Inhibition-induced theta resonance in cortical circuits

Stark, Eichler, Roux, Fujisawa, Rotstein, Buzsáki · Neuron · 2013 · neuroscience · 10.1016/j.neuron.2013.09.033 · record stark2013-inhibition-induced-theta-resonance
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Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. Extraction is PMC HTML, so citation brackets carry extra spaces (e.g. '( Stark et al., 2012 )') and the subscript current is rendered 'I h'; quotes preserve that spacing exactly. The paper also contains a biophysical simulation (Figure 8) alongside the recordings, but the primary method statement is the in vivo extracellular recording plus optogenetics, so method is 'electrophysiology'. The paper contrasts its wide-band in vivo result with in vitro subthreshold-resonance work (Leung and Yu, 1998; Hu et al., 2002 and others) but the contrast sentence itself does not name those works, so no contradicts/extends relation was recorded for it. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of th 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
adaptation 2 fields · cell type 2 fields · coherence 2 fields · white-noise 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 30 concept tags on this paper, 1 are grounded in a quoted sentence. All carry the tagger's gloss of what the term means in this paper, which is not something the article can license.
resonance subthreshold resonance spiking resonance theta PYR PV INT HCN1 I h ZD7288 ChR2 CaMKII chirp white-noise coherence theta-index ZD-index gain rebound CA1 neocortical OLM synaptic depression band-pass filter low-pass filter frequency correlation time correlation adaptation LFP diode-probe periodic PV inhibition hyperpolarizes pyramidal cells, activating HCN/Ih channels whose deinactivation produces time-locked post-inhibitory rebound spikes at theta frequency rebound spiking of a fixed latency after release from inhibition acts as a band-pass filter on the inhibitory input frequency at high input frequencies dense PV spiking tonically suppresses targets while at low frequencies gaps in inhibition let pyramidal cells fire, which alone acts as a low-pass filter short-term depression of the inhibitory synapse weakens hyperpolarization at low input frequencies, removing the drive for Ih activation and so suppressing sub-theta rebound PV interneurons of the active assembly suppress competing cells, and release from that inhibition triggers rebound spikes that seed the next cell assembly on the opposite theta phase spiking gain cell type chirp direction light intensity baseline rate Kolmogorov-Smirnov test Kolmogorov-Smirnov test with a uniform null permutation test permutation test with a zero correlation null chi-squared test Mann-Whitney U test Mann-Whitney U-test Kruskal-Wallis test Kruskal-Wallis test corrected for multiple comparisons Wilcoxon signed-rank test Wilcoxon’s paired signed-rank test t-test Bonferroni-corrected paired t-test rank correlation Poisson test Rayleigh test binomial test exact Binomial test circular-linear correlation spectral coherence (multi-taper estimate) multi-taper coherence standard error of the mean linear regression with R-squared U-test electrophysiology

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relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
contributioncontributionwhat the paper claims to add
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
object of studyobject_of_studywhat the paper is about — the thing it investigates
phenomenonphenomenonthe effect or regularity under study
research questionresearch_questionthe question the paper sets itself
sensesensesa distinct use of a term, quoted where the paper fixes it
transfertransfersa method or concept carried in from another field

The paper

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Every tag on this page

alternatives 3 · claim_relations 7 · claim_type 1 · concept_edges 11 · concepts 1 · content_tags 93 · contribution 1 · controls 1 · limitations 10 · mechanisms 11 · method 1 · object_of_study 1 · phenomenon 1 · research_question 1 · senses 7 · transfers 2

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 11 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
object_of_studywhether the theta-band resonance seen in the membrane potential in vitro appears in the spiking of the same cells in a behaving animal
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object_of_studythe paper's words
research_questionwhether and how subthreshold resonance is translated to the spiking regime in behaving animals
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research_questionthe paper's words
contributionspiking resonance at theta is not intrinsic to the pyramidal cell but is conferred on it by rhythmic PV inhibition, and it requires HCN currents
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contributionthe paper's words
claim_typemechanism
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claim_typethe paper's words
phenomenontheta-band spiking resonance in cortical pyramidal cells
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
mechanismsmechanisms
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mechanisms[2]the tagger's words
mechanismsmechanisms
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mechanisms[3]the tagger's words
mechanismsmechanisms
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status: the paper's own words: We hypothesize that
mechanisms[4]the tagger's words
mechanismsthe inductive effects of the hyperpolarization-activated current create a negative feedback that opposes voltage changes, and that feedback is what creates resonance
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mechanisms[5]1.0the tagger's words
mechanismsa low-pass account is available too: dense PV spiking tonically suppresses targets at high frequencies while low frequencies leave windows in which pyramidal cells can still fire
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mechanisms[6]1.0the tagger's words
mechanismsHCN alone gives rebound at sub-theta frequencies as well, so a timing mechanism is needed to suppress the low end and turn a low-pass into a band-pass
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mechanisms[7]1.0the tagger's words
mechanismsan OLM interneuron released from inhibition just in time can block the low-frequency rebound, which is one way to implement that timing mechanism
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mechanisms[8]1.0the tagger's words
mechanismsdepression of the inhibitory synapses is the other way: at low input frequencies the presynaptic rate is higher, the synapses depress, and the hyperpolarisation that would drive HCN is reduced
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mechanisms[9]1.0the tagger's words
mechanismsPV cells themselves show no frequency preference, which is consistent with basket cells lacking the current that produces it
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mechanisms[10]1.0the tagger's words
limitationsThe pharmacological result shows Ih is necessary but not sufficient for theta spiking resonance
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what this limits: the Ih result: THE PHARMACOLOGICAL EXPERIMENTS ESTABLISHED THE REQUIREMENT OF Ih FOR THETA-BAND SPIKING RESONANCE BUT NOT ITS SUFFICIENCY
limitations[0]the tagger's words
limitationsHCN channels are not the whole story; further mechanisms may sharpen the resonance in intact networks
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what this limits: the HCN account as complete: further mechanisms may sharpen the resonance in the intact network beyond the CRITICAL ROLE OF HCN CHANNELS the experiments support
limitations[1]the tagger's words
limitationsThe proposed assembly-seeding function of rebound spikes is acknowledged as speculative
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what this limits: the assembly-seeding hypothesis: WHILE SPECULATIVE, THIS HYPOTHESIS IS COMPATIBLE WITH ALL KNOWN OBSERVATIONS ON PUTATIVE BASKET NEURONS
limitations[2]the tagger's words
limitationsthe blockade establishes that HCN is required and explicitly not that it is sufficient
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what this limits: the same scope as limitations[0], with the response: TO INVESTIGATE WHETHER Ih ALONE IS SUFFICIENT, WE CONSTRUCTED A BIOPHYSICAL MODEL
limitations[3]1.0the tagger's words
limitationsfurther mechanisms beyond HCN are expected to sharpen the resonance in the intact network
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what this limits: the same scope as limitations[1] - HCN is critical but not the whole mechanism
limitations[4]1.0the tagger's words
limitationsthe assembly-seeding account of the rebound spikes is labelled speculative by the authors
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duplicate of: limitations[2] · what this limits: the same scope as limitations[2] - the rebound-spike account is labelled speculative
limitations[5]1.0the tagger's words
limitationsa gain-baseline correlation is offered with its own artefactual reading, a spiking rate ceiling
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what this limits: the gain-baseline correlation: PRESUMABLY DUE TO a ceiling on spiking rate, not a property of the circuit (RANK CORRELATION -0.31; n=110; p<0.001)
limitations[6]1.0the tagger's words
limitationsa coherence-baseline correlation is likewise offered as possibly a floor effect, since silent cells cannot be suppressed further
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what this limits: the coherence-baseline correlation: THIS INCREASED COHERENCE MAY SIMPLY BE A FLOOR EFFECT AS SILENT CELLS CANNOT BE coherent (RANK CORRELATION 0.31; p=0.003)
limitations[7]1.0the tagger's words
limitationsthe number of interneurons actually illuminated is an estimate spanning an order of magnitude
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what this limits: the size of the manipulation: THE WEAK FOCAL PHOTOSTIMULATION AFFECTED AN ESTIMATED 2-20 PV INTERNEURONS, an order-of-magnitude range
limitations[8]1.0the tagger's words
limitationshalf the recorded units were classified by waveform rather than by tagging, and low-confidence ones were dropped
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what this limits: half the recorded units: NON-TAGGED UNITS (692 OF 1413, 51%) ARE CLASSIFIED AS PUTATIVE PYRAMIDAL CELLS (PYR) OR INTERNEURONS (INT) ACCORDING TO WAVEFORM MORPHOLOGY
limitations[9]1.0the tagger's words
transfersthe chirp - a linear frequency sweep - used as a stimulus to read a biological system's frequency response
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transfers[0]1.0the tagger's words
transferslow-pass filter and band-pass filter as the names for the two candidate explanations of the same band-limited discharge
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transfers[1]1.0the tagger's words
controlsthe inhibition-induced theta-band spiking reproduced in a pyramidal cell-interneuron model that included the I_h current
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eliminates: an in-vivo result with no mechanism behind it - the model has only the components the explanation names, so if the effect appears there it does not need anything else · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
conceptsgain
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also in: gain
concepts[17]0.85the paper's words
sensesresonance here is defined generically as amplification in a limited frequency band, which is what lets the same word cover a membrane potential effect and a spiking effect that this paper shows come apart
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senses[0]1.0the tagger's words
sensessubthreshold and suprathreshold resonance are separate claims: the first is established in vitro, the second is what this paper asks about, and directly-driven pyramidal cells do NOT show the second
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senses[1]1.0the tagger's words
sensesINT is defined by a NEGATIVE result - interneurons NOT driven by the light - so the class is an outcome of the manipulation rather than a cell type, and the authors say some of them are probably PV cells that the light missed
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senses[2]1.0the tagger's words
sensesthe opsin's specificity and sensitivity are measured separately: every labelled cell was PV, but 10 percent of PV cells were unlabelled
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senses[3]1.0the tagger's words
sensesa well-isolated unit is defined by three explicit numerical thresholds on amplitude, cluster quality and refractory violations
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senses[4]1.0the tagger's words
sensesthe theta index is a ratio to the cell's own broadband coherence, so it equals 1 under no bias - the measure carries its own null
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senses[5]1.0the tagger's words
sensesthe ZD-index is a normalised difference between control and drug coherence, built so that the drug effect can be shown to be specific to a frequency band and a cell type rather than global
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senses[6]1.0the tagger's words
alternativesclaim_type: mechanism
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a second reading reaching the same value. Recorded: mechanism — note: a second reading reaching the same value from a different sentence. Not applied - a person decides.
alternatives.claim_typethe tagger's words
alternativesmethod: optogenetic chirp and white-noise stimulation through multi-shank diode-probes with extracellular unit recording, an HCN channel blocker, and a two-cell biophysical model
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a second reading DIFFERING from the recorded value. Recorded: electrophysiology — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.methodthe tagger's words
alternativesphenomenon: excess post-inhibitory spiking of pyramidal cells confined to the theta band when PV interneurons are driven rhythmically
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a second reading DIFFERING from the recorded value. Recorded: theta-band spiking resonance in cortical pyramidal cells — note: a second reading, verbatim-verified, disagreeing with the value on the record. Not applied - a person decides.
alternatives.phenomenonthe tagger's words
claim_relationsbuilds-on → Zemankovics et al., 2010 (lack of Ih in basket cells)
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claim_relations[0]the tagger's words
claim_relationsreplicates → Stark et al., 2012 (local activation by the light cone of diode-probes)
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claim_relations[1]the tagger's words
claim_relationsqualifies → the in vitro finding of theta-band subthreshold resonance in cortical principal neurons under intracellular sinusoidal injection
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claim_relations[2]1.0the tagger's words
claim_relationsbuilds-on → Cobb 1995's demonstration that basket cell burst discharge induces rebound spikes after release from hyperpolarization in vitro
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claim_relations[3]0.8the tagger's words
claim_relationsextends → the account of theta generation as a consortium of septal pacemaker, circuit interactions and intrinsic neuronal properties
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claim_relations[4]0.9the tagger's words
claim_relationssupports → an HCN-mediated mechanism for post-hyperpolarization rebound spiking
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claim_relations[5]1.0the tagger's words
claim_relationscritiques → the use of grand averages to describe the relationship between pyramidal cells and perisomatic interneurons
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claim_relations[6]1.0the tagger's words
concept_edgessubthreshold resonance —distinct-from→ spiking resonance
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strength of the relation: 1 · note: THE JOIN HAZARD: one word, two regimes. The paper's own sentence separates them - the subthreshold effect was NOT communicated to the spiking regime, while the spiking effect grew with inhibition
concept_edges[0]1.0the tagger's words
concept_edgesPV —causes→ spiking resonance
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strength of the relation: 1 · note: the resonance is conferred by the inhibitory partner, not intrinsic to the resonating cell
also in: PV · spiking resonance
concept_edges[1]1.0the tagger's words
concept_edgesPV —distinct-from→ INT
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strength of the relation: 0.7 · note: CONTAMINATION DECLARED: INT means 'not driven by the light', which is not the same as 'not PV' Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says a subset of INT MAY be PV cells not activated by light; distinct-from is hedged.
also in: PV · INT
concept_edges[2]1.0the tagger's words
concept_edgesI h —causes→ resonance
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strength of the relation: 1 · note: MECHANISM: an inductive negative feedback opposing voltage change
also in: I h · resonance
concept_edges[3]1.0the tagger's words
concept_edgesHCN1 —part-of→ CA1
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strength of the relation: 1 · note: abundant in distal apical dendrites of CA1 AND neocortical layer 5 pyramidal cells - which is why the same effect turns up in both regions Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says HCN1 channels are abundant in the dendrites of CA1 pyramidal cells; part-of is loose.
also in: HCN1 · CA1
concept_edges[6]1.0the tagger's words
concept_edgeschirp —contrasted-with→ white-noise
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strength of the relation: 1 · note: THE DESIGNED CONTRAST: the same cells get both stimuli, and periodicity is the only thing that differs Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says responses to chirp and white-noise stimuli were compared; contrasted-with is loose.
also in: chirp · white-noise
concept_edges[7]1.0the tagger's words
concept_edgesfrequency correlation —contrasted-with→ time correlation
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strength of the relation: 1 · note: EACH EQUALS 1 UNDER ONE HYPOTHESIS: two measures constructed so that the rival predicts a specific number, not merely a direction
concept_edges[8]1.0the tagger's words
concept_edgesband-pass filter —contrasted-with→ low-pass filter
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differs in: THE AXIS IS INPUT FREQUENCY, WITH THE MECHANISM GIVEN AT BOTH ENDS. 'Quotation withheld.' The same circuit is one filter or the other depending on the frequency it is driven at, so the two descriptions are not rival claims but the same mechanism at two operating points. · strength of the relation: 1 · note: the two rival accounts are named by the filter each would produce, which is what makes them separable by measurement
concept_edges[10]1.0the tagger's words
concept_edgesOLM —causes→ band-pass filter
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strength of the relation: 1 · note: the timing mechanism that removes the low-frequency rebound HCN alone would produce
also in: OLM · band-pass filter
concept_edges[11]1.0the tagger's words
concept_edgessynaptic depression —causes→ I h
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strength of the relation: 1 · note: SIGN: negative - depression reduces the hyperpolarisation that would drive the current, and it bites hardest at low frequencies Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says depression REDUCES the hyperpolarization drive to I h activation; the direction is not stated on the edge.
concept_edges[12]1.0the tagger's words
concept_edgestheta-index —operationalised-as→ coherence
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strength of the relation: 1 · note: the measure is a ratio to the cell's own broadband value, so its null is 1 by construction
concept_edges[14]1.0the tagger's words
content_tagsKolmogorov-Smirnov test
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content_tags.statistics[0]the tagger's words
content_tagspermutation test
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content_tags.statistics[1]the tagger's words
content_tagschi-squared test
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content_tags.statistics[2]the tagger's words
content_tagsMann-Whitney U test
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content_tags.statistics[3]the tagger's words
content_tagsKruskal-Wallis test
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content_tags.statistics[4]the tagger's words
content_tagsWilcoxon signed-rank test
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content_tags.statistics[5]the tagger's words
content_tagst-test
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also in: t-test
content_tags.statistics[6]the tagger's words
content_tagsrank correlation
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content_tags.statistics[7]the tagger's words
content_tagsPoisson test
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also in: Poisson test
content_tags.statistics[8]the tagger's words
content_tagsRayleigh test
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also in: Rayleigh test
content_tags.statistics[9]the tagger's words
content_tagsbinomial test
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also in: binomial test
content_tags.statistics[10]the tagger's words
content_tagscircular-linear correlation
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content_tags.statistics[11]the tagger's words
content_tagsspectral coherence (multi-taper estimate)
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content_tags.statistics[12]the tagger's words
content_tagsstandard error of the mean
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content_tags.statistics[13]the tagger's words
content_tagslinear regression with R-squared
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content_tags.statistics[14]the tagger's words
content_tagspermutation test
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content_tags.statistics[15]1.0the tagger's words
content_tagsKolmogorov-Smirnov test
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content_tags.statistics[16]1.0the tagger's words
content_tagsrank correlation
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content_tags.statistics[17]1.0the tagger's words
content_tagsU-test
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also in: U-test
content_tags.statistics[18]1.0the tagger's words
content_tagsDirectly photoactivated pyramidal cells each spiked in a narrow frequency band, but the preferred band differed between cells and across the population covered the whole 0-40 Hz range, i.e. no group-level theta preference.
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content_tags.findings[0]the tagger's words
content_tagsWhen PV interneurons rather than pyramidal cells were driven with the chirp, pyramidal-cell spiking became coherent with the stimulus specifically in the 4-11 Hz theta band.
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content_tags.findings[1]the tagger's words
content_tagsNearly half of the light-modulated pyramidal cells fired excess rebound spikes at the trough of the theta-band chirp, with a median firing-rate gain of 3.2 over baseline.
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content_tags.findings[2]the tagger's words
content_tagsDespite strong PV activation, white-noise inhibition frequency-modulated only 0.7% (2 of 271) of pyramidal cells.
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content_tags.findings[3]the tagger's words
content_tagsResonant pyramidal spiking upon PV activation did not result from adaptation, and required a rhythmic pattern of inhibition.
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content_tags.findings[4]the tagger's words
content_tagsTheta-resonant pyramidal spiking depended on the effective magnitude of local inhibition.
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content_tags.findings[5]the tagger's words
content_tagsBlocking Ih pharmacologically abolished the theta resonance.
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content_tags.findings[6]the tagger's words
content_tagsPyramidal cells fired at a similar theta phase during chirp PV activation as during spontaneous LFP theta, at the population level.
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content_tags.findings[7]the tagger's words
content_tagsIn the model, theta-band resonance was most robust with a timing mechanism that prevented spikes at low frequencies: an OLM interneuron or synaptic depression of the inhibitory synapse.
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content_tags.findings[8]the tagger's words
content_tagsindividual PYR tended to spike at narrow frequency bands, but the band differed from cell to cell and at the group level spanned the entire range of tested frequencies
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content_tags.findings[9]1.0the tagger's words
content_tagsdriving PV interneurons instead produced band-limited pyramidal spiking confined mainly to the trough of the stimulus
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content_tags.findings[10]1.0the tagger's words
content_tagsthe coherence between light and spiking was predominantly in the 4 to 11 Hz theta band
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content_tags.findings[11]1.0the tagger's words
content_tags45 percent of light-modulated pyramidal cells rebounded at the theta trough with a median gain of 3.2
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content_tags.findings[12]1.0the tagger's words
content_tagsTWO RIVAL MECHANISMS ENUMERATED IN ADVANCE, each named by the filter it would produce: tonic suppression giving a low-pass, or rebound giving a band-pass
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content_tags.findings[13]1.0the tagger's words
content_tagspyramidal cells were less suppressed at low frequencies, which is compatible with the first of the two
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content_tags.findings[14]1.0the tagger's words
content_tagsTHE NULL: white-noise activation of PV cells left only 0.7 percent of pyramidal cells frequency modulated
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content_tags.findings[15]1.0the tagger's words
content_tagsFIRST DEFENCE OF THE NULL: overall spiking gain rose during both chirp and white noise, so the stimulation was not ineffective
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content_tags.findings[16]1.0the tagger's words
content_tagsSECOND DEFENCE: white-noise and chirp spiking gains correlated cell by cell at 0.58, so the suppression was not inefficient
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content_tags.findings[17]1.0the tagger's words
content_tagsTHIRD DEFENCE: PV cells followed the white-noise stimulus no less precisely than the chirp, so spike following was not impaired
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content_tags.findings[18]1.0the tagger's words
content_tagswhite noise in fact suppressed pyramidal spiking MORE strongly than the chirp, 0.28 against 0.49 gain
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content_tags.findings[19]1.0the tagger's words
content_tagsthe conclusion the three defences license: periodic inhibition, not inhibition as such, is what creates spiking resonance
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content_tags.findings[20]1.0the tagger's words
content_tagsTWO MEASURES BUILT SO EACH EQUALS 1 UNDER ONE RIVAL: frequency correlation is 1 for a purely frequency-dependent unit, time correlation is 1 for a purely adapting one
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content_tags.findings[21]1.0the tagger's words
content_tagsfrequency correlation was 0.19 and 0.32 and significant, while time correlation was 0.054 and 0.02 and largely not
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content_tags.findings[22]1.0the tagger's words
content_tagsso the resonance is not adaptation, and a rhythmic inhibition pattern is required
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content_tags.findings[23]1.0the tagger's words
content_tagstheta preference grew with the strength of PV activation, while subthreshold resonance never reached the spiking regime even at low direct drive
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content_tags.findings[24]1.0the tagger's words
content_tagstheta resonant pyramidal spiking depends on the effective magnitude of local inhibition
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content_tags.findings[25]1.0the tagger's words
content_tagsunder chirp PV activation cells spiked near the stimulus trough, the same phase relationship they show during spontaneous theta
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content_tags.findings[26]1.0the tagger's words
content_tagsblocking HCN abolished the theta preference of pyramidal but not PV spiking, at population and single-unit level
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content_tags.findings[27]1.0the tagger's words
content_tagsDRUG SPECIFICITY SHOWN, NOT ASSUMED: synaptic transmission survived the infusion, since PV activation still silenced pyramidal spiking
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content_tags.findings[28]1.0the tagger's words
content_tagsNECESSITY ESTABLISHED AND SUFFICIENCY EXPLICITLY NOT: the blockade shows HCN is required, and a model was built to ask whether it is enough
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content_tags.findings[29]1.0the tagger's words
content_tagsTHE MODEL REFUSED TO CONFIRM: HCN alone produced rebound at sub-theta frequencies too, and only an added timing mechanism made the resonance theta-specific
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content_tags.findings[30]1.0the tagger's words
content_tagsPV cells followed light up to 40 Hz with no frequency preference, consistent with basket cells lacking the current
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content_tags.findings[31]1.0the tagger's words
content_tagsthe disagreement with in vitro work is attributed to the preparation: synaptic activity present in vivo, and the depolarising rather than hyperpolarising drive
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content_tags.findings[32]1.0the tagger's words
content_tagsthe current is largely deactivated near spike threshold, which is offered as why directly depolarised cells showed no theta resonance
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content_tags.findings[33]1.0the tagger's words
content_tagsmembrane resistance is much lower in a waking animal than in vitro, which may let neurons follow higher input frequencies
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content_tags.findings[34]1.0the tagger's words
content_tagsARTEFACTUAL READING OFFERED BY THE AUTHORS: the negative gain-baseline correlation is attributed to a spiking rate ceiling
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content_tags.findings[35]1.0the tagger's words
content_tagsAND AGAIN: the positive coherence-baseline correlation may simply be a floor effect, since silent cells cannot be suppressed further
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content_tags.findings[36]1.0the tagger's words
content_tagsthe opsin was fully specific but not fully sensitive: every labelled cell was PV, and 90 percent of PV cells were labelled
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content_tags.findings[37]1.0the tagger's words
content_tags1413 units were recorded, 1151 classified as pyramidal, 240 as interneurons and 22 left unclassified
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content_tags.findings[38]1.0the tagger's words
content_tagsresonance
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also in: resonance
content_tags.definitions[0]the tagger's words
content_tagstheta-index
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also in: theta-index
content_tags.definitions[1]the tagger's words
content_tagsZD-index
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also in: ZD-index
content_tags.definitions[2]the tagger's words
content_tagsspiking gain
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also in: spiking gain
content_tags.definitions[3]the tagger's words
content_tagsfrequency correlation
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content_tags.definitions[5]the tagger's words
content_tagsresonance
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also in: resonance
content_tags.definitions[6]1.0the tagger's words
content_tagstheta-index
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: theta-index
content_tags.definitions[7]1.0the tagger's words
content_tagsZD-index
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also in: ZD-index
content_tags.definitions[8]1.0the tagger's words
content_tagsINT
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also in: INT
content_tags.definitions[9]1.0the tagger's words
content_tagsfrequency correlation
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[10]1.0the tagger's words
content_tagscell type
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also in: cell type
content_tags.variables[0]the tagger's words
content_tagschirp direction
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[3]the tagger's words
content_tagslight intensity
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[4]the tagger's words
content_tagsspiking gain
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: spiking gain
content_tags.variables[7]the tagger's words
content_tagsbaseline rate
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: baseline rate
content_tags.variables[8]the tagger's words
content_tagscoherence
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: coherence
content_tags.variables[9]1.0the tagger's words
content_tagsgain
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also in: gain
content_tags.variables[10]1.0the tagger's words
content_tagstheta-index
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: theta-index
content_tags.variables[11]1.0the tagger's words
content_tags33% (101/309) — locally stimulated pyramidal cells directly activated by light in CaMKII::ChR2 mice, versus 59% (108/184) of interneurons in PV::ChR2 mice
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content_tags.quantities[0]the tagger's words
content_tags50/110 (45%) — light-modulated pyramidal cells showing rebound spiking at the theta chirp trough; median gain 3.2
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content_tags.quantities[1]the tagger's words
content_tags0.7% (2/271) — pyramidal cells frequency-modulated by white-noise PV activation
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content_tags.quantities[2]the tagger's words
content_tags1413 — total units recorded in chronic animals: 1151 pyramidal, 240 interneurons, 22 unclassified
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content_tags.quantities[3]the tagger's words
content_tags142±13 spikes/sec — mean firing rate of directly driven PV interneurons during chirp photostimulation
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content_tags.quantities[4]the tagger's words
content_tags0.19±0.04 and 0.32±0.04 — frequency correlation between ascending and descending chirp coherences (CaMKII and PV mice), against time correlations of 0.054±0.04 and 0.02±0.05
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content_tags.quantities[5]the tagger's words
content_tags0.49±0.09 — pyramidal-cell spiking gain during chirp PV activation versus 0.28±0.07 during white-noise PV activation
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content_tags.quantities[6]the tagger's words
content_tags0.52 — rank correlation between same-shank interneuron theta peak gain and pyramidal-cell chirp coherence, across all pyramidal cells
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content_tags.quantities[7]the tagger's words
content_tags9.8±0.9 Hz — peak resonance frequency of CA1 pyramidal spiking under PV chirp activation before Ih blockade
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content_tags.quantities[8]the tagger's words
content_tags121/257, 47% — pyramidal cells significantly modulated by the chirp during direct CaMKII stimulation, versus 27/46 (59%) of interneurons
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content_tags.quantities[9]the tagger's words
content_tags4–11 Hz — the theta band in which coherence and excess spiking are concentrated
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content_tags.quantities[10]1.0the tagger's words
content_tags50/110 (45%) — share of light-modulated pyramidal cells that rebounded at the theta trough
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content_tags.quantities[11]1.0the tagger's words
content_tags0.7% (2/271) — pyramidal cells frequency-modulated under white-noise PV activation - the null
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content_tags.quantities[12]1.0the tagger's words
content_tags0.19±0.04 and 0.32±0.04 — frequency correlations, against time correlations of 0.054 and 0.02
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content_tags.quantities[13]1.0the tagger's words
content_tags100% and 90% — all 84 EYFP+ cells were PV+, and 84 of 93 PV+ cells were EYFP+
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content_tags.quantities[14]1.0the tagger's words
content_tags2–20 PV interneurons — estimated number of cells the focal light actually reached
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content_tags.quantities[15]1.0the tagger's words
content_tags692 of 1413, 51% — units classified by waveform rather than by tagging
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content_tags.quantities[16]1.0the tagger's words

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