Navigating from hippocampus to parietal cortex

Whitlock, Sutherland, Witter, Moser, Moser · Proceedings of the National Academy of Sciences of the United States of America · 2008 · neuroscience · 10.1073/pnas.0804216105 · record Whitlock2008-navigating-from-hippocampus-to-parietal-cort
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. This is a hypothesis-advancing review/perspective, not a study reporting new data, so method is coded review and replication status untested - the proposed transformation is offered as a hypothesis ("Quotation withheld") and no test of it is reported. The paper also flags an unresolved controversy over the anatomical delineation of rat PPC, which is recorded as background rather than a limitation of its own claim. 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
19 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
This record’s own method is review, and the tags below follow from that. A review’s findings, quantities and statistics are things stated IN this paper, and some of them report results obtained elsewhere. No tag on this page names a different author. Measured across every review in this corpus, 81% of a review’s tags carry no citation at all — most of them are the review speaking. The corpus does not adjudicate the rest: read an unmarked tag as a claim this paper makes, not necessarily one it made first.
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Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 13 concept tags on this paper, none is grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
posterior parietal cortex PPC grid cells place cells path integration medial entorhinal cortex cognitive map allocentric body-based coordinates head direction cytoarchitecture somatosensory cortex pulvinar Output of the medial entorhinal grid-cell circuit is transformed into body-based coordinates in parietal cortex, and parietal projections to motor and premotor cortex then convert those coordinates into locomotor commands. World-referenced and body-referenced signals converge multiplicatively on single PPC neurons, and this conjunctive (gain-field) coding is what performs the allocentric-to-egocentric conversion. myeloarchitecture bregma dorsal stream saccade reach firing fields hippocampus navigation grid cell posterior parietal cortex (PPC) parietal cortex place field grid error in initial heading review

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second readingalternativesan independent re-reading of a facet, recorded whether or not it agrees
relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1073/pnas.0804216105. The reading view exists for the papers whose licence permits it.

Every tag on this page

alternatives 3 · claim_relations 7 · claim_type 1 · concept_edges 2 · content_tags 27 · contribution 1 · limitations 10 · mechanisms 8 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 4 · transfers 2

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 2 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

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facettagfieldconf.whose words
object_of_studyhow allocentric spatial maps in entorhinal cortex and hippocampus are converted into body-centred signals that can guide movement
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object_of_studythe paper's words
research_questionwhich structure performs the transformation from map coordinates to egocentric motor output
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research_questionthe paper's words
contributionproposes posterior parietal cortex as the site of that transformation, and assembles the primate and rodent evidence for it
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenonspatial navigation in rodents
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phenomenonthe paper's words
methodreview
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also in: review
methodthe paper's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
status: the paper's own words: We propose here that
mechanisms[0]the tagger's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[1]the tagger's words
mechanismsPPC neurons multiply world-referenced by body-referenced signals, which is what a coordinate transformation requires
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mechanisms[2]1.0the tagger's words
mechanismsgrid cells are argued to rest on path integration because a periodic firing pattern persists through constantly changing speed and direction
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mechanisms[3]1.0the tagger's words
mechanismsgrids keep their relative geometry across environments, unlike place fields which remap
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mechanisms[4]1.0the tagger's words
mechanismspath integration drifts without recalibration against landmarks, which is why both mechanisms are needed
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mechanisms[5]1.0the tagger's words
mechanismsself-motion generates the firing but external cues anchor where it occurs
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mechanisms[6]1.0the tagger's words
mechanismsPPC delay activity tracks the movement to be made rather than the target location, switching when the required effector changes
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mechanisms[7]1.0the tagger's words
limitationsWhether PPC deficits actually reflect a failure to transform self-location into locomotor action is not established by the existing evidence.
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what this limits: the central proposal of the review: WHETHER THEY DO REMAINS OPEN; AT PRESENT, THE EVIDENCE IS AMBIGUOUS
limitations[0]the tagger's words
limitationsThe direct medial entorhinal projection to PPC is weak and may not carry usable location information.
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what this limits: the anatomical route the account depends on: THIS CONNECTION IS RELATIVELY WEAK, AND IT IS UNCERTAIN WHETHER IT IS ABLE TO CONVEY LOCATION INFORMATION
limitations[1]the tagger's words
limitationsIt is unknown whether medial entorhinal output actually targets the PPC neurons involved in action preparation.
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what this limits: the link from grid-cell coding to action preparation: IT HAS NOT BEEN DETERMINED WHETHER THE MEDIAL ENTORHINAL OUTPUT targets the relevant PPC neurons
limitations[2]the tagger's words
limitationsWhich of the candidate hippocampal-entorhinal to PPC routes actually carries the signal is unresolved.
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what this limits: any claim identifying which pathway carries the signal: THE RELATIVE CONTRIBUTIONS OF THE VARIOUS PATHWAYS REMAIN UNCERTAIN
limitations[3]the tagger's words
limitationsThe whole account is at an early stage.
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what this limits: the maturity of the whole account: WE ARE JUST BEGINNING TO SCRATCH THE SURFACE OF THIS MULTITUDE OF NAVIGATIONAL CONTROL PATHWAYS
limitations[4]the tagger's words
limitationsin most lesion studies navigation impairments cannot be separated from memory impairments
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what this limits: every lesion-based navigation claim cited: THE IMPAIRMENTS IN NAVIGATION CAN UNFORTUNATELY NOT BE DISTINGUISHED FROM EFFECTS ON MEMORY
limitations[5]1.0the tagger's words
limitationsthe exact anatomical definition of rodent PPC remains a subject of debate
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what this limits: every result attributed to rodent PPC: AN EXACT ANATOMICAL DEFINITION FOR THE PPC IN RODENTS REMAINS A SUBJECT OF DEBATE - the region quantified over is not agreed
limitations[6]1.0the tagger's words
limitationswhether to include parts of Oc2 is still controversial
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what this limits: the extent of that region specifically: WHETHER OR NOT TO INCLUDE PARTS OF OC2 IN THE PPC ... IS STILL CONTROVERSIAL
limitations[7]1.0the tagger's words
limitationshead restraint in the primate work prevents any analysis of PPC during free locomotion
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what this limits: the transfer of the primate PPC findings to navigation: MOVEMENT RESTRICTIONS INHERENT TO THE HEAD-RESTRAINED SYSTEM PREVENT AN ANALYSIS during free locomotion
limitations[8]1.0the tagger's words
limitationsa study contradicting the hippocampal path-integration account is set aside on the grounds that a dragged food cup may have left odour trails
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what this limits: the standing of the evidence against the path-integration hypothesis: WE SUGGEST THAT THE STUDY IS NOT DECISIVE IN NEGATING THE HYPOTHESIS, on the stated ground that odour trails may have been available
limitations[9]1.0the tagger's words
transfersthe multiplicative gain-field mechanism for coordinate transformation, imported as the account of how a rodent map becomes motor output
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transfers[0]1.0the tagger's words
transfersthe dorsal and ventral stream distinction and the deficits of parietal patients, used to motivate PPC's spatial role
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transfers[1]0.9the tagger's words
sensesparietal cortex is defined in the first line of the definition box by an overlying BONE, then immediately refined by cytoarchitecture, myeloarchitecture, neurochemistry and connectivity
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senses[0]1.0the tagger's words
sensesPPC is delimited by what it is between and by which thalamic inputs it lacks - a definition by exclusion and by neighbours rather than by intrinsic property
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senses[1]1.0the tagger's words
sensesplace cells remap between environments while grid cells keep their relative geometry - the distinction that makes one a map of a place and the other a metric
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senses[2]1.0the tagger's words
sensesthe primate PPC literature shifted from a general spatial framework to multiple action-specific representations, so PPC function means something different before and after that shift
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senses[3]1.0the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: narrative review across rodent and primate literatures, with an explicit proposal and a boxed treatment of how the target region is defined
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a second reading DIFFERING from the recorded value. Recorded: review — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: path integration and goal-directed navigation
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a second reading DIFFERING from the recorded value. Recorded: spatial navigation in rodents — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsextends → previous models in which parietal cortex mediates translation between external and first-person spatial representations (ref. 32)
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claim_relations[0]the tagger's words
claim_relationsbuilds-on → O'Keefe and Dostrovsky (1971) (ref. 4)
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claim_relations[1]the tagger's words
claim_relationscontradicts → the study reporting that rats with partial hippocampal lesions returned to the start position (ref. 30)
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claim_relations[2]the tagger's words
claim_relationsextends → models proposing that parietal cortex translates between external and first-person spatial representations
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claim_relations[3]1.0the tagger's words
claim_relationsqualifies → the study reporting intact path integration after partial hippocampal lesions
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claim_relations[4]1.0the tagger's words
claim_relationssupports → the cognitive map account of hippocampal place cells
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claim_relations[5]0.9the tagger's words
claim_relationssupports → the intention account of primate PPC delay activity
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claim_relations[6]1.0the tagger's words
concept_edgesgrid cells —distinct-from→ place cells
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differs in: THE AXIS IS DEPENDENCE ON THE PARTICULAR ENVIRONMENT. 'Quotation withheld.' Both are spatially tuned; only one re-maps, so a result obtained in a single environment cannot distinguish them at all - the distinction exists only across environments. · strength of the relation: 1 · note: grids keep relative geometry across environments; place fields do not
concept_edges[1]1.0the tagger's words
concept_edgesPPC —distinct-from→ somatosensory cortex
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strength of the relation: 1 · note: distinguished by which thalamic inputs it LACKS, plus callosal connections - definition by exclusion
concept_edges[3]1.0the tagger's words
content_tagsThe paper's central claim is that the posterior parietal cortex converts the world-centred position signal carried by place cells and grid cells into the body-centred coordinates that locomotion requires.
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content_tags.findings[0]the tagger's words
content_tagsRats with PPC lesions cannot return directly to a refuge on a curtained circular arena on the basis of their outbound movements.
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content_tags.findings[1]the tagger's words
content_tagsRat PPC cells fire for conjunctions of a particular movement with a particular place - for instance only during outward forward running, or only during left turns at the end of an arm.
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content_tags.findings[2]the tagger's words
content_tagsPPC firing fields rescale with the size of a maze segment even when hippocampal place fields do not, a dissociation implying PPC does not code perceived space.
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content_tags.findings[3]the tagger's words
content_tagsNo direct connections reach PPC from dentate gyrus, hippocampus or subiculum; the dorsal lateral band of medial entorhinal cortex projects to it directly.
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content_tags.findings[4]the tagger's words
content_tagsRetrosplenial cortex damage causes strong, lasting disruption of spatial navigation, in the water maze and in path integration back to a home base in darkness.
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content_tags.findings[5]the tagger's words
content_tagsthe entorhinal-hippocampal circuit alone cannot convert spatial information into goal-oriented motor output
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content_tags.findings[6]1.0the tagger's words
content_tagsa multiplicative mechanism is what is needed to translate the allocentric entorhinal representation into goal-directed movement
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content_tags.findings[7]1.0the tagger's words
content_tagsPPC cells are thought to form a distributed representation of movement plans or intentions toward specific goal locations
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content_tags.findings[8]1.0the tagger's words
content_tags77% of neurons in a medial PPC region responded to conjunctions of movement and location during virtual navigation
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content_tags.findings[9]1.0the tagger's words
content_tagsgrid fields keep their relative shift and rotation across environments, unlike place fields
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[10]1.0the tagger's words
content_tagsplace and grid firing persists without external cues but is anchored by them
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[11]1.0the tagger's words
content_tagsgrid cell
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also in: grid cell
content_tags.definitions[1]the tagger's words
content_tagscognitive map
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also in: cognitive map
content_tags.definitions[2]the tagger's words
content_tagsposterior parietal cortex (PPC)
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content_tags.definitions[3]the tagger's words
content_tagspath integration
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content_tags.definitions[4]the tagger's words
content_tagsparietal cortex
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[5]1.0the tagger's words
content_tagsPPC
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: PPC
content_tags.definitions[6]1.0the tagger's words
content_tagsplace field
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: place field
content_tags.definitions[7]1.0the tagger's words
content_tagsgrid
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: grid
content_tags.definitions[8]1.0the tagger's words
content_tags77% — proportion of medial-PPC neurons in monkeys responding to conjunctions of specific movements with specific locations during virtual navigation
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content_tags.quantities[0]the tagger's words
content_tags≈2–6 mm posterior to bregma and 2–5 mm lateral — stereotaxic extent of the rat cortical area targeted in most PPC lesion studies
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content_tags.quantities[1]the tagger's words
content_tagsabout 2 to 6 mm posterior to bregma and 2 to 5 mm lateral — where most rat PPC lesion studies have focused - compare Bucci2009, which gives 3.5 to 5.0 posterior and 1.0 or 1.5 to 5.0 lateral for the same region
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content_tags.quantities[2]1.0the tagger's words
content_tagsfour published delineations, in red, yellow, magenta and blue — the number of incompatible published boundaries for rat parietal cortex, drawn on one brain in Figure 3
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content_tags.quantities[3]1.0the tagger's words
content_tags77% — neurons responding to movement-location conjunctions in virtual navigation
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content_tags.quantities[4]1.0the tagger's words
content_tagsfour areas 7a, b, m and ip — the macaque subdivision whose applicability to rat is disputed
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content_tags.quantities[5]0.9the tagger's words
content_tagserror in initial heading
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content_tags.variables[1]0.8the tagger's words

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