+ cells are broadly tuned in mouse V1, which lacks orientation columns
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content_tags.findings[15]1.0the tagger's words
content_tagsthe tag was quantified in both directions and in two reporter lines: over 97 percent of PV-stained cells carried the opsin, and over 97 percent of reporter cells stained for PV
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content_tags.findings[16]1.0the tagger's words
content_tagsA CONTAMINATION BOUND COMPUTED RATHER THAN ASSERTED: from under 1 percent pyramidal-morphology reporter cells and 24 of 68 recordings in layer V, the sample is estimated to contain fewer than 0.24 pyramidal neurons
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content_tags.findings[17]1.0the tagger's words
content_tagsPV+ cells did have narrower spikes, 0.75 against 0.93 ms
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content_tags.findings[18]1.0the tagger's words
content_tagsbut the distributions overlapped on every waveform measure: 27 of 72 PV- cells had narrow spikes, 29 had negative endslopes, 17 had low peak/trough ratios
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content_tags.findings[19]1.0the tagger's words
content_tagsTHE PROXY QUANTIFIED AND REJECTED: any single waveform measure could misclassify up to 40 percent, and PV+ and FS are overlapping but non-identical populations
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content_tags.findings[20]1.0the tagger's words
content_tagsand there is no consensus spike-width cutoff in the literature, because it may depend on the recording technology
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content_tags.findings[21]1.0the tagger's words
content_tagstwo reasons the proxy cannot work: extracellular duration depends on cell size and electrode position, and even intracellularly the fast-spiking to PV relation is not one to one
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content_tags.findings[22]1.0the tagger's words
content_tagsSOME CELLS GOT A LABEL INSTEAD OF A NUMBER: a sound-responsive neuron whose Gaussian fit was poor was categorized as untuned rather than given a tuning width
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content_tags.findings[23]1.0the tagger's words
content_tagsthe untuned criterion was declared arbitrary and varying it by plus or minus 0.2 did not change the result
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content_tags.findings[24]1.0the tagger's words
content_tagsfurther cells were dropped when best frequency exceeded the speaker range, leaving 31 PV+ and 34 PV- for tuning width
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content_tags.findings[25]1.0the tagger's words
content_tagsNO A PRIORI LATENCY CONSTRAINTS, and imposing several exclusion criteria afterwards did not change the results
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content_tags.findings[26]1.0the tagger's words
content_tagsand the latency result was confirmed with an alternative estimation method
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content_tags.findings[27]1.0the tagger's words
content_tagsPV+ neurons had markedly faster response latencies, read as feedforward inhibition driven by thalamocortical excitation
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content_tags.findings[28]1.0the tagger's words
content_tagsPV+ rate-level functions were more monotonic at characteristic frequency, supporting a role in shaping intensity tuning
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content_tags.findings[29]1.0the tagger's words
content_tagsSTIMULUS-DEPENDENT: for white noise, gain, dynamic range and monotonicity did not separate the two classes at all
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content_tags.findings[30]1.0the tagger's words
content_tagsthe broadly-tuned-inhibition version of lateral inhibition is inconsistent with equal tuning widths
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content_tags.findings[31]1.0the tagger's words
content_tagsand the far-projecting version is inconsistent with PV+ tuning matching the local field potential and with equal connectivity spread
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content_tags.findings[32]1.0the tagger's words
content_tagsso the results favour cotuning with only moderate impact on frequency tuning
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content_tags.findings[33]1.0the tagger's words
content_tagsthough lateral inhibition remains possible through a different network configuration or through other inhibitory cell types
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content_tags.findings[34]1.0the tagger's words
content_tagsA DISSOCIATION BETWEEN THE GENETIC AND PHYSIOLOGICAL CLASSES: tuning was equal for PV+ and PV- but slightly broader for FS cells, hinting at two distinct inhibitory networks
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content_tags.findings[35]1.0the tagger's words
content_tagswell tuned PV+ cells would also follow from selective connectivity, which the data cannot exclude
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content_tags.findings[36]1.0the tagger's words
content_tagsthe recorded depth distribution matched the anatomical one, with deep layers slightly underrepresented
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content_tags.findings[37]1.0the tagger's words
content_tagsmonotonicity index (MI)
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content_tags.definitions[0]the tagger's words
content_tagscharacteristic frequency
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content_tags.definitions[1]the tagger's words
content_tagsresponse gain
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also in: response gain
content_tags.definitions[2]the tagger's words
content_tagsendslope
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also in: endslope
content_tags.definitions[3]the tagger's words
content_tagsmonotonicity index
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content_tags.definitions[5]1.0the tagger's words
content_tagsuntuned
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also in: untuned
content_tags.definitions[6]1.0the tagger's words
content_tagsFS
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also in: FS
content_tags.definitions[7]1.0the tagger's words
content_tagscotuning
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also in: cotuning
content_tags.definitions[8]1.0the tagger's words
content_tagsfrequency tuning width
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content_tags.variables[3]the tagger's words
content_tagsresponse latency
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content_tags.variables[4]the tagger's words
content_tagssound-evoked firing rate
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content_tags.variables[5]the tagger's words
content_tagsmaximal evoked firing rate
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content_tags.variables[7]the tagger's words
content_tagsdepth distributions
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content_tags.variables[8]the tagger's words
content_tagstuning width
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also in: tuning width
content_tags.variables[9]1.0the tagger's words
content_tagsspike width
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also in: spike width
content_tags.variables[10]1.0the tagger's words
content_tagslatency
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also in: latency
content_tags.variables[11]1.0the tagger's words
content_tagsn = 68 — PV+ interneurons identified in vivo by their short-latency responses to blue light
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content_tags.quantities[0]the tagger's words
content_tagsMore than 97% — proportion of PV-immunostained cells that expressed the ChR2-eYFP optogenetic tag (expression specificity)
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content_tags.quantities[1]the tagger's words
content_tags31 PV+ and 34 PV− — cells surviving the tuning-curve exclusion criteria and entering the tuning-width analysis
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content_tags.quantities[2]the tagger's words
content_tags0.75 ± 0.18 ms / 0.93 ± 0.29 ms — mean extracellular spike width of PV+ versus PV- cells
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content_tags.quantities[3]the tagger's words
content_tagsup to 40% — misclassification rate incurred by identifying PV+ cells from any single extracellular waveform measure
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content_tags.quantities[4]the tagger's words
content_tagsσ = 0.17 octaves to σ = 2.3 octaves — full range of measured frequency tuning widths across the 65 analysed cells
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content_tags.quantities[5]the tagger's words
content_tags0.76 ± 0.22 / 0.55 ± 0.28 — mean monotonicity index at characteristic frequency for PV+ versus PV- cells
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content_tags.quantities[6]the tagger's words
content_tags21.1 ± 18.3 Hz / 8.6 ± 6.5 Hz — firing-rate dynamic range of PV+ versus PV- rate-level functions
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content_tags.quantities[7]the tagger's words
content_tags32 ± 18 dB / 19 ± 15 dB — sound-level dynamic range over which firing rate kept increasing, PV+ versus PV-
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content_tags.quantities[8]the tagger's words
content_tagsup to 40% — misclassification rate from separating cells by any single waveform measure
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content_tags.quantities[9]1.0the tagger's words
content_tags0.8 ms — the fast-spiking cutoff, set from this dataset because the literature has no consensus value
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content_tags.quantities[10]1.0the tagger's words
content_tags<0.24 pyramidal neurons — computed expected contamination of the 68-cell PV+ sample
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content_tags.quantities[11]1.0the tagger's words
content_tags0.75 ± 0.18 ms and 0.93 ± 0.29 ms — PV+ and PV- spike widths; PV+ cells indeed had narrower spikes
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content_tags.quantities[12]1.0the tagger's words
content_tags27/72 — PV- cells that would have been called fast-spiking on spike width alone
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content_tags.quantities[13]1.0the tagger's words
content_tags31 PV+ and 34 PV− — cells surviving both exclusions for the tuning width comparison, from 68 and 72 recorded
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content_tags.quantities[14]1.0the tagger's words

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