Development of Inhibitory Timescales in Auditory Cortex

Oswald, Reyes · Cerebral Cortex · 2011 · neuroscience · 10.1093/cercor/bhq214 · record Oswald2011-development-of-inhibitory-timescales-in-audi
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Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. Replication status is 'contested' because the paper's own IPSP-amplitude result is explicitly set against two lines of prior work (other cortical areas showing increases with age; in vivo AI studies showing stable inhibitory strength), and the paper itself notes the excitatory/inhibitory tuning-lag literature is disputed ('but also see Sun et al. 2010'). The central timing claim is not itself reported as replicated or refuted. Claim type is 'mechanism' because the paper attributes the change in inhibitory timescale to specified maturing intrinsic and synaptic properties. One evidence quote for the fourth limitation contains curly quotation marks around FS, copied as they appear in the source. 2026-08-13, 2026-08-15 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
standard deviation 3 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 18 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
FS PCs EPSP IPSP IPSC membrane time constant input resistance integration window short-term depression paired pulse ratio afterhyperpolarizations rheobase G42 biocytin L2/3 tonotopic map GABA A sag Shortening of the postsynaptic membrane time constant during development speeds the decay of synaptic potentials Falling input resistance of the postsynaptic pyramidal cell offsets a rising inhibitory current, so the measured IPSP amplitude declines with age Later IPSP peak times in young animals reduce excitation-inhibition overlap and thereby widen the synaptic integration window Inhibitory decay constants longer than excitatory ones impose an upper frequency limit on responses to closely spaced inputs Developmental expression of leak and repolarizing potassium channels in PV+ FS cells drives the change in intrinsic excitability A switch from slow alpha-3 to faster alpha-1 GABA_A receptor subunits accelerates IPSP rise and decay spike frequency adaptation failure rate EPSP latency PSP latency spike threshold amplitude of the sag step current IPSP amplitude decay of the EPSP reversal potential ANOVA univariate analysis of variance (ANOVA) Tukey's HSD post hoc test Tukey's honestly significant difference post hoc test Levene's test for homogeneity of variance Levene's test for homogeneity Mann-Whitney U test nonparametric Mann–Whitney U test standard deviation mean ± standard deviation (SD) least-squares curve fitting (chi-squared minimisation) Levenberg-Marquardt nonlinear, least-squares fitting algorithm correlation F statistic F values and P values are for ANOVA comparisons Mann–Whitney U test electrophysiology

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relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field
unrecordable relationunhoused_relationsa relation the paper asserts that this vocabulary cannot express, with the reason

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1093/cercor/bhq214. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 3 · claim_relations 9 · claim_type 1 · concept_edges 6 · content_tags 66 · contribution 1 · controls 1 · limitations 9 · mechanisms 11 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 5 · transfers 2 · unhoused_relations 1

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 6 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studyhow the timing of cortical inhibition matures over the weeks after hearing onset
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object_of_studythe paper's words
research_questionwhich intrinsic and synaptic properties set the speed of inhibitory recruitment, and how each changes between P10 and P29
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research_questionthe paper's words
contributionshows fast-spiking cells and their synapses both speed up over development, and that the temporal properties of inhibition mature later than those of excitation
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenonpostnatal development of inhibitory timing in auditory cortex layer 2/3
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsmechanisms
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mechanisms[3]the tagger's words
mechanismsmechanisms
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mechanisms[4]the tagger's words
mechanismsmechanisms
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mechanisms[5]the tagger's words
mechanismsfaster firing in older cells follows from shorter membrane time constants, briefer afterhyperpolarisations and narrower spikes
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mechanisms[6]1.0the tagger's words
mechanismsthe speed-up coincides with development of potassium channels handling leak and spike repolarisation
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mechanisms[7]0.8the tagger's words
mechanismsexcitatory decay tracks the membrane time constant of the receiving cell, so a synaptic timescale is partly a membrane timescale
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mechanisms[8]1.0the tagger's words
mechanismsinhibitory rise, peak and decay times shorten with age, attributed in part to the falling membrane time constant of the receiving pyramidal cell
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mechanisms[9]0.9the tagger's words
mechanismsshorter inhibitory decays let older cells follow inputs at 20-40 Hz where younger ones summate and stop responding above 10 Hz
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mechanisms[10]1.0the tagger's words
limitationsVoltage clamp was deliberately not used, limiting the measurements to current-clamp postsynaptic potentials.
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what this limits: every synaptic measurement in the paper: VOLTAGE CLAMP RECORDINGS WERE NOT PERFORMED BECAUSE THE STANDARD INTERNAL SOLUTIONS ... WOULD PROHIBIT THE CHARACTERIZATION OF INTRINSIC NEURAL P[roperties] - one measurement excludes the other
limitations[0]the tagger's words
limitationsWhether the paired-cell changes in inhibitory strength hold at the population level in vivo is unknown.
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what this limits: the extrapolation from paired recordings to the intact animal: IT REMAINS TO BE DETERMINED HOW CHANGES IN INHIBITORY STRENGTH BETWEEN PAIRS OF NEURONS ARE REFLECTED AT THE POPULATION LEVEL IN VIVO
limitations[1]the tagger's words
limitationsThe functional consequences for auditory processing were not tested and require in vivo work.
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what this limits: any functional claim about auditory processing: FURTHER IN VIVO STUDIES ARE NECESSARY TO ELUCIDATE FUNCTIONAL IMPLICATIONS
limitations[2]the tagger's words
limitationsIdentifying fast-spiking cells electrophysiologically is unreliable in the youngest animals.
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what this limits: the fast-spiking classification in the youngest animals: THE IDENTIFICATION OF FS CELLS BASED ON ELECTROPHYSIOLOGICAL PROPERTIES CAN BE DIFFICULT PARTICULARLY IN YOUNG ANIMALS (P10-P14) SINCE FS RESPONSES ARE LESS APPARENT
limitations[3]the tagger's words
limitationsvoltage clamp was deliberately not used, because the solutions needed for it would have prevented measuring intrinsic properties and bidirectional connections
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duplicate of: limitations[0] · what this limits: the same scope as limitations[0] - the trade-off between clamp quality and intrinsic properties
limitations[4]1.0the tagger's words
limitationsthe age bins were divided arbitrarily
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what this limits: every developmental comparison in the paper: THE TRANSITIONAL PERIOD WAS DIVIDED ARBITRARILY INTO AN EARLY PHASE (P10-P14) - the independent variable's boundaries are declared arbitrary
limitations[5]1.0the tagger's words
limitationsonly postsynaptic potentials that fitted the double-exponential model well were analysed
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what this limits: the fitted decay parameters: ONLY PSPS THAT WERE WELL FIT BY EQUATION 1 (CHI2 < 1.75) WERE CHOSEN - a goodness-of-fit threshold decides which data enter
limitations[6]1.0the tagger's words
limitationsreceptor composition changes are not excluded as an additional cause of the synaptic decay changes
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what this limits: the mechanistic attribution of the decay changes: OUR RESULTS DO NOT PRECLUDE THE POSSIBILITY THAT DEVELOPMENTAL CHANGES IN AMPA AND/OR NMDA RECEPTOR COMPOSITION also contribute
limitations[7]1.0the tagger's words
limitationshow paired-cell inhibitory strength maps onto the population level in the intact animal is left open
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duplicate of: limitations[1] · what this limits: the same scope as limitations[1] - paired cells versus population in vivo
limitations[8]1.0the tagger's words
transfersa GFP line used not as the object of study but as a check on an electrophysiological classification
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transfers[0]1.0the tagger's words
transfersthe expectation that a synaptic potential's time course follows the membrane time constant of the cell receiving it
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transfers[1]0.9the tagger's words
controlsthe location of AI verified in a subset of slices by stimulating the MG and recording field potential responses in layers 3 and 4
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eliminates: recording from the wrong cortical field - the functional check is independent of the stereotaxic estimate it verifies · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
unhoused_relationsEPSPs → FS cell membrane time constants
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CORRELATED THROUGHOUT DEVELOPMENT, with no manipulation of either quantity. Recording it as 'causes' in either direction asserts more than the sentence does.
unhoused_relations[0]the tagger's words
sensesFS is an ELECTROPHYSIOLOGICAL category whose defining features are absent in the youngest animals, which is exactly the age this paper is about
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senses[0]1.0the tagger's words
sensesthe transgenic label covers only a SUBSET - the PV cells that are also fast-spiking express EGFP - so GFP-positive is narrower than PV-positive
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senses[1]1.0the tagger's words
sensesIPSP and IPSC are not interchangeable measures of inhibitory strength: they differ by the postsynaptic input resistance, which itself falls with age
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senses[2]1.0the tagger's words
sensesreported PSP amplitudes are averaged over all trials INCLUDING failures, so they are a product of size and reliability rather than a size alone
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senses[3]1.0the tagger's words
sensesa successful PSP is defined by a three-part criterion on onset, amplitude and peak time, with anything else counted as a failure of amplitude zero
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senses[4]1.0the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: paired whole-cell current-clamp recording from connected fast-spiking and pyramidal cells in auditory thalamocortical slices across three age bins
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: the developmental narrowing of the synaptic integration window in auditory cortex
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a second reading DIFFERING from the recorded value. Recorded: postnatal development of inhibitory timing in auditory cortex layer 2/3 — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsextends → Oswald and Reyes 2008 (development of L2/3 pyramidal cells in AI)
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claim_relations[0]the tagger's words
claim_relationsbuilds-on → Oswald and Reyes 2008 (companion study on PC–PC circuitry)
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claim_relations[1]the tagger's words
claim_relationscontradicts → Doischer et al. 2008; Kobayashi et al. 2008 (age-related increase in IPSC amplitude in other cortical areas)
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claim_relations[2]the tagger's words
claim_relationscontradicts → Dorrn et al. 2010; Sun et al. 2010 (in vivo reports that inhibitory strength is stable in early development)
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claim_relations[3]the tagger's words
claim_relationscontradicts → reports from other cortical areas that inhibitory postsynaptic amplitudes increase with age
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claim_relations[4]1.0the tagger's words
claim_relationsreconciles → that disagreement, by proposing that falling input resistance converts a rising current into a falling voltage
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claim_relations[5]1.0the tagger's words
claim_relationsextends → their own companion study on pyramidal cell development in the same layer
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claim_relations[6]1.0the tagger's words
claim_relationssupports → the proposal that inhibitory tuning lags excitatory tuning, which the paper notes is itself disputed
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claim_relations[7]1.0the tagger's words
claim_relationsbuilds-on → in vivo work on thalamorecipient layers, by adding the supragranular circuit
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claim_relations[8]1.0the tagger's words
concept_edgesinput resistance —causes→ IPSP
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strength of the relation: 1 · note: the conversion factor between the measures is itself a developing variable, which is why a cross-paper comparison of inhibitory strength needs to know which was measured Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but 'one LIKELY explanation' is that decreasing input resistance counters rising IPSC amplitude; causes is hedged.
concept_edges[1]1.0the tagger's words
concept_edgesmembrane time constant —causes→ IPSP
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strength of the relation: 0.8 · note: same route on the inhibitory side, with a receptor subunit switch offered as an additional cause Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the IPSP time changes 'MAY, in part, be attributed to' the membrane time constant; causes is hedged.
concept_edges[3]1.0the tagger's words
concept_edgesGABA A —causes→ IPSP
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strength of the relation: 0.7 · note: the alpha-3 to alpha-1 switch; an alternative not separated from the membrane route here Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the GABA A subunit transition 'MAY ALSO contribute' to IPSP kinetics; causes is hedged.
also in: GABA A · IPSP
concept_edges[4]1.0the tagger's words
concept_edgesFS —contrasted-with→ PCs
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strength of the relation: 1 · note: the mature separation rests on firing rate, spike width and afterhyperpolarisation - all of which are absent before P15
also in: FS · PCs
concept_edges[6]1.0the tagger's words
concept_edgesIPSP —causes→ integration window
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strength of the relation: 1 · note: SIGN: later inhibitory peaks widen the window, so young cells accept less precisely timed inputs Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but later-peaking IPSPs 'WOULD LIKELY' broaden the integration window; causes is hedged.
concept_edges[7]1.0the tagger's words
concept_edgesshort-term depression —operationalised-as→ paired pulse ratio
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strength of the relation: 1
concept_edges[8]1.0the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[0]the tagger's words
content_tagsTukey's HSD post hoc test
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content_tags.statistics[1]the tagger's words
content_tagsLevene's test for homogeneity of variance
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content_tags.statistics[2]the tagger's words
content_tagsMann-Whitney U test
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content_tags.statistics[3]the tagger's words
content_tagsstandard deviation
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content_tags.statistics[4]the tagger's words
content_tagsleast-squares curve fitting (chi-squared minimisation)
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content_tags.statistics[5]the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.statistics[6]the tagger's words
content_tagsF statistic
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about this quote: This quote ends with the stray word 'The', the first word of the next sentence. It is not trimmed, because the quote without it occurs more than once in the paper's text and could not be tied to one place. The claim is carried by the sentence before 'The'.
also in: F statistic
content_tags.statistics[7]the tagger's words
content_tagsMann–Whitney U test
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content_tags.statistics[8]1.0the tagger's words
content_tagsANOVA
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also in: ANOVA
content_tags.statistics[9]1.0the tagger's words
content_tagsBetween P10 and P29 the firing rates of fast-spiking interneurons rose, driven by shorter membrane time constants, briefer afterhyperpolarizations and narrower action potentials.
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content_tags.findings[0]the tagger's words
content_tagsIPSP latency, rise time and peak time, together with the decay constants of both EPSPs and IPSPs, all shortened between P10 and P29.
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content_tags.findings[1]the tagger's words
content_tagsExcitatory PC-to-FS synapses in the youngest animals depressed most strongly (paired-pulse ratio 0.4) and this depression weakened with age (0.7 at P15-P18 and 0.8 at P19-P29).
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content_tags.findings[2]the tagger's words
content_tagsBecause short-term depression at PC-to-FS synapses weakened with age, older synapses sustained their responses better during repetitive stimulation.
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content_tags.findings[3]the tagger's words
content_tagsThe temporal properties that determine when inhibition is recruited mature later than the corresponding properties of excitation.
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content_tags.findings[4]the tagger's words
content_tagsIPSP amplitude fell from 0.8 mV at P10-P14 to 0.5 mV at P19-P29.
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content_tags.findings[5]the tagger's words
content_tagsThe EPSP decay time constant shortened from 37 ms at P10-P14 to 16 ms at P19-P29 while the rise time constant did not change with age.
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content_tags.findings[6]the tagger's words
content_tagsFS-to-PC inhibitory responses to single pulses were entirely GABA_A-receptor mediated, being abolished by bicuculline.
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content_tags.findings[7]the tagger's words
content_tagsAt resting potential, PC-to-FS excitatory responses were entirely AMPA-receptor mediated, being abolished by DNQX.
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content_tags.findings[8]the tagger's words
content_tagsFS-cell intrinsic membrane and action-potential properties were indistinguishable between the GFP-expressing G42 line and Swiss Webster mice at every age tested.
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content_tags.findings[9]the tagger's words
content_tagsExcept for latency, the rise, peak and decay of the IPSP were significantly longer than the corresponding excitatory timescales.
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content_tags.findings[10]the tagger's words
content_tagsFast-spiking cells at P10-P14 were the least mature electrically, with the longest membrane time constants, highest input resistance and most depolarized resting potential.
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content_tags.findings[11]the tagger's words
content_tagsspikes narrowed and afterhyperpolarisations shortened with age, raising firing rates
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content_tags.findings[13]1.0the tagger's words
content_tagsthe hyperpolarisation-activated sag was prominent at P10-P14
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content_tags.findings[14]1.0the tagger's words
content_tagsexcitatory amplitudes fell with age and correlated with input resistance across all ages
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content_tags.findings[15]1.0the tagger's words
content_tagsshort-term depression at excitatory synapses weakened with age, making repetitive responses more sustained
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content_tags.findings[16]1.0the tagger's words
content_tagsinhibitory rise, peak and decay times all shortened with age
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content_tags.findings[17]1.0the tagger's words
content_tagsinhibitory decays stayed longer than excitatory ones at every age, setting an upper frequency bound
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content_tags.findings[18]1.0the tagger's words
content_tagsproperties transitioned between P10 and P18 and plateaued from P19 to P29
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content_tags.findings[19]1.0the tagger's words
content_tagsexcitatory potentials were fully blocked by an AMPA receptor antagonist
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content_tags.findings[20]1.0the tagger's words
content_tagsCONTROL: GFP-labelled cells in the transgenic line and electrophysiologically identified cells did not differ at any age
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content_tags.findings[21]1.0the tagger's words
content_tagsUNEXPECTED RESULT: inhibitory potential amplitudes fell with age, where other cortical areas report the current rising
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content_tags.findings[22]1.0the tagger's words
content_tagsRESOLUTION OFFERED: falling input resistance would convert a rising inhibitory current into a falling inhibitory voltage
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content_tags.findings[23]1.0the tagger's words
content_tagsthe classification of fast-spiking cells is hardest exactly in the youngest animals, where the defining responses are less apparent
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content_tags.findings[24]1.0the tagger's words
content_tagsspike frequency adaptation
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content_tags.definitions[0]the tagger's words
content_tagsfailure rate
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also in: failure rate
content_tags.definitions[1]the tagger's words
content_tagspaired pulse ratio
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content_tags.definitions[2]the tagger's words
content_tagsEPSP latency
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also in: EPSP latency
content_tags.definitions[3]the tagger's words
content_tagsPSP latency
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also in: PSP latency
content_tags.definitions[4]the tagger's words
content_tagsspike threshold
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content_tags.definitions[5]the tagger's words
content_tagsamplitude of the sag
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content_tags.definitions[6]the tagger's words
content_tagspaired pulse ratio
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content_tags.definitions[7]0.9the tagger's words
content_tagsintegration window
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content_tags.definitions[8]0.9the tagger's words
content_tagssag
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also in: sag
content_tags.definitions[9]0.9the tagger's words
content_tagsstep current
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also in: step current
content_tags.variables[1]the tagger's words
content_tagsIPSP amplitude
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content_tags.variables[3]the tagger's words
content_tagsdecay of the EPSP
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content_tags.variables[4]the tagger's words
content_tagsreversal potential
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content_tags.variables[5]the tagger's words
content_tagsmembrane time constant
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content_tags.variables[6]1.0the tagger's words
content_tagspaired pulse ratio
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content_tags.variables[7]1.0the tagger's words
content_tagsinput resistance
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content_tags.variables[8]1.0the tagger's words
content_tags116 FS cells / 134 PCs — number of fast-spiking interneurons recorded and pyramidal cells they were synaptically connected to
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content_tags.quantities[0]the tagger's words
content_tags0.4 ± 0.1 vs 0.8 ± 0.2 — paired-pulse ratio at PC-to-FS synapses in the youngest versus oldest age group
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content_tags.quantities[1]the tagger's words
content_tags1.4 ± 0.3 — spike-frequency adaptation ratio (last/first interspike interval) in P10-P14 FS cells, higher than in older animals
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content_tags.quantities[2]the tagger's words
content_tags23 ± 11 ms; 294 ± 183 MΩ — membrane time constant and input resistance of FS cells at P10-P14, the highest values recorded
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content_tags.quantities[3]the tagger's words
content_tagsR : 0.88 — correlation between mean EPSP decay constant and mean FS-cell membrane time constant across ages
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content_tags.quantities[4]the tagger's words
content_tagsR : 0.77 — correlation between postsynaptic pyramidal-cell input resistance and mean IPSP amplitude
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content_tags.quantities[5]the tagger's words
content_tagsχ 2 < 1.75, n = 155 EPSPs, n = 167 IPSPs — goodness-of-fit cutoff and the number of postsynaptic potentials that passed it for kinetic analysis
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content_tags.quantities[6]the tagger's words
content_tags60–200 ms — IPSP duration in young animals, long enough to summate and suppress responsiveness above 10 Hz
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content_tags.quantities[7]the tagger's words
content_tags25–50 ms — IPSP duration in older animals, permitting responses to 20-40 Hz inputs
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content_tags.quantities[8]the tagger's words
content_tags116 and 134 — fast-spiking cells and connected pyramidal cells recorded
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content_tags.quantities[9]1.0the tagger's words
content_tagsP10 to P29 — age range, spanning hearing onset to the plateau
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content_tags.quantities[10]1.0the tagger's words
content_tags60-200 ms against 25-50 ms — inhibitory potential durations in young against older animals
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content_tags.quantities[11]1.0the tagger's words
content_tagsabove 10 Hz against 20-40 Hz — input frequencies the young and older circuits can follow
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content_tags.quantities[12]1.0the tagger's words
content_tags0.4 against 0.8 — paired pulse ratio at 10 Hz in the youngest against the oldest group
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content_tags.quantities[13]1.0the tagger's words
content_tags72 — neurons filled with biocytin to confirm identity morphologically
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content_tags.quantities[14]1.0the tagger's words

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