Hippocampal CA1 and CA3 neural recording in the human brain: validation of depth electrode placement through high-resolution imaging and electrophysiology

Wicks, Witcher, Couture, Laxton, Popli, Whitlow, Fetterhoff, Dakos, Roeder, Deadwyler, Hampson · Neurosurgical Focus · 2020 · neuroscience · 10.3171/2020.4.focus20164 · record wicks2020-hippocampal-ca1-and-ca3-neural-rec
tag layer · index · concepts · authors · עברית
Where this record's text came from. faceted 2026-08 by reading the locally held text (pdftext); every evidence string verified as an exact substring of that text before merging. Claim type is method: the paper's product is a validated placement-verification procedure, not a new neural phenomenon; the supporting result ('Cross-correlation analysis confirmed that nearly 80% of putative CA3-to-CA1 cell pairs exhibited positive correlations...') is evidence for the method rather than the claim itself. Only one claim_relation entered: the Ulbert et al. comparison is the single place where the paper explicitly positions its own approach against named prior work, and even there the name falls in the preceding sentence, so the quoted evidence carries the contrast ('this approach required additional time and risk... In this study we demonstrate...') without the name. The favourable comparison to '20%-25% feed-forward correlation noted in animal studies' cites numbered references only, with no named authors in the text, so no relation was recorded for it. Note also that the abstract/table counts are internally inconsistent (744 neurons in Table 1 and abstract-level text versus 'a total of 813 neurons' in the Discussion); this is reported, not resolved. 2026-08-14 and 2026-08-25 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
How to read this page. The article itself is not reproduced here — this paper is not cleared for redistribution, so what follows is the tag layer alone. The evidence sentences are withheld with the article. The table at the foot lists every tag the record carries; each row names the facet it belongs to, and the whose words column says whether the tag records the paper's own wording or the tagger's sentence about the paper. Every tag links to each other paper in the corpus carrying it. The machine-readable edition of the same thing is the TEI file beside this one, where the tags live in standOff, and the article is at its publisher via the link below. When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.
Other fields define these differently the same word, defined another way in another discipline
standard deviation 3 fields · functional connectivity 2 fields

Tags on this paper

Every tag the record carries, each linking to every other paper in the corpus that carries it. A tag appears here whether or not its words occur in the article — the spans below are only the ones a sentence in this paper licenses. Of the 6 concept tags on this paper, all 6 are grounded in a quoted sentence.
interneurons principal neurons functional connectivity inverse correlation synaptic connectivity feed-forward correlations Monosynaptic Schaffer collateral transmission from CA3 to CA1 produces the 2-5 msec lagged firing correlation, while shared perforant path input to both subfields produces the 0-msec synchronous correlation. Delayed-Match-to-Sample cross-correlograms line noise t-test pairwise t-test cross-correlation cross-correlograms were computed as spike-triggered histograms standard deviation standard deviation outside of sample and match phases p-value electrophysiology

Legend

relation to other workclaim_relationshow this paper stands to another: agrees, contradicts, extends, qualifies
claim typeclaim_typethe shape of the claim: existence, mechanism, method, critique, prediction, null
concept edgeconcept_edgesan asserted relation between two concepts, with the sentence asserting it
conceptconceptsan idea the paper works with, quoted where the paper uses it
content tagcontent_tagsa finding, definition, quantity, statistic or variable named in the paper
controlcontrolsan experiment run to eliminate a rival explanation
limitationlimitationswhat the paper says its evidence cannot support
mechanismmechanismshow the reported effect is said to come about
methodmethodhow the paper produced its evidence
phenomenonphenomenonthe effect or regularity under study
sensesensesa distinct use of a term, quoted where the paper fixes it

The paper

The full text is not reproduced here. This article is not cleared for redistribution, so the page carries the tag layer only. Its evidence sentences are withheld; the grounding status remains with each tag, and the article itself is at https://doi.org/10.3171/2020.4.focus20164. The reading view exists for the papers whose licence permits it.

Every tag on this page

claim_relations 1 · claim_type 1 · concept_edges 1 · concepts 6 · content_tags 18 · controls 1 · limitations 5 · mechanisms 1 · method 1 · phenomenon 1 · senses 3

Relations on this page carry a quotation for the claim. Where a relation was separately evidenced — and so tested against the vocabulary for its type — the row says so; none of 1 relation here carry that mark. The rest are the tagger’s reading of the sentence quoted beside them.

facettagfieldconf.whose words
claim_typemethod
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
claim_typethe paper's words
phenomenonlocalization of single-neuron recordings in human hippocampal CA1 and CA3
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phenomenonthe paper's words
methodelectrophysiology
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methodthe paper's words
mechanismsmechanisms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
mechanisms[0]the tagger's words
limitationsOnly the 2-5 msec feed-forward correlations can be taken as definitive evidence of CA3-to-CA1 synaptic connectivity; the synchronous and long-lag pairs are inferred to be correctly assigned rather than proven so.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
what this limits: the connectivity claim, separated from the suggestive part: ONLY THE 2- TO 5-MSEC FEED-FORWARD CORRELATIONS (20.3%) CAN BE DEFINITIVELY IDENTIFIED AS CA3-TO-CA1 SYNAPTIC CONNECTIVITY
limitations[0]the tagger's words
limitationsThe localization procedure used here is not a standardized stereotactic system, which the authors say would be needed for cross-centre standardization.
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what this limits: any comparison across surgical centres: LOCALIZATION USING STANDARDIZED TEMPORAL STEREOTACTIC SYSTEMS ... WOULD BE USEFUL FOR FUTURE ITERATIONS OR FOR STANDARDIZATION ACROSS SURGICAL CENTERS
limitations[1]the tagger's words
limitationsA cell type is inferred from a firing-rate threshold and those cells are excluded from the sample.
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what this limits: any proportion reported over these neurons: cells with steady-state resting firing rates above 20 Hz were treated as clearly interneurons and were not recorded
limitations[2]1.0the tagger's words
limitationsThe cell-type labels are confirmed by the connectivity pattern they are used to demonstrate.
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what this limits: the identification of these neurons as CA3 and CA1: cells were selected as candidates on waveform and firing-rate characteristics and then confirmed within the CA3-to-CA1 projection pathways via measures of functional connectivity
limitations[3]1.0the tagger's words
limitationsThe human proportion is validated by its resemblance to published animal numbers.
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what this limits: the 26% feed-forward correlation reported here: the authors support it by noting that it favourably compares to reports of 20%-25% feedforward CA3-CA1 correlation in published animal studies
limitations[4]1.0the tagger's words
controlspost-operative electrode placement verified by MRI
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
eliminates: assigning CA1 and CA3 recordings to the wrong subfield, which is the entire distinction the paper rests on · outcome (stated by the tagger, no quotation): held
controls[0]0.85the tagger's words
conceptsinterneurons
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: interneurons
concepts[0]the paper's words
conceptsprincipal neurons
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concepts[1]the paper's words
conceptsfunctional connectivity
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concepts[2]the paper's words
conceptsinverse correlation
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concepts[3]the paper's words
conceptssynaptic connectivity
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concepts[4]the paper's words
conceptsfeed-forward correlations
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
concepts[5]the paper's words
sensesan interneuron, here - A FIRING RATE ABOVE 20 Hz: the classification is made in a parenthesis and acted on in the main clause, so a rate threshold becomes a cell type and then an exclusion, and every proportion in the paper is computed over what remained
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[0]1.0the tagger's words
sensesa CA3 or CA1 principal neuron - CANDIDATE BY WAVEFORM, CONFIRMED BY CONNECTIVITY: the label is assigned from waveform and firing rate and then confirmed by the projection pattern it predicts, so the classification and the finding it supports rest on each other
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[1]1.0the tagger's words
sensesthe argument for the labels - AN EXPECTED SIGNATURE OF ERROR: misidentification is said to be expected to yield a higher percentage of inverse correlation, so the low inverse rate is offered as evidence the labels are right - sound only if misidentification could not also produce the observed pattern
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
senses[2]1.0the tagger's words
claim_relationsextends → Ulbert et al., intraoperative layer-specific human hippocampal recordings with postoperative histology
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claim_relations[0]the tagger's words
concept_edgesfeed-forward correlations —operationalised-as→ synaptic connectivity
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holds when: only for correlations in the 2- to 5-msec window · strength of the relation: 1 Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span says the correlations can be IDENTIFIED as connectivity; operationalised-as is loose.
concept_edges[0]the tagger's words
content_tagst-test
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: t-test
content_tags.statistics[0]the tagger's words
content_tagscross-correlation
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.statistics[1]the tagger's words
content_tagsstandard deviation
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content_tags.statistics[2]the tagger's words
content_tagsp-value
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
also in: p-value
content_tags.statistics[3]the tagger's words
content_tagsNearly 80% of putative CA3-to-CA1 cell pairs showed positive cross-correlations compatible with a feed-forward connection, whereas only 2.6% showed inverse (feedback) correlation.
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content_tags.findings[0]the tagger's words
content_tagsFeed-forward correlation was found in 1,071 of 4,070 CA3-CA1 pairs (26%), a rate close to the 20%-25% reported in animal studies, even after synchronous and long-latency correlations were excluded.
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content_tags.findings[1]the tagger's words
content_tagsIn non-epileptic patients the CA1 region lay at an average depth of 36.06 mm from the outer table of the skull on the left and 34.84 mm on the right.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[2]the tagger's words
content_tagsOnly the 2-5 msec feed-forward correlations (20.3%) are definitive CA3-to-CA1 synaptic connectivity, but positive correlations dominated (77.8%) and inverse correlations were rare, which the authors read as evidence that the cells were correctly assigned to CA3 and CA1.
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.findings[3]the tagger's words
content_tagsAnterior hippocampal neurons fired mainly at the sample response, whereas posterior hippocampal neurons fired at elevated rates in the interval between the sample and the match responses.
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content_tags.findings[4]the tagger's words
content_tagsAbout five times as many recorded hippocampal neurons fired below 5.0 Hz as fired above 5.0 Hz.
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content_tags.findings[5]the tagger's words
content_tagsDelayed-Match-to-Sample
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.definitions[1]the tagger's words
content_tagscross-correlograms
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.variables[0]the tagger's words
content_tagsline noise
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also in: line noise
content_tags.variables[3]the tagger's words
content_tags2.6% — proportion of CA3-CA1 cell pairs showing feedback (inverse) correlation, taken as the misidentification rate
Quotation withheld — this record is not cleared for redistribution. The sentence is in the paper at the link above.
content_tags.quantities[0]the tagger's words
content_tags1071 (26%) of 4070 — number and share of cell pairs showing feed-forward CA3-to-CA1 correlation
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content_tags.quantities[1]the tagger's words
content_tags77.8% — share of CA3-CA1 pairs showing any positive (synchronous, short-lag or long-lag) correlation
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content_tags.quantities[2]the tagger's words
content_tags36.06 ± 2.88 mm — mean depth of left-hemisphere CA1 from the outer table of the skull in non-epileptic patients
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content_tags.quantities[3]the tagger's words
content_tags744 — number of neurons recorded across the 23 implanted patients (per Table 1)
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content_tags.quantities[4]the tagger's words

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