Intelligibility in microbial complex systems: Wittgenstein and the score of life — TEI-tagged view

Fernando Baquero, Andrés Moya · 2012 · philosophy-of-art · doi:10.3389/fcimb.2012.00088 · TEI xml · tagged edition · index · concepts · authors
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Other fields define these differently the same word, defined another way in another discipline
representation 47 fields · epistemology 2 fields
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intelligibility3 complex systems representation17 score of life book of life music score musical score score2 music4 life genome3 genomic sequences metaphor2 epistemology3 family resemblances experience of meaning half-thinking, half-seeing legibility imageability3 major transition law of projection Chinese room proposition the will of life reductionism2 systems biology internal similarity facts world conceptual-analysis217
Method, as described: conceptual and epistemological analysis applying Wittgenstein's Tractatus (theorem 4.0141 on score/gramophone, the picture theory) and later Philosophical Investigations (family resemblance, experience of meaning), together with Schopenhauer, to the genome-as-score metaphor

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Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenonlife and music can be shown but not thought: their representations (genomes, musical scores) are mere representations of obscure realities, and diversification of knowledge paradoxically reduces intelligibility— “Therefore, neither from the outside, in which life can only be shown (and even that, without certitude), nor from the inside (life is invisible for life-determining structures), life seems to be thinkable. “We feel that even if all possible scientific questions be answered, the problems of life have still not been touched at all. Of course…
claim-typecritique— “In the way of thinking of Ludwig Wittgenstein, and even more sharply in his friend and commenter, Moritz Schlick (Schlick, 1936 ), the meaning of the word “life” can only be shown , not understood and consequently not clearly expressed in propositions. It might sound paradoxical to attach to this statement in the age of glory of genomics…
method — evidence— “The Ludwig Wittgenstein's “ Tractatus logico-philosophicus ,” published in English in 1922 under the guidance of Bertrand Russell, is widely recognized as one of the main post-kantian approaches devoted to explore the possibilities of human knowledge of natural world (Wittgenstein, 1921 ). In its theorem 4.0141, Wittgenstein compares…
object of study — evidence— “Knowledge in microbiology is reaching an extreme level of diversification and complexity, which paradoxically results in a strong reduction in the intelligibility of microbial life. In our days, the “score of life” metaphor is more accurate to express the complexity of living systems than the classic “book of life.” Music and life can be…
research question — evidence— “Life is a highly complex system, including the most complex objects in the known universe (Bedau, 1996 ). The genomics revolution has catapulted molecular biology, and particularly microbiology (Westerhoff and Palsson, 2004 ), into the realms of systems biology approaches to complex systems. Such a trend was based on the growing compelling…
contribution — evidence— “Of course the musical metaphor is exploited by the later Wittgenstein of “Last writings on the Philosophy of Psychology” in an identical sense (Wittgenstein, 1949–1951 ; Worth, 1997 ). Music results from a complex dynamic interplay of elements, has not a clear semantic structure and, as the face, produces effects, an experience of meaning…
mechanismreading the score produces music A general rule (the law of projection) lets an interpreter read a symphony out of a static score, and the same rule inverts to reconstruct the score from the sound on a gramophone record - the internal similarity that makes these transitions possible.— “In the fact that there is a general rule by which the musician is able to read the symphony out of the score, and that there is a rule by which one could reconstruct the symphony from the line on a gramophone record and from this again—by means of the first rule—construct the score, herein lies the internal similarity between these things…mechanisms[0]
mechanismlaw of projection Wittgenstein's rule of translation projects the symphony into the language of the musical score and translates that language into the gramophone record, and runs in reverse.— “In the fact that there is a general rule by which the musician is able to read the symphony out of the score, and that there is a rule by which one could reconstruct the symphony from the line on a gramophone record and from this again—by means of the first rule—construct the score, herein lies the internal similarity between these things…mechanisms[1]
mechanismmajor transition A collection of small parts assembles to produce a qualitatively different larger whole - groove-pattern to music, genes to a bacterial cell, cells to an ecological community.— “Between the groove pattern and the music there is a “major transition,” essentially a qualitative transition. Similarly, between the genes and the life of a bacterial cell, or between cells and the complex living expressions of an ecologically-integrated community of cells, there are major transitions, as those identified by Maynard Smith and…mechanisms[2]
mechanismgenerational representation Reproduction of a bacterial organism or a string quartet depends entirely on its representation (genome or score), while the higher living level leads by selecting the representation.— “The continuous interplay between hierarchical levels is a trade-mark of life (Campbell, 1974 ). Some kind of unity based on reciprocal trans-hierarchical effects occurs there between what is represented and the representation itself. Indeed it is easy to imagine that the life of a particular bacterial organism is to a certain extent…mechanisms[3]
mechanismhalf-thinking, half-seeing Understanding a complex system combines analysis of its representation (half-thinking) with a non-propositional experience of meaning that can only be seen or shown (half-seeing).— “Of course the musical metaphor is exploited by the later Wittgenstein of “Last writings on the Philosophy of Psychology” in an identical sense (Wittgenstein, 1949–1951 ; Worth, 1997 ). Music results from a complex dynamic interplay of elements, has not a clear semantic structure and, as the face, produces effects, an experience of meaning…mechanisms[4]
builds-on Wittgenstein's Tractatus logico-philosophicus (theorem 4.0141 and the picture theory of representation)— “The Ludwig Wittgenstein's “ Tractatus logico-philosophicus ,” published in English in 1922 under the guidance of Bertrand Russell, is widely recognized as one of the main post-kantian approaches devoted to explore the possibilities of human knowledge of natural world (Wittgenstein, 1921 ). In its theorem 4.0141, Wittgenstein compares…claim_relations[0]
builds-on Schopenhauer's account of music as a copy of the will (The World as Will and Representation)— “This simultaneous experimentability and unthinkability of music was analyzed in detail by Arthur Schopenhauer, in one of the…claim_relations[1]
extends Dennis Noble's 'music of life' metaphor
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builds-on Maynard Smith and Szathmary's theory of major evolutionary transitions
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contrasts-with the classic 'book of life' metaphor for the genome
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recommends developing complex models of complex systems through convergent, multidisciplinary 'Big Science'
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sensereading - human/sequential sense: a text read in one way only, sequentially, involving all characters
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senses[0]
sensereading - cellular/genomic sense: genetic texts 'read' by cellular mechanisms in several different ways, each using a different selection of characters while skipping others
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senses[1]
senseintelligibility - linguistic-theory sense: the trade-off between hierarchical levels in a shared world (Komarova and Niyogi)
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senses[2]
senseintelligibility - the authors' epistemological sense: the construction of meaningful (thinkable) models reflecting complex natural systems
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senses[3]
senserepresentation - Wittgenstein's picture sense: a proposition/picture sharing a logical form with the fact it represents
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senses[4]
senserepresentation - Schopenhauer's sense: music as a copy of the will itself, resembling an original reality that cannot be copied
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senses[5]
senserepresentation - biological sense: genomic sequences representing life, meaningful only when a living system is present
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senses[6]
sensescore - musical sense: the notation from which a symphony can be reconstructed by a general rule (Tractatus 4.0141)
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senses[7]
sensescore - 'score of life' sense: the genomic language, proposed as a better image than the book of life
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senses[8]
sensewill - Schopenhauer's metaphysical sense: the will itself, of which music is a copy and the Ideas its objectivity
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senses[9]
senseharmony - sensibility-relative sense: an ordered score follows rules of harmony, yet that harmony may be totally useless for a different sensibility and out of any aesthetic possibility
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senses[10]
noteWittgenstein's Tractatus logico-philosophicus (theorem 4.0141 and the picture theory of representation) — The essay takes the Tractatus as its main post-Kantian framework for the limits of knowledge of the natural world.
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weightWittgenstein's Tractatus logico-philosophicus (theorem 4.0141 and the picture theory of representation) — 0.9
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noteSchopenhauer's account of music as a copy of the will (The World as Will and Representation) — The will represented in music is read as a representation of the will of life.
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weightSchopenhauer's account of music as a copy of the will (The World as Will and Representation) — 0.85
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noteDennis Noble's 'music of life' metaphor — The essay extends Noble's music-of-life idea to the intelligibility of microbial life.
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weightDennis Noble's 'music of life' metaphor — 0.85
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noteMaynard Smith and Szathmary's theory of major evolutionary transitions — Major transitions between hierarchical levels frame the score-to-music and genes-to-life passages.
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weightMaynard Smith and Szathmary's theory of major evolutionary transitions — 0.9
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notethe classic 'book of life' metaphor for the genome — The 'score of life' is proposed as a better image of the genomic language.
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weightthe classic 'book of life' metaphor for the genome — 0.85
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notedeveloping complex models of complex systems through convergent, multidisciplinary 'Big Science' — The half-seeing part needs more powerful model tools integrating all the -omics data.
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weightdeveloping complex models of complex systems through convergent, multidisciplinary 'Big Science' — 0.85
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auditlife —is-a→ music — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span quotes a metaphor ('a kind of music'); is-a states it literally.
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concept_edges[0]
notelife —is-a→ music — Figurative is-a via Noble's metaphor ('a kind of music'); low weight marks the hedge.
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relationlife —is-a→ music — Quoting Noble, life is figuratively cast as a kind of music - a symphonic interplay between genes, cells, organs, body and environment.
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weightlife —is-a→ music — 0.6
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concept_edges[0]
auditmusic score —causes→ music — Audit 2026-09-28: RESTORED AND DOUBTFUL - the full span was re-read; kept, but the full span says 'the music score gives rise to music only if interpreters are available' - the relation is stated but only on that condition, which the edge drops; the withdrawal said the span does not say a score causes music. The earlier withdrawal is kept in the record.
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notemusic score —causes→ music — Positive production ('gives rise to'); conditional on interpretation, hence not fully flat.
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relationmusic score —causes→ music — The music score gives rise to music, but only when an interpreter is available to read the notation and convert it into sounds.
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weightmusic score —causes→ music — 0.85
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auditfacts —part-of→ world — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span is about propositions; part-of 'world' is loose.
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notefacts —part-of→ world — Flat categorical composition stated as a Tractatus theorem (the world constituted by the totality of facts).
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relationfacts —part-of→ world — On Wittgenstein's theorem 1.1
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concept_edges[2]
auditscore of life —contrasted-with→ book of life — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the 'score of life' 'could be a better image'; hedged.
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concept_edges[3]
notescore of life —contrasted-with→ book of life — Differentiator stated: sequential single reading versus multiple simultaneous cellular readings.
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relationscore of life —contrasted-with→ book of life — The 'score of life' is contrasted with the classic 'book of life': human texts are read one way only and sequentially, whereas genetic texts are read by cellular mechanisms in several different ways.
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concept_edges[3]
weightscore of life —contrasted-with→ book of life — 0.85
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concept_edges[3]
relationrepresentation → reproduction — Representation and reproduction stand in a cyclic, blind, trans-hierarchical correlation.
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unhoused_relations[0]
weightrepresentation → reproduction — 0.7
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unhoused_relations[0]
relationmusic → the will of life — Music represents the will of life; a common will is shown in both.
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weightmusic → the will of life — 0.6
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unhoused_relations[1]
relationgenome → life — The genome represents the life of the organism, but subordinate to what is represented.
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weightgenome → life — 0.8
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unhoused_relations[2]
relationlower levels → higher levels — Lower hierarchical levels blindly represent higher ones.
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weightlower levels → higher levels — 0.5
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unhoused_relations[3]
relationscore → genetic language — The music score is the analogue of the genetic language.
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weightscore → genetic language — 0.7
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unhoused_relations[4]
no type for thisrepresentation → reproduction — A trans-hierarchical cyclic correlation ties representation to reproduction, produced blindly in both senses.
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unhoused_relations[0]
no type for thismusic → the will of life — Reinterpreting Schopenhauer, the will represented in music is a representation of the will of life; a common will is independently perceived in both.
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unhoused_relations[1]
no type for thisgenome → life — The life of a particular bacterial organism is, to a certain extent, represented in the organization of its genome, as a Mozart quartet is represented in its score.
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unhoused_relations[2]
no type for thislower levels → higher levels — It is tempting to propose that the lower levels of the hierarchy blindly 'represent' the higher levels, though the higher levels categorically impose organisations on the lower.
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unhoused_relations[3]
no type for thisscore → genetic language — In the central analogy, reading the score corresponds to reading the genetic language, producing music as reading the genome produces life.
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unhoused_relations[4]
limitationAnalysis of scores and genomic sequences yields mechanistic, phylogenetic and evolutionary insight, but not the real dynamics or nature of music and life, which remain unthinkable.
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limitations[0]
limitationFollowing Wittgenstein, the meaning of the word 'life' can only be shown, not understood, and consequently cannot be clearly expressed in propositions.
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limitations[1]
limitationIn the absence of correct interpretation, a music score cannot be differentiated from a random sequence of notes.
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limitations[2]
limitationSystems Biology models are insufficient by themselves for full intelligibility, because deducing models of function from a complex system's behaviour is an inverse problem that is impossible to solve.
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limitations[3]
limitationValidating models by comparing them with 'reality' may be a circular problem, since 'reality' can only be defined by models.
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limitations[4]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingIncreasing diversification and complexity in microbiology paradoxically results in a strong reduction of the intelligibility of microbial life.
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content_tags.findings[0]
findingThe 'score of life' is a better image of the genomic language than the classic 'book of life', because genetic texts are read by cellular mechanisms in several different ways rather than sequentially.
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content_tags.findings[1]
findingBoth life and music can be shown but not thought; genomic sequences and musical scores are mere representations of these obscure realities.
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content_tags.findings[2]
findingA strategy of half-thinking and half-seeing is needed to expand knowledge of complex systems such as life and music.
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content_tags.findings[3]
findingThe epistemological process for complex biological systems has three phases: legibility, imageability, and intelligibility.
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content_tags.findings[4]
definitionintelligibility
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content_tags.definitions[0]
definitionscore
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content_tags.definitions[1]
definitionlegibility
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content_tags.definitions[2]
definitionimageability
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content_tags.definitions[3]
definitionexperience of meaning
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content_tags.definitions[4]
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
conceptintelligibility — not defined in this paper's own words; the possibility of trans-hierarchical understanding; the authors' sense is the construction of thinkable models of complex natural systems
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concepts[0]
conceptcomplex systems — not defined in this paper's own words; systems such as life or music, composed of thinkable and only showable parts
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concepts[1]
conceptrepresentation — not defined in this paper's own words; a picture/model corresponding to what is represented, necessarily at a different hierarchical level
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[2]
conceptscore of life — not defined in this paper's own words; the genome reconceived as a musical score rather than a book - a better image of the genomic language
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[3]
conceptbook of life — not defined in this paper's own words; the classic metaphor of the genome as a text/book, read sequentially
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[4]
conceptmusic score — not defined in this paper's own words; the static written notation that gives rise to music only through an interpreter
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[5]
conceptmusical score — not defined in this paper's own words; the series of staves projecting a symphony into a readable language (Tractatus 4.0141)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[6]
conceptscore — not defined in this paper's own words; written notation, musical or genomic - a static representation read to reproduce music or life
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[7]
conceptmusic — not defined in this paper's own words; a dynamic phenomenon that can be shown but not thought; the lower-hierarchy analogue of life
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[8]
conceptlife — not defined in this paper's own words; a highly complex, dynamic system that, following Wittgenstein, can only be shown, not thought
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[9]
conceptgenome — not defined in this paper's own words; the genetic-genomic sequence representing a living system, meaningful only when that system is present
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[10]
conceptgenomic sequences — not defined in this paper's own words; lower-level representations of life, analogous to music scores
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[11]
conceptmetaphor — not defined in this paper's own words; a non-logical epistemological aid scientists use to think about reality
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[12]
conceptepistemology — not defined in this paper's own words; the sound grounding that is a prerequisite for modern biology
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[13]
conceptfamily resemblances — not defined in this paper's own words; the kinship, revealed in a face, between seeing an aspect and the experience of meaning
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[14]
conceptexperience of meaning — not defined in this paper's own words; a half-thinking perception of fine shades of meaning enabling connection and comparison
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[15]
concepthalf-thinking, half-seeing — not defined in this paper's own words; the HT-HS strategy combining analysis of representations with non-propositional seeing
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[16]
conceptlegibility — not defined in this paper's own words; the descriptive level of anatomy/physiology; composition of atomic facts and propositions
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[17]
conceptimageability — not defined in this paper's own words; the stage of a holistic, comparable image of a living structure that can be seen or shown
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[18]
conceptmajor transition — not defined in this paper's own words; a qualitative transition where small parts assemble into a different larger whole (Maynard Smith and Szathmary)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[19]
conceptlaw of projection — not defined in this paper's own words; Wittgenstein's rule projecting a symphony into the language of the musical score and back
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[20]
conceptChinese room — not defined in this paper's own words; Searle's situation - an intermediary produces correct responses in an unknown language by rules, without understanding, like a score or genome unaware of its function
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[21]
conceptproposition — not defined in this paper's own words; a model of reality; a description of a fact, having sense rather than meaning
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[22]
conceptthe will of life — not defined in this paper's own words; Schopenhauer's will as the obscure dynamics of life, of which music is a representation
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[23]
conceptreductionism — not defined in this paper's own words; the question whether understanding life reduces to understanding the genetic-genomic language
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[24]
conceptsystems biology — not defined in this paper's own words; a computational integrative approach to complex systems, insufficient by itself for full intelligibility
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[25]
conceptinternal similarity — not defined in this paper's own words; the shared structure between a representation (score, groove) and what it reproduces, despite surface difference
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[26]
conceptfacts — not defined in this paper's own words; the totality of which constitutes the world (Tractatus 1.1), not things
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[27]
conceptworld — the totality of facts, not of things
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[28]

When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

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