Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations

Stark, Roux, Eichler, Senzai, Royer, Buzsáki · Neuron · 2014 · neuroscience · 10.1016/j.neuron.2014.06.023 · record Stark2014-pyramidal-cell-interneuron-interactions-unde
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Note the verbatim evidence for the second relation contains the paper's own typo 'IN-INT' for INT-INT; it is reproduced unaltered as required. Method is tagged electrophysiology, but the study combines high-density recording with multisite/multicolour closed-loop optogenetics and focal picrotoxin infusion, and the fourth relation shows it builds directly on the diode-probe tool paper Stark et al. 2012 (also in this batch). Replication status is untested for this paper's own mechanistic claim; the 'replicates' relation concerns a prior observation the paper reproduces, not independent replication of its own result. 2026-08-13, 2026-08-15 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
standard deviation 3 fields · cell type 2 fields · coherence 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 25 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
ripple fast gamma fast ripples sharp wave iHFOs pyramidal cells interneurons PV SOM axonal plexus connexin 36 GABA A picrotoxin PYR-INT-INT INT-INT PYR-INT loop axon-net model coherence summed PYR closed-loop memory consolidation volume-conducted opsin desensitization deep superficial Sharp-wave-driven transient excitation of pyramidal cells combines with the pacing supplied by interneuron-interneuron interactions to produce the ripple (PYR-INT-INT hybrid model) CA1 interneuron-interneuron interactions bind multiple independent local ripple oscillators cycle by cycle into one spatially coherent event Stronger excitation recruits the PV interneuron population more strongly, and that population sets the oscillation frequency, which is why both sharp-wave amplitude and light intensity raise ripple frequency induced high-frequency oscillations (iHFOs) gain threshold light intensity summed INT receptor blockade global frequency coherence between nearby sites light intensity distance cell type sublayer Wilcoxon signed-rank test Wilcoxon’s paired signed-rank test Mann-Whitney U test chi-squared test Fisher’s exact test rank correlation median rank correlation circular correlation circular-circular correlation circular-linear correlation Rayleigh test F-test with Bonferroni correction Bonferroni-corrected F test standard deviation Wilcoxon's paired signed-rank test electrophysiology

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

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Every tag on this page

alternatives 3 · claim_relations 11 · claim_type 1 · concept_edges 8 · content_tags 67 · contribution 1 · controls 2 · limitations 9 · mechanisms 9 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 5 · transfers 3

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 8 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studywhich local circuit interactions generate the hippocampal ripple, and which of three long-standing competing models survives a direct test
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object_of_studythe paper's words
research_questionwhether pyramidal cells, interneuron-interneuron interactions, or pyramidal-interneuron loops set the ripple rhythm in the intact brain
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research_questionthe paper's words
contributionshows pyramidal activation is necessary and fast GABA-A inhibition obligatory, that PV activation alone cannot make a ripple but can pace one, and proposes a hybrid PYR-INT-INT model
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenonhippocampal ripple oscillations
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsdepolarising 80-100 nearby pyramidal cells is enough to make a ripple-like oscillation, so the minimal generating network is small
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mechanisms[3]1.0the tagger's words
mechanismsfast GABA-A inhibition is obligatory: blocking it locally abolishes the oscillation entirely
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mechanisms[4]1.0the tagger's words
mechanismsPV interneuron activation cannot create a field ripple but does organise spiking into coherent ripple-frequency patterning
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mechanisms[5]1.0the tagger's words
mechanismscoherence across sites is not volume conduction; it comes from correlated input driving several local oscillators at once
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mechanisms[6]1.0the tagger's words
mechanismssynchronisation needs only the RISING phase of inhibition to be fast, because each pyramidal cell fires about once per ripple and a different set fires on each cycle
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mechanisms[7]1.0the tagger's words
mechanismsremoving inhibition does not simply stop the rhythm - it converts it into a faster, pathological one
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mechanisms[8]1.0the tagger's words
limitationsIn transgenic mice, light may also have activated CA2/CA3 terminals rather than only CA1 pyramidal cells.
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what this limits: results from the transgenic animals: IN TRANSGENIC MICE WE CANNOT EXCLUDE THE POSSIBILITY THAT TERMINALS OF THE CA2/CA3 INPUTS WERE ALSO ACTIVATED BY LIGHT - answered by THE CONSISTENT OBSERVATIONS IN VIRUS-INJECTED WILD-TYPE ANIMALS
limitations[0]the tagger's words
limitationsThe effect of the induced oscillations on the content and sequence of spiking during natural ripples was not tested.
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what this limits: any claim that induced oscillations carry native spike content: HOW THE OPTOGENETICALLY INDUCED HFOs AFFECT THE SPIKE CONTENT, INCIDENCE, AND SEQUENTIAL NEURONAL ACTIVITY DURING NATIVE RIPPLES REMAINS TO BE ADDRESSED
limitations[1]the tagger's words
limitationsThe pharmacological and some optogenetic experiments were done under urethane anaesthesia.
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what this limits: the receptor-blockade and some optogenetic results: THEY WERE CARRIED OUT IN ANESTHETIZED ANIMALS, though SEVERAL CONTROL EXPERIMENTS SUGGESTED THAT THE RESULTS APPLY TO THE DRUG-FREE BRAIN
limitations[2]the tagger's words
limitationsChanges in oscillation amplitude and frequency during long light pulses may be an opsin artefact rather than a network property.
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what this limits: the long-pulse amplitude and frequency observations: THIS CHANGE CAN ALSO REFLECT OPSIN DESENSITISATION rather than a property of the network
limitations[3]the tagger's words
limitationsin transgenic animals the light may also have activated CA2/CA3 terminals, addressed by repeating in virus-injected wild-types
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duplicate of: limitations[0] · what this limits: the same scope as limitations[0] - the transgenic experiments, checked against
limitations[4]1.0the tagger's words
limitationsinduced oscillations differ from spontaneous ones in mean frequency and in the phase separation between cell types
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what this limits: any claim that induced and spontaneous oscillations are the same thing: A RELATIVELY LOWER MEAN FREQUENCY OF iHFOs ASSOCIATED WITH A RELATIVELY LARGER PHASE SEPARATION BETWEEN PYRAMIDAL CELLS AND INTERNEURONS DURING iHFOs
limitations[5]1.0the tagger's words
limitationsthe waxing and waning under long illumination may be opsin desensitisation rather than a network property
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what this limits: the same scope as limitations[3] - the waxing and waning under PROLONGED ILLUMINATION (E.G., 400 ms SQUARE PULSE)
limitations[6]1.0the tagger's words
limitationswhether induced oscillations carry the same spike content as native ripples is left open
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what this limits: the same scope as limitations[1] - spike content during native ripples, left open
limitations[7]1.0the tagger's words
limitationsduring the pathological fast ripples single neurons cannot be resolved at all, so that state is measurable only at the field level
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what this limits: single-neuron claims during the pathological state: DURING THE SUPERSYNCHRONOUS FAST RIPPLES, ACTION POTENTIALS OF INDIVIDUAL NEURONS COULD NOT BE DISCRIMINATED DUE TO THE TEMPORALLY SUPERIMPOSED SPIKES OF MANY NEURONS
limitations[8]1.0the tagger's words
transferscell-type-specific activation and silencing, used here to convert a correlative question into an interventional one
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transfers[0]1.0the tagger's words
transfersclosed-loop feedback: detect the event in real time and perturb it while it is happening
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transfers[1]0.9the tagger's words
transfersspike-train coherence between spatially separated sites as the test of a common timing source
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transfers[2]0.9the tagger's words
controlslight stimulation applied IN ALTERNATION, so every session yields both sham (detection without stimulation) and light (detection with stimulation) conditions
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eliminates: that a difference between stimulated and unstimulated events is drift across the session - alternation puts both conditions in the same minutes · outcome (stated by the tagger, no quotation): held
controls[0]0.95the tagger's words
controlssham events were classified as true or false positives by the same overlap rule applied to offline-detected ripples
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eliminates: that the detector's hit rate is measured on stimulated events alone, where the stimulation itself could create the thing being detected · outcome (stated by the tagger, no quotation): held
controls[1]0.95the tagger's words
sensesripple vs fast-gamma: two names for events separated only by frequency and amplitude, which THIS paper merges by fiat into 'ripples' - the boundary is a convention, not a joint
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senses[0]1.0the tagger's words
sensesfast ripples = NOT a faster kind of ripple but a nonphysiological epileptic oscillation at 200-300 Hz; the name looks like a subtype and the referent is a pathology
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senses[1]1.0the tagger's words
sensesiHFO = the optogenetically induced oscillation, deliberately named apart from 'ripple' so that the model is not confused with the thing modelled
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senses[2]1.0the tagger's words
sensesPYR and INT here are OPTOGENETICALLY tagged, not waveform-guessed: classification uses the light response plus physiological criteria
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senses[3]0.9the tagger's words
sensessummed PYR = all pyramidal spikes on a shank agglomerated into one train; a unit of analysis constructed for statistical power, which nearly triples the coherent fraction
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senses[4]1.0the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: multisite optogenetic activation and closed-loop ripple-triggered silencing in freely behaving rodents, with focal GABA-A blockade and dense extracellular recording
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: the sharp wave-ripple: a high-frequency field oscillation in CA1 associated with memory consolidation
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a second reading DIFFERING from the recorded value. Recorded: hippocampal ripple oscillations — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationscontradicts → the hypothesis that tonic GABA release facilitates axonally generated spikes in the axon-net model (Traub et al., 2003; Bähner et al., 2011)
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differs in: the DIRECTION of the effect of more GABA: activation of PV and SOM interneurons, ACCOMPANIED BY PRESUMED INCREASE OF RELEASED GABA, ABORTED RATHER THAN FACILITATED spontaneous ripples
claim_relations[0]the tagger's words
claim_relationscontradicts → the simple interneuron-interneuron (INT-INT) model of ripple generation
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differs in: whether pyramidal cell activity rises: LFP RIPPLES ARE NOT MAINTAINED DURING INTER-NEURON ACTIVATION IN THE ABSENCE OF INCREASED PYRAMIDAL CELL ACTIVITY
claim_relations[1]the tagger's words
claim_relationsreplicates → Ponomarenko et al., 2004; Nguyen et al., 2009; Sullivan et al., 2011 (within-event deceleration of ripple frequency)
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claim_relations[2]the tagger's words
claim_relationsbuilds-on → Stark et al., 2012 (diode-probe optical fibres)
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claim_relations[3]the tagger's words
claim_relationscontradicts → the axon-net / gap junction model of ripple generation
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differs in: which cell type the coupling was shown in, and what the blocker also does: CONNEXIN COUPLING BETWEEN CA1 PYRAMIDAL CELLS HAVE NOT BEEN DEMONSTRATED, AND GAP JUNCTION BLOCKERS OFTEN INTERFERE WITH RECEPTOR-MEDIATED INHIBITION - while ELECTRICAL COUPLING BETWEEN INTERNEURONS IS WELL DEMONSTRATED
claim_relations[4]1.0the tagger's words
claim_relationscontradicts → the hypothesis that tonic GABA release facilitates axonally generated spikes
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differs in: the DIRECTION of the effect: ABORTED RATHER THAN FACILITATED
claim_relations[5]1.0the tagger's words
claim_relationscontradicts → the simple interneuron-interneuron model, which predicts interneuron activation alone should suffice
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differs in: which cells are driven, and whether the drive is rhythmic: IN CONTRAST TO PYR ACTIVATION, WHICH READILY GENERATES iHFOs, NON-RHYTHMIC ACTIVATION OF PV INTERNEURONS CANNOT INDUCE LFP OSCILLATIONS
claim_relations[6]1.0the tagger's words
claim_relationscontradicts → recurrent collateral excitation as the ripple timer
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differs in: the region: THIS HYPOTHESIS DOES NOT EXPLAIN WHY RIPPLES IN THE CA3 REGION WITH ITS RICH RECURRENT NETWORK ARE LESS EXPRESSED - the structure with more recurrence has fewer ripples
claim_relations[7]1.0the tagger's words
claim_relationscritiques → in vitro studies that dismissed inhibition on the strength of KCl-reinstated oscillations
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differs in: the frequency and the burst structure of the oscillation being compared: THE KCl-INDUCED OSCILLATIONS WERE VERY FAST (>200 Hz) AND WERE COUPLED WITH LONG SPIKE BURSTS OF PYRAMIDAL CELLS, UNLIKE NATURALLY OCCURRING RIPPLES
claim_relations[8]1.0the tagger's words
claim_relationscritiques → systemic diazepam evidence for inhibitory pacing, confounded by effects on ripple occurrence and amplitude
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differs in: what else the drug changed: THE DRUGS ALSO REDUCED THE OCCURRENCE, AMPLITUDE, AND DURATION OF RIPPLES, so the pacing reading is not isolated
claim_relations[9]1.0the tagger's words
claim_relationsreconciles → the interneuron-interneuron and pyramidal-interneuron model families, as a hybrid PYR-INT-INT scheme
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differs in: whether transient pyramidal excitation is included: a HYBRID MODEL THAT INCLUDES SPW-INDUCED TRANSIENT EXCITATION OF PYRAMIDAL CELLS, COMBINED WITH THE PACING ABILITY OF INTERNEURON INTERACTIONS
claim_relations[10]1.0the tagger's words
concept_edgesfast ripples —distinct-from→ ripple
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strength of the relation: 1 · note: CRITERION: 200-300 Hz and nonphysiological/epileptic. The name reads as a subtype of the healthy phenomenon and denotes a pathology Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says PTX was followed by higher-frequency epileptic oscillations; distinct-from is loose.
also in: fast ripples · ripple
concept_edges[0]1.0the tagger's words
concept_edgesfast gamma —same-as→ ripple
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strength of the relation: 0.6 — the record marks this weak · note: identity asserted BY FIAT for convenience within this paper - 'for simplicity, we will refer to them as ripples'. True here, not licensed elsewhere Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says fast gamma and ripples will be referred to together for simplicity; same-as is a naming choice.
also in: fast gamma · ripple
concept_edges[1]1.0the tagger's words
concept_edgesiHFOs —contrasted-with→ ripple
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differs in: THE AXIS IS WHERE THE DRIVE COMES FROM. 'Quotation withheld.' Two events that look alike in the local field are separated by the breadth of their input, which is not visible in the signal being compared - so a study classifying events by waveform is classifying by something other than the mechanism. · strength of the relation: 0.8 · note: the induced oscillation is kept terminologically separate from the spontaneous one, and the paper lists where they diverge
also in: iHFOs · ripple
concept_edges[2]1.0the tagger's words
concept_edgesGABA A —causes→ iHFOs
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strength of the relation: 1 · note: necessary, shown by abolition under focal blockade - which is also what defeats the axon-net model
also in: GABA A · iHFOs
concept_edges[5]1.0the tagger's words
concept_edgespicrotoxin —causes→ fast ripples
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strength of the relation: 1 · note: removing inhibition does not stop the rhythm, it converts it to the pathological one Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says epileptic oscillations emerged after PTX; causes is loose.
concept_edges[6]1.0the tagger's words
concept_edgesPV —is-a→ interneurons
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strength of the relation: 1
also in: PV · interneurons
concept_edges[7]0.9the tagger's words
concept_edgesiHFOs —distinct-from→ volume-conducted
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strength of the relation: 0.9 · note: distance falloff excludes passive spread as the source of multi-site coherence Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says ripple coherence across sites is not a volume-conducted effect; distinct-from iHFOs is loose.
concept_edges[11]1.0the tagger's words
concept_edgessuperficial —contrasted-with→ deep
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strength of the relation: 0.9
also in: superficial · deep
concept_edges[12]1.0the tagger's words
content_tagsWilcoxon signed-rank test
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content_tags.statistics[0]the tagger's words
content_tagsMann-Whitney U test
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content_tags.statistics[1]the tagger's words
content_tagschi-squared test
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content_tags.statistics[2]the tagger's words
content_tagsrank correlation
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content_tags.statistics[3]the tagger's words
content_tagscircular correlation
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content_tags.statistics[4]the tagger's words
content_tagscircular-linear correlation
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content_tags.statistics[5]the tagger's words
content_tagsRayleigh test
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also in: Rayleigh test
content_tags.statistics[6]the tagger's words
content_tagsF-test with Bonferroni correction
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content_tags.statistics[7]the tagger's words
content_tagsstandard deviation
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content_tags.statistics[8]the tagger's words
content_tagsWilcoxon's paired signed-rank test
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content_tags.statistics[9]1.0the tagger's words
content_tagsMann-Whitney U test
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content_tags.statistics[10]0.8the tagger's words
content_tagscoherence
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also in: coherence
content_tags.statistics[11]1.0the tagger's words
content_tagsrank correlation
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content_tags.statistics[12]0.7the tagger's words
content_tagsOptogenetically depolarizing a small local group of CA1 pyramidal cells was enough to generate ripple-frequency oscillations, while silencing pyramidal cells directly or indirectly (by driving PV or somatostatin interneurons) terminated ripples that were already underway.
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content_tags.findings[0]the tagger's words
content_tagsFocal blockade of GABA-A receptors completely abolished locally induced high-frequency oscillations, showing that pyramidal-pyramidal interactions by themselves cannot produce ripples and that fast inhibition is required.
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content_tags.findings[1]the tagger's words
content_tagsNon-rhythmic activation of PV interneurons could not induce field-potential ripples, so a simple interneuron-interneuron model cannot account for LFP ripples.
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content_tags.findings[2]the tagger's words
content_tagsAlthough PV activation produced no field ripple, it did impose ripple-frequency coherence on ensemble spiking, so interneuron-interneuron interactions can set the timing even when they cannot create the oscillation.
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content_tags.findings[3]the tagger's words
content_tagsBlocking fast inhibition reduced the phase coherence between simultaneously induced oscillations at separate sites, showing that interneurons are what keeps spatially separate ripple oscillators locked together.
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content_tags.findings[4]the tagger's words
content_tagsPyramidal cells fired roughly a quarter-cycle (about 90 degrees) ahead of interneurons on every ripple cycle, with mean phases of 157 degrees for pyramidal cells and 242 degrees for interneurons.
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content_tags.findings[5]the tagger's words
content_tagsSuperficial CA1 pyramidal cells were entrained to ripples more often (64% versus 57%) and with higher peak firing gain (12.4 versus 9.2) than deep pyramidal cells.
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content_tags.findings[6]the tagger's words
content_tagsPhysiological ripples and pathological "fast ripples" are produced by different mechanisms, because removing fast inhibition destroys the first while creating the second.
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content_tags.findings[7]the tagger's words
content_tagsLocally induced oscillations fell to 2% of local power 400 micrometres away and to baseline beyond that.
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content_tags.findings[8]the tagger's words
content_tagsdepolarising a small local group of pyramidal cells is sufficient to induce a ripple-like oscillation
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content_tags.findings[9]1.0the tagger's words
content_tagsfocal GABA-A blockade abolishes the induced oscillation completely, so pyramidal-pyramidal interaction alone cannot generate it
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content_tags.findings[10]1.0the tagger's words
content_tagssilencing pyramidal cells, directly or via PV or SOM interneurons, aborts ongoing spontaneous ripples
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content_tags.findings[11]1.0the tagger's words
content_tagstonic PV activation cannot induce a field ripple, but does organise ensemble spiking into coherent ripple-frequency oscillations
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content_tags.findings[12]1.0the tagger's words
content_tagssimultaneous multisite induction produces coherence at distances where single-site induction gives chance
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content_tags.findings[13]1.0the tagger's words
content_tagsremoving inhibition converts the physiological rhythm into 200-300 Hz epileptic fast ripples
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content_tags.findings[14]1.0the tagger's words
content_tagsthe same spikes give 12.4% coherent pairs as single units and 35% when agglomerated per shank
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content_tags.findings[15]1.0the tagger's words
content_tagsconnexin 36 ablation does not alter in vivo ripples, and pyramidal-pyramidal connexin coupling was never demonstrated
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content_tags.findings[16]1.0the tagger's words
content_tagssuperficial pyramidal cells are entrained more often and more strongly than deep ones
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content_tags.findings[17]1.0the tagger's words
content_tagsthe same induction works in dentate gyrus and in layer 5 of somatosensory cortex, so the mechanism is not hippocampus-specific
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content_tags.findings[18]1.0the tagger's words
content_tagsinduced high-frequency oscillations (iHFOs)
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content_tags.definitions[0]the tagger's words
content_tagsgain
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also in: gain
content_tags.definitions[1]the tagger's words
content_tagsthreshold light intensity
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content_tags.definitions[2]the tagger's words
content_tagssummed INT
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also in: summed INT
content_tags.definitions[3]the tagger's words
content_tagsripple
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also in: ripple
content_tags.definitions[4]the tagger's words
content_tagssharp wave
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also in: sharp wave
content_tags.definitions[5]1.0the tagger's words
content_tagsiHFOs
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also in: iHFOs
content_tags.definitions[6]1.0the tagger's words
content_tagsaxon-net model
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content_tags.definitions[7]1.0the tagger's words
content_tagsINT-INT
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content_tags.definitions[8]1.0the tagger's words
content_tagsPYR-INT loop
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content_tags.definitions[9]1.0the tagger's words
content_tagsPYR-INT-INT
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content_tags.definitions[10]1.0the tagger's words
content_tagssummed PYR
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content_tags.definitions[11]1.0the tagger's words
content_tagsreceptor blockade
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content_tags.variables[1]the tagger's words
content_tagsglobal frequency
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content_tags.variables[3]the tagger's words
content_tagscoherence between nearby sites
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content_tags.variables[4]the tagger's words
content_tagslight intensity
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content_tags.variables[5]1.0the tagger's words
content_tagsdistance
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also in: distance
content_tags.variables[6]0.9the tagger's words
content_tagscell type
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also in: cell type
content_tags.variables[7]1.0the tagger's words
content_tagssublayer
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also in: sublayer
content_tags.variables[8]1.0the tagger's words
content_tags115,204 ripples — total number of spontaneous fast-gamma/ripple events analysed, with median frequency 148 Hz and duration 43 ms
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content_tags.quantities[0]the tagger's words
content_tags80–100 — upper estimate of the number of CA1 pyramidal cells directly illuminated at maximum light intensity, taken as the size of the minimal ripple-generating network
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content_tags.quantities[1]the tagger's words
content_tags6-fold — increase in CA1 neuron firing rate during spontaneous ripples relative to no-ripple epochs
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content_tags.quantities[2]the tagger's words
content_tags3,885 — total putative single cells recorded from CA1 across 47 animals
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content_tags.quantities[3]the tagger's words
content_tags2% ± 0.3% — induced oscillation power at 400 micrometres from the illuminated shank, relative to power at the illuminated site
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content_tags.quantities[4]the tagger's words
content_tags258/737 (35%) — proportion of summed-pyramidal/summed-interneuron spike-train pairs showing significant ripple-band coherence during spontaneous ripples
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content_tags.quantities[5]the tagger's words
content_tags790/6369 (12.4%) — proportion of coherent pairs when the same spikes were analysed as single neurons instead of summed populations
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content_tags.quantities[6]the tagger's words
content_tags23% — median reduction of inter-site ripple-band coherence after GABA-A receptor blockade
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content_tags.quantities[7]the tagger's words
content_tags16% — median Bayes error of the classifier separating true from false online ripple detections
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content_tags.quantities[8]the tagger's words
content_tags80-100 — CA1 pyramidal cells directly illuminated at maximum light - the size of the minimal generating network
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content_tags.quantities[9]1.0the tagger's words
content_tags148 Hz, 43 ms, 115,204 — median frequency, median duration and total number of ripples recorded
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content_tags.quantities[10]1.0the tagger's words
content_tags200-300 Hz — frequency of the epileptic fast ripples that follow GABA-A blockade
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content_tags.quantities[11]1.0the tagger's words
content_tags90-140 Hz vs 140-180 Hz — the published frequency bands separating fast gamma from ripple
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content_tags.quantities[12]1.0the tagger's words
content_tags2% at 400 um — induced oscillation power two shanks away, against 89% for spontaneous ripples at the same distance
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content_tags.quantities[13]0.9the tagger's words
content_tags12.4% vs 35% — coherent pairs from the same spikes, as single units versus agglomerated per shank
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content_tags.quantities[14]1.0the tagger's words
content_tags1 mM picrotoxin, 13-52 nl — the focal GABA-A blockade dose and volume
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content_tags.quantities[15]1.0the tagger's words

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