Role of the Hippocampus in Distinct Memory Traces: Timing of Match and Mismatch Enhancement Revealed by Intracranial Recording — TEI-tagged view

Ni, Wu, Yu, Zhu, Li, Liu · 2017 · neuroscience · doi:10.1007/s12264-017-0172-8 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. Replication status is 'replicated' in the direction of this paper replicating an earlier finding: it reuses Duncan's stimuli and reports the same match/mismatch dissociation with intracranial recording instead of fMRI. Its own novel contribution - the ~150 ms latency gap - is itself untested; the facet cannot express both directions at once. Sample is small and clinical (8 epilepsy patients), which the paper acknowledges only indirectly via the task-modification sentence quoted as a limitation. 2026-08-12 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
2 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
Other fields define these differently the same word, defined another way in another discipline
prediction error 6 fields · working memory 4 fields · latency 2 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
working memory27 goal match enhancement perceptual mismatch enhancement match enhancement4 mismatch enhancement delayed-match-to-sample3 hippocampus29 left posterior hippocampus right posterior hippocampus intracranial field potential event-related potentials2 relational memory pattern completion3 novelty detection prediction error9 linear discriminant analysis3 Monte Carlo permutations hippocampal sclerosis2 perirhinal cortex5 simulation of a specific future event electrophysiology110

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenonhippocampal match and mismatch enhancement in working memory— “Emerging evidence has revealed that, within the hippocampus, neurons discriminate between novel and familiar stimuli through a firing rate increase to previously encountered stimuli (match enhancement), or through a firing rate increase to novel stimuli (mismatch enhancement) [ 17 – 19 ].”
claim-typeexistence— “We also found that this effect happened within 520 ms to 735 ms after the probe onset, ~150 ms later than the perceptual mismatch enhancement found bilaterally in both the anterior and posterior hippocampus.”
method — evidence— “Intracranial field potentials were recorded from 120 depth electrode contacts implanted in 8 human epilepsy patients who suffered from pharmaco-resistant epilepsy in Xuanwu Hospital (5 male, 3 female).”
object of study — evidence— “However, the timing information in this process is unknown.”
research question — evidence— “It is still unclear if and how the hippocampus is involved in working memory.”
contribution — evidence— “We also found that this effect happened within 520 ms to 735 ms after the probe onset, ~150 ms later than the perceptual mismatch enhancement found bilaterally in both the anterior and posterior hippocampus.”
transferfrom monkey electrophysiology: the dissociation between repetition suppression and sample-matched enhancement, imported as the template for what to look for in human hippocampus— “This revealed that in the perirhinal cortex some neurons are suppressed by any picture repetition, regardless of relevance, whereas others are enhanced, but only when a picture matches the sample”transfers[0]
transferfrom machine learning: linear discriminant analysis after principal component reduction, used to ask whether the task instruction is recoverable from a single trial— “We used a statistical learning approach [ 34 ] to quantify whether the information from IFPs available in single trials was sufficient to distinguish whether it is memory maintenance (match task) or simulation of a specific future event (switch task).”transfers[1]
mechanismwhether an incoming event matches or mismatches expectation drives the hippocampus to switch between memory encoding and memory retrieval modes— “Whether the incoming events match or mismatch what we expect can influence the ability of the hippocampus to switch between memory encoding and retrieval modes.”mechanisms[0]
mechanismdecoding of task demand was degraded because participants defaulted to maintaining the sample in both tasks instead of simulating a new scene on switch trials, so the two tasks engaged more similar mental operations than the design intended— “Rather than maintaining the sample when it was the match task and simulating a new scenario when it was the switch task, the participant tended to maintain the sample no matter what the task was, which may lead to a poor performance in decoding.”mechanisms[1]
mechanismthe same probe display is a goal match or a perceptual match depending only on a verbal instruction, which dissociates the two within identical stimuli— “Thus, there were 4 possible object configurations in the Probe display: 1, the same objects at the same locations, called BOTH in the match task (correct response for this trial is ‘yes’) or PERCEPT in the switch task (correct response is ‘no’); 2, the same objects but switched locations, called NEITHER in the match task (correct response is…mechanisms[2]
mechanismthis is exactly what the earlier imaging work could not do, and the paper says why— “An event-related functional magnetic resonance imaging study has revealed enhanced hippocampal activation for images that match a maintained goal. However, due to the task, mixing perceptual-mismatches with goal-matches is inevitable”mechanisms[3]
mechanisma two-step contrast is used: first find where the two instruction conditions differ, then ask within that window which of the two enhancement patterns holds— “If at least 10 ms consecutive time points of the t -test trace crossed the significance threshold of 0.05, and GOAL > PERCEPT, that time window was defined as a potential significant interval.”mechanisms[4]
mechanismlatencies are validated against 1000 label permutations rather than taken from the contrast alone— “We checked the statistical significance of these effects through Monte Carlo permutations.”mechanisms[5]
mechanismthe identical electrode configuration across patients is what makes grand averaging across individuals defensible— “This electrode configuration was used for every patient and allowed us to collect neuronal response data from the same (or at least similar) brain region, with the same electrode order across patients, making grand average of event-related potentials (ERPs) possible”mechanisms[6]
mechanismpatients with hippocampal sclerosis are excluded so that the recorded tissue is morphologically intact— “We included only patients with a depth electrode in a morphologically intact hippocampus (as defined by MRI).”mechanisms[7]
mechanismdisplay timings were shortened because the constraint that set them belonged to a method this study does not use— “The durations of the displays and intervals used in the current version were also much shorter than those…mechanisms[8]
mechanismthe task was modified to fit the patients rather than the patients excluded to fit the task, which is disclosedmechanisms[9]
mechanismthe single-participant threshold is loosened relative to the group analysis, and the loosening is stated
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mechanisms[10]
mechanismsingle-trial decoding is used to ask whether task demand is recoverable at all, independently of the averaged contrasts
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mechanisms[11]
mechanismthe decoding result is then argued to be an underestimate, because subjects probably maintained the sample regardless of instruction
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mechanisms[12]
replicates Duncan et al.'s fMRI dissociation of goal match and perceptual mismatch enhancement (reference [29])
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claim_relations[0]
builds-on Duncan (reference [29]) - stimuli and task design reused
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claim_relations[1]
extends previous electrophysiological research on match and mismatch enhancement (references [18], [19])
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claim_relations[2]
extends the fMRI study proposing parallel goal-match and perceptual-mismatch traces, by adding the timing it could not resolve
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claim_relations[3]
critiques earlier imaging designs in which perceptual mismatches and goal matches are unavoidably mixed
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claim_relations[4]
contradicts the traditional view that the hippocampus subserves long-term declarative memory only
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claim_relations[5]
builds-on Miller and Desimone, who dissociated repetition suppression from sample-specific match enhancement in perirhinal cortex
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claim_relations[6]
supports evidence that the hippocampus is engaged when features must be bound to location but not for single features
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claim_relations[7]
extends fMRI work that found only a subtle perceptual mismatch effect, by resolving it with intracranial timing
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claim_relations[8]
senseworking memory - as measured by a digit span, where these patients are intact, versus as measured by feature integration, where they are impaired; the same patients on two tests
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senses[0]
sensematch enhancement - as a response to a goal state versus as a response to a previously perceived stimulus; the paradigm separates them within identical displays
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senses[1]
sensethe same probe display - counting as GOAL or PERCEPT depending only on the verbal instruction that preceded it
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senses[2]
senseenhancement - a match effect where BOTH exceeds NEITHER, against a mismatch effect where NEITHER exceeds BOTH; two opposite orderings of the same four conditions
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senses[3]
sensea late perceptual match effect that fits neither pattern cleanly, with BOTH above NEITHER but GOAL below PERCEPT
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senses[4]
sensehippocampal role - as long-term declarative memory only, versus as also serving working memory encoding and retrieval
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senses[5]
controltrials with potential artifacts rejected on the amplitude of the data from 1 to 700 ms, per participant, after baseline correction — held — rules out movement and electrical artifacts entering an averaged evoked response, with the threshold applied per participant rather than globally
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controls[0]
auditgoal match enhancement —contrasted-with→ perceptual mismatch enhancement — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but endpoint by anaphora: 'this effect' = the goal match enhancement effect (previous sentence).
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concept_edges[0]
edgematch enhancement —contrasted-with→ mismatch enhancement
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concept_edges[1]
outcome (stated by the tagger, no quotation)control — heldcontrols[0]
for which uselimitation — the single-trial decoding result: THE RESULT OF THE DECODING MIGHT BE COMPROMISED, BECAUSE THE DISSOCIATION BETWEEN THE SWITCH AND MATCH TASK RELIES ON A DIFFERENT MENTAL MANIPULATION
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limitations[0]
for which uselimitation — any comparison with the original task or with unimpaired participants: THIS MODIFICATION WAS IMPLEMENTED TO AID PATIENT PERFORMANCE BECAUSE ... THEIR MEMORY PERFORMANCE WAS IMPAIRED COMPARED TO NORMAL PARTICIPANTS
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limitations[1]
for which uselimitation — the same scope as limitations[0], with the direction given: THE PARTICIPANT TENDED TO MAINTAIN THE SAMPLE NO MATTER WHAT THE TASK WAS, WHICH MAY LEAD TO A POOR PERFORMANCE IN DECODING
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limitations[2]
for which uselimitation — the same scope as limitations[1] - the paradigm is a modified one, with THE REPEATED PRESENTATION OF THE SAMPLE AFTER THE AUDITORY INSTRUCTION added
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limitations[3]
for which uselimitation — which structures could be observed at all: THE ELECTRODE LOCATIONS WERE BASED EXCLUSIVELY ON CLINICAL CRITERIA
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limitations[4]
for which uselimitation — any attribution of the hippocampal signal to one factor: A COMBINATION OF TWO STREAMS OF INFORMATION, OBJECT IDENTITY AND POSITION, ARE INVOLVED IN THE TASK
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limitations[5]
for which uselimitation — the convergent-evidence argument: the spatial-memory role is well understood, THOUGH ANIMAL MODELS WERE USED IN MOST OF THE STUDIES
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limitations[6]
for which uselimitation — the causal question the recordings cannot reach: IT WILL BE OF INTEREST TO TEST THE RESULTS FROM THE ANIMAL MODELS ON EPILEPSY PATIENTS BEFORE AND AFTER RESECTION
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limitations[7]
replicationreplicated
limitationThe single-trial decoding result may be weakened because participants tended to maintain the sample regardless of which task was instructed.
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limitations[0]
limitationThe task had to be modified from the original because the epilepsy patients' memory performance was impaired relative to healthy participants.
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limitations[1]
limitationthe decoding may understate the effect because participants likely maintained the sample whatever the task
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limitations[2]
limitationthe paradigm was altered from the original to make it performable by patients
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limitations[3]
limitationelectrode placement was dictated entirely by clinical need
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limitations[4]
limitationthe task inseparably combines object identity with location, so the hippocampal involvement cannot be attributed to either alone
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limitations[5]
limitationthe supporting spatial-memory literature comes mostly from animal models
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limitations[6]
limitationtesting patients before and after resection is proposed as the missing comparison
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limitations[7]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingGoal match enhancement appeared only at contacts in the left posterior hippocampus, whereas perceptual mismatch enhancement appeared bilaterally across both anterior and posterior hippocampus.
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content_tags.findings[0]
findingThe perceptual mismatch signal began before the goal match signal in every one of the eight participants.
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content_tags.findings[1]
findingThe two hippocampal signals divide by content: match enhancement tracks the match to the maintained goal while mismatch enhancement tracks perceptual mismatch, dissociating components of working memory within the hippocampus.
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content_tags.findings[2]
findingParticipants whose right posterior hippocampus produced a later perceptual mismatch enhancement were more accurate, a positive correlation between latency and memory performance.
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content_tags.findings[3]
findingThat latency-accuracy link is read as evidence that the right posterior hippocampal mismatch latency indexes the quality of memory retrieval.
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content_tags.findings[4]
findingIn six of the eight patients, single-trial intracranial field potentials from the right hippocampus were sufficient to classify whether the trial was a match task or a switch task.
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content_tags.findings[5]
findingBehaviourally, responses were faster in the match task than in the switch task.
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content_tags.findings[6]
findingHippocampal engagement here is attributed to the task requiring object identity and location to be bound together, in both the match and the switch task.
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content_tags.findings[7]
findinggoal match enhancement appeared in the left posterior hippocampus between about 520 and 735 ms after probe onset
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content_tags.findings[8]
findingperceptual mismatch enhancement appeared bilaterally in anterior and posterior hippocampus, averaging 376 to 555 ms
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content_tags.findings[9]
findingmismatch enhancement began earlier than match enhancement in every participant
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content_tags.findings[10]
findingregion latencies were 524 ms for goal match and about 405 to 430 ms for perceptual mismatch across the four subdivisions
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content_tags.findings[11]
findinga late perceptual match effect appeared on two electrodes at 717 and 900 ms
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content_tags.findings[12]
findingfor each electrode and effect, the probability of the observed latency was below 0.05
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content_tags.findings[13]
findingmismatch latency in the right posterior hippocampus correlated positively with memory accuracy
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content_tags.findings[14]
findingtask demand was decodable from single trials in 6 of 8 patients, always from the right hippocampus
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content_tags.findings[15]
findingresponses were faster in the match task than in the switch task
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content_tags.findings[16]
findingover 80% of trials survived artifact rejection
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content_tags.findings[17]
quantity120 ... 8 — depth electrode contacts recorded, and epilepsy patients implanted
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content_tags.quantities[0]
quantity126 — trials per experimental run
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content_tags.quantities[1]
quantity>80% — proportion of trials retained after artifact rejection
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content_tags.quantities[2]
quantity1000 — random permutations computed per electrode to test the observed enhancement latencies
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content_tags.quantities[3]
quantity<0.05 — permutation probability of the observed latency, for every electrode and every significant effect
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content_tags.quantities[4]
quantity6 out of 8 — patients whose hippocampal field potentials reliably represented the task demand in single-trial decoding
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content_tags.quantities[5]
quantity120 depth electrode contacts in 8 patients — the sample
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content_tags.quantities[6]
quantity520 ms to 735 ms — window of goal match enhancement after probe onset
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content_tags.quantities[7]
quantity376 ms to 555 ms — window of perceptual mismatch enhancement
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content_tags.quantities[8]
quantity~150 ms — how much earlier mismatch precedes match
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content_tags.quantities[9]
quantityρ = 0.74 — correlation between right posterior mismatch latency and accuracy
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content_tags.quantities[10]
quantity126 trials per run, 3 to 5 runs — to obtain at least 80 correct trials per participant
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content_tags.quantities[11]
quantity6 out of 8 — patients whose task demand was decodable from hippocampal signal
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content_tags.quantities[12]
variableobject configuration (independent)
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content_tags.variables[1]
variablelocal field potential (dependent)
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content_tags.variables[3]
variablelatency of the enhancement effect (dependent)
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content_tags.variables[4]
variablereaction time and accuracy (dependent)
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content_tags.variables[5]
variableelectrode configuration (control)
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content_tags.variables[7]
variablelatency
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content_tags.variables[9]
variabletask demand
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content_tags.variables[10]
variablecorrect percentage
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content_tags.variables[11]
definitionmismatch enhancement
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content_tags.definitions[0]
definitionlatency of the enhancement effect
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content_tags.definitions[3]
definitionmatch enhancement
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content_tags.definitions[4]
definitiondelayed-match-to-sample
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[5]
definitionintracranial field potential
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[6]
key-termsworking memory, goal match enhancement, perceptual mismatch enhancement, match enhancement, mismatch enhancement, delayed-match-to-sample, hippocampus, intracranial field potential, event-related potentials, relational memory, pattern completion, novelty detection, prediction error, linear discriminant analysis, Monte Carlo permutations, hippocampal sclerosis, perirhinal cortex, ECoG, depth electrodes, medial temporal lobe
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
paired t-test t as written: Paired sample t tests
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[0]
t-test (sample-by-sample, time-resolved) t as written: The sample-by-sample t -test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[1]
ANOVA (two-way) as written: sample-by-sample two-way analysis of variance (ANOVA)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[2]
permutation test as written: Monte Carlo permutations
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[3]
ANOVA (three-way) with Bonferroni correction for multiple comparisons as written: multiple comparison of three-way ANOVA analysis with Bonferroni confidence interval adjustment
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[4]
correlation as written: significantly correlated with the accuracy of memory performance
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[5]
linear discriminant analysis with principal component analysis as written: A linear discriminant analysis ... with the principal component analysis approach for dimensionality reduction
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[6]
standard error of the mean
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[7]
p-value as written: the probability of the observed latency was <0.05
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[8]
sample-by-sample t -test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[9]
Monte Carlo permutations
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[10]
linear discriminant analysis
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[11]
Bonferroni confidence interval adjustment
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[12]
Second readings
a facet read a second time, independently, from its own sentence — and whether the two readings agree
claim typeexistence — a second reading reaching the same value; recorded: existence
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.claim_type
methodintracranial field potentials from depth electrodes along the hippocampal axis during a modified delayed-match-to-sample task in which a verbal instruction determines whether a display counts as a goal match or a perceptual match — a second reading DIFFERING from the recorded value; recorded: electrophysiology
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.method
phenomenonmatch and mismatch signals in the hippocampus during working memory maintenance — a second reading DIFFERING from the recorded value; recorded: hippocampal match and mismatch enhancement in working memory
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.phenomenon

When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

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