Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

Rudy, Fishell, Lee, Hjerling-Leffler · Developmental Neurobiology · 2011 · neuroscience · 10.1002/dneu.20853 · record Rudy2011-three-groups-of-interneurons-account-for-nea
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. This is a review/perspective that synthesises the authors' own prior work (chiefly Lee et al., 2010, which shares an author with this article) rather than reporting a new experiment; that is why method is 'review' and the method quote is the article's own statement of what it is based on. It also cites unpublished observations (Jeong and Rudy; Xu and Rudy). The 'contradicts' relation is a caveat rather than a flat denial - the paper questions whether McGarry's extra SST subtypes are real or artefacts of using P10-18 mice. A qualification the facets do not carry: the paper itself notes PV/SST overlap at the mRNA level (<10%, up to ~16.3% in layer VI) even though protein expression does not overlap. 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
This record’s own method is review, and the tags below follow from that. A review’s findings, quantities and statistics are things stated IN this paper, and some of them report results obtained elsewhere. 6 tags on this page name the author the result belongs to. Measured across every review in this corpus, 81% of a review’s tags carry no citation at all — most of them are the review speaking. The corpus does not adjudicate the rest: read an unmarked tag as a claim this paper makes, not necessarily one it made first.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 20 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
PV SST 5HT3aR GABAergic basket cells chandelier cells Martinotti cells X94 neurogliaform cells VIP fast-spiking IHC ISH EGFP calretinin reelin input resistance facilitating depressing serotonin excitatory synapses onto Martinotti cells facilitate, so sustained firing of a single pyramidal cell builds up enough drive to make the Martinotti cell fire and inhibit pyramidal cells across layers and columns because those inputs facilitate, the strength of Martinotti-mediated feedback inhibition grows with the rate and duration of presynaptic discharge the delay between thalamocortical excitation of pyramidal cells and disynaptic inhibition from FS cells opens a brief integration window that limits temporal summation ionotropic serotonin and acetylcholine receptors let neuromodulatory systems recruit 5HT3aR interneurons fast enough to be gated by brain state and behavioral context a locally different chloride concentration at the axon initial segment shifts the GABA-A reversal potential, so chandelier-cell GABA release depolarizes rather than inhibits the pyramidal cell neurogliaform axonal varicosities lacking classical synaptic contacts still hyperpolarize neighbours, implying GABA acts by volume release into the extracellular space the low input resistance of X94 SST cells prevents a single excitatory cell from driving them unless a muscarinic agonist raises their excitability basket cells and chandelier cells genetic inducible fate mapping (GIFM) multipolar bursting late spiking (LS) firing pattern Local somatic application of mCPBG double ISH review

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1002/dneu.20853. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 2 · claim_relations 7 · claim_type 1 · concept_edges 10 · content_tags 74 · contribution 1 · limitations 10 · mechanisms 13 · method 1 · object_of_study 1 · phenomenon 1 · senses 6 · transfers 2

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 10 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

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facettagfieldconf.whose words
object_of_studywhether the diversity of neocortical inhibitory interneurons can be exhaustively partitioned by three molecular markers
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object_of_studythe paper's words
contributionparvalbumin, somatostatin and 5HT3a receptor expression together account for nearly 100 percent of GABAergic interneurons in somatosensory cortex
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contributionthe paper's words
claim_typeexistence
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claim_typethe paper's words
phenomenonneocortical GABAergic interneuron diversity
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phenomenonthe paper's words
methodreview
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also in: review
methodthe paper's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[2]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[3]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[4]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[5]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[6]the tagger's words
mechanismsfast-spiking basket cells fire sustained high-frequency trains with the lowest input resistance and fastest membrane time constant of all interneurons, which is what makes their inhibition fast
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mechanisms[7]1.0the tagger's words
mechanismsexcitatory synapses onto fast-spiking cells depress while those onto Martinotti cells facilitate, which is the key functional difference between the two groups
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mechanisms[8]1.0the tagger's words
mechanismsbecause of that facilitation, repetitive firing of a single pyramidal cell can drive a Martinotti cell and produce feedback inhibition across layers and columns
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mechanisms[9]1.0the tagger's words
mechanismsthe two groups may therefore be recruited at opposite ends of network activity, one when activity is high and the other transiently when it is low
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mechanisms[10]0.8the tagger's words
mechanisms5HT3aR interneurons are heterogeneous but all are potently modulated by ionotropic serotonin receptors, and no response was seen in PV or SST cells
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mechanisms[11]1.0the tagger's words
mechanismsneurogliaform cells may act by volume release of GABA rather than through classical synaptic contacts
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mechanisms[12]0.8the tagger's words
limitationsSubtype frequencies within the three groups cannot be estimated because specific markers are lacking.
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what this limits: any quantitative claim about subtypes within the three groups: THE LACK OF SPECIFIC MARKERS MAKES IT DIFFICULT TO ESTIMATE THE FREQUENCIES OF EACH OF THE SUBTYPES
limitations[0]the tagger's words
limitationsThe random sample from the 5HT3aR mouse is still too small to fix subtype proportions.
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what this limits: the subtype proportions specifically: THE SAMPLE IS NOT YET SUFFICIENTLY LARGE TO DEFINITELY ESTABLISH SUBTYPE PROPORTIONS
limitations[1]the tagger's words
limitationsThe exhaustive-partition conclusion is established mainly for one cortical area, S1.
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what this limits: the scope of the exhaustive-partition claim itself: the conclusion that these neurons ACCOUNT FOR nearly all remaining interneurons rests mainly on S1, not on neocortex at large
limitations[2]the tagger's words
limitationsOutput connectivity and function of the 5HT3aR group are largely unknown apart from neurogliaform cells.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: any functional or circuit claim about the 5HT3aR group: OTHER THAN NEUROGLIAFORM CELLS, LITTLE IS KNOWN ABOUT THE OUTPUT CONNECTIONS AND FUNCTION OF 5HT3AR INTERNEURONS
limitations[3]the tagger's words
limitationsThe size of any preoptic-area contribution to the 5HT3aR population is unresolved.
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what this limits: the developmental-origin account: IT REMAINS TO BE SHOWN DIRECTLY WHETHER THE NKX5-1 CRE LABELED NEURONS EXPRESS 5HT3AR, and the size of the POA contribution is undetermined
limitations[4]the tagger's words
limitationssubtype frequencies within the three groups cannot be estimated for want of specific markers, and the samples are not large enough to settle proportions from firing patterns
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what this limits: the same scope as items 0 and 1 - subtype frequencies, not the three-group partition
limitations[5]1.0the tagger's words
limitationsthe correspondence between subtypes described by different investigators is not easy to establish, which the authors say calls for better classification tools
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what this limits: any attempt to read this classification against another lab's: THE CORRESPONDENCE BETWEEN THE SUBTYPES ... IS NOT EASY TO ESTABLISH - the categories do not map across investigators
limitations[6]1.0the tagger's words
limitationsoutside neurogliaform cells, little is known about the outputs or function of the 5HT3aR group, which is less understood than the other two
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what this limits: the same scope as limitations[3] - outputs and function of the 5HT3aR group
limitations[7]1.0the tagger's words
limitationsthe preponderance of this class of PV neurons is not known and it has not been described by other investigators, perhaps because Blatow et al. used 14-day-old mice and recorded at room temperature
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: the PV class in question, whose existence may be an age effect: THE PREPONDERANCE OF THIS CLASS OF PV NEURONS IS NOT KNOWN AND HAS NOT BEEN DESCRIBED BY OTHER INVESTIGATORS; PERHAPS BECAUSE BLATOW ET AL. USED 14-DAY-OLD MICE, SOMEWHAT YOUNGER THAN WHAT IS TYPICALLY USED IN THE FIELD
limitations[8]1.0the tagger's words
limitationstwo extra SST subtypes reported in one study were not seen by others using the same mouse line, and immaturity at the ages used is offered as an explanation
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: the two additional SST groups: SEVERAL INVESTIGATORS HAVE USED THE GIN LINE TO STUDY MARTINOTTI CELLS AND HAVE NOT REPORTED THE TWO OTHER GROUPS OF SST NEURONS DESCRIBED BY MCGARRY ET AL.
limitations[9]1.0the tagger's words
transfersa bacterial artificial chromosome reporter line used to make an uncountable population countable
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transfers[0]1.0the tagger's words
transfersderivation from different areas during development, offered as a feature arguing for a true delineation between two marker-defined Martinotti subtypes
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transfers[1]1.0the tagger's words
sensesTHE PARTITION DEPENDS ON THE ASSAY: PV and SST are non-overlapping by protein immunofluorescence, but under in situ hybridisation up to 16.3 percent of PV cells in layer VI carry SST mRNA, and by RT-PCR a large percentage do
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senses[0]1.0the tagger's words
sensesand the conflict is resolved by CHOOSING the assay: protein expression is taken to define the two groups, with the mRNA overlap explained as levels too low to detect
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senses[1]1.0the tagger's words
sensesthe 5HT3aR class could not be counted before the tool existed - there are no antibodies to the receptor, so the group had no size until a BAC transgenic line reported it
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senses[2]1.0the tagger's words
sensesthe reporter line was validated in both directions: no cell carried EGFP without the transcript, and 99.8 percent of receptor-expressing cells carried EGFP
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senses[3]1.0the tagger's words
sensesONE CELL TYPE, FOUR NAMES, IN ONE SENTENCE: regular adapting nonpyramidal, burst spiking nonpyramidal, intrinsic bursting and low-threshold spike all denote the same Martinotti cells
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senses[4]1.0the tagger's words
sensesthe claim runs one way only: virtually all PV cells are fast-spiking, which does NOT entail that fast-spiking cells are PV
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senses[5]1.0the tagger's words
alternativesmethod: review
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a second reading reaching the same value. Recorded: review — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: a cortical interneuron population that had resisted exhaustive classification
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a second reading DIFFERING from the recorded value. Recorded: neocortical GABAergic interneuron diversity — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsbuilds-on → Lee et al. (2010)
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claim_relations[0]the tagger's words
claim_relationsreplicates → Gonchar and Burkhalter (1997); Kawaguchi and Kubota (1997); Ascoli et al. (2008) - PV and SST as non-overlapping interneuron markers
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claim_relations[1]the tagger's words
claim_relationscontradicts → McGarry et al. (2010) report of two additional SST subtypes in GIN mice
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claim_relations[2]the tagger's words
claim_relationsextends → the use of calcium-binding proteins and neuropeptides as markers distinguishing cortical interneurons
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claim_relations[3]1.0the tagger's words
claim_relationscritiques → the treatment of VIP, NPY, cholecystokinin, calretinin and calbindin as markers of independent interneuron classes
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claim_relations[4]1.0the tagger's words
claim_relationsbuilds-on → Lee 2010's double in situ hybridisation quantification of the three marker populations
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claim_relations[5]1.0the tagger's words
claim_relationsqualifies → the view that parvalbumin cells are the largest interneuron class
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
claim_relations[6]1.0the tagger's words
concept_edgesPV —distinct-from→ SST
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 · note: BY PROTEIN. The same two groups OVERLAP by mRNA, so this edge is only true relative to the assay named in it
also in: PV · SST
concept_edges[0]1.0the tagger's words
concept_edges5HT3aR —part-of→ GABAergic
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 · note: the third of three groups that together account for nearly all of them
also in: 5HT3aR · GABAergic
concept_edges[3]1.0the tagger's words
concept_edgesPV —part-of→ GABAergic
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 · note: one of the three groups whose union is claimed to be the whole population
also in: PV · GABAergic
concept_edges[4]1.0the tagger's words
concept_edgesbasket cells —part-of→ PV
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but basket cells are one of 'two types of PV neurons'; is-a, not part-of.
also in: basket cells · PV
concept_edges[8]1.0the tagger's words
concept_edgeschandelier cells —part-of→ PV
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but chandelier cells are one of 'two types of PV neurons'; is-a, not part-of.
also in: chandelier cells · PV
concept_edges[9]1.0the tagger's words
concept_edgesMartinotti cells —part-of→ SST
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but SST expression is 'typically been associated with' Martinotti cells; part-of is loose.
also in: Martinotti cells · SST
concept_edges[10]1.0the tagger's words
concept_edgesfacilitating —contrasted-with→ depressing
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 · note: CRITERION: the synaptic dynamics of the INPUTS, not the cell itself - and even that has a layer VI exception the paper names Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says FS input synapses are depressing; the facilitating contrast is implied.
concept_edges[12]1.0the tagger's words
concept_edgesVIP —part-of→ 5HT3aR
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strength of the relation: 1 · note: all VIP cells are in this group, and they are about 40 percent of it
also in: VIP · 5HT3aR
concept_edges[13]1.0the tagger's words
concept_edgesneurogliaform cells —part-of→ 5HT3aR
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 · note: the group is defined by three exclusions and one inclusion: reelin-positive, VIP-negative, SST-negative
concept_edges[14]1.0the tagger's words
concept_edgescalretinin —part-of→ SST
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 0.4 — the record marks this weak · note: A MARKER THAT CROSSES BOUNDARIES: about a third of SST cells carry it, and so do many VIP cells - which is why it cannot define a group Audit 2026-09-28: DOUBTFUL - read against its span and kept, but a third of SST interneurons contain calretinin; part-of is loose.
also in: calretinin · SST
concept_edges[15]1.0the tagger's words
content_tagsNeurons expressing PV, SST or the 5HT3a receptor together account for nearly all GABAergic interneurons of primary somatosensory cortex, with the 5HT3aR group making up about 30%.
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content_tags.findings[0]the tagger's words
content_tagsPV and SST protein expression define two independent groups of GABAergic interneurons.
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content_tags.findings[1]the tagger's words
content_tagsIn layers I-III the 5HT3aR interneurons outnumber PV interneurons two to one, overturning the assumption that PV cells are the largest interneuron class there.
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content_tags.findings[2]the tagger's words
content_tagsEvery VIP-expressing interneuron in somatosensory cortex also expresses the 5HT3a receptor, placing the whole VIP class inside the 5HT3aR group.
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WHOSE RESULT THIS IS: Lee et al. (2010) found - THE EVIDENCE FOR THIS ROW ATTRIBUTES THE WORK TO SOMEBODY ELSE. The cited name is the subject of a result verb and the sentence carries no first-person marker, so the finding, quantity or definition is the CITED author's rather than this record's. The claim is true and the quote is verbatim - what is wrong is whose result the corpus says it is. Nothing edited, nothing withdrawn: the row is marked so a page can name the source. Where the record is a commentary or review, its claim relations layer usually already names the paper being discussed - the record knows at one layer and forgets at another.
content_tags.findings[3]the tagger's words
content_tagsThe 5HT3aR agonist mCPBG depolarized every 5HT3aR-positive subtype tested across all layers.
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content_tags.findings[4]the tagger's words
content_tagsPV- and SST-expressing neurons showed no response to the same agonist.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[5]the tagger's words
content_tagsThe caudal ganglionic eminence gives rise to about 30% of cortical interneurons, including the bipolar calretinin cells, the entire VIP population and the reelin-positive/SST-negative neurogliaform cells.
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content_tags.findings[6]the tagger's words
content_tagsThe EGFP reporter line had no false positives: no EGFP-positive cell lacked 5HT3aR mRNA.
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content_tags.findings[7]the tagger's words
content_tagsIn olfactory cortex inhibition moves from dendrite to soma during a burst, the reverse of the soma-then-dendrite sequence in neocortex and hippocampus, even though the interneurons themselves look alike.
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content_tags.findings[8]the tagger's words
content_tagsThe marker proportions may not carry over to primates: 74% of GABAergic neurons in macaque V1 express PV, far more than in rodents.
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WHOSE RESULT THIS IS: er than the values reported in rodents ( Van Brederode et al., 1990 ). - THE RESULT OR THE NUMBER IS THE CITED WORK'S. Read, not swept - the trailing-citation shape is about 55% precise and the main clause is what decides it. Second reading pass over the 25 candidates left after 2026-08-25 11:39: 9 marked, 16 refused. 'it has been reported…' - Van Brederode et al. 1990's number.
content_tags.findings[9]the tagger's words
content_tagsthree marker-defined groups account for nearly all, if not all, GABAergic interneurons in primary somatosensory cortex
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content_tags.findings[10]1.0the tagger's words
content_tagsQuotation withheld
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[11]1.0the tagger's words
content_tagsAN EXHAUSTIVE PARTITION CONSTRAINS EVERY OTHER MARKER: VIP, NPY, CCK, calretinin and calbindin must either label small populations or fall inside the three groups
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content_tags.findings[12]1.0the tagger's words
content_tagsthe third group is the majority interneuron population in layers I to III and outnumbers parvalbumin cells there twofold
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content_tags.findings[13]1.0the tagger's words
content_tagsTHE REPORTER WAS VALIDATED IN BOTH DIRECTIONS: no cell carried EGFP without the transcript, and 99.8 percent of receptor-expressing cells carried EGFP
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WHOSE RESULT THIS IS: Lee et al. (2010) found - THE EVIDENCE FOR THIS ROW ATTRIBUTES THE WORK TO SOMEBODY ELSE. The cited name is the subject of a result verb and the sentence carries no first-person marker, so the finding, quantity or definition is the CITED author's rather than this record's. The claim is true and the quote is verbatim - what is wrong is whose result the corpus says it is. Nothing edited, nothing withdrawn: the row is marked so a page can name the source. Where the record is a commentary or review, its claim relations layer usually already names the paper being discussed - the record knows at one layer and forgets at another.
content_tags.findings[14]1.0the tagger's words
content_tagsand the transcript was checked against function, with responses to a selective agonist in more than 40 reporter-positive cells
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content_tags.findings[15]1.0the tagger's words
content_tagsneurons expressing PV, as detected by immunofluorescence, do not express SST protein and vice versa
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content_tags.findings[16]1.0the tagger's words
content_tagsBUT BY mRNA THEY DO: under 10 percent of PV cells carry SST transcripts overall, 16.3 percent in layer VI, and a large percentage by RT-PCR of sorted cells
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content_tags.findings[17]1.0the tagger's words
content_tagsand the conflict is settled by choosing protein as the definition, with the transcripts explained as levels too low to detect
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content_tags.findings[18]1.0the tagger's words
content_tagsA CATEGORY THAT NEEDED A TOOL TO EXIST: there are no antibodies to the 5HT3a receptor, so this population could not be counted until a reporter line was made
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content_tags.findings[19]1.0the tagger's words
content_tagsbefore that, its size was a qualitative impression from fluorescence
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content_tags.findings[20]1.0the tagger's words
content_tagsONE CELL TYPE, FOUR NAMES IN ONE SENTENCE: burst spiking nonpyramidal, intrinsic bursting and low-threshold spike all name the regular adapting Martinotti cells
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content_tags.findings[21]1.0the tagger's words
content_tagsAND THREE MORE FOR ANOTHER: rapid-adapting, fast-adapting and IS2 name the same VIP subtype
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content_tags.findings[22]1.0the tagger's words
content_tagsLS1 cells correspond to neurogliaform cells, whereas LS2 cells have larger somata and longer, less branching dendrites
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content_tags.findings[23]1.0the tagger's words
content_tagsA CLASS REPORTED ONCE AND NOT REPLICATED: the preponderance of this class of PV neurons is not known and it has not been described by other investigators
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content_tags.findings[24]1.0the tagger's words
content_tagswith two specific methodological differences offered as the reason: 14-day-old mice and room-temperature recording
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content_tags.findings[25]1.0the tagger's words
content_tagsseveral investigators have used the GIN line and have not reported the two other groups of SST neurons described by McGarry et al., whose diversity may reflect the presence of immature neurons
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content_tags.findings[26]1.0the tagger's words
content_tagsTHE CORRESPONDENCE PROBLEM STATED OUTRIGHT: subtypes described by different investigators cannot easily be matched to one another, which calls for better classification tools
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content_tags.findings[27]1.0the tagger's words
content_tagsand subtype frequencies cannot be estimated at all for lack of specific markers
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content_tags.findings[28]1.0the tagger's words
content_tagsvirtually all parvalbumin cells recorded across several mouse lines were fast-spiking
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content_tags.findings[29]1.0the tagger's words
content_tagsfast-spiking cells have the lowest input resistance and fastest membrane time constant of all interneurons
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content_tags.findings[30]1.0the tagger's words
content_tagsexcitatory synapses onto fast-spiking cells depress, with one layer VI exception that facilitates
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content_tags.findings[31]1.0the tagger's words
content_tagsexcitatory inputs onto Martinotti cells facilitate instead, which is called the key feature distinguishing them from fast-spiking cells
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content_tags.findings[32]1.0the tagger's words
content_tagsso a single pyramidal cell firing repetitively can drive a Martinotti cell and produce feedback inhibition across layers and columns
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content_tags.findings[33]1.0the tagger's words
content_tagschandelier cell function is contested, with their GABA release possibly depolarising and even excitatory at the axon initial segment
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content_tags.findings[34]1.0the tagger's words
content_tagsabout a third of SST cells contain calretinin, and the two subtypes differ in dendritic field, spike width and connectivity
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content_tags.findings[35]1.0the tagger's words
content_tagsand they arise from different developmental regions, which is offered as evidence that the delineation is real
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content_tags.findings[36]1.0the tagger's words
content_tagsall VIP cells express the 5HT3a receptor and make up about 40 percent of that group
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WHOSE RESULT THIS IS: Lee et al. (2010) found - THE EVIDENCE FOR THIS ROW ATTRIBUTES THE WORK TO SOMEBODY ELSE. The cited name is the subject of a result verb and the sentence carries no first-person marker, so the finding, quantity or definition is the CITED author's rather than this record's. The claim is true and the quote is verbatim - what is wrong is whose result the corpus says it is. Nothing edited, nothing withdrawn: the row is marked so a page can name the source. Where the record is a commentary or review, its claim relations layer usually already names the paper being discussed - the record knows at one layer and forgets at another.
content_tags.findings[37]1.0the tagger's words
content_tagsthe non-VIP 60 percent are mostly reelin-positive and include over 90 percent of layer I neurons
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content_tags.findings[38]1.0the tagger's words
content_tagsneurogliaform cells uniquely form electrical synapses with other interneuron types rather than only with their own kind
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content_tags.findings[39]1.0the tagger's words
content_tagsand may act by volume release of GABA rather than at classical synaptic contacts
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content_tags.findings[40]1.0the tagger's words
content_tagsevery 5HT3aR subtype responded to a selective serotonin agonist while PV and SST cells did not
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content_tags.findings[41]1.0the tagger's words
content_tagsand 5HT3aR cells are also excited by cholinergic agonists acting on nicotinic receptors, a common property independently of layer location or electrophysiological or morphological subtype
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content_tags.findings[42]1.0the tagger's words
content_tagsFS versus non-FS GABAergic interneurons in superficial layers are differentially modulated depending on brain state and behavioural context, which the authors take to be this group
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[43]0.8the tagger's words
content_tagsbasket cells and chandelier cells
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[1]the tagger's words
content_tagsMartinotti cells
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content_tags.definitions[2]the tagger's words
content_tagsgenetic inducible fate mapping (GIFM)
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[4]the tagger's words
content_tagsmultipolar bursting
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[5]the tagger's words
content_tagslate spiking (LS) firing pattern
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[6]the tagger's words
content_tagsfast-spiking
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also in: fast-spiking
content_tags.definitions[7]1.0the tagger's words
content_tagsMartinotti cells
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[8]1.0the tagger's words
content_tagsneurogliaform cells
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[9]0.8the tagger's words
content_tags5HT3aR
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also in: 5HT3aR
content_tags.definitions[10]0.9the tagger's words
content_tagsLocal somatic application of mCPBG
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[0]the tagger's words
content_tagsinput resistance
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[3]1.0the tagger's words
content_tagsfacilitating
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: facilitating
content_tags.variables[4]1.0the tagger's words
content_tags40 and 30% — share of somatosensory-cortex GABAergic interneurons that are PV-expressing and SST-expressing respectively
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[0]the tagger's words
content_tags99.8 ± 0.3% — proportion of 5HT3aR-mRNA-expressing neocortical cells that were EGFP positive in the reporter line
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[1]the tagger's words
content_tags~16.3% — share of layer VI PV cells carrying SST mRNA, the largest PV/SST mRNA overlap found
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[2]the tagger's words
content_tags~60% — share of all interneurons in layers I-III that are 5HT3aR-expressing
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[3]the tagger's words
content_tags~40% — share of the 5HT3aR population in S1 that expresses VIP
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[4]the tagger's words
content_tags60% — share of 5HT3aR neurons that do not express VIP
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[5]the tagger's words
content_tagsMore than 80% — share of non-VIP 5HT3aR interneurons expressing reelin
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content_tags.quantities[6]the tagger's words
content_tags10–20% — GABAergic interneurons as a proportion of all cortical neurons in rodents
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[7]the tagger's words
content_tags24–30% — proportion of cortical neurons that are GABAergic in primates, versus about 15% in rodents
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[8]the tagger's words
content_tagsnine electrophysiologically different subtypes, of which six accounted for >93% — electrophysiological subtypes among caudal-ganglionic-eminence-derived interneurons, and how much of the population six of them cover
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content_tags.quantities[9]the tagger's words
content_tags>16 classes — number of hippocampal CA1 GABAergic interneuron classes in an earlier classification, offered as the comparison standard
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content_tags.quantities[10]the tagger's words
content_tags40 and 30% — parvalbumin and somatostatin shares of the interneuron population
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[11]1.0the tagger's words
content_tags~30% — the 5HT3aR share, completing the partition
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[12]1.0the tagger's words
content_tags99.8 ± 0.3% — receptor-expressing cells that were reporter-positive - the sensitivity of the tag
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
WHOSE RESULT THIS IS: Lee et al. (2010) found - THE EVIDENCE FOR THIS ROW ATTRIBUTES THE WORK TO SOMEBODY ELSE. The cited name is the subject of a result verb and the sentence carries no first-person marker, so the finding, quantity or definition is the CITED author's rather than this record's. The claim is true and the quote is verbatim - what is wrong is whose result the corpus says it is. Nothing edited, nothing withdrawn: the row is marked so a page can name the source. Where the record is a commentary or review, its claim relations layer usually already names the paper being discussed - the record knows at one layer and forgets at another.
content_tags.quantities[13]1.0the tagger's words
content_tags<10% and ~16.3% — PV cells carrying SST mRNA overall and in layer VI - the overlap that protein staining does not show
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content_tags.quantities[14]1.0the tagger's words
content_tags~60% of all interneurons — the 5HT3aR share within layers I to III
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[15]1.0the tagger's words
content_tags~40% — VIP share of the 5HT3aR group
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
WHOSE RESULT THIS IS: Lee et al. (2010) found - THE EVIDENCE FOR THIS ROW ATTRIBUTES THE WORK TO SOMEBODY ELSE. The cited name is the subject of a result verb and the sentence carries no first-person marker, so the finding, quantity or definition is the CITED author's rather than this record's. The claim is true and the quote is verbatim - what is wrong is whose result the corpus says it is. Nothing edited, nothing withdrawn: the row is marked so a page can name the source. Where the record is a commentary or review, its claim relations layer usually already names the paper being discussed - the record knows at one layer and forgets at another.
content_tags.quantities[16]1.0the tagger's words
content_tagsdouble ISH
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also in: double ISH
content_tags.statistics[0]0.8the tagger's words

Interpretive choices

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