Inhibition-induced theta resonance in cortical circuits — TEI-tagged view

Stark, Eichler, Roux, Fujisawa, Rotstein, Buzsáki · 2013 · neuroscience · doi:10.1016/j.neuron.2013.09.033 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. Extraction is PMC HTML, so citation brackets carry extra spaces (e.g. '( Stark et al., 2012 )') and the subscript current is rendered 'I h'; quotes preserve that spacing exactly. The paper also contains a biophysical simulation (Figure 8) alongside the recordings, but the primary method statement is the in vivo extracellular recording plus optogenetics, so method is 'electrophysiology'. The paper contrasts its wide-band in vivo result with in vitro subthreshold-resonance work (Leung and Yu, 1998; Hu et al., 2002 and others) but the contrast sentence itself does not name those works, so no contradicts/extends relation was recorded for it. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of th 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
Other fields define these differently the same word, defined another way in another discipline
adaptation 2 fields · cell type 2 fields · coherence 2 fields · white-noise 2 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
resonance3 subthreshold resonance spiking resonance theta15 PYR4 PV22 INT3 HCN1 I h ZD7288 ChR211 CaMKII2 chirp white-noise4 coherence6 theta-index ZD-index gain10 rebound2 CA116 neocortical OLM synaptic depression2 band-pass filter low-pass filter frequency correlation time correlation adaptation9 LFP8 diode-probe electrophysiology110

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenontheta-band spiking resonance in cortical pyramidal cells— “In vitro, pyramidal cells exhibit theta-band membrane potential (subthreshold) resonance, but whether and how sub-threshold resonance translates into spiking resonance in behaving animals is unknown.”
claim-typemechanism— “Thus, PV interneurons mediate pyramidal cell spiking resonance in intact cortical networks, favoring transmission at theta frequency.”
method — evidence— “Using large scale extracellular recordings and optogenetics in freely-behaving mice, we showed that wide-band periodic but not random noise activation of PV interneurons induces theta frequency-favored spiking in hippocampal and neocortical pyramidal cells accompanied by post-inhibitory rebound spiking.”
object of study — evidence— “In vitro, pyramidal cells exhibit theta-band membrane potential (subthreshold) resonance, but whether and how sub-threshold resonance translates into spiking resonance in behaving animals is unknown.”
research question — evidence— “Yet, it is not clear if and how subthreshold resonance is translated to the suprathreshold (spiking) regime ( Magee, 1998 ; Pike at all., 2000 ; Ulrich, 2002 ; Richardson et al., 2003 ) in behaving animals.”
contribution — evidence— “Thus, PV interneurons mediate pyramidal cell spiking resonance in intact cortical networks, favoring transmission at theta frequency.”
transferfrom engineering signal analysis: the chirp - a linear frequency sweep - used as a stimulus to read a biological system's frequency response— “In principle, part of the frequency preference of individual cells could result from slow adaptation (due to e.g., ChR2 dynamics, cellular adaptation, and/or calcium buildup). To examine this possibility we tested a subset of units with both ascending (0–40 Hz) and descending (40-0 Hz) chirps”transfers[0]
transferfrom filter theory: low-pass filter and band-pass filter as the names for the two candidate explanations of the same band-limited discharge— “Theta band-limited discharge of PYR upon PV neuron activation can occur for at least two reasons. First, at high frequencies the high density of spikes emitted by PV cells can tonically suppress their targets, whereas at lower frequencies PYR can still fire in longer windows devoid of strong PV activity, creating in effect a low-pass filter.…transfers[1]
mechanismperiodic PV inhibition hyperpolarizes pyramidal cells, activating HCN/Ih channels whose deinactivation produces time-locked post-inhibitory rebound spikes at theta frequency— “Although several mechanisms might account for the theta band spiking resonance ( Hu et al., 2002 ), our experiments suggest that to a large part, the effect is mediated by the activation of HCN channels in pyramidal cells, since pharmacological blockade of HCN channels largely abolished theta-band spiking resonance.”mechanisms[0]
mechanismrebound spiking of a fixed latency after release from inhibition acts as a band-pass filter on the inhibitory input frequency— “Second, active properties of pyramidal cells ( Hu et al., 2002 ; Stuart et al., 2007 ) may induce time-locked rebound spiking upon recovery from inhibition ( Llinas et al., 1982 ; Cobb et al., 1995 ) of specific duration, creating in effect a band-pass filter.”mechanisms[1]
mechanismat high input frequencies dense PV spiking tonically suppresses targets while at low frequencies gaps in inhibition let pyramidal cells fire, which alone acts as a low-pass filter— “First, at high frequencies the high density of spikes emitted by PV cells can tonically suppress their targets, whereas at lower frequencies PYR can still fire in longer windows devoid of strong PV activity, creating in effect a low-pass filter.”mechanisms[2]
mechanismshort-term depression of the inhibitory synapse weakens hyperpolarization at low input frequencies, removing the drive for Ih activation and so suppressing sub-theta rebound— “Following intense presynaptic INT spiking, the inhibitory synapses on the PYR are less activated, so the hyperpolarization drive to I h activation is reduced.”mechanisms[3]
mechanismPV interneurons of the active assembly suppress competing cells, and release from that inhibition triggers rebound spikes that seed the next cell assembly on the opposite theta phase— “We hypothesize that the rebound spikes, induced by release from PV interneuron-mediated inhibition, contribute to the initiation of runner-up assemblies.”mechanisms[4]
mechanismthe inductive effects of the hyperpolarization-activated current create a negative feedback that opposes voltage changes, and that feedback is what creates resonance— “The inductive effects of I h create a negative feedback that opposes the voltage changes and thus creates resonance”mechanisms[5]
mechanisma low-pass account is available too: dense PV spiking tonically suppresses targets at high frequencies while low frequencies leave windows in which pyramidal cells can still fire— “Theta band-limited discharge of PYR upon PV neuron activation can occur for at least two reasons. First, at high frequencies the high density of spikes emitted by PV cells can tonically suppress their targets, whereas at lower frequencies PYR can still fire in longer windows devoid of strong PV activity, creating in effect a low-pass filter.…mechanisms[6]
mechanismHCN alone gives rebound at sub-theta frequencies as well, so a timing mechanism is needed to suppress the low end and turn a low-pass into a band-pass— “When the PYR model included I h , INT activation in the low frequency range induced rebound PYR spiking ( Figure 8A ). However, this range included sub-theta frequencies. Theta-band spiking regime resonance was especially robust when the model included a timing mechanism that prevented the generation of action potentials at low frequencies…mechanisms[7]
mechanisman OLM interneuron released from inhibition just in time can block the low-frequency rebound, which is one way to implement that timing mechanism— “During low-frequency INT stimulation, the OLM cell was inhibited by the INT and released from inhibition “just in time” to inhibit PYR and prevent post-inhibitory rebound during the high stimulus phase, in effect creating a PYR spiking band-pass filter.”mechanisms[8]
mechanismdepression of the inhibitory synapses is the other way: at low input frequencies the presynaptic rate is higher, the synapses depress, and the hyperpolarisation that would drive HCN is reduced— “Following intense presynaptic INT spiking, the inhibitory synapses on the PYR are less activated, so the hyperpolarization drive to I h activation is reduced. Synaptic depression is more effective at lower input frequencies where the pre-synaptic input spiking is higher. Thus, at low stimulation frequencies, post-inhibitory rebound spiking is…mechanisms[9]
mechanismPV cells themselves show no frequency preference, which is consistent with basket cells lacking the current that produces it— “Individual locally-recorded PV cells reliably followed the alternating light patterns up to 40 Hz but showed no particular frequency preference, consistent with the lack of I h in basket cells”mechanisms[10]
builds-on Zemankovics et al., 2010 (lack of Ih in basket cells)— “Individual locally-recorded PV cells reliably followed the alternating light patterns up to 40 Hz but showed no particular frequency preference, consistent with the lack of I h in basket cells ( Zemankovics et al., 2010 ).”claim_relations[0]
replicates Stark et al., 2012 (local activation by the light cone of diode-probes)— “During single-shank chirp pattern PV activation, non-local units were weakly activated or not activated, similar to DC pulses ( Figure 1C ) and confirming previous demonstrations of local activation by the light cone ( Stark et al., 2012 ).”claim_relations[1]
qualifies the in vitro finding of theta-band subthreshold resonance in cortical principal neurons under intracellular sinusoidal injection— “The in vitro tests typically examined resonance by intracellular current injection of a chirp pattern at a hyperpolarized membrane potential while synaptic activity was blocked pharmacologically. The…claim_relations[2]
builds-on Cobb 1995's demonstration that basket cell burst discharge induces rebound spikes after release from hyperpolarization in vitroclaim_relations[3]
extends the account of theta generation as a consortium of septal pacemaker, circuit interactions and intrinsic neuronal propertiesclaim_relations[4]
supports an HCN-mediated mechanism for post-hyperpolarization rebound spiking
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claim_relations[5]
critiques the use of grand averages to describe the relationship between pyramidal cells and perisomatic interneurons
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claim_relations[6]
senseresonance here is defined generically as amplification in a limited frequency band, which is what lets the same word cover a membrane potential effect and a spiking effect that this paper shows come apart
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senses[0]
sensesubthreshold and suprathreshold resonance are separate claims: the first is established in vitro, the second is what this paper asks about, and directly-driven pyramidal cells do NOT show the second
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senses[1]
senseINT is defined by a NEGATIVE result - interneurons NOT driven by the light - so the class is an outcome of the manipulation rather than a cell type, and the authors say some of them are probably PV cells that the light missed
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senses[2]
sensethe opsin's specificity and sensitivity are measured separately: every labelled cell was PV, but 10 percent of PV cells were unlabelled
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senses[3]
sensea well-isolated unit is defined by three explicit numerical thresholds on amplitude, cluster quality and refractory violations
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senses[4]
sensethe theta index is a ratio to the cell's own broadband coherence, so it equals 1 under no bias - the measure carries its own null
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senses[5]
sensethe ZD-index is a normalised difference between control and drug coherence, built so that the drug effect can be shown to be specific to a frequency band and a cell type rather than global
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senses[6]
controlthe inhibition-induced theta-band spiking reproduced in a pyramidal cell-interneuron model that included the I_h current — held — rules out an in-vivo result with no mechanism behind it - the model has only the components the explanation names, so if the effect appears there it does not need anything else
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controls[0]
notesubthreshold resonance —distinct-from→ spiking resonance — THE JOIN HAZARD: one word, two regimes. The paper's own sentence separates them - the subthreshold effect was NOT communicated to the spiking regime, while the spiking effect grew with inhibition
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concept_edges[0]
notePV —causes→ spiking resonance — the resonance is conferred by the inhibitory partner, not intrinsic to the resonating cell
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concept_edges[1]
auditPV —distinct-from→ INT — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says a subset of INT MAY be PV cells not activated by light; distinct-from is hedged.
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concept_edges[2]
notePV —distinct-from→ INT — CONTAMINATION DECLARED: INT means 'not driven by the light', which is not the same as 'not PV'
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concept_edges[2]
weightPV —distinct-from→ INT — 0.7
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concept_edges[2]
noteI h —causes→ resonance — MECHANISM: an inductive negative feedback opposing voltage change
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concept_edges[3]
auditHCN1 —part-of→ CA1 — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says HCN1 channels are abundant in the dendrites of CA1 pyramidal cells; part-of is loose.
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concept_edges[6]
noteHCN1 —part-of→ CA1 — abundant in distal apical dendrites of CA1 AND neocortical layer 5 pyramidal cells - which is why the same effect turns up in both regions
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concept_edges[6]
auditchirp —contrasted-with→ white-noise — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says responses to chirp and white-noise stimuli were compared; contrasted-with is loose.
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concept_edges[7]
notechirp —contrasted-with→ white-noise — THE DESIGNED CONTRAST: the same cells get both stimuli, and periodicity is the only thing that differs
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concept_edges[7]
notefrequency correlation —contrasted-with→ time correlation — EACH EQUALS 1 UNDER ONE HYPOTHESIS: two measures constructed so that the rival predicts a specific number, not merely a direction
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concept_edges[8]
differs inband-pass filter —contrasted-with→ low-pass filter — THE AXIS IS INPUT FREQUENCY, WITH THE MECHANISM GIVEN AT BOTH ENDS. 'at high frequencies the high density of spikes emitted by PV cells can tonically suppress their targets, whereas at lower frequencies PYR can still fire in longer windows devoid of strong PV activity, creating in effect a low-pass filter.' The same circuit is one filter or the other depending on the frequency it is driven at, so the two descriptions are not rival claims but the same mechanism at two operating points.
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concept_edges[10]
noteband-pass filter —contrasted-with→ low-pass filter — the two rival accounts are named by the filter each would produce, which is what makes them separable by measurement
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concept_edges[10]
noteOLM —causes→ band-pass filter — the timing mechanism that removes the low-frequency rebound HCN alone would produce
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concept_edges[11]
auditsynaptic depression —causes→ I h — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says depression REDUCES the hyperpolarization drive to I h activation; the direction is not stated on the edge.
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concept_edges[12]
notesynaptic depression —causes→ I h — SIGN: negative - depression reduces the hyperpolarisation that would drive the current, and it bites hardest at low frequencies
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concept_edges[12]
notetheta-index —operationalised-as→ coherence — the measure is a ratio to the cell's own broadband value, so its null is 1 by construction
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concept_edges[14]
outcome (stated by the tagger, no quotation)control — heldcontrols[0]
for which uselimitation — the Ih result: THE PHARMACOLOGICAL EXPERIMENTS ESTABLISHED THE REQUIREMENT OF Ih FOR THETA-BAND SPIKING RESONANCE BUT NOT ITS SUFFICIENCY
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limitations[0]
for which uselimitation — the HCN account as complete: further mechanisms may sharpen the resonance in the intact network beyond the CRITICAL ROLE OF HCN CHANNELS the experiments support
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limitations[1]
for which uselimitation — the assembly-seeding hypothesis: WHILE SPECULATIVE, THIS HYPOTHESIS IS COMPATIBLE WITH ALL KNOWN OBSERVATIONS ON PUTATIVE BASKET NEURONS
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limitations[2]
for which uselimitation — the same scope as limitations[0], with the response: TO INVESTIGATE WHETHER Ih ALONE IS SUFFICIENT, WE CONSTRUCTED A BIOPHYSICAL MODEL
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limitations[3]
for which uselimitation — the same scope as limitations[1] - HCN is critical but not the whole mechanism
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limitations[4]
duplicate oflimitation — limitations[2]
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limitations[5]
for which uselimitation — the same scope as limitations[2] - the rebound-spike account is labelled speculative
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limitations[5]
for which uselimitation — the gain-baseline correlation: PRESUMABLY DUE TO a ceiling on spiking rate, not a property of the circuit (RANK CORRELATION -0.31; n=110; p<0.001)
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limitations[6]
for which uselimitation — the coherence-baseline correlation: THIS INCREASED COHERENCE MAY SIMPLY BE A FLOOR EFFECT AS SILENT CELLS CANNOT BE coherent (RANK CORRELATION 0.31; p=0.003)
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limitations[7]
for which uselimitation — the size of the manipulation: THE WEAK FOCAL PHOTOSTIMULATION AFFECTED AN ESTIMATED 2-20 PV INTERNEURONS, an order-of-magnitude range
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limitations[8]
for which uselimitation — half the recorded units: NON-TAGGED UNITS (692 OF 1413, 51%) ARE CLASSIFIED AS PUTATIVE PYRAMIDAL CELLS (PYR) OR INTERNEURONS (INT) ACCORDING TO WAVEFORM MORPHOLOGY
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limitations[9]
evidential statusmechanism — the paper's own words: We hypothesize that
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mechanisms[4]
replicationuntested
limitationThe pharmacological result shows Ih is necessary but not sufficient for theta spiking resonance
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limitations[0]
limitationHCN channels are not the whole story; further mechanisms may sharpen the resonance in intact networks
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limitations[1]
limitationThe proposed assembly-seeding function of rebound spikes is acknowledged as speculative
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limitations[2]
limitationthe blockade establishes that HCN is required and explicitly not that it is sufficient
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limitations[3]
limitationfurther mechanisms beyond HCN are expected to sharpen the resonance in the intact network
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limitations[4]
limitationthe assembly-seeding account of the rebound spikes is labelled speculative by the authors
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limitations[5]
limitationa gain-baseline correlation is offered with its own artefactual reading, a spiking rate ceiling
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limitations[6]
limitationa coherence-baseline correlation is likewise offered as possibly a floor effect, since silent cells cannot be suppressed further
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limitations[7]
limitationthe number of interneurons actually illuminated is an estimate spanning an order of magnitude
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limitations[8]
limitationhalf the recorded units were classified by waveform rather than by tagging, and low-confidence ones were dropped
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limitations[9]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingDirectly photoactivated pyramidal cells each spiked in a narrow frequency band, but the preferred band differed between cells and across the population covered the whole 0-40 Hz range, i.e. no group-level theta preference.
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content_tags.findings[0]
findingWhen PV interneurons rather than pyramidal cells were driven with the chirp, pyramidal-cell spiking became coherent with the stimulus specifically in the 4-11 Hz theta band.
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content_tags.findings[1]
findingNearly half of the light-modulated pyramidal cells fired excess rebound spikes at the trough of the theta-band chirp, with a median firing-rate gain of 3.2 over baseline.
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content_tags.findings[2]
findingDespite strong PV activation, white-noise inhibition frequency-modulated only 0.7% (2 of 271) of pyramidal cells.
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content_tags.findings[3]
findingResonant pyramidal spiking upon PV activation did not result from adaptation, and required a rhythmic pattern of inhibition.
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content_tags.findings[4]
findingTheta-resonant pyramidal spiking depended on the effective magnitude of local inhibition.
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content_tags.findings[5]
findingBlocking Ih pharmacologically abolished the theta resonance.
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content_tags.findings[6]
findingPyramidal cells fired at a similar theta phase during chirp PV activation as during spontaneous LFP theta, at the population level.
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content_tags.findings[7]
findingIn the model, theta-band resonance was most robust with a timing mechanism that prevented spikes at low frequencies: an OLM interneuron or synaptic depression of the inhibitory synapse.
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content_tags.findings[8]
findingindividual PYR tended to spike at narrow frequency bands, but the band differed from cell to cell and at the group level spanned the entire range of tested frequencies
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content_tags.findings[9]
findingdriving PV interneurons instead produced band-limited pyramidal spiking confined mainly to the trough of the stimulus
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content_tags.findings[10]
findingthe coherence between light and spiking was predominantly in the 4 to 11 Hz theta band
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content_tags.findings[11]
finding45 percent of light-modulated pyramidal cells rebounded at the theta trough with a median gain of 3.2
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content_tags.findings[12]
findingTWO RIVAL MECHANISMS ENUMERATED IN ADVANCE, each named by the filter it would produce: tonic suppression giving a low-pass, or rebound giving a band-pass
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content_tags.findings[13]
findingpyramidal cells were less suppressed at low frequencies, which is compatible with the first of the two
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content_tags.findings[14]
findingTHE NULL: white-noise activation of PV cells left only 0.7 percent of pyramidal cells frequency modulated
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content_tags.findings[15]
findingFIRST DEFENCE OF THE NULL: overall spiking gain rose during both chirp and white noise, so the stimulation was not ineffective
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content_tags.findings[16]
findingSECOND DEFENCE: white-noise and chirp spiking gains correlated cell by cell at 0.58, so the suppression was not inefficient
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content_tags.findings[17]
findingTHIRD DEFENCE: PV cells followed the white-noise stimulus no less precisely than the chirp, so spike following was not impaired
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content_tags.findings[18]
findingwhite noise in fact suppressed pyramidal spiking MORE strongly than the chirp, 0.28 against 0.49 gain
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content_tags.findings[19]
findingthe conclusion the three defences license: periodic inhibition, not inhibition as such, is what creates spiking resonance
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content_tags.findings[20]
findingTWO MEASURES BUILT SO EACH EQUALS 1 UNDER ONE RIVAL: frequency correlation is 1 for a purely frequency-dependent unit, time correlation is 1 for a purely adapting one
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content_tags.findings[21]
findingfrequency correlation was 0.19 and 0.32 and significant, while time correlation was 0.054 and 0.02 and largely not
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content_tags.findings[22]
findingso the resonance is not adaptation, and a rhythmic inhibition pattern is required
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content_tags.findings[23]
findingtheta preference grew with the strength of PV activation, while subthreshold resonance never reached the spiking regime even at low direct drive
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content_tags.findings[24]
findingtheta resonant pyramidal spiking depends on the effective magnitude of local inhibition
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content_tags.findings[25]
findingunder chirp PV activation cells spiked near the stimulus trough, the same phase relationship they show during spontaneous theta
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content_tags.findings[26]
findingblocking HCN abolished the theta preference of pyramidal but not PV spiking, at population and single-unit level
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content_tags.findings[27]
findingDRUG SPECIFICITY SHOWN, NOT ASSUMED: synaptic transmission survived the infusion, since PV activation still silenced pyramidal spiking
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content_tags.findings[28]
findingNECESSITY ESTABLISHED AND SUFFICIENCY EXPLICITLY NOT: the blockade shows HCN is required, and a model was built to ask whether it is enough
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content_tags.findings[29]
findingTHE MODEL REFUSED TO CONFIRM: HCN alone produced rebound at sub-theta frequencies too, and only an added timing mechanism made the resonance theta-specific
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content_tags.findings[30]
findingPV cells followed light up to 40 Hz with no frequency preference, consistent with basket cells lacking the current
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content_tags.findings[31]
findingthe disagreement with in vitro work is attributed to the preparation: synaptic activity present in vivo, and the depolarising rather than hyperpolarising drive
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content_tags.findings[32]
findingthe current is largely deactivated near spike threshold, which is offered as why directly depolarised cells showed no theta resonance
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content_tags.findings[33]
findingmembrane resistance is much lower in a waking animal than in vitro, which may let neurons follow higher input frequencies
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content_tags.findings[34]
findingARTEFACTUAL READING OFFERED BY THE AUTHORS: the negative gain-baseline correlation is attributed to a spiking rate ceiling
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content_tags.findings[35]
findingAND AGAIN: the positive coherence-baseline correlation may simply be a floor effect, since silent cells cannot be suppressed further
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content_tags.findings[36]
findingthe opsin was fully specific but not fully sensitive: every labelled cell was PV, and 90 percent of PV cells were labelled
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content_tags.findings[37]
finding1413 units were recorded, 1151 classified as pyramidal, 240 as interneurons and 22 left unclassified
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content_tags.findings[38]
quantity33% (101/309) — locally stimulated pyramidal cells directly activated by light in CaMKII::ChR2 mice, versus 59% (108/184) of interneurons in PV::ChR2 mice
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content_tags.quantities[0]
quantity50/110 (45%) — light-modulated pyramidal cells showing rebound spiking at the theta chirp trough; median gain 3.2
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content_tags.quantities[1]
quantity0.7% (2/271) — pyramidal cells frequency-modulated by white-noise PV activation
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content_tags.quantities[2]
quantity1413 — total units recorded in chronic animals: 1151 pyramidal, 240 interneurons, 22 unclassified
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content_tags.quantities[3]
quantity142±13 spikes/sec — mean firing rate of directly driven PV interneurons during chirp photostimulation
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content_tags.quantities[4]
quantity0.19±0.04 and 0.32±0.04 — frequency correlation between ascending and descending chirp coherences (CaMKII and PV mice), against time correlations of 0.054±0.04 and 0.02±0.05
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content_tags.quantities[5]
quantity0.49±0.09 — pyramidal-cell spiking gain during chirp PV activation versus 0.28±0.07 during white-noise PV activation
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content_tags.quantities[6]
quantity0.52 — rank correlation between same-shank interneuron theta peak gain and pyramidal-cell chirp coherence, across all pyramidal cells
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content_tags.quantities[7]
quantity9.8±0.9 Hz — peak resonance frequency of CA1 pyramidal spiking under PV chirp activation before Ih blockade
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content_tags.quantities[8]
quantity121/257, 47% — pyramidal cells significantly modulated by the chirp during direct CaMKII stimulation, versus 27/46 (59%) of interneurons
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content_tags.quantities[9]
quantity4–11 Hz — the theta band in which coherence and excess spiking are concentrated
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content_tags.quantities[10]
quantity50/110 (45%) — share of light-modulated pyramidal cells that rebounded at the theta trough
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content_tags.quantities[11]
quantity0.7% (2/271) — pyramidal cells frequency-modulated under white-noise PV activation - the null
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content_tags.quantities[12]
quantity0.19±0.04 and 0.32±0.04 — frequency correlations, against time correlations of 0.054 and 0.02
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content_tags.quantities[13]
quantity100% and 90% — all 84 EYFP+ cells were PV+, and 84 of 93 PV+ cells were EYFP+
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content_tags.quantities[14]
quantity2–20 PV interneurons — estimated number of cells the focal light actually reached
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content_tags.quantities[15]
quantity692 of 1413, 51% — units classified by waveform rather than by tagging
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content_tags.quantities[16]
variablecell type (independent)
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content_tags.variables[0]
variablechirp direction (independent)
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content_tags.variables[3]
variablelight intensity (independent)
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content_tags.variables[4]
variablespiking gain (dependent)
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content_tags.variables[7]
variablebaseline rate (covariate)
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content_tags.variables[8]
variablecoherence
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content_tags.variables[9]
variablegain
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content_tags.variables[10]
variabletheta-index
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[11]
definitionresonance
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content_tags.definitions[0]
definitiontheta-index
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content_tags.definitions[1]
definitionZD-index
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content_tags.definitions[2]
definitionspiking gain
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content_tags.definitions[3]
definitionfrequency correlation
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content_tags.definitions[5]
definitionresonance
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content_tags.definitions[6]
definitiontheta-index
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content_tags.definitions[7]
definitionZD-index
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[8]
definitionINT
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content_tags.definitions[9]
definitionfrequency correlation
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content_tags.definitions[10]
key-termsresonance, subthreshold resonance, spiking resonance, theta, PYR, PV, INT, HCN1, ZD7288, chirp, white-noise, coherence, theta-index, rebound, CA1, adaptation
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
conceptgain — not defined in this paper's own words; firing rate during stimulation divided by baseline
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concepts[17]
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
Kolmogorov-Smirnov test as written: Kolmogorov-Smirnov test with a uniform null
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content_tags.statistics[0]
permutation test as written: permutation test with a zero correlation null
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content_tags.statistics[1]
chi-squared test χ 2 as written: χ 2 test
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content_tags.statistics[2]
Mann-Whitney U test U
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content_tags.statistics[3]
Kruskal-Wallis test as written: Kruskal-Wallis test corrected for multiple comparisons
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content_tags.statistics[4]
Wilcoxon signed-rank test as written: Wilcoxon’s paired signed-rank test
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content_tags.statistics[5]
t-test as written: Bonferroni-corrected paired t-test
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content_tags.statistics[6]
rank correlation as written: the rank correlation was 0.3 for light-modulated PYR
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content_tags.statistics[7]
Poisson test
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content_tags.statistics[8]
Rayleigh test
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content_tags.statistics[9]
binomial test as written: exact Binomial test
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content_tags.statistics[10]
circular-linear correlation
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content_tags.statistics[11]
spectral coherence (multi-taper estimate) as written: multi-taper coherence
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content_tags.statistics[12]
standard error of the mean SEM as written: mean±SEM
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content_tags.statistics[13]
linear regression with R-squared R 2 as written: linear phase model: Φ(f)=(π+0.12)+0.06f; R 2 =0.87
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content_tags.statistics[14]
permutation test
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content_tags.statistics[15]
Kolmogorov-Smirnov test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[16]
rank correlation
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[17]
U-test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[18]
Second readings
a facet read a second time, independently, from its own sentence — and whether the two readings agree
claim typemechanism — a second reading reaching the same value; recorded: mechanism
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alternatives.claim_type
methodoptogenetic chirp and white-noise stimulation through multi-shank diode-probes with extracellular unit recording, an HCN channel blocker, and a two-cell biophysical model — a second reading DIFFERING from the recorded value; recorded: electrophysiology
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alternatives.method
phenomenonexcess post-inhibitory spiking of pyramidal cells confined to the theta band when PV interneurons are driven rhythmically — a second reading DIFFERING from the recorded value; recorded: theta-band spiking resonance in cortical pyramidal cells
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alternatives.phenomenon

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