A Neural Correlate of Working Memory in the Monkey Primary Visual Cortex

Supèr, Spekreijse, Lamme · Science · 2001 · visual-neuroscience · 10.1126/science.1060496 · record sup-r2001-a-neural-correlate-of-working-memo
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (pdftext); every evidence string verified as an exact substring of that text before merging. limitations left empty: the report states no limitation of its own. Its nearest passages rule out a rival interpretation rather than qualify the result - 'Quotation withheld' - and the final claim is hedged ('We propose that this component may link sensory activity with memory activity.'), which is caution, not a stated limit. Claim relations left empty: this Science report cites only by number and its reference list is not in the extracted text (what precedes and follows the report body is the tail of an unrelated Tip60/APP article that shared the journal page), so no prior work is actually named. The paper does relate itself to earlier findings - e.g. 'In that sense, Quotation withheld (13) or prefrontal (14) cortex.' and 'Contextual modulation in V1 depends on feedback from higher visual areas (7-9), Quotation withheld.' - but with bare numeric citations only, so recording a target would mean guessing. 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
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Other fields define these differently the same word, defined another way in another discipline
working memory 4 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 5 concept tags on this paper, all 5 are grounded in a quoted sentence.
contextual modulation recurrent processing working memory delayed-response task receptive fields Figure-ground contextual modulation in V1, generated by recurrent feedback, is carried on past stimulus offset and thereby converts the sensory representation into a working-memory trace. Two processes act on V1 during the delay in opposite directions: one suppresses overall firing while a second preserves the figure-versus-ground difference. visual persistence relative degree of modulation persistence correct trial latency of the cue time strength of contextual modulation directions of motion p-value regression fitted a linear regression line standard error of the mean mean Population average of modulation ratios electrophysiology

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relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.1126/science.1060496. The reading view exists for the papers whose licence permits it.

Every tag on this page

claim_relations 3 · claim_type 1 · concept_edges 2 · concepts 5 · content_tags 27 · controls 1 · limitations 3 · mechanisms 2 · method 1 · phenomenon 1 · senses 3

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 2 relations here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
claim_typeexistence
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claim_typethe paper's words
phenomenonvisual working memory in primary visual cortex
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
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mechanisms[0]the tagger's words
mechanismsmechanisms
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mechanisms[1]the tagger's words
limitationsThe signal recorded in V1 is stated to depend on feedback from higher areas, so the site of the recording is not the site of the process.
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what this limits: this result as a finding about primary visual cortex: the modulation depends on feedback from higher visual areas, which the authors say makes it a specific correlate of recurrent processing rather than of local V1 computation
limitations[0]1.0the tagger's words
limitationsThe early figure-ground signal is the same whether the animal later remembers or forgets; only the late persistence separates them.
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what this limits: an early V1 figure-ground measurement as an index of what will be remembered: segregation is equally good on correct and incorrect trials, and the two only diverge later in the delay
limitations[1]1.0the tagger's words
limitationsThe memory signal decays with the length of the delay, so its strength depends on how long the animal is asked to wait.
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what this limits: a modulation strength quoted from this paper: it is related to the delay period and becomes weaker for longer delays, so the figure is only comparable at a matched delay
limitations[2]1.0the tagger's words
controlsthe whole delayed-response experiment repeated with a STATIC orientation-defined figure in place of the moving one, followed by a mask
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eliminates: any peculiarity of the MOVING stimulus as the source of the sustained contextual modulation - motion has its own persistence, so a modulation that outlasts a moving figure could be an aftereffect of the motion rather than a memory trace · outcome: held
controls[0]0.95the tagger's words
conceptscontextual modulation
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concepts[0]the paper's words
conceptsrecurrent processing
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concepts[1]the paper's words
conceptsworking memory
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concepts[2]the paper's words
conceptsdelayed-response task
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concepts[3]the paper's words
conceptsreceptive fields
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concepts[4]the paper's words
sensescontextual modulation - AS A CORRELATE OF RECURRENT PROCESSING: a V1 signal whose source is feedback from higher visual areas, so it indexes a loop rather than the area it is recorded in
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senses[0]1.0the tagger's words
sensesthe memory signal - DEFINED BY THE ANIMAL'S REPORT: trials are sorted after the fact into correct and incorrect by whether the saccade landed on the remembered location within 500 ms, and the neural difference is computed between those two sets
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senses[1]1.0the tagger's words
sensesthe figure-ground difference - NOT STIMULUS-DRIVEN BY CONSTRUCTION: the motion on the receptive field was arranged to be identical on average for figure and ground, so the difference cannot be attributed to the local stimulus
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senses[2]1.0the tagger's words
claim_relationsexplains-away → fMRI studies finding little delay activation in early visual areas (ref. 15)
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differs in: WHETHER THE MEASURE CAN SEE THE SIGNAL. Two mechanisms run in opposite directions: 'one mechanism suppresses overall activity in V1 during the delay, Quotation withheld.' A method reading overall activity therefore records a decrease while the memory signal - a DIFFERENCE between two conditions - is maintained. The paper offers this as why 'very little delay activation is found in early visual areas' in imaging
claim_relations[0]0.9the tagger's words
claim_relationsdistinguishes-from → delay-period activity in temporal (ref. 13) and prefrontal (ref. 14) cortex
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differs in: WHAT IS MAINTAINED DURING THE DELAY. Elsewhere it is the firing rate; here the rate falls and what persists is a CONTRAST between figure and ground - 'In that sense, Quotation withheld OR PREFRONTAL CORTEX.' Two things called delay activity that a rate measure would score in opposite directions
claim_relations[1]0.9the tagger's words
claim_relationsbuilds-on → the criterion that stored information is held only if needed (ref. 11)
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differs in: WHETHER PERSISTENCE ALONE DEMONSTRATES STORAGE. The distractor condition supplies the missing half: modulation persists when the figure is the target and decays when the same figure is the distractor, so 'the continuation of modulation is Quotation withheld of information needed for the animal's goal'. The same stimulus with the same retinal input yields opposite signals according to task relevance
claim_relations[2]0.9the tagger's words
concept_edgesrecurrent processing —causes→ contextual modulation
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strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says contextual modulation depends on feedback, which IMPLIES it correlates with recurrent processing; causes is loose.
concept_edges[0]the tagger's words
concept_edgesworking memory —operationalised-as→ delayed-response task
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span describes the delayed-response task used for the working memory of the previous sentence; operationalised-as is loose.
concept_edges[1]the tagger's words
content_tagsp-value
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also in: p-value
content_tags.statistics[0]the tagger's words
content_tagsregression
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also in: regression
content_tags.statistics[1]the tagger's words
content_tagsstandard error of the mean
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about this quote: DAMAGED GLYPHS IN THIS QUOTE: (cid:222). These are raw PDF font glyph indices that leaked out in place of the characters they stand for - usually a mathematical operator. The quote is verbatim to the staged text and its anchor is sound; the STAGED TEXT is what is damaged. NOT repaired: the cid-to-character mapping is defined by the font embedded in that particular PDF, so guessing it would produce a clean and unverifiable quote. Repair needs the source PDF and is a re-staging job.
content_tags.statistics[2]the tagger's words
content_tagsmean
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about this quote: DAMAGED GLYPHS IN THIS QUOTE: (cid:222). These are raw PDF font glyph indices that leaked out in place of the characters they stand for - usually a mathematical operator. The quote is verbatim to the staged text and its anchor is sound; the STAGED TEXT is what is damaged. NOT repaired: the cid-to-character mapping is defined by the font embedded in that particular PDF, so guessing it would produce a clean and unverifiable quote. Repair needs the source PDF and is a re-staging job.
also in: mean
content_tags.statistics[3]the tagger's words
content_tagsAfter the figure was removed from the screen, V1 responses to the figure stayed stronger than responses to the ground throughout the delay, so figure-ground contextual modulation continues in the absence of the stimulus.
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content_tags.findings[0]the tagger's words
content_tagsThe strength of the maintained figure-ground modulation shrinks as the required memory delay gets longer.
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content_tags.findings[1]the tagger's words
content_tagsOn correct and incorrect trials alike, the figure was equally well segregated from the ground in the first 250 ms.
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content_tags.findings[2]the tagger's words
content_tagsIn the late part of the delay, contextual modulation vanished entirely on trials where the monkey later made the wrong saccade, while it continued on trials answered correctly.
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content_tags.findings[3]the tagger's words
content_tagsThe continuation of modulation is not passive but reflects active storage of information the animal needs for its goal.
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content_tags.findings[4]the tagger's words
content_tagsDuring the delay V1 shows two dissociable effects at once: overall firing is suppressed while the figure-versus-ground difference is preserved.
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content_tags.findings[5]the tagger's words
content_tagsThe maintained activity is highly unlikely to be a neural correlate of visual persistence.
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content_tags.findings[6]the tagger's words
content_tagsThe monkeys detected the figure well overall but their performance dropped as the delay lengthened, confirming the task taxes short-term memory.
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content_tags.findings[7]the tagger's words
content_tagsThe same phenomenon appeared in a control experiment using a static rather than a moving stimulus.
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content_tags.findings[8]the tagger's words
content_tagscontextual modulation
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content_tags.definitions[0]the tagger's words
content_tagsvisual persistence
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content_tags.definitions[1]the tagger's words
content_tagsrelative degree of modulation persistence
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content_tags.definitions[2]the tagger's words
content_tagscorrect trial
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also in: correct trial
content_tags.definitions[3]the tagger's words
content_tagslatency of the cue time
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content_tags.variables[0]the tagger's words
content_tagsstrength of contextual modulation
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content_tags.variables[2]the tagger's words
content_tagsdirections of motion
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content_tags.variables[4]the tagger's words
content_tags28 ms — how long the motion-defined figure was shown before it had to be remembered
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content_tags.quantities[0]the tagger's words
content_tags0 and 2000 ms — range over which the memory delay (cue-time latency) was varied
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content_tags.quantities[1]the tagger's words
content_tagsP , 1027 — significance of the decline in modulation strength across the delay for the 1000 and 2000 ms delays
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content_tags.quantities[2]the tagger's words
content_tagsP , 0.0005 — significance of the difference in remaining modulation between figure-as-target and figure-as-distractor
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content_tags.quantities[3]the tagger's words
content_tags900 ms — length of the memory period over which modulation persisted in the static-texture control experiment
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content_tags.quantities[4]the tagger's words
content_tagsP , 1025 — significance of the correct-versus-incorrect difference in modulation in the final 250 ms before cue time (initial 250 ms did not differ, P . 0.1)
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content_tags.quantities[5]the tagger's words
content_tagstwo monkeys — number of animals from which V1 multiunit activity was recorded
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content_tags.quantities[6]the tagger's words

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