Local generation of multineuronal spike sequences in the hippocampal CA1 region

Stark, Roux, Eichler, Buzsáki · Proceedings of the National Academy of Sciences of the United States of America · 2015 · neuroscience · 10.1073/pnas.1508785112 · record Stark2015-local-generation-of-multineuronal-spike-sequ
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. Claim type is mechanism because the contribution is an explanation of what produces sequence order (local synaptic interactions plus intrinsic biophysics) rather than a bare existence claim. The paper contains an internal robustness check (template vs pair-wise methods, freely moving vs urethane-anesthetized cohorts) but makes no claim about external replication, so replication status is untested. All three claim relations use numeric reference markers rather than author names - that is how this journal's HTML renders citations; each quoted sentence still explicitly positions this paper against a specific identified prior study, which is why they were retained rather than dropped as bare citations. 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
12 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.
Other fields define these differently the same word, defined another way in another discipline
principal component analysis 5 fields · cross-validation 3 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 20 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
spike sequences synthetic ripples spontaneous ripples theta PYR INT CA3 CA1 entorhinal consistency spike gain phase replay preplay permutation test Gaussian mixture model diode probes urethane intrinsic properties local connectivity Three sources intersect to produce the sequences: patterned drive from CA3, a wide spread of intrinsic cellular excitability, and heterogeneous local connectivity, the last two making neurons respond unequally to the same extrinsic input Biophysical heterogeneity across pyramidal cells converts even an identical input ramp into diverse spike patterns and hence into a reproducible sequential order Each interneuron is driven by a limited set of pyramidal assemblies and silences the competing assemblies, which places it at a fixed point in the sequence and gives pyramidal spiking a temporal scaffold gain cross-class consistency threshold intensity light stimulation rank correlation light intensity rank correlations Wilcoxon signed-rank test Wilcoxon’s signed-rank paired test binomial test exact Binomial test Mann-Whitney U test Mann–Whitney U test Kruskal-Wallis test Kruskal–Wallis test circular correlation circular–circular correlation coefficient chi-squared test cross-validation cross-validated template method principal component analysis significance level α level Wilcoxon Rayleigh test electrophysiology

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field
unrecordable relationunhoused_relationsa relation the paper asserts that this vocabulary cannot express, with the reason

The paper

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Every tag on this page

alternatives 3 · claim_relations 8 · claim_type 1 · concept_edges 10 · content_tags 67 · contribution 1 · controls 1 · limitations 7 · mechanisms 7 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 5 · transfers 2 · unhoused_relations 1

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; 1 of 10 relations here carries that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studywhether the ordered firing of CA1 neurons during ripples is imported from CA3 or assembled locally
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object_of_studythe paper's words
research_questionwhether sequences survive when the usual upstream driver is bypassed and the same neurons are activated directly by light
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research_questionthe paper's words
contributionshows that sequence order is partly preserved across theta, spontaneous ripples and optically induced ripples, and that interneuron spiking is what carries the consistency
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenonmultineuronal spike sequences in hippocampal CA1
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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status: the paper's own words: We hypothesize that
mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismseven if every neuron received an identical ramp of input current, diverse and sequential spiking would still follow from intrinsic neuronal and circuit heterogeneity
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mechanisms[3]1.0the tagger's words
mechanismsinterneurons are each controlled by a few pyramidal assemblies and suppress the rest, which is why they appear in orderly positions
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mechanisms[4]0.9the tagger's words
mechanismsthe proposal is a three-way intersection: sequential drive from CA3, spread of intrinsic cellular properties, and differences in local connectivity
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mechanisms[5]1.0the tagger's words
mechanismsthe preexisting order may itself be the residue of earlier experience or of development, which the design cannot separate
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mechanisms[6]0.8the tagger's words
limitationsOnly a limited number of pyramidal cells could be monitored with silicon probes; larger ensemble recordings are needed to test the hypothesis.
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what this limits: the completeness of every sequence reported: MANY MORE PYRAMIDAL NEURONS TOOK PART IN THE SEQUENTIAL PATTERNING OF ACTIVITY THAN THOSE MONITORED HERE BY THE SILICON PROBES
limitations[0]the tagger's words
limitationsThe theta/ripple correlation results on their own cannot separate a CA3 from a CA1 origin of the sequences.
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what this limits: the local-generation claim: SEQUENCES MAY BE GENERATED BY THE UPSTREAM CA3 REGION OR LOCALLY IN CA1 BUT THESE RESULTS ALONE CANNOT DISAMBIGUATE THE CONTRIBUTIONS OF THE TWO REGIONS
limitations[1]the tagger's words
limitationsThe measured sequence consistency is loose - rank correlations were widely spread and rarely above 0.5.
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what this limits: how tightly the sequences repeat: RANK CORRELATIONS WERE WIDELY DISTRIBUTED AND RARELY EXCEEDED VALUES OF 0.5 ... INDICATING RELATIVELY LOOSE SELF- AND CROSS-CLASS CONSISTENCY
limitations[2]the tagger's words
limitationsthe theta-ripple correlation alone cannot disambiguate the contributions of CA3 and of CA1
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duplicate of: limitations[1] · what this limits: the same scope as limitations[1] - CA3 and CA1 origins are not separated by these correlations
limitations[3]1.0the tagger's words
limitationsfar more pyramidal cells probably participate than the probes could record, and larger ensembles are needed
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duplicate of: limitations[0] · what this limits: the same scope as limitations[0] - larger ensemble recordings are needed to test the hypothesis
limitations[4]1.0the tagger's words
limitationswith pyramidal cells alone the cross-class correlation is not significant - though the paper notes the same holds within a single condition
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what this limits: the pyramidal-only analysis: THE CORRELATION BETWEEN SPONTANEOUS AND INDUCED OSCILLATIONS WAS NOT SIGNIFICANT. HOWEVER, THIS WAS ALSO THE CASE WHEN SEQUENCE PATTERNS WERE CORRELATED WITHIN THE SAME CONDITIONS
limitations[5]1.0the tagger's words
limitationswhether the preexisting order reflects experience or development is not addressed
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what this limits: the origin of the preexisting order: THE PREEXISTING SEQUENCES MAY THEMSELVES REFLECT THE LOCAL CIRCUIT CONFIGURATIONS SHAPED BY PREVIOUS EXPERIENCES, BY THE DEVELOPMENTAL GENETIC PROGRAM, OR ANY COMBINATION THEREOF
limitations[6]0.9the tagger's words
transfersrank-order templates with permutation-based significance, used so that sequence order can be tested without assuming timing distributions
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transfers[0]1.0the tagger's words
transfersdirect local activation used specifically to bypass the upstream input whose contribution is in question
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transfers[1]1.0the tagger's words
controlsshort events under 15 ms discarded and adjacent events with gaps under 15 ms merged, before the sequence analysis
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eliminates: one event being counted as two, or noise being counted as an event, in a measure built on counting events · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
unhoused_relationsCA3 → CA1
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THE TWO CANNOT BE SEPARATED IN THIS STUDY - the DESIGN form of the negative relation / No edge type can express it: all eight assert that a relation HOLDS. A confounding statement bounds what the paper's own results can mean, and it lives where nothing downstream will find it. THE SAME PAIR DRIEU2019 WAS MIS-READ AS CONTRASTING. 'Quotation withheld' One paper cannot separate them; another paper's glossary was read as distinguishing them. The corpus now holds the inability next to the mistake.
unhoused_relations[0]the tagger's words
sensessynthetic ripple is the same construct Stark2014 named iHFO and Wu2015 reused - an optically induced high-frequency oscillation, kept terminologically apart from the spontaneous ripple throughout
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senses[0]1.0the tagger's words
sensessequence consistency here is a RANK correlation between the firing order in one event and a template built from other events, so it measures order and not timing
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senses[1]1.0the tagger's words
sensesself-consistency (order repeats within a class of events) and cross-class consistency (order carries between classes) are different measures, and the paper's claim rests on the second
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senses[2]1.0the tagger's words
sensesspike gain is the same within-unit ratio used in Wu2015 - rate during the event over baseline rate - so the two records are comparable on this measure
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senses[3]1.0the tagger's words
sensesPYR and INT are assigned by a Gaussian mixture model over waveform features, the same classification route as Wu2015
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senses[4]0.9the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: simultaneous multi-site recording with per-shank light delivery in freely moving and anaesthetised mice, with rank-order sequence templates and permutation tests
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: recurring order of firing across a population of CA1 neurons within an oscillatory event
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a second reading DIFFERING from the recorded value. Recorded: multineuronal spike sequences in hippocampal CA1 — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsbuilds-on → The authors' own earlier demonstration (ref. 26) that local optogenetic stimulation of CA1 pyramidal cells induces fast LFP oscillations resembling spontaneous ripples
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claim_relations[0]the tagger's words
claim_relationscontradicts → The prevailing assumption (refs 4, 12, 16, 21, 23) that CA1 sequential firing during ripples and theta is generated in CA3 recurrent networks and inherited synaptically by CA1
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status: the paper's own words: has not been shown
claim_relations[1]the tagger's words
claim_relationsreplicates → A previous study (ref. 34) of the stability of sequential activation of pyramidal cells and interneurons during neocortical slow oscillations
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claim_relations[2]the tagger's words
claim_relationscontradicts → the tacit assumption that CA1 ripple sequences are synaptically inherited from CA3 assemblies
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claim_relations[3]1.0the tagger's words
claim_relationsextends → Stark et al. 2014, which showed local optogenetic activation is sufficient to induce ripple-like oscillations
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claim_relations[4]1.0the tagger's words
claim_relationscritiques → the inference from waking-sleep correlation to experience-induced synaptic plasticity
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claim_relations[5]1.0the tagger's words
claim_relationssupports → preplay reports of correlations present before a novel experience
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claim_relations[6]0.9the tagger's words
claim_relationsconfirms → neocortical work finding stable pyramidal-interneuron sequences during slow oscillations
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claim_relations[7]0.9the tagger's words
concept_edgesEVIDENCE CORRECTED (RE-GROUNDED) · INT —causes→ consistency
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EVIDENCE CORRECTED: RE-GROUNDED. The old span attested 'INT' only inside 'interneurons'. The paper defines INT as its label for interneurons and uses it 46 times; this sentence writes it as a word and states the effect on consistency with its size. — strength of the relation: 1 · note: 12% of the units carry the sequence; dropping them sends cross-class consistency to chance Audit 2026-09-28: DOUBTFUL - read against its span and kept, but interneurons made a large contribution to sequence consistency; causes is loose.
also in: INT · consistency
concept_edges[1]1.0the tagger's words
concept_edgesEVIDENCE CORRECTED (RE-GROUNDED) · consistency —operationalised-as→ permutation test
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EVIDENCE CORRECTED: RE-GROUNDED. The old span described the ranking procedure. This sentence names both and states the test outright - '…CONSISTENCY was determined BY A PERMUTATION TEST, randomly…'. — strength of the relation: 1 · note: significance comes from shuffling unit labels, so the null is order-specific rather than rate-specific Audit 2026-09-28: DOUBTFUL - read against its span and kept, but sequence consistency was tested with a permutation test; operationalised-as is loose.
concept_edges[3]1.0the tagger's words
concept_edgesEVIDENCE CORRECTED (RE-GROUNDED FROM AN INFERENCE TO THE INTERVENTION IT RESTS ON) · CA1 —causes→ spike sequences
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EVIDENCE CORRECTED: RE-GROUNDED FROM AN INFERENCE TO THE INTERVENTION IT RESTS ON. The old span reports a conclusion - 'These results INDICATE…' that mechanisms in CA1 contribute to ripple- and theta-associated sequences - which names one endpoint and hedges the mechanism (mechanisms confined to CA1). The replacement is the experiment: 'We show that OPTOGENETIC ACTIVATION…' of a small group of CA1 pyramidal cells yields consistent spike sequences. A manipulation and its result, both endpoints named. For a 'causes' edge an intervention is better evidence than an inference drawn from one. — strength of the relation: 0.9 · note: the paper's own claim: local mechanisms contribute, not that CA3 does not Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span writes 'neuronal sequences' / 'sequential spiking patterns', not 'spike sequences'.
also in: CA1 · spike sequences
concept_edges[5]1.0the tagger's words
concept_edgesreplay —contrasted-with→ preplay
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strength of the relation: 0.9 · note: the warning this paper leaves the field: a correlation read as learning may predate the learning Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span is cut before the replay-preplay contrast.
also in: replay · preplay
concept_edges[8]1.0the tagger's words
concept_edgesPYR —contrasted-with→ INT
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strength of the relation: 1 · note: the 4.7-fold against 1.8-fold rate rise is the evidence that light drove PYR directly and INT through the circuit
also in: PYR · INT
concept_edges[9]1.0the tagger's words
concept_edgesEVIDENCE CORRECTED (RE-GROUNDED) · theta —contrasted-with→ spontaneous ripples
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EVIDENCE CORRECTED: RE-GROUNDED. The old span set up a comparison without naming its terms. This sentence names them as the study's own design - '…during THETA oscillations, SPONTANEOUS RIPPLES, and focal…' - so the contrast is the experiment rather than an observation about it. — strength of the relation: 1 · note: two states with different drivers whose sequences nonetheless match, which is what motivates the local-circuit hypothesis Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span compares ripple sequences with theta cycles; contrasted-with is loose.
concept_edges[10]1.0the tagger's words
concept_edgesINT —causes→ consistency
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strength of the relation: 1 · note: RE-GROUNDS another row of this record:, the endpoint was attested mid-word. Audit 2026-09-28: DOUBTFUL - read against its span and kept, but including interneurons doubles cross-class consistency; causes is loose.
also in: INT · consistency
concept_edges[11]1.0the tagger's words
concept_edgesconsistency —operationalised-as→ permutation test
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strength of the relation: 1 · note: RE-GROUNDS another row of this record: the old span named ONE endpoint. Audit 2026-09-28: DOUBTFUL - read against its span and kept, but significance of consistency was determined by permutation; operationalised-as is loose.
concept_edges[12]1.0the tagger's words
concept_edgestheta —contrasted-with→ spontaneous ripples
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strength of the relation: 1 · note: RE-GROUNDS another row of this record: the old span named ONE endpoint. Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span lists the three conditions the study compared; contrasted-with is loose.
concept_edges[13]1.0the tagger's words
concept_edgesCA1 —causes→ spike sequences
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the relation itself is separately evidenced · strength of the relation: 0.9
also in: CA1 · spike sequences
concept_edges[14]1.0the tagger's words
content_tagsrank correlation
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content_tags.statistics[0]the tagger's words
content_tagspermutation test
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content_tags.statistics[1]the tagger's words
content_tagsWilcoxon signed-rank test
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content_tags.statistics[2]the tagger's words
content_tagsbinomial test
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also in: binomial test
content_tags.statistics[3]the tagger's words
content_tagsMann-Whitney U test
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content_tags.statistics[4]the tagger's words
content_tagsKruskal-Wallis test
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content_tags.statistics[5]the tagger's words
content_tagscircular correlation
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content_tags.statistics[6]the tagger's words
content_tagschi-squared test
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content_tags.statistics[7]the tagger's words
content_tagscross-validation
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content_tags.statistics[8]the tagger's words
content_tagsGaussian mixture model
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content_tags.statistics[9]the tagger's words
content_tagsprincipal component analysis
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content_tags.statistics[10]the tagger's words
content_tagssignificance level
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content_tags.statistics[11]the tagger's words
content_tagspermutation test
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content_tags.statistics[12]1.0the tagger's words
content_tagsrank correlation
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content_tags.statistics[13]1.0the tagger's words
content_tagsWilcoxon
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also in: Wilcoxon
content_tags.statistics[14]0.85the tagger's words
content_tagsexact Binomial test
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content_tags.statistics[15]1.0the tagger's words
content_tagsRayleigh test
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also in: Rayleigh test
content_tags.statistics[16]1.0the tagger's words
content_tagsMann-Whitney U test
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content_tags.statistics[17]1.0the tagger's words
content_tagsIndividual neurons' firing rates, their rate modulation, and the order in which pyramidal cells and interneurons fired were all correlated across three different network states: theta oscillations, spontaneous ripples, and optogenetically induced ripples.
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content_tags.findings[0]the tagger's words
content_tagsBecause sequences recur during locally induced ripples that receive no CA3 or entorhinal patterning, the sequential order of CA1 spiking cannot be purely inherited from upstream regions and must partly arise from CA1's own circuitry and single-cell biophysics.
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content_tags.findings[1]the tagger's words
content_tagsHalf of the optogenetically induced spike sequences matched the spontaneous ripple sequence recorded at the same site, with a median rank correlation of 0.13.
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content_tags.findings[2]the tagger's words
content_tagsInterneurons made up only 12% of the participating units and were only indirectly driven by the light, yet they contributed importantly to sequence consistency in both spontaneous and induced ripples.
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content_tags.findings[3]the tagger's words
content_tagsWith pyramidal cells alone the correlation between theta-cycle and ripple sequence order dropped to chance, so the shared ordering across states depends on including interneurons.
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content_tags.findings[4]the tagger's words
content_tagsThe preferred firing phase of each unit within the ripple cycle was the same for spontaneous and light-induced ripples, so cycle-level spike timing is conserved between the two.
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content_tags.findings[5]the tagger's words
content_tagsSequence consistency was real but weak: rank correlations were broadly spread and seldom above 0.5, and the same conclusions followed whether a template or a pairwise comparison method was used.
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content_tags.findings[6]the tagger's words
content_tagsUnder anaesthesia, spontaneous and induced sequences were not consistent with each other.
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content_tags.findings[7]the tagger's words
content_tagsfiring rates during theta and during ripples were correlated neuron by neuron
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content_tags.findings[8]1.0the tagger's words
content_tagssequences recorded during ripples matched those during theta cycles in 10 of 11 sessions
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content_tags.findings[9]1.0the tagger's words
content_tagsspike phase within the cycle was preserved between spontaneous and induced ripples
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content_tags.findings[10]1.0the tagger's words
content_tagspyramidal cells fired about 1.8 ms before interneurons on each ripple cycle
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content_tags.findings[11]1.0the tagger's words
content_tagssequences repeated across spontaneous ripple events at 23 of 27 recording sites
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content_tags.findings[12]1.0the tagger's words
content_tagshalf the induced sequences matched their own site's spontaneous sequences
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content_tags.findings[13]1.0the tagger's words
content_tagstheta sequences and induced-ripple sequences also matched, at 10 of 25 sites
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content_tags.findings[14]1.0the tagger's words
content_tagswith interneurons alone, sequences stayed consistent across classes
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content_tags.findings[15]1.0the tagger's words
content_tagsinterneurons are 12% of the units and carry the consistency
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content_tags.findings[16]1.0the tagger's words
content_tagsin the pyramidal-only session analysis three sessions were consistent and three were REVERSED, so the group mean describes neither
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content_tags.findings[17]1.0the tagger's words
content_tagsCONTROL NULL: illumination of an opsin-free mouse produced no spikes, no oscillations and no artefact
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content_tags.findings[18]1.0the tagger's words
content_tagsCONTROL: induced-ripple rates track spontaneous rates, so the induced pattern is not set by opsin level or distance from the light
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content_tags.findings[19]1.0the tagger's words
content_tagsspontaneous and induced ripples occurred predominantly in the same brain state
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content_tags.findings[20]1.0the tagger's words
content_tagsSCOPE TO CHECK: the main text reports similar results under anaesthesia, and the supplementary caption it cites states cross-class sequences are NOT consistent there
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content_tags.findings[21]1.0the tagger's words
content_tagsSCOPE TO CHECK, second half: the supplementary figure caption states plainly that spontaneous and induced sequences are not consistent under anaesthesia
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content_tags.findings[22]1.0the tagger's words
content_tagssynthetic ripples
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content_tags.definitions[1]the tagger's words
content_tagsgain
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also in: gain
content_tags.definitions[2]the tagger's words
content_tagscross-class consistency
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content_tags.definitions[3]the tagger's words
content_tagsthreshold intensity
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content_tags.definitions[4]the tagger's words
content_tagsspike gain
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also in: spike gain
content_tags.definitions[5]0.85the tagger's words
content_tagsconsistency
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also in: consistency
content_tags.definitions[6]1.0the tagger's words
content_tagssynthetic ripples
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content_tags.definitions[7]1.0the tagger's words
content_tagspreplay
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also in: preplay
content_tags.definitions[8]1.0the tagger's words
content_tagslight stimulation
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content_tags.variables[0]the tagger's words
content_tagsrank correlation
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content_tags.variables[1]the tagger's words
content_tagslight intensity
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content_tags.variables[4]the tagger's words
content_tagsconsistency
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also in: consistency
content_tags.variables[5]1.0the tagger's words
content_tagsspike gain
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also in: spike gain
content_tags.variables[6]0.85the tagger's words
content_tagsphase
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also in: phase
content_tags.variables[7]1.0the tagger's words
content_tags5.1-fold — increase in pyramidal cell firing rate during spontaneous ripples, versus 4.1-fold for interneurons
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content_tags.quantities[0]the tagger's words
content_tags582 — total well-isolated CA1 cells recorded across freely moving and anaesthetized mice
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content_tags.quantities[1]the tagger's words
content_tags56 — recording sites that met the criteria for sequence analysis, across 16 sessions
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content_tags.quantities[2]the tagger's words
content_tags0.28 — median rank correlation quantifying self-consistency of multineuronal sequences during spontaneous ripples (85% of sites significant)
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content_tags.quantities[3]the tagger's words
content_tags3.4 times — factor by which cross-class rank correlations dropped when interneurons were excluded and only pyramidal cells were used
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content_tags.quantities[4]the tagger's words
content_tags156 ± 1.7°, 254 ± 6.7° — mean preferred ripple-cycle phases of pyramidal cells and interneurons, a 1.8 ms lag
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content_tags.quantities[5]the tagger's words
content_tags13 of 26 (50%) — induced-ripple sequences that were consistent with the spontaneous ripple sequence at the same site
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content_tags.quantities[6]the tagger's words
content_tags268 and 37 — pyramidal cells and interneurons recorded from four freely moving mice
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content_tags.quantities[7]1.0the tagger's words
content_tags12% — share of participating units that are interneurons, which nonetheless carry the sequence
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content_tags.quantities[8]1.0the tagger's words
content_tags1.8 ms — lead of pyramidal over interneuron spiking within a ripple cycle
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content_tags.quantities[9]1.0the tagger's words
content_tags4.7-fold vs 1.8-fold — rate increase of pyramidal cells against interneurons during induced ripples - the signature of direct versus indirect drive
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content_tags.quantities[10]1.0the tagger's words
content_tags3 and 3 — sessions with consistent and with reversed pyramidal-only sequences, out of eleven
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content_tags.quantities[11]1.0the tagger's words

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