Cortical interneurons that specialize in disinhibitory control

Pi, Hangya, Kvitsiani, Sanders, Huang, Kepecs · Nature · 2013 · neuroscience · 10.1038/nature12676 · record Pi2013-cortical-interneurons-that-specialize-in-dis
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. 'extends' rather than 'replicates' for the single relation: the prior work being confirmed was anatomical/connectivity-based inference, and this paper carries that claim into awake in vivo function rather than repeating a prior experiment. The comparison with the layer 1 cholinergic disinhibition studies (refs 13, 18) is recorded as a limitation instead of a relation, because the paper states the overlap is undetermined rather than asserting agreement or conflict. 2026-08-12, 2026-08-15 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
bootstrap 2 fields · confidence interval 2 fields · statistical-significance 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 20 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
disinhibition VIP VIP interneurons Som Pv pyramidal neurons fast-spiking interneurons narrow spike widths gain modulation divisive gain modulation baseline firing rate reinforcement conserved motif adaptive spike density function PSTH isolation distance L-ratio c-Fos immunohistochemistry Bayesian information criterion Light-driven VIP firing inhibits other interneurons, which releases a subset of pyramidal cells from inhibition — an excitation-inhibition-excitation sequence that is the signature of disinhibition. Long-range or neuromodulatory inputs recruit VIP cells, and the resulting disinhibition selectively raises the gain of particular pyramidal ensembles. Because the disinhibition lands preferentially on tone-selective neurons, relaying the reinforcement signal through VIP cells could implement cortical learning. The same disinhibitory microcircuit appears in two cytoarchitectonically different areas, so it is proposed to be a repeated neocortical motif. somatostatin parvalbumin interneuron divisive optogenetic ChR2 auditory cortex medial prefrontal cortex IPSCs fast-spiking spike width disinhibitory control tone-responsive neuron tone-selectivity ΔResponse narrow spiking impact recruitment light-induced changes of firing rate ChR2 expression time movement bouts decay time constant Mann-Whitney U test two-tailed Mann-Whitney U-test statistical-significance t-test paired t-test unpaired t-test Wilcoxon signed-rank test Wilcoxon signed rank test, two-tailed normality test Lilliefors-test mean All central tendencies were reported as mean ± SEM confidence interval bootstrap bootstrapped distribution of correlation coefficients nonlinear least-squares curve fitting robust fit with non-linear least squares method correlation waveform correlation Mann-Whitney U-test Wilcoxon signed rank test isolation distance and L-ratio electrophysiology

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

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alternatives 3 · claim_relations 6 · claim_type 1 · concept_edges 6 · content_tags 66 · contribution 1 · controls 1 · limitations 11 · mechanisms 11 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 6 · transfers 2

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facettagfieldconf.whose words
object_of_studyVIP-expressing cortical interneurons and the disinhibitory circuit they form
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object_of_studythe paper's words
research_questionwhether a specific interneuron type mediates disinhibition in vivo, and under what behavioural conditions it is recruited
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research_questionthe paper's words
contributionmaps one circuit function onto one molecularly defined cell type in two cortical areas, and identifies reinforcement feedback as the condition that recruits it
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenoncortical disinhibition by VIP interneurons
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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status: the paper's own words: we propose that
mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsmechanisms
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mechanisms[3]the tagger's words
mechanismsthe excitation-inhibition-excitation sequence after a light pulse is read as the signature of disinhibition: VIP cells inhibit other interneurons, releasing pyramidal cells
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mechanisms[4]1.0the tagger's words
mechanismsVIP cells inhibit a large fraction of Som interneurons and a smaller fraction of Pv interneurons, with different decay constants and depression
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mechanisms[5]1.0the tagger's words
mechanismspyramidal neurons are only a minor monosynaptic target, so the effect on them is indirect
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mechanisms[6]1.0the tagger's words
mechanismsthe disinhibited population is functionally specific - biased toward tone-responsive, frequency-tuned cells
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mechanisms[7]1.0the tagger's words
mechanismsinhibited cells show divisive gain modulation while delayed-activated cells show an additive baseline shift
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mechanisms[8]1.0the tagger's words
mechanismsVIP cells are proposed as the substrate by which long-range or neuromodulatory signals raise the gain of specific pyramidal ensembles
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mechanisms[9]0.9the tagger's words
mechanismscell identity in vivo is inferred from spike width and firing rate, then confirmed in vitro with genetic labels and by c-Fos with a pyramidal marker
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mechanisms[10]1.0the tagger's words
limitationsHow far this circuit overlaps with the previously described layer 1 disinhibitory circuit is undetermined.
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what this limits: the relation to the layer 1 circuit: THE EXTENT TO WHICH THESE TWO DISINHIBITORY CIRCUITS OVERLAP REMAINS TO BE DETERMINED, AS ONLY A FRACTION OF LAYER 1 INTERNEURONS EXPRESS VIP
limitations[0]the tagger's words
limitationsThe experimenter could not be fully blinded.
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what this limits: every effect measured in these experiments: CONDUCTING THE EXPERIMENTS REQUIRED MONITORING THE EFFECT OF VIP-PHOTOSTIMULATION ON MULTIUNIT ACTIVITY; THEREFORE, IT WAS NOT POSSIBLE TO FULLY BLIND THE EXPERIMENTER
limitations[1]the tagger's words
limitationsThe immunohistochemical estimate of VIP expression specificity and efficiency is not a gold-standard measure.
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what this limits: the VIP expression specificity figures: IMMUNOHISTOCHEMISTRY IS NOT CONSIDERED A GOLD STANDARD METHOD FOR ASSESSING GENE EXPRESSION, SINCE BOTH ITS SPECIFICITY AND SENSITIVITY DEPENDS ON EXTERNAL factors
limitations[2]the tagger's words
limitationsthe experimenter could not be fully blinded, because finding the effect was necessary to position the electrodes; disclosed with its mitigation
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what this limits: the same scope as limitations[1], with the mitigation: THIS INFORMATION WAS ONLY USED TO GUIDE DECISIONS ABOUT electrode placement
limitations[3]1.0the tagger's words
limitationsimmunohistochemistry, used to estimate the specificity of VIP labelling, is stated by the authors not to be a gold standard for gene expression
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what this limits: the same scope as limitations[2] - the specificity estimate rests on a non-gold-standard assay
limitations[4]1.0the tagger's words
limitationsthe exclusion thresholds were relaxed for VIP cells specifically, using light-evoked waveform correlation instead
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what this limits: the VIP unit sample: SOME OF THE VIP NEURONS DID NOT REACH THE THRESHOLD OF ISOLATION DISTANCE AND L-RATIO. FOR THESE NEURONS, WE EXPLOITED THE WAVEFORM INFORMATION CARRIED BY LIGHT-EVOKED ACTION POTENTIALS
limitations[5]1.0the tagger's words
limitationsanalysis windows differed between the two recorded areas, chosen from the observed response latencies
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what this limits: any comparison of latencies or firing between the two areas: the analysis windows were set separately for each, from the observed response latencies
limitations[6]1.0the tagger's words
limitationsdatasets were pooled across layers and areas on the strength of null results rather than demonstrated equivalence
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what this limits: every pooled result: THERE WAS NO SIGNIFICANT DIFFERENCES IN IPSC AMPLITUDE AND FRACTION OF RESPONDED NEURONS IN DIFFERENT CORTICAL LAYERS AND THE RESULTS WERE COMBINED - pooling on a null, not on demonstrated equivalence
limitations[7]1.0the tagger's words
limitationsthe difference in VIP yield between the two areas is attributed to delivery method rather than biology
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what this limits: the ACx-versus-mPFC yield comparison: THE DIFFERENCE IN THE RELATIVE PROPORTION OF RECORDED VIP NEURONS IN ACx AND mPFC IS LIKELY DUE TO TECHNICAL REASONS - ChR2 WAS DELIVERED VIRALLY INTO mPFC, WHEREAS WE USED A REPORTER LINE (Ai32) FOR ACx
limitations[8]1.0the tagger's words
limitationsthe overlap between this circuit and the layer 1 disinhibitory circuit is left undetermined
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duplicate of: limitations[0] · what this limits: the same scope as limitations[0] - the overlap with the layer 1 circuit is undetermined
limitations[9]1.0the tagger's words
limitationssynchronous optogenetic activation is defended as physiologically plausible by appeal to the homogeneity of the natural response, which is an argument rather than a control
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what this limits: the synchronous-activation method: THE HOMOGENEOUS BEHAVIOURAL RECRUITMENT OF VIPs SUGGESTS THAT THE SYNCHRONOUS ChR2-MEDIATED ACTIVATION TO PROBE THEIR CIRCUIT FUNCTION WAS PHYSIOLOGICALLY PLAUSIBLE - the plausibility rests on that homogeneity
limitations[10]0.9the tagger's words
transfersgating and gain modulation as the functions a disinhibitory motif could serve
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transfers[0]1.0the tagger's words
transfersBayesian information criterion used to choose between additive, divisive and combined descriptions of a tuning-curve change
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transfers[1]1.0the tagger's words
controlsChR2 expression time held constant and comparable at 4 to 6 weeks across the two mouse lines
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eliminates: a difference between the lines that is really a difference in how long the opsin had to express - more expression means more current, whatever the cell type does · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
sensesdisinhibition here is a specific circuit motif - inhibitory cells targeting other inhibitory cells - not a general loosening of inhibition
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senses[0]1.0the tagger's words
sensesVIP names a molecular marker used as a cell class; the paper's whole argument is that a marker-defined population has a single circuit function
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senses[1]1.0the tagger's words
sensesPv identity in the in vivo data is a PROXY: inferred from narrow spike width and high firing rate, hedged as many but not all and usually
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senses[2]1.0the tagger's words
sensesgain modulation is split into two distinguishable senses here - divisive (multiplying the tuning curve) versus an additive baseline shift - and the two populations show different ones
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senses[3]1.0the tagger's words
sensesimpact and recruitment are coined by this paper as the two directions of a cell type's role: what it drives, and what drives it
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senses[4]1.0the tagger's words
sensesSDF, PSTH and PETH are used for the same computed object in this paper, with the renaming declared in the text
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senses[5]1.0the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: optogenetic tagging with ChR2 in VIP-Cre mice, tetrode recording in awake mice, slice recording from genetically labelled Som and Pv cells, and an auditory go/no-go task
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: disinhibition - inhibitory neurons that suppress other inhibitory neurons, amplifying local processing
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a second reading DIFFERING from the recorded value. Recorded: cortical disinhibition by VIP interneurons — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsextends → previous connectivity-based proposals that VIP interneurons provide disinhibitory control (refs 10-12)
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claim_relations[0]the tagger's words
claim_relationsconfirms → connectivity-based proposals that VIP interneurons specialise in targeting other interneurons
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claim_relations[1]1.0the tagger's words
claim_relationsextends → the layer 1 disinhibitory circuit enabling associative learning
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status: the paper's own words: remains to be determined
claim_relations[2]0.95the tagger's words
claim_relationsqualifies → the additive account of how VIP activation changes tuning curves
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claim_relations[3]1.0the tagger's words
claim_relationssupports → the view that different interneuron types perform distinct circuit operations
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claim_relations[4]0.95the tagger's words
claim_relationsgeneralises → the disinhibitory motif across cytoarchitectonically different cortical areas
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claim_relations[5]0.9the tagger's words
concept_edgesVIP interneurons —causes→ Som
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strength of the relation: 0.95 · note: inhibits: elicited IPSCs from a large fraction
also in: VIP interneurons · Som
concept_edges[0]1.0the tagger's words
concept_edgesVIP interneurons —causes→ Pv
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strength of the relation: 0.7 · note: a smaller fraction; the weight carries the difference from the Som connection
also in: VIP interneurons · Pv
concept_edges[1]1.0the tagger's words
concept_edgesfast-spiking interneurons —operationalised-as→ Pv
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strength of the relation: 0.75 · note: backwards-looking: spike width and rate are the in vivo PROXY for Pv identity, hedged as many but not all and usually Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but fast-spiking interneurons are 'USUALLY expressing' parvalbumin; operationalised-as is loose.
concept_edges[2]1.0the tagger's words
concept_edgesdivisive gain modulation —contrasted-with→ baseline firing rate
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differs in: THE AXIS IS MULTIPLICATIVE SCALING VERSUS ADDITIVE OFFSET. 'one-parameter gain modulation models (additive or multiplicative) fitted the light-induced changes in average tuning curves: THE INHIBITED POPULATION SHOWED DIVISIVE GAIN MODULATION, WHEREAS THE CHANGE IN DELAYED ACTIVATED NEURONS WAS CONSISTENT WITH AN ADDITIVE SHIFT OF THE BASELINE FIRING RATE.' Both populations change their firing under the same manipulation; they differ on WHICH PARAMETER OF THE TUNING CURVE moves, which is the distinction the one-parameter models were fitted to decide. · strength of the relation: 1 · note: the two one-parameter models, and the two populations show different ones
concept_edges[4]1.0the tagger's words
concept_edgesadaptive spike density function —same-as→ PSTH
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strength of the relation: 1 · note: a synonymy DECLARED by the authors for this paper - termed ... and abbreviated ... hereinafter. locally true by stipulation; SDF and PSTH are not generally the same object.
concept_edges[5]1.0the tagger's words
concept_edgesVIP interneurons —operationalised-as→ disinhibition
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strength of the relation: 0.9 · note: the paper's central move: one circuit function mapped onto one molecularly defined cell type Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span maps disinhibitory control onto VIP cells; operationalised-as is loose.
concept_edges[6]1.0the tagger's words
content_tagsMann-Whitney U test
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content_tags.statistics[0]the tagger's words
content_tagsstatistical-significance
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content_tags.statistics[1]the tagger's words
content_tagst-test
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also in: t-test
content_tags.statistics[2]the tagger's words
content_tagst-test
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also in: t-test
content_tags.statistics[3]the tagger's words
content_tagsWilcoxon signed-rank test
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content_tags.statistics[4]the tagger's words
content_tagsBayesian information criterion
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content_tags.statistics[5]the tagger's words
content_tagsnormality test
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content_tags.statistics[6]the tagger's words
content_tagsmean
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also in: mean
content_tags.statistics[7]the tagger's words
content_tagsconfidence interval
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content_tags.statistics[8]the tagger's words
content_tagsbootstrap
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also in: bootstrap
content_tags.statistics[9]the tagger's words
content_tagsnonlinear least-squares curve fitting
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content_tags.statistics[10]the tagger's words
content_tagscorrelation
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also in: correlation
content_tags.statistics[11]the tagger's words
content_tagsMann-Whitney U-test
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content_tags.statistics[12]0.9the tagger's words
content_tagsBayesian information criterion
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content_tags.statistics[13]1.0the tagger's words
content_tagsWilcoxon signed rank test
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content_tags.statistics[14]1.0the tagger's words
content_tagsisolation distance and L-ratio
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content_tags.statistics[15]0.85the tagger's words
content_tagsVIP-expressing interneurons carry out disinhibitory control across several neocortical areas and are switched on by reinforcement signals.
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content_tags.findings[0]the tagger's words
content_tagsThe circuit module is VIP activation transiently suppressing somatostatin interneurons and a subset of parvalbumin interneurons, which respectively control principal-cell input and output.
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content_tags.findings[1]the tagger's words
content_tagsOnly a small fraction of pyramidal neurons responded to VIP activation, suggesting they are a minor monosynaptic target of VIP cells.
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content_tags.findings[2]the tagger's words
content_tagsVIP-evoked IPSCs in parvalbumin cells decay about three times faster than in somatostatin cells and depress more strongly with repeated stimulation.
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content_tags.findings[3]the tagger's words
content_tagsEight percent of c-Fos-positive neurons expressed VIP; the rest expressed the pyramidal marker CaMKIIα.
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content_tags.findings[4]the tagger's words
content_tagsThe disinhibited cells in auditory cortex are not random: they are preferentially the tone-responsive, frequency-tuned neurons.
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content_tags.findings[5]the tagger's words
content_tagsVIP stimulation changes tuning curves in two different ways: divisively scaling down the inhibited cells and additively raising the baseline of the delayed-activated cells.
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content_tags.findings[6]the tagger's words
content_tagsIn every VIP neuron, punishment (air puff or foot shock) evoked strong phasic activation at short latency.
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content_tags.findings[7]the tagger's words
content_tagsVIP neurons respond to reinforcement uniformly as a class, unlike the heterogeneous responses of the surrounding cortical population.
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content_tags.findings[8]the tagger's words
content_tagsThe study maps a specific circuit operation, disinhibition, onto a genetically defined cell type.
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content_tags.findings[9]the tagger's words
content_tagsan excitation-inhibition-excitation sequence appears in two functionally different cortical areas
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content_tags.findings[11]1.0the tagger's words
content_tagsfirst in vivo demonstration of cell-type-specific disinhibition
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content_tags.findings[12]1.0the tagger's words
content_tagsVIP activation elicited IPSCs in a large fraction of Som interneurons
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content_tags.findings[13]1.0the tagger's words
content_tagspyramidal cells are only a minor direct target of VIP cells
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content_tags.findings[14]1.0the tagger's words
content_tagsthe disinhibited cells are disproportionately tone-responsive and frequency-tuned
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content_tags.findings[15]1.0the tagger's words
content_tagspunishment activates every recorded VIP neuron at short latency, and two different punishments do the same
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content_tags.findings[16]1.0the tagger's words
content_tagsVIP cells respond in unison where the rest of the population responds heterogeneously
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content_tags.findings[17]1.0the tagger's words
content_tagsthe divisive gain model beat a baseline shift plus threshold in 22 of 25 inhibited neurons
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content_tags.findings[18]1.0the tagger's words
content_tagsdisinhibitory control
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content_tags.definitions[0]the tagger's words
content_tagstone-responsive neuron
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content_tags.definitions[1]the tagger's words
content_tagsadaptive spike density function
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content_tags.definitions[2]the tagger's words
content_tagstone-selectivity
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content_tags.definitions[3]the tagger's words
content_tagsΔResponse
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also in: ΔResponse
content_tags.definitions[4]the tagger's words
content_tagsdisinhibition
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also in: disinhibition
content_tags.definitions[5]1.0the tagger's words
content_tagsnarrow spiking
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content_tags.definitions[7]1.0the tagger's words
content_tagsimpact
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also in: impact
content_tags.definitions[8]1.0the tagger's words
content_tagsrecruitment
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also in: recruitment
content_tags.definitions[9]1.0the tagger's words
content_tagslight-induced changes of firing rate
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content_tags.variables[3]the tagger's words
content_tagsIPSCs
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also in: IPSCs
content_tags.variables[4]the tagger's words
content_tagsChR2 expression time
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content_tags.variables[5]the tagger's words
content_tagsmovement bouts
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content_tags.variables[7]the tagger's words
content_tagsspike width
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also in: spike width
content_tags.variables[8]1.0the tagger's words
content_tagsdecay time constant
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content_tags.variables[9]1.0the tagger's words
content_tags~20% — proportion of recorded cortical cells whose firing rate changed significantly after a single 1 ms VIP light pulse
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content_tags.quantities[0]the tagger's words
content_tags~10% — share of all cortical interneurons that express VIP
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content_tags.quantities[1]the tagger's words
content_tags98/343 — single units in awake auditory cortex that could be classified into one of the three light-response groups
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content_tags.quantities[2]the tagger's words
content_tags5-fold — increase in c-Fos expression in mPFC after VIP photostimulation relative to controls
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content_tags.quantities[3]the tagger's words
content_tags28/46, 61% — share of delayed-activated neurons that were tone-responsive, versus 29% in the whole population
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content_tags.quantities[4]the tagger's words
content_tagsSom: 18±2ms, Pv: 6±1ms — IPSC decay time constants in somatostatin versus parvalbumin interneurons
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content_tags.quantities[5]the tagger's words
content_tags50±12ms — latency of the peak VIP response to punishment
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content_tags.quantities[6]the tagger's words
content_tags22 out of 25 neurons — inhibited cells for which the divisive activity-gain model fit better than a baseline shift with threshold
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content_tags.quantities[7]the tagger's words
content_tagsNS, 39.0±10.0 ms; WS, 86.5±7.6 ms — offset of light-induced suppression in narrow-spiking versus wide-spiking neurons
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content_tags.quantities[8]the tagger's words
content_tagsVIP is about 10% of interneurons and 1-2% of cortical neurons — the size of the population
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value source note: THE VALUE DRAWS ON THE PAPER BEYOND THIS QUOTE: part of it is printed elsewhere in the paper, not in this quote ('interneurons (1–2% of cortical neurons 19 , 20 ) resulted…').
content_tags.quantities[9]0.95the tagger's words
content_tagsEVIDENCE CORRECTED (RE-GROUNDED - THE POINTER WAS WRONG, NOT THE CLAIM) · ACx 130/495 and mPFC 26/155 cells changed firing — the breadth of the effect
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EVIDENCE CORRECTED: RE-GROUNDED - THE POINTER WAS WRONG, NOT THE CLAIM. The old evidence was verbatim, anchored and correctly cut, and it contained NONE of this claim's numbers (130, 155, 26, 495). The paper states the claim in one sentence elsewhere and the tagger did not use it. the project, 2026-08-23: 'WE HAVE SPENT THE DAY VERIFYING THAT QUOTES ARE REAL AND NONE OF IT ASKS WHETHER THEY ARE RELEVANT.' Confirmed by reading the claim, the old span and the candidate together; the candidate carries every number AND the claim's own content words.
content_tags.quantities[10]0.9the tagger's words
content_tagsSom decay 18 plus or minus 2 ms, Pv decay 6 plus or minus 1 ms — IPSC kinetics distinguishing the two targets
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content_tags.quantities[11]1.0the tagger's words
content_tags275 microseconds — the stipulated spike-width cut between narrow and wide spiking
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content_tags.quantities[12]1.0the tagger's words
content_tagsisolation distance < 20 or L-ratio > 0.1 — the exclusion thresholds
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content_tags.quantities[13]1.0the tagger's words
content_tags5-fold — increase in c-Fos after VIP photostimulation
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content_tags.quantities[14]1.0the tagger's words
content_tags40 of 43 neurons — unaffected by movement bouts, the control for head-restraint movement
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content_tags.quantities[15]1.0the tagger's words
content_tagsBIC -399.6, -398.3 and -354.7 — combined, divisive and baseline-shift models for the inhibited group
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content_tags.quantities[16]1.0the tagger's words

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