Intelligibility in microbial complex systems: Wittgenstein and the score of life

Fernando Baquero, Andrés Moya · 2012 · philosophy-of-art · 10.3389/fcimb.2012.00088 · record intelligibility-in-microbial-complex-systems
tag layer · index · concepts · authors · עברית
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Other fields define these differently the same word, defined another way in another discipline
representation 47 fields · epistemology 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 29 concept tags on this paper, all 29 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
intelligibility complex systems representation score of life book of life music score musical score score music life genome genomic sequences metaphor epistemology family resemblances experience of meaning half-thinking, half-seeing legibility imageability major transition law of projection Chinese room proposition the will of life reductionism systems biology internal similarity facts world reading the score produces music generational representation conceptual-analysis
Method, as described: conceptual and epistemological analysis applying Wittgenstein's Tractatus (theorem 4.0141 on score/gramophone, the picture theory) and later Philosophical Investigations (family resemblance, experience of meaning), together with Schopenhauer, to the genome-as-score metaphor

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conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
unrecordable relationunhoused_relationsa relation the paper asserts that this vocabulary cannot express, with the reason

The paper

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claim_relations 6 · claim_type 1 · concept_edges 4 · concepts 29 · content_tags 10 · contribution 1 · limitations 5 · mechanisms 5 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 11 · unhoused_relations 5

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facettagfieldconf.whose words
object_of_studythe intelligibility of microbial (and biological) life: the epistemology of representing complex living systems, reframed through the metaphor of the genome as a 'score of life' rather than a 'book of life'
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object_of_studythe paper's words
research_questionhow to cross the epistemological gaps between the successive hierarchical levels of the complex system of life, and whether life can be rendered intelligible by reducing it to the genetic-genomic language
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research_questionthe paper's words
contributiona 'half-thinking, half-seeing' (HT-HS) strategy for complex biological systems: combining analysis of representations (genomes, scores) with a non-propositional experience of meaning, to move through legibility and imageability toward higher intelligibility
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contributionthe paper's words
claim_typecritique
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claim_typethe paper's words
phenomenonlife and music can be shown but not thought: their representations (genomes, musical scores) are mere representations of obscure realities, and diversification of knowledge paradoxically reduces intelligibility
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phenomenonthe paper's words
methodconceptual-analysis
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methodthe paper's words
mechanismsA general rule (the law of projection) lets an interpreter read a symphony out of a static score, and the same rule inverts to reconstruct the score from the sound on a gramophone record - the internal similarity that makes these transitions possible.
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mechanisms[0]0.9the tagger's words
mechanismsWittgenstein's rule of translation projects the symphony into the language of the musical score and translates that language into the gramophone record, and runs in reverse.
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mechanisms[1]0.9the tagger's words
mechanismsA collection of small parts assembles to produce a qualitatively different larger whole - groove-pattern to music, genes to a bacterial cell, cells to an ecological community.
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mechanisms[2]0.92the tagger's words
mechanismsReproduction of a bacterial organism or a string quartet depends entirely on its representation (genome or score), while the higher living level leads by selecting the representation.
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mechanisms[3]0.9the tagger's words
mechanismsUnderstanding a complex system combines analysis of its representation (half-thinking) with a non-propositional experience of meaning that can only be seen or shown (half-seeing).
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mechanisms[4]0.9the tagger's words
limitationsAnalysis of scores and genomic sequences yields mechanistic, phylogenetic and evolutionary insight, but not the real dynamics or nature of music and life, which remain unthinkable.
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limitations[0]0.9the tagger's words
limitationsFollowing Wittgenstein, the meaning of the word 'life' can only be shown, not understood, and consequently cannot be clearly expressed in propositions.
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limitations[1]0.9the tagger's words
limitationsIn the absence of correct interpretation, a music score cannot be differentiated from a random sequence of notes.
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limitations[2]0.88the tagger's words
limitationsSystems Biology models are insufficient by themselves for full intelligibility, because deducing models of function from a complex system's behaviour is an inverse problem that is impossible to solve.
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limitations[3]0.9the tagger's words
limitationsValidating models by comparing them with 'reality' may be a circular problem, since 'reality' can only be defined by models.
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limitations[4]0.9the tagger's words
conceptsintelligibility
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concepts[0]0.95the paper's words
conceptscomplex systems
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concepts[1]0.92the paper's words
conceptsrepresentation
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concepts[2]0.95the paper's words
conceptsscore of life
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also in: score of life
concepts[3]0.93the paper's words
conceptsbook of life
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also in: book of life
concepts[4]0.92the paper's words
conceptsmusic score
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: music score
concepts[5]0.92the paper's words
conceptsmusical score
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also in: musical score
concepts[6]0.9the paper's words
conceptsscore
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also in: score
concepts[7]0.9the paper's words
conceptsmusic
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: music
concepts[8]0.92the paper's words
conceptslife
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also in: life
concepts[9]0.93the paper's words
conceptsgenome
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also in: genome
concepts[10]0.92the paper's words
conceptsgenomic sequences
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concepts[11]0.9the paper's words
conceptsmetaphor
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also in: metaphor
concepts[12]0.9the paper's words
conceptsepistemology
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also in: epistemology
concepts[13]0.88the paper's words
conceptsfamily resemblances
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[14]0.9the paper's words
conceptsexperience of meaning
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concepts[15]0.9the paper's words
conceptshalf-thinking, half-seeing
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[16]0.9the paper's words
conceptslegibility
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also in: legibility
concepts[17]0.88the paper's words
conceptsimageability
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also in: imageability
concepts[18]0.88the paper's words
conceptsmajor transition
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concepts[19]0.9the paper's words
conceptslaw of projection
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concepts[20]0.9the paper's words
conceptsChinese room
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also in: Chinese room
concepts[21]0.88the paper's words
conceptsproposition
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also in: proposition
concepts[22]0.88the paper's words
conceptsthe will of life
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[23]0.85the paper's words
conceptsreductionism
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also in: reductionism
concepts[24]0.88the paper's words
conceptssystems biology
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concepts[25]0.88the paper's words
conceptsinternal similarity
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concepts[26]0.9the paper's words
conceptsfacts
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also in: facts
concepts[27]0.88the paper's words
conceptsworld
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: world
concepts[28]0.85the paper's words
unhoused_relationsrepresentation → reproduction
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A trans-hierarchical cyclic correlation ties representation to reproduction, produced blindly in both senses. — the relation stated: Representation and reproduction stand in a cyclic, blind, trans-hierarchical correlation.
unhoused_relations[0]0.9the tagger's words
unhoused_relationsmusic → the will of life
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
Reinterpreting Schopenhauer, the will represented in music is a representation of the will of life; a common will is independently perceived in both. — the relation stated: Music represents the will of life; a common will is shown in both.
unhoused_relations[1]0.85the tagger's words
unhoused_relationsgenome → life
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
The life of a particular bacterial organism is, to a certain extent, represented in the organization of its genome, as a Mozart quartet is represented in its score. — the relation stated: The genome represents the life of the organism, but subordinate to what is represented.
unhoused_relations[2]0.9the tagger's words
unhoused_relationslower levels → higher levels
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It is tempting to propose that the lower levels of the hierarchy blindly 'represent' the higher levels, though the higher levels categorically impose organisations on the lower. — the relation stated: Lower hierarchical levels blindly represent higher ones.
unhoused_relations[3]0.85the tagger's words
unhoused_relationsscore → genetic language
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
In the central analogy, reading the score corresponds to reading the genetic language, producing music as reading the genome produces life. — the relation stated: The music score is the analogue of the genetic language.
unhoused_relations[4]0.88the tagger's words
sensesreading - human/sequential sense: a text read in one way only, sequentially, involving all characters
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senses[0]0.92the tagger's words
sensesreading - cellular/genomic sense: genetic texts 'read' by cellular mechanisms in several different ways, each using a different selection of characters while skipping others
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senses[1]0.92the tagger's words
sensesintelligibility - linguistic-theory sense: the trade-off between hierarchical levels in a shared world (Komarova and Niyogi)
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senses[2]0.9the tagger's words
sensesintelligibility - the authors' epistemological sense: the construction of meaningful (thinkable) models reflecting complex natural systems
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senses[3]0.9the tagger's words
sensesrepresentation - Wittgenstein's picture sense: a proposition/picture sharing a logical form with the fact it represents
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senses[4]0.9the tagger's words
sensesrepresentation - Schopenhauer's sense: music as a copy of the will itself, resembling an original reality that cannot be copied
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senses[5]0.88the tagger's words
sensesrepresentation - biological sense: genomic sequences representing life, meaningful only when a living system is present
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senses[6]0.9the tagger's words
sensesscore - musical sense: the notation from which a symphony can be reconstructed by a general rule (Tractatus 4.0141)
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senses[7]0.9the tagger's words
sensesscore - 'score of life' sense: the genomic language, proposed as a better image than the book of life
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senses[8]0.9the tagger's words
senseswill - Schopenhauer's metaphysical sense: the will itself, of which music is a copy and the Ideas its objectivity
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senses[9]0.85the tagger's words
sensesharmony - sensibility-relative sense: an ordered score follows rules of harmony, yet that harmony may be totally useless for a different sensibility and out of any aesthetic possibility
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senses[10]0.85the tagger's words
claim_relationsbuilds-on → Wittgenstein's Tractatus logico-philosophicus (theorem 4.0141 and the picture theory of representation)
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note: The essay takes the Tractatus as its main post-Kantian framework for the limits of knowledge of the natural world.
claim_relations[0]0.95the tagger's words
claim_relationsbuilds-on → Schopenhauer's account of music as a copy of the will (The World as Will and Representation)
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note: The will represented in music is read as a representation of the will of life.
claim_relations[1]0.9the tagger's words
claim_relationsextends → Dennis Noble's 'music of life' metaphor
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note: The essay extends Noble's music-of-life idea to the intelligibility of microbial life.
claim_relations[2]0.92the tagger's words
claim_relationsbuilds-on → Maynard Smith and Szathmary's theory of major evolutionary transitions
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note: Major transitions between hierarchical levels frame the score-to-music and genes-to-life passages.
claim_relations[3]0.9the tagger's words
claim_relationscontrasts-with → the classic 'book of life' metaphor for the genome
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note: The 'score of life' is proposed as a better image of the genomic language.
claim_relations[4]0.92the tagger's words
claim_relationsrecommends → developing complex models of complex systems through convergent, multidisciplinary 'Big Science'
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note: The half-seeing part needs more powerful model tools integrating all the -omics data.
claim_relations[5]0.88the tagger's words
concept_edgeslife —is-a→ music
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the relation itself is separately evidenced · strength of the relation: 0.6 — the record marks this weak · note: Figurative is-a via Noble's metaphor ('a kind of music'); low weight marks the hedge. · the relation stated: Quoting Noble, life is figuratively cast as a kind of music - a symphonic interplay between genes, cells, organs, body and environment. Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span quotes a metaphor ('a kind of music'); is-a states it literally.
also in: life · music
concept_edges[0]0.8the tagger's words
concept_edgesmusic score —causes→ music
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the relation itself is separately evidenced · strength of the relation: 0.85 · note: Positive production ('gives rise to'); conditional on interpretation, hence not fully flat. · the relation stated: The music score gives rise to music, but only when an interpreter is available to read the notation and convert it into sounds. Audit 2026-09-28: RESTORED AND DOUBTFUL - the full span was re-read; kept, but the full span says 'the music score gives rise to music only if interpreters are available' - the relation is stated but only on that condition, which the edge drops; the withdrawal said the span does not say a score causes music. The earlier withdrawal is kept in the record.
also in: music score · music
concept_edges[1]0.85the tagger's words
concept_edgesfacts —part-of→ world
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the relation itself is separately evidenced · strength of the relation: 1 · note: Flat categorical composition stated as a Tractatus theorem (the world constituted by the totality of facts). · the relation stated: On Wittgenstein's theorem 1.1 Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span is about propositions; part-of 'world' is loose.
also in: facts · world
concept_edges[2]0.9the tagger's words
concept_edgesscore of life —contrasted-with→ book of life
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
the relation itself is separately evidenced · strength of the relation: 0.85 · note: Differentiator stated: sequential single reading versus multiple simultaneous cellular readings. · the relation stated: The 'score of life' is contrasted with the classic 'book of life': human texts are read one way only and sequentially, whereas genetic texts are read by cellular mechanisms in several different ways. Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the 'score of life' 'could be a better image'; hedged.
concept_edges[3]0.85the tagger's words
content_tagsIncreasing diversification and complexity in microbiology paradoxically results in a strong reduction of the intelligibility of microbial life.
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content_tags.findings[0]0.9the tagger's words
content_tagsThe 'score of life' is a better image of the genomic language than the classic 'book of life', because genetic texts are read by cellular mechanisms in several different ways rather than sequentially.
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content_tags.findings[1]0.9the tagger's words
content_tagsBoth life and music can be shown but not thought; genomic sequences and musical scores are mere representations of these obscure realities.
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content_tags.findings[2]0.9the tagger's words
content_tagsA strategy of half-thinking and half-seeing is needed to expand knowledge of complex systems such as life and music.
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content_tags.findings[3]0.9the tagger's words
content_tagsThe epistemological process for complex biological systems has three phases: legibility, imageability, and intelligibility.
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content_tags.findings[4]0.9the tagger's words
content_tagsthe construction of meaningful (thinkable) models in response to the assimilation of knowledge, able to reflect to some extent the reality of complex natural systems
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content_tags.definitions[0]0.92the tagger's words
content_tagsa series of staves on which all the instrumental and/or vocal parts of a musical work are written in vertical alignment so the parts may be read simultaneously
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also in: score
content_tags.definitions[1]0.95the tagger's words
content_tagsthe descriptive level of anatomy and physiology - the composition of Wittgensteinian atomic facts and propositions
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also in: legibility
content_tags.definitions[2]0.88the tagger's words
content_tagsthe stage at which a holistic, physiognomically comparable image of a living structure can be seen or shown
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also in: imageability
content_tags.definitions[3]0.88the tagger's words
content_tagsa half-thinking perception of fine shades of meaning - a kinship between seeing an aspect and understanding that enables connections and comparisons
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content_tags.definitions[4]0.9the tagger's words

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