Cooperative Subnetworks of Molecularly Similar Interneurons in Mouse Neocortex — TEI-tagged view

Karnani, Jackson, Ayzenshtat, Tucciarone, Manoocheri, Snider, Yuste · 2016 · neuroscience · doi:10.1016/j.neuron.2016.02.037 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. method is tagged 'electrophysiology' because multi-cell patch clamp and paired recordings carry the mechanistic argument, but the paper is genuinely multi-method: in vivo two-photon calcium imaging establishes the co-activity phenomenon, and rabies tracing maps presynaptic partners; the single method facet cannot hold all three. The paper also proposes a revised connectivity model ('We therefore propose an updated standard model for IN connectivity in the neocortex...'), which is a critique/model-revision element the claim type facet cannot carry alongside 'mechanism'. 2026-08-13, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
1 quotation on this page contains a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
Other fields define these differently the same word, defined another way in another discipline
model 4 fields · population 3 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
VIP14 SOM12 PV22 interneuron24 population15 co-activity cooperativity2 PCs2 excitation7 inhibit disinhibition6 electrical coupling GABAergic7 depressing2 facilitating2 correlation108 binarized shuffled3 locomotion8 ongoing rabies4 presynaptic2 subnetwork2 L-EPSC positive control intersomatic spontaneous6 labelling2 dyad hierarchy4 model22 team marker4 epilepsy8 V16 electrophysiology110

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenonwithin-population co-activity of neocortical interneurons— “Here we show in vivo and in vitro that members of two non-overlapping neocortical IN populations, expressing somatostatin (SOM) or vasoactive intestinal peptide (VIP), are active as populations rather than individually.”
claim-typemechanism— “We demonstrate a variety of synergistic mechanisms, involving population-specific local excitation, GABAergic disinhibition and excitation through electrical coupling, which likely underlie IN population co-activity.”
method — evidence— “To probe this directly, we used multi-cell patch clamp to assess connectivity parameters between nearby (intersomatic distances 20–100 µm) PCs and VIPs or SOMs in triple-transgenic VIP-cre∷LSL-TOM∷SOM-GFP(GIN) slices (see Methods).”
object of study — evidence— “Here we show in vivo and in vitro that members of two non-overlapping neocortical IN populations, expressing somatostatin (SOM) or vasoactive intestinal peptide (VIP), are active as populations rather than individually. We demonstrate a variety of synergistic mechanisms, involving population-specific local excitation, GABAergic disinhibition…
research question — evidence— “However, it is unclear how interneurons coordinate their activity within subpopulations. It is particularly puzzling how mutually inhibitory interneuron populations manage to operate together while embedded within a highly interconnected network.”
contribution — evidence— “We therefore propose an updated standard model for IN connectivity in the neocortex featuring reciprocally inhibitory population dyads rather than sequential hierarchy of populations and groups rather than individual neurons as computational units”
transferfrom viral tracing: monosynaptic rabies tracing from genetically defined starter cells, used to ask how much local input each class receives— “To address this, we assessed the extent to which VIPs, compared to SOMs, are innervated by nearby PCs, by tracing presynaptic neurons of VIPs and SOMs with rabies (see Methods). Since similar experiments have been performed in V1”transfers[0]
transferfrom two-photon photostimulation: sequential stimulation of soma-sized volumes while recording two cells, to ask whether their inputs are shared— “Since these data suggest that VIPs and SOMs do not share presynaptic partners, as a positive control we ran the same protocol on PVs. We chose PVs because they had the highest subthreshold cross-correlations in our data ( Figure S3C ), suggesting that they share many presynaptic partners”transfers[1]
transferfrom motor control: agonist and antagonist muscle pairs, used as the argument for why two mutually inhibitory populations should not share excitatory drive— “The situation is similar to motor coordination of agonist/antagonist muscle pairs where simultaneous contraction of both would not be energetically advantageous. Along this line of reasoning, it would make sense to segregate PC networks to feed only into one population of a mutually inhibitory pair of IN populations. Our data in Figures 3 and…transfers[2]
transferfrom ensemble physiology: co-activity of principal cells during ongoing activity, imported as the question to ask of inhibitory cells— “Co-activation of neurons inevitably depends on synaptic connectivity of excitatory as well as inhibitory neurons, but while co-activity of neocortical principal cells (PCs) has been studied extensively ( Ch’ng and Reid, 2010 , Miller et al., 2014 , Bathellier et al., 2012 , Sakata and Harris, 2009 ), that of inhibitory interneurons (INs) has…transfers[3]
mechanismFour converging circuit mechanisms recruit members of the same interneuron class: electrical coupling, absent or scarce within-population inhibition, disinhibition via inhibition of the reciprocally inhibitory class, and cholinergic self-excitation of VIPs.— “Our data suggest that VIPs and SOMs recruit their population members through four mechanisms: electrical coupling, complete lack (SOMs) or relative scarcity (VIPs) of within-population inhibition (see also ( Hu et al., 2011 , Ma et al., 2012 )), strong within-population disinhibition through inhibition of the reciprocally inhibitory…mechanisms[0]
mechanismVIPs inhibiting SOMs (and vice versa) removes inhibition from their own population members, so firing in a few cells raises the co-activity of the whole population.— “Through the inhibitory synapses between VIPs and SOMs, these INs can disinhibit members of the same population, effectively increasing the co-activity of the population.”mechanisms[1]
mechanismAcetylcholine produced by VIPs recruits further VIPs that are themselves ACh-sensitive, closing a positive feedback loop.— “The recruitment of VIPs by exogenous ACh ( Figure S6 ) and their mecamylamine-sensitive population-recruitment ( Figure 5H ), combined with their ability to produce ACh ( von Engelhardt et al., 2007 ) suggest that ambient ACh recruits a positive feedback loop via VIPs.”mechanisms[2]
mechanismStrongly facilitating, slow-kinetics inhibitory synapses between SOMs and VIPs grow during sustained firing, sustaining disinhibition of the partner population over hundreds of milliseconds.— “Facilitating synapses are ideal for promoting activity of population members on >100 ms timescales through inhibition of a reciprocally connected inhibitory population (see next section).”mechanisms[3]
mechanismfour mechanisms recruit members of the same class: electrical coupling, absent or scarce within-population inhibition, disinhibition through the reciprocally inhibitory population, and self-excitation of VIPs— “Our data suggest that VIPs and SOMs recruit their population members through four mechanisms: electrical coupling, complete lack (SOMs) or relative scarcity (VIPs) of within-population inhibition (see also ( Hu et al., 2011 , Ma et al., 2012 )), strong within-population disinhibition through inhibition of the reciprocally inhibitory…mechanisms[4]
mechanismand a fifth from outside: the surrounding excitatory network drives each population with its own synaptic dynamics, depressing onto VIPs and facilitating onto SOMs— “PCs formed excitatory synapses onto VIPs and SOMs at similar rates, but synapses onto VIPs were depressing, while those onto SOMs were facilitating ( Figure 2A ). Additional recordings in primary somatosensory cortex (S1) also demonstrated a depressing synaptic PC->VIP connection (5/38 connections, 13%) suggesting that the organization of…mechanisms[5]
mechanismthe recruitment of VIPs by exogenous ACh and their mecamylamine-sensitive population-recruitment, combined with their ability to produce ACh, suggest that ambient ACh recruits a positive feedback loop via VIPs— “The recruitment of VIPs by exogenous ACh ( Figure S6 ) and their mecamylamine-sensitive population-recruitment ( Figure 5H ), combined with their ability to produce ACh ( von Engelhardt et al., 2007 ) suggest that ambient ACh recruits a positive feedback loop via VIPs.”mechanisms[6]
mechanismseparating the excitatory sources of two mutually inhibitory populations is likened to agonist and antagonist muscles, where contracting both at once would waste energy— “The situation is similar to motor coordination of agonist/antagonist muscle pairs where simultaneous contraction of both would not be energetically advantageous. Along this line of reasoning, it would make sense to segregate PC networks to feed only into one population of a mutually inhibitory pair of IN populations. Our data in Figures 3 and…mechanisms[7]
mechanismthe proposed function is supralinear amplification of one kind of inhibition as demand grows, for instance before excitation overwhelms the circuit— “IN population cooperativity may be advantageous to circuit operation by predictively amplifying the particular type of inhibition (dendrite targeting, perisomatic or disinhibitory) provided by the population. Thus these multiple cooperative specializations would operate together to deliver wider-spread and increased inhibition in a…mechanisms[8]
contradicts Pfeffer et al. (2013) on target-selective inhibition by PV interneurons— “In contrast to previous findings ( Pfeffer et al., 2013 ), we find that PVs inhibit IN targets unselectively ( Figure 4A , S4 ).”claim_relations[0]
extends Hofer et al. (2011) on PV interneuron co-activity— “Here we showed that SOMs and VIPs demonstrate within-population co-activity ( Figure 1 , 5 ) on a timescale of hundreds of milliseconds, and previous work has shown that…claim_relations[1]
replicates Hu et al. (2011) and Ma et al. (2012) on the absence of SOM-to-SOM inhibitionclaim_relations[2]
contradicts the prevailing hierarchical disinhibitory model built from activating one interneuron population at a time
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claim_relations[3]
extends the demonstration that parvalbumin interneurons are co-active during ongoing activity, generalised here to two more classes
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claim_relations[4]
qualifies the account of VIP interneurons as specialists in long-range excitation, by showing comparable local input
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claim_relations[5]
supports reports that within-population inhibition is absent among somatostatin cells
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claim_relations[6]
qualifies its own generalisation, since the mice were naive and some of this wiring is reported to change with learning
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claim_relations[7]
senseTHE EXPERIMENT THAT WOULD SETTLE IT IS NAMED, AND THE REAGENT DOES NOT EXIST: suitable loss-of-function tests would need synaptic blockers simultaneously specific to both the presynaptic and the postsynaptic population, so the mechanisms are implied by correlation rather than directly
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senses[0]
senseand the single exception is marked as such - one figure directly demonstrates the GABAergic role in cooperative recruitment, and the paper says which one
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senses[1]
senseA POSITIVE CONTROL CHOSEN ON THE STRENGTH OF AN EARLIER MEASUREMENT IN THE SAME DATASET: PVs are used to validate the shared-input assay because they had the highest subthreshold cross-correlations here, so they should share presynaptic partners
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senses[2]
senseand the null is only interpretable because that control worked - shared inputs were detectable in PV pairs and indistinguishable from zero in VIP-SOM pairs
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senses[3]
senseTHE MEASURE IS BUILT BY SUBTRACTING THE BASELINE INTO EXISTENCE: laser-EPSCs are the post-stimulus count minus the pre-stimulus count, so the quantity itself is a difference and can legitimately come out negative
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senses[4]
sensethe correlation analysis is repeated on binarized data specifically to avoid systematic biases in the fluorescence measure it was first computed on
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senses[5]
senseTHE CATEGORIES ARE DECLARED CONVENIENT RATHER THAN FUNDAMENTAL: the three markers are used because transgenic lines exist for them, and further subpopulations are expected inside each
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senses[6]
senseAND THE UNIT OF COMPUTATION IS PROPOSED TO CHANGE: groups rather than individual neurons, and reciprocally inhibitory dyads rather than a sequential hierarchy
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senses[7]
sensea distance threshold is set from the data rather than chosen: correlations approach zero beyond 150 micrometres, which is read as the range over which inputs are shared and then used as the analysis cutoff
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senses[8]
controlrunning the identical protocol on PV cells, where shared presynaptic partners ARE expected — held — rules out the protocol's inability to detect shared presynaptic partners as the reason none were found between VIPs and SOMs - a positive control against a null result
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controls[0]
controlcomparing baseline firing rate between control and GABA receptor blockade - a manipulation check reported inside a parenthesis — held — rules out a shift in baseline firing rate as the explanation of the change in cooperativity: 1.9 +/- 0.2 Hz against 1.9 +/- 0.3 Hz, P = 0.68
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controls[1]
controlinspecting active and passive electrophysiological properties of VIPs grouped by cooperativity and by their response to GABA blockade - the sentence states the check and not its result, so no outcome is recorded — absent-not-in-staged-text — rules out that the spread in VIP cooperativity is one population varying, when it may be two subclasses - the check groups cells by cooperativity and by their response to GABA blockade and asks whether the electrophysiology follows
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controls[2]
noteVIP —distinct-from→ SOM — two non-overlapping populations, each shown to be active as a population rather than individually
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concept_edges[0]
effect directionlocomotion —causes→ correlation — increases
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concept_edges[5]
notelocomotion —causes→ correlation — which is why the data are split by movement state before anything is compared
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concept_edges[5]
auditlocomotion —causes→ VIP — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says VIP and SOM activity is modulated by movement; 'locomotion causes VIP' drops 'activity'.
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concept_edges[6]
notedepressing —contrasted-with→ facilitating — the same excitatory cells drive the two populations with opposite short-term dynamics, so they peak at different times during a train
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concept_edges[7]
auditdisinhibition —distinct-from→ electrical coupling — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span lists coupling and disinhibition among recruitment mechanisms; distinct-from is loose.
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concept_edges[20]
notedisinhibition —distinct-from→ electrical coupling — FOUR MECHANISMS, NOT ONE: electrical coupling, absent or scarce within-population inhibition, disinhibition through the opposing population, and self-excitation
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concept_edges[20]
auditGABAergic —causes→ cooperativity — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span shows GABAergic inhibition's role in cooperative recruitment of SOMs; 'cooperativity' is terse.
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concept_edges[21]
noteGABAergic —causes→ cooperativity — AND THE ONE DIRECT DEMONSTRATION IS MARKED AS THE EXCEPTION, with the figure named
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concept_edges[21]
notedyad —contrasted-with→ hierarchy — AND THE UNIT OF COMPUTATION CHANGES WITH THE MODEL: groups rather than individual neurons, dyads rather than a sequence
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concept_edges[26]
auditRETRACTED (A DECLARED UNKNOWN, AND THE EDGE IS A TRUISM THE SPAN DOES NOT ASSERT) · interneuron —part-of→ population — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but interneurons within subpopulations; part-of is loose.
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concept_edges[33]
noteRETRACTED (A DECLARED UNKNOWN, AND THE EDGE IS A TRUISM THE SPAN DOES NOT ASSERT) · interneuron —part-of→ population — and the puzzle stated plainly - how mutually inhibitory populations manage to operate together inside a densely interconnected network
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concept_edges[33]
retractedRETRACTED (A DECLARED UNKNOWN, AND THE EDGE IS A TRUISM THE SPAN DOES NOT ASSERT) · interneuron —part-of→ population — A DECLARED UNKNOWN, AND THE EDGE IS A TRUISM THE SPAN DOES NOT ASSERT. The edge is 'interneuron --part-of--> population'. The span: '…unclear how interneurons coordinate their activity within…' The sentence is about what is NOT known. That interneurons belong to populations is background vocabulary it uses in passing, not a relation it establishes.
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concept_edges[33]
outcome (stated by the tagger, no quotation)control — heldcontrols[0]
outcome (stated by the tagger, no quotation)control — heldcontrols[1]
outcome (stated by the tagger, no quotation)control — absent-not-in-staged-textcontrols[2]
for which uselimitation — every mechanistic claim in the paper: SUITABLE LOSS-OF-FUNCTION EXPERIMENTS TO TEST THE CONTRIBUTION OF THESE MECHANISMS ... DO NOT YET EXIST, so the support is correlational by necessity rather than by choice
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limitations[0]
for which uselimitation — the recruitment results specifically: THIS BROAD ACTIVATION OF THE LOCAL MICROCIRCUIT INCLUDES AXON TERMINALS EXPRESSING C1V1, THEREFORE THESE RESULTS MAY BE DUE TO MULTIPLE COMPLEX NETWORK INTERACTIONS
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limitations[1]
for which uselimitation — every claim stated at the level of the three marker classes: they are CONVENIENTLY CATEGORIZED BY THE NON-OVERLAPPING MARKERS SOM, PV AND VIP TO UTILIZE TRANSGENIC MICE, and THERE ARE LIKELY FURTHER SUBPO[pulations] - the taxonomy follows the available reagents
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limitations[2]
duplicate oflimitation — limitations[0]
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limitations[3]
for which uselimitation — the same scope as limitations[0] - correlation, because the loss-of-function tool does not exist
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limitations[3]
duplicate oflimitation — limitations[1]
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limitations[4]
for which uselimitation — the same scope as limitations[1] - axon terminals are excited too
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limitations[4]
for which uselimitation — the same scope as limitations[2], with the consequence: the framework is expected to hold on average over classes that are convenient rather than fundamental
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limitations[5]
for which uselimitation — the cell-type identification across lines: labelling was verified in one line, the rest taken on the strength of prior documentation
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limitations[6]
for which uselimitation — the transfer of the wiring result to trained animals: WE USED NAIVE MICE, and other evidence suggests VIPS AND PVS CAN WIRE INTO A MUTUALLY INHIBITORY DYAD DURING LEARNING
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limitations[7]
for which uselimitation — the team/compartment account specifically: WE HYPOTHESIZE FOR FURTHER STUDIES - offered as a hypothesis, not a result
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limitations[8]
duplicate ofmechanism — mechanisms[4]
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mechanisms[0]
replicationuntested
limitationThe proposed mechanisms are supported mostly by correlation because the cell-type-specific loss-of-function tools needed do not exist.
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limitations[0]
limitationBroad optogenetic activation also stimulates axon terminals, so the recruitment results may reflect complex network interactions rather than direct drive.
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limitations[1]
limitationThe marker-defined populations probably contain finer subpopulations that were not resolved here.
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limitations[2]
limitationthe mechanisms are implied by correlation rather than shown directly, because the loss-of-function reagent that would be needed does not exist
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limitations[3]
limitationbroad optogenetic activation also excites axon terminals, so those results may reflect complex network interactions
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limitations[4]
limitationthe three marker classes are convenient rather than fundamental, and the framework is expected to hold on average for populations known to contain further subtypes
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limitations[5]
limitationcell-type labelling was verified in only one of the mouse lines, the rest taken on the strength of prior documentation
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limitations[6]
limitationthe animals were naive, and other work suggests some of this wiring changes with learning
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limitations[7]
limitationthe compartmentalisation of cooperativity into local teams is offered as a hypothesis for future study
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limitations[8]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingIn awake mice, VIP interneurons were more strongly correlated with other VIPs than with non-VIP cells, showing within-population co-activity during ongoing activity.
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content_tags.findings[0]
findingNearby pyramidal cells contact VIPs and SOMs at similar rates but with opposite short-term dynamics, depressing onto VIPs and facilitating onto SOMs.
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content_tags.findings[1]
findingTwo-photon input mapping found essentially no shared presynaptic excitatory cells between a VIP and a SOM, whereas PV pairs shared about a fifth of their inputs.
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content_tags.findings[2]
findingVIP-SOM pairs had significantly lower membrane-potential correlations than all other pairs, supporting innervation by distinct sets of pyramidal cells.
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content_tags.findings[3]
findingForcing three SOM interneurons to fire significantly increased the spontaneous firing of a fourth, uninduced SOM, demonstrating cooperative within-population recruitment.
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content_tags.findings[4]
findingBlocking GABA-A and GABA-B receptors sharply reduced the SOM cooperative recruitment effect, identifying disinhibition as a main driver.
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content_tags.findings[5]
findingVIP cooperativity was insensitive to GABA blockade but reduced by nicotinic blockade, implicating acetylcholine released by VIPs in recruiting other VIPs.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[6]
findingInhibitory connectivity was lowest within SOMs (0%), within VIPs, and from VIPs to PVs.
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content_tags.findings[7]
findingContrary to an earlier report, PV interneurons were found to inhibit other interneuron types without selectivity.
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content_tags.findings[8]
findingmembers of two non-overlapping interneuron populations are active as populations rather than individually
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content_tags.findings[9]
findingand the conclusion is that these populations work as cooperative units, generating an amplifying nonlinearity in circuit output
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content_tags.findings[10]
findingco-activity of principal cells had been studied extensively while that of inhibitory cells had received little attention
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content_tags.findings[11]
findingongoing activity is argued to be the optimal condition, because it shows circuit flow without thalamic drive
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content_tags.findings[12]
findingTHE PUZZLE STATED PLAINLY: how mutually inhibitory populations manage to operate together inside a densely interconnected network
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content_tags.findings[13]
findingboth classes were more correlated with their own members than with anything else, in awake mice in a dark room
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content_tags.findings[14]
findingTHE ANALYSIS IS REPEATED ON BINARIZED DATA to avoid systematic biases in the fluorescence correlations
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content_tags.findings[15]
findingand the co-activity counts are held against shuffled surrogates as well as against the other cells in the field
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content_tags.findings[16]
findingthe data are split by movement state because locomotion modulates both populations
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content_tags.findings[17]
findingand locomotion raised the within-population correlations in both
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content_tags.findings[18]
findingthe same excitatory cells drive the two populations with opposite short-term dynamics, depressing onto one and facilitating onto the other
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content_tags.findings[19]
findingwhich shows up in network activation: one class fires a single spike and falls silent while the other ramps up
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content_tags.findings[20]
findingwith a caveat attached in the same paragraph, that broad activation reaches axon terminals too
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content_tags.findings[21]
findingrabies tracing was run in a different cortical area precisely because the published version had been done in the other one
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content_tags.findings[22]
findingVIPs and SOMs received input from nearby cells to a similar extent, most heavily from L2/3.
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content_tags.findings[23]
findingshared spontaneous depolarisations were frequent within a class and rare across the two
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content_tags.findings[24]
findingcorrelations approached zero beyond 150 um intersomatic distance, suggesting they reflect shared input from nearby cells
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content_tags.findings[25]
findingcorrelation coefficients were not significantly different between SOM-SOM, VIP-PV and VIP-VIP pairs, while VIP-SOM pairs had significantly lower correlations
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content_tags.findings[26]
findingTHE MEASURE IS A DIFFERENCE BY CONSTRUCTION: laser-EPSCs are the post-stimulus count minus the pre-stimulus count
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content_tags.findings[27]
findingwith the stimulation first shown to have recruited presynaptic cells at all
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content_tags.findings[28]
findingA POSITIVE CONTROL CHOSEN ON THE STRENGTH OF AN EARLIER MEASUREMENT IN THE SAME DATASET: the class with the highest subthreshold cross-correlations, which should therefore share inputs
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content_tags.findings[29]
findingand it worked - both shared and unique inputs were detected in those pairs
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content_tags.findings[30]
findingwhile the shared proportion across the two test classes was indistinguishable from zero
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content_tags.findings[31]
findingwith the conclusion hedged in the sentence itself - innervated at least in part by non-overlapping excitatory subnetworks
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content_tags.findings[32]
findingAN INHERITED ASSUMPTION WITH ONE SPOT-CHECK: since the high reliability of cell-type specific labelling in these mouse lines has been documented before, labelling was only confirmed in one of them with immunohistochemistry
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content_tags.findings[33]
findingtwo cortical areas were checked to agree before being pooled, with the separated data kept in a supplement
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content_tags.findings[34]
findingonly PVs showed high within-population inhibition; the lowest rates were within SOMs
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content_tags.findings[35]
findingFOUR MECHANISMS, NOT ONE: electrical coupling, absent or scarce within-population inhibition, disinhibition through the opposing population, and self-excitation
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content_tags.findings[36]
findingTHE EXPERIMENT THAT WOULD SETTLE IT IS NAMED AND THE REAGENT DOES NOT EXIST: blockers simultaneously specific to both the presynaptic and the postsynaptic population would be needed
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content_tags.findings[37]
findingand the single direct demonstration is marked as the exception, with the figure named
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content_tags.findings[38]
findingambient acetylcholine is proposed to close a positive feedback loop through cells that both respond to it and produce it
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content_tags.findings[39]
findingTHE CATEGORIES ARE DECLARED CONVENIENT RATHER THAN FUNDAMENTAL, with further subpopulations expected inside each and the framework claimed to hold on average
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content_tags.findings[40]
findingand a compartmentalisation hypothesis is offered for future work - nearby members cooperating while a distant group of the same class stays independent
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content_tags.findings[41]
findingthe argument for segregated excitatory drive is borrowed from agonist and antagonist muscle pairs
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content_tags.findings[42]
findingwith the generalisation offered that non-overlapping input may hold for every reciprocally inhibitory pair
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content_tags.findings[43]
findingand a limit stated: the mice were naive, and this wiring is reported to change with learning
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content_tags.findings[44]
findingAND THE UNIT OF COMPUTATION IS PROPOSED TO CHANGE: groups rather than individual neurons, dyads rather than a sequential hierarchy
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content_tags.findings[45]
findingwith the model being replaced traced to a design that activates one population at a time
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content_tags.findings[46]
findingthe proposed function is supralinear amplification of one kind of inhibition as demand grows
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content_tags.findings[47]
quantity~85% — share of neocortical interneurons covered by the three non-overlapping PV, SOM and VIP populations
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[0]
quantity68%, 8643/12641 cells — proportion of rabies-labelled presynaptic cells with clear pyramidal morphology
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[1]
quantity68 ± 22 % — increase in spontaneous firing of the fourth SOM when three other SOMs were driven to fire
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[2]
quantity22.6 ± 5.6 % vs −0.8 ± 4.9 % — estimated proportion of shared presynaptic cells for PV-PV pairs versus VIP-SOM pairs
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[3]
quantityR = 0.07 ± 0.01 to R = 0.13 ± 0.03, P = 0.038 — rise in within-VIP pairwise correlation from stationary to locomotion epochs
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content_tags.quantities[4]
quantity86.3% / 94.9% — specificity and sensitivity of the VIP-cre reporter line checked by immunohistochemistry
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[5]
quantity55 % / 8.8 % / 24 % — share of spontaneous depolarizing activations shared within SOM pairs, across SOM-VIP pairs, and within VIP pairs
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[6]
quantity16 ± 7 %, P = 0.007 — residual SOM firing-rate increase surviving GABA-A and GABA-B receptor blockade
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[7]
quantity150 mm — the intersomatic distance beyond which subthreshold correlations vanish, read from the data and then used as the analysis cutoff
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content_tags.quantities[8]
quantity86.3% — labelled cells that were immunoreactive in the one line checked, against 94.9 percent the other way
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[9]
quantity55 % — spontaneous activations shared within a class, against 8.8 percent across the two
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[10]
quantity26 ± 7 Hz — average firing rate SOMs ramped up to during the light pulse, while VIPs tended to fire a single AP at the beginning followed by quiescence
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[11]
variableGABA receptor blockade (independent)
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content_tags.variables[1]
variablespontaneous firing rate (dependent)
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content_tags.variables[2]
variablebaseline firing rate (control)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[5]
variablecorrelation
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[6]
variableL-EPSC
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[7]
variableintersomatic
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[8]
variablelocomotion
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content_tags.variables[9]
definitionensembles
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content_tags.definitions[0]
definitionlaser-EPSCs
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content_tags.definitions[1]
definitionsummation ratio
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content_tags.definitions[2]
definitionincreased firing
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content_tags.definitions[4]
definitionL-EPSC
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content_tags.definitions[5]
definitionco-activation
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content_tags.definitions[6]
definitiondyad
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content_tags.definitions[7]
definitionpositive control
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content_tags.definitions[8]
key-termsVIP, SOM, PV, interneuron, population, co-activity, cooperativity, PCs, excitation, inhibit, disinhibition, electrical coupling, GABAergic, depressing, facilitating, correlation, binarized, shuffled, locomotion, ongoing, rabies, presynaptic, subnetwork, L-EPSC, positive control, intersomatic, spontaneous, labelling, dyad, hierarchy, model, team, marker, epilepsy, V1
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
conceptcorrelation — not defined in this paper's own words; the pairwise quantity every in vivo and subthreshold claim rests on
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[15]
conceptlocomotion — not defined in this paper's own words; the state the data are split by, because it modulates both populations
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[18]
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
paired t-test P
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[0]
t-test as written: unpaired Student t-tests
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content_tags.statistics[1]
correlation R as written: Pearson correlation coefficients
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content_tags.statistics[2]
z-test P as written: z-test against zero
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content_tags.statistics[3]
standard error of the mean SEM as written: mean ± SEM
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content_tags.statistics[4]
cross-correlation as written: subthreshold membrane potential cross-correlograms
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content_tags.statistics[5]
surrogate/shuffled data test as written: shuffled surrogate data
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content_tags.statistics[6]
paired T-test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[7]
z-test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[8]
correlation coefficients
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[9]
Second readings
a facet read a second time, independently, from its own sentence — and whether the two readings agree
claim typemechanism — a second reading reaching the same value; recorded: mechanism
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alternatives.claim_type
methodcorrelation of calcium signals in labelled cells in awake mice, then paired and quadruple patch clamp, rabies tracing and two-photon input mapping in slices — a second reading DIFFERING from the recorded value; recorded: electrophysiology
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alternatives.method
phenomenonwithin-population co-activity: members of one interneuron class active together during ongoing activity — a second reading DIFFERING from the recorded value; recorded: within-population co-activity of neocortical interneurons
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alternatives.phenomenon

When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

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