Role of the Hippocampus in Distinct Memory Traces: Timing of Match and Mismatch Enhancement Revealed by Intracranial Recording

Ni, Wu, Yu, Zhu, Li, Liu · Neuroscience Bulletin · 2017 · neuroscience · 10.1007/s12264-017-0172-8 · record Ni2017-role-of-the-hippocampus-in-distinct-memory-t
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Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. Replication status is 'replicated' in the direction of this paper replicating an earlier finding: it reuses Duncan's stimuli and reports the same match/mismatch dissociation with intracranial recording instead of fMRI. Its own novel contribution - the ~150 ms latency gap - is itself untested; the facet cannot express both directions at once. Sample is small and clinical (8 epilepsy patients), which the paper acknowledges only indirectly via the task-modification sentence quoted as a limitation. 2026-08-12 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
2 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
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Other fields define these differently the same word, defined another way in another discipline
prediction error 6 fields · working memory 4 fields · latency 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 20 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
working memory goal match enhancement perceptual mismatch enhancement match enhancement mismatch enhancement delayed-match-to-sample hippocampus left posterior hippocampus right posterior hippocampus intracranial field potential event-related potentials relational memory pattern completion novelty detection prediction error linear discriminant analysis Monte Carlo permutations hippocampal sclerosis perirhinal cortex simulation of a specific future event whether an incoming event matches or mismatches expectation drives the hippocampus to switch between memory encoding and memory retrieval modes decoding of task demand was degraded because participants defaulted to maintaining the sample in both tasks instead of simulating a new scene on switch trials, so the two tasks engaged more similar mental operations than the design intended ECoG depth electrodes medial temporal lobe latency of the enhancement effect object configuration local field potential reaction time and accuracy electrode configuration latency task demand correct percentage paired t-test Paired sample t tests t-test (sample-by-sample, time-resolved) The sample-by-sample t -test ANOVA (two-way) sample-by-sample two-way analysis of variance (ANOVA) permutation test ANOVA (three-way) with Bonferroni correction for multiple comparisons multiple comparison of three-way ANOVA analysis with Bonferroni confidence interval adjustment correlation significantly correlated with the accuracy of memory performance linear discriminant analysis with principal component analysis A linear discriminant analysis ... with the principal component analysis approach for dimensionality reduction standard error of the mean p-value sample-by-sample t -test Bonferroni confidence interval adjustment electrophysiology

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relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
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transfertransfersa method or concept carried in from another field

The paper

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Every tag on this page

alternatives 3 · claim_relations 9 · claim_type 1 · concept_edges 2 · content_tags 57 · contribution 1 · controls 1 · limitations 8 · mechanisms 13 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 6 · transfers 2

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facettagfieldconf.whose words
object_of_studythe timing of goal-match and perceptual-mismatch signals in the human hippocampus during a working memory task
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object_of_studythe paper's words
research_questionif and how the hippocampus is involved in working memory, and whether its components separate in time
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research_questionthe paper's words
contributionseparates goal-match from perceptual-mismatch enhancement within identical stimuli and times them, finding mismatch about 150 ms earlier and localised bilaterally where match is left posterior
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contributionthe paper's words
claim_typeexistence
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claim_typethe paper's words
phenomenonhippocampal match and mismatch enhancement in working memory
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsthe same probe display is a goal match or a perceptual match depending only on a verbal instruction, which dissociates the two within identical stimuli
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mechanisms[2]1.0the tagger's words
mechanismsthis is exactly what the earlier imaging work could not do, and the paper says why
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mechanisms[3]1.0the tagger's words
mechanismsa two-step contrast is used: first find where the two instruction conditions differ, then ask within that window which of the two enhancement patterns holds
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mechanisms[4]1.0the tagger's words
mechanismslatencies are validated against 1000 label permutations rather than taken from the contrast alone
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mechanisms[5]1.0the tagger's words
mechanismsthe identical electrode configuration across patients is what makes grand averaging across individuals defensible
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mechanisms[6]1.0the tagger's words
mechanismspatients with hippocampal sclerosis are excluded so that the recorded tissue is morphologically intact
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mechanisms[7]1.0the tagger's words
mechanismsdisplay timings were shortened because the constraint that set them belonged to a method this study does not use
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mechanisms[8]1.0the tagger's words
mechanismsthe task was modified to fit the patients rather than the patients excluded to fit the task, which is disclosed
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mechanisms[9]1.0the tagger's words
mechanismsthe single-participant threshold is loosened relative to the group analysis, and the loosening is stated
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mechanisms[10]1.0the tagger's words
mechanismssingle-trial decoding is used to ask whether task demand is recoverable at all, independently of the averaged contrasts
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mechanisms[11]1.0the tagger's words
mechanismsthe decoding result is then argued to be an underestimate, because subjects probably maintained the sample regardless of instruction
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mechanisms[12]1.0the tagger's words
limitationsThe single-trial decoding result may be weakened because participants tended to maintain the sample regardless of which task was instructed.
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what this limits: the single-trial decoding result: THE RESULT OF THE DECODING MIGHT BE COMPROMISED, BECAUSE THE DISSOCIATION BETWEEN THE SWITCH AND MATCH TASK RELIES ON A DIFFERENT MENTAL MANIPULATION
limitations[0]the tagger's words
limitationsThe task had to be modified from the original because the epilepsy patients' memory performance was impaired relative to healthy participants.
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what this limits: any comparison with the original task or with unimpaired participants: THIS MODIFICATION WAS IMPLEMENTED TO AID PATIENT PERFORMANCE BECAUSE ... THEIR MEMORY PERFORMANCE WAS IMPAIRED COMPARED TO NORMAL PARTICIPANTS
limitations[1]the tagger's words
limitationsthe decoding may understate the effect because participants likely maintained the sample whatever the task
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what this limits: the same scope as limitations[0], with the direction given: THE PARTICIPANT TENDED TO MAINTAIN THE SAMPLE NO MATTER WHAT THE TASK WAS, WHICH MAY LEAD TO A POOR PERFORMANCE IN DECODING
limitations[2]1.0the tagger's words
limitationsthe paradigm was altered from the original to make it performable by patients
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what this limits: the same scope as limitations[1] - the paradigm is a modified one, with THE REPEATED PRESENTATION OF THE SAMPLE AFTER THE AUDITORY INSTRUCTION added
limitations[3]1.0the tagger's words
limitationselectrode placement was dictated entirely by clinical need
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what this limits: which structures could be observed at all: THE ELECTRODE LOCATIONS WERE BASED EXCLUSIVELY ON CLINICAL CRITERIA
limitations[4]1.0the tagger's words
limitationsthe task inseparably combines object identity with location, so the hippocampal involvement cannot be attributed to either alone
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what this limits: any attribution of the hippocampal signal to one factor: A COMBINATION OF TWO STREAMS OF INFORMATION, OBJECT IDENTITY AND POSITION, ARE INVOLVED IN THE TASK
limitations[5]1.0the tagger's words
limitationsthe supporting spatial-memory literature comes mostly from animal models
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what this limits: the convergent-evidence argument: the spatial-memory role is well understood, THOUGH ANIMAL MODELS WERE USED IN MOST OF THE STUDIES
limitations[6]1.0the tagger's words
limitationstesting patients before and after resection is proposed as the missing comparison
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what this limits: the causal question the recordings cannot reach: IT WILL BE OF INTEREST TO TEST THE RESULTS FROM THE ANIMAL MODELS ON EPILEPSY PATIENTS BEFORE AND AFTER RESECTION
limitations[7]0.9the tagger's words
transfersthe dissociation between repetition suppression and sample-matched enhancement, imported as the template for what to look for in human hippocampus
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transfers[0]0.95the tagger's words
transferslinear discriminant analysis after principal component reduction, used to ask whether the task instruction is recoverable from a single trial
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transfers[1]0.95the tagger's words
controlstrials with potential artifacts rejected on the amplitude of the data from 1 to 700 ms, per participant, after baseline correction
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eliminates: movement and electrical artifacts entering an averaged evoked response, with the threshold applied per participant rather than globally · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
sensesworking memory - as measured by a digit span, where these patients are intact, versus as measured by feature integration, where they are impaired; the same patients on two tests
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senses[0]1.0the tagger's words
sensesmatch enhancement - as a response to a goal state versus as a response to a previously perceived stimulus; the paradigm separates them within identical displays
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senses[1]1.0the tagger's words
sensesthe same probe display - counting as GOAL or PERCEPT depending only on the verbal instruction that preceded it
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senses[2]1.0the tagger's words
sensesenhancement - a match effect where BOTH exceeds NEITHER, against a mismatch effect where NEITHER exceeds BOTH; two opposite orderings of the same four conditions
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senses[3]0.95the tagger's words
sensesa late perceptual match effect that fits neither pattern cleanly, with BOTH above NEITHER but GOAL below PERCEPT
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senses[4]0.95the tagger's words
senseshippocampal role - as long-term declarative memory only, versus as also serving working memory encoding and retrieval
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senses[5]1.0the tagger's words
alternativesclaim_type: existence
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a second reading reaching the same value. Recorded: existence — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: intracranial field potentials from depth electrodes along the hippocampal axis during a modified delayed-match-to-sample task in which a verbal instruction determines whether a display counts as a goal match or a perceptual match
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: match and mismatch signals in the hippocampus during working memory maintenance
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a second reading DIFFERING from the recorded value. Recorded: hippocampal match and mismatch enhancement in working memory — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsreplicates → Duncan et al.'s fMRI dissociation of goal match and perceptual mismatch enhancement (reference [29])
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claim_relations[0]the tagger's words
claim_relationsbuilds-on → Duncan (reference [29]) - stimuli and task design reused
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claim_relations[1]the tagger's words
claim_relationsextends → previous electrophysiological research on match and mismatch enhancement (references [18], [19])
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claim_relations[2]the tagger's words
claim_relationsextends → the fMRI study proposing parallel goal-match and perceptual-mismatch traces, by adding the timing it could not resolve
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claim_relations[3]1.0the tagger's words
claim_relationscritiques → earlier imaging designs in which perceptual mismatches and goal matches are unavoidably mixed
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claim_relations[4]1.0the tagger's words
claim_relationscontradicts → the traditional view that the hippocampus subserves long-term declarative memory only
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claim_relations[5]0.95the tagger's words
claim_relationsbuilds-on → Miller and Desimone, who dissociated repetition suppression from sample-specific match enhancement in perirhinal cortex
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claim_relations[6]1.0the tagger's words
claim_relationssupports → evidence that the hippocampus is engaged when features must be bound to location but not for single features
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claim_relations[7]1.0the tagger's words
claim_relationsextends → fMRI work that found only a subtle perceptual mismatch effect, by resolving it with intracranial timing
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claim_relations[8]0.95the tagger's words
concept_edgesgoal match enhancement —contrasted-with→ perceptual mismatch enhancement
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but endpoint by anaphora: 'this effect' = the goal match enhancement effect (previous sentence).
concept_edges[0]the tagger's words
concept_edgesmatch enhancement —contrasted-with→ mismatch enhancement
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strength of the relation: 1
concept_edges[1]the tagger's words
content_tagspaired t-test
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also in: paired t-test
content_tags.statistics[0]the tagger's words
content_tagst-test (sample-by-sample, time-resolved)
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content_tags.statistics[1]the tagger's words
content_tagsANOVA (two-way)
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content_tags.statistics[2]the tagger's words
content_tagspermutation test
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content_tags.statistics[3]the tagger's words
content_tagsANOVA (three-way) with Bonferroni correction for multiple comparisons
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content_tags.statistics[4]the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.statistics[5]the tagger's words
content_tagslinear discriminant analysis with principal component analysis
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content_tags.statistics[6]the tagger's words
content_tagsstandard error of the mean
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content_tags.statistics[7]the tagger's words
content_tagsp-value
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also in: p-value
content_tags.statistics[8]the tagger's words
content_tagssample-by-sample t -test
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content_tags.statistics[9]1.0the tagger's words
content_tagsMonte Carlo permutations
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content_tags.statistics[10]1.0the tagger's words
content_tagslinear discriminant analysis
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content_tags.statistics[11]0.85the tagger's words
content_tagsBonferroni confidence interval adjustment
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content_tags.statistics[12]0.7the tagger's words
content_tagsGoal match enhancement appeared only at contacts in the left posterior hippocampus, whereas perceptual mismatch enhancement appeared bilaterally across both anterior and posterior hippocampus.
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content_tags.findings[0]the tagger's words
content_tagsThe perceptual mismatch signal began before the goal match signal in every one of the eight participants.
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content_tags.findings[1]the tagger's words
content_tagsThe two hippocampal signals divide by content: match enhancement tracks the match to the maintained goal while mismatch enhancement tracks perceptual mismatch, dissociating components of working memory within the hippocampus.
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content_tags.findings[2]the tagger's words
content_tagsParticipants whose right posterior hippocampus produced a later perceptual mismatch enhancement were more accurate, a positive correlation between latency and memory performance.
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content_tags.findings[3]the tagger's words
content_tagsThat latency-accuracy link is read as evidence that the right posterior hippocampal mismatch latency indexes the quality of memory retrieval.
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content_tags.findings[4]the tagger's words
content_tagsIn six of the eight patients, single-trial intracranial field potentials from the right hippocampus were sufficient to classify whether the trial was a match task or a switch task.
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content_tags.findings[5]the tagger's words
content_tagsBehaviourally, responses were faster in the match task than in the switch task.
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content_tags.findings[6]the tagger's words
content_tagsHippocampal engagement here is attributed to the task requiring object identity and location to be bound together, in both the match and the switch task.
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content_tags.findings[7]the tagger's words
content_tagsgoal match enhancement appeared in the left posterior hippocampus between about 520 and 735 ms after probe onset
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content_tags.findings[8]1.0the tagger's words
content_tagsperceptual mismatch enhancement appeared bilaterally in anterior and posterior hippocampus, averaging 376 to 555 ms
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content_tags.findings[9]1.0the tagger's words
content_tagsmismatch enhancement began earlier than match enhancement in every participant
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content_tags.findings[10]1.0the tagger's words
content_tagsregion latencies were 524 ms for goal match and about 405 to 430 ms for perceptual mismatch across the four subdivisions
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content_tags.findings[11]1.0the tagger's words
content_tagsa late perceptual match effect appeared on two electrodes at 717 and 900 ms
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content_tags.findings[12]1.0the tagger's words
content_tagsfor each electrode and effect, the probability of the observed latency was below 0.05
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content_tags.findings[13]1.0the tagger's words
content_tagsmismatch latency in the right posterior hippocampus correlated positively with memory accuracy
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content_tags.findings[14]1.0the tagger's words
content_tagstask demand was decodable from single trials in 6 of 8 patients, always from the right hippocampus
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content_tags.findings[15]1.0the tagger's words
content_tagsresponses were faster in the match task than in the switch task
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content_tags.findings[16]1.0the tagger's words
content_tagsover 80% of trials survived artifact rejection
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content_tags.findings[17]1.0the tagger's words
content_tagsmismatch enhancement
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content_tags.definitions[0]the tagger's words
content_tagslatency of the enhancement effect
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content_tags.definitions[3]the tagger's words
content_tagsmatch enhancement
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content_tags.definitions[4]1.0the tagger's words
content_tagsdelayed-match-to-sample
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content_tags.definitions[5]1.0the tagger's words
content_tagsintracranial field potential
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content_tags.definitions[6]0.8the tagger's words
content_tagsobject configuration
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content_tags.variables[1]the tagger's words
content_tagslocal field potential
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content_tags.variables[3]the tagger's words
content_tagslatency of the enhancement effect
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content_tags.variables[4]the tagger's words
content_tagsreaction time and accuracy
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content_tags.variables[5]the tagger's words
content_tagselectrode configuration
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content_tags.variables[7]the tagger's words
content_tagslatency
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: latency
content_tags.variables[9]1.0the tagger's words
content_tagstask demand
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: task demand
content_tags.variables[10]0.85the tagger's words
content_tagscorrect percentage
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[11]0.9the tagger's words
content_tags120 ... 8 — depth electrode contacts recorded, and epilepsy patients implanted
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[0]the tagger's words
content_tags126 — trials per experimental run
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[1]the tagger's words
content_tags>80% — proportion of trials retained after artifact rejection
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[2]the tagger's words
content_tags1000 — random permutations computed per electrode to test the observed enhancement latencies
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[3]the tagger's words
content_tags<0.05 — permutation probability of the observed latency, for every electrode and every significant effect
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[4]the tagger's words
content_tags6 out of 8 — patients whose hippocampal field potentials reliably represented the task demand in single-trial decoding
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[5]the tagger's words
content_tags120 depth electrode contacts in 8 patients — the sample
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[6]1.0the tagger's words
content_tags520 ms to 735 ms — window of goal match enhancement after probe onset
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[7]1.0the tagger's words
content_tags376 ms to 555 ms — window of perceptual mismatch enhancement
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[8]1.0the tagger's words
content_tags~150 ms — how much earlier mismatch precedes match
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[9]1.0the tagger's words
content_tagsρ = 0.74 — correlation between right posterior mismatch latency and accuracy
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content_tags.quantities[10]1.0the tagger's words
content_tags126 trials per run, 3 to 5 runs — to obtain at least 80 correct trials per participant
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[11]1.0the tagger's words
content_tags6 out of 8 — patients whose task demand was decodable from hippocampal signal
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[12]1.0the tagger's words

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