A new neural framework for visuospatial processing — TEI-tagged view

Kravitz, Saleem, Baker, Mishkin · 2011 · neuroscience · doi:10.1038/nrn3008 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. Claim type is 'existence' (three anatomically distinct pathways exist and carry distinct functions) rather than 'critique', even though the review's rhetorical thrust is that the Where/How dichotomy is insufficient; the critical element is recorded in the claim_relations. Note the source text renders 'parieto–medial temporal' with an en dash in the abstract and 'parieto – medial temporal' with spaces in the body — the quotes preserve each form exactly as it appears. Because this is a review with no new data, replication status is 'untested'. 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
14 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
This record’s own method is review, and the tags below follow from that. A review’s findings, quantities and statistics are things stated IN this paper, and some of them report results obtained elsewhere. No tag on this page names a different author. Measured across every review in this corpus, 81% of a review’s tags carry no citation at all — most of them are the review speaking. The corpus does not adjudicate the rest: read an unmarked tag as a claim this paper makes, not necessarily one it made first.
Other fields define these differently the same word, defined another way in another discipline
connectivity 2 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
dorsal stream3 ventral stream2 parieto spatial working memory3 visually guided action navigation3 egocentric5 allocentric5 retrosplenial3 posterior cingulate cortex2 topographic disorientation parahippocampal place area head-direction cells2 place cells13 agranular review319

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenondorsal-stream visuospatial processing— “The division of cortical visual processing into distinct dorsal and ventral streams is a key framework that has guided visual neuroscience.”
claim-typeexistence— “We review anatomical and functional evidence in primates indicating that the dorsal stream actually gives rise to three distinct, major pathways; a parieto–prefrontal pathway, a parieto–premotor pathway and a parieto–medial temporal pathway ( FIG. 1c ), which primarily support spatial working memory, visually guided action and spatial…
method — evidence— “Here, we review anatomical evidence, primarily from monkeys, in order to update the circuitry within the classical dorsal visual stream, after which we show that there is a trifurcation of this stream beyond the parietal cortex.”
object of study — evidence— “The characterization of the ventral stream as a ‘What’ pathway is relatively uncontroversial, but the nature of dorsal stream processing is less clear. Originally proposed as mediating spatial perception (‘Where’), more recent accounts suggest it primarily serves non-conscious visually guided action”
research question — evidence— “The existence of these multiple pathways, each mediating a different class of visuospatial functions, suggests that earlier characterizations of the dorsal stream as being either a perceptual Where or a motoric How pathway were insufficient to adequately capture the diversity of its visuospatial functions.”
contribution — evidence— “We review anatomical and functional evidence in primates indicating that the dorsal stream actually gives rise to three distinct, major pathways; a parieto–prefrontal pathway, a parieto–premotor pathway and a parieto–medial temporal pathway ( FIG. 1c ), which primarily support spatial working memory, visually guided action and spatial…
transferfrom human neuropsychology: the single-patient dissociation in D.F., which grounded the How account of the whole dorsal stream— “Later, a patient with agnosia (D.F.), who has a large bilateral lesion of the occipitotemporal cortex and a small left-sided lesion of the occipitoparietal cortex ( FIG. 1b ) 4 , 5 , was found to have impaired perception of objects but intact ability to reach to objects, including shaping her grasping hand to reflect the size, shape and…transfers[0]
transferfrom resting-state fMRI: functional connectivity in humans, used to corroborate a circuit established by tract tracing in monkeys— “Strong correlations were also observed between time courses of fMRI responses in regions that constitute the parieto–medial temporal pathway — that is, the IPL, PCC and RSC — and the parahippocampal cortex ( FIG. 3 ; see REF. 53 for similar results in monkey and see REF. 54 for related results in human connectivity).”transfers[1]
mechanismThe three pathways acquire their different functions from their differing cortical targets rather than from their overlapping parietal sources — granular six-layered targets support perception while the agranular premotor target supports action— “To account for how these three pathways support such distinctly different visuospatial functions — conscious perception and nonconscious action — and yet emerge from overlapping sources within the posterior parietal cortex, we suggest that their differential cortical targets are largely responsible.”mechanisms[0]
mechanismRegional function is generated by the region's pattern of connectivity, so densely and reciprocally connected regions necessarily share functional properties and functions blend in gradients along a pathway— “A major premise in this perspective is that the function of a region emerges from its particular pattern of connectivity, and that densely and reciprocally interconnected regions must share at least some functional properties.”mechanisms[1]
mechanismThe PCC and RSC sit mid-pathway and perform the conversion of egocentric parietal space codes into the allocentric codes used by the medial temporal lobe— “Consistent with its position in the parieto – medial temporal pathway, the PCC has also been proposed as an area that contributes to the translation between the egocentric representations of space in the posterior parietal cortex and the allocentric representations in the MTL (for example, REF. 119 ).”mechanisms[2]
mechanismthe occipito-parietal circuit is the shared antecedent from which all three pathways diverge— “This stream is now known to consist of a set of projections from early visual cortical areas to posterior regions of the parietal cortex — the latter including medial portions of the superior parietal lobule (SPL) — together with interconnections among those parietal regions.”mechanisms[3]
mechanismposterior parietal representations are predominantly egocentric while medial temporal ones are mainly allocentric, with PCC and RSC coordinating between them— “The posterior parietal region seems to contain predominantly egocentric representations of space, whereas the MTL contains spatial representations of scenes that are mainly allocentric.”mechanisms[4]
mechanismdamage at different points along the pathway produces predictably different forms of topographic disorientation— “In addition, we show that damage to the parieto–medial temporal pathway in humans results in various forms of topographic disorientation 15 that differ predictably depending on where along the pathway the damage has occurred.”mechanisms[5]
mechanisma speculative anatomical account: the perception pathways target granular six-layered cortex while the action pathway targets agranular five-layered cortex— “It may not be a coincidence that the targets of the parieto – prefrontal and parieto – medial temporal (‘perception’) pathways are six-layered…mechanisms[6]
mechanismhuman resting-state functional connectivity reproduces the monkey tract-tracing circuit
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mechanisms[7]
builds-on Milner and Goodale's 'How' account of the dorsal stream
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claim_relations[0]
contradicts the hypothesis (from patient D.F.) that the dorsal stream serves only non-conscious action and that only the ventral stream yields conscious representations
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claim_relations[1]
builds-on Margulies and colleagues (ref. 51), human/monkey functional connectivity of medial parietal areas
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claim_relations[2]
contradicts the characterisation of the dorsal stream as either a perceptual Where or a motoric How pathway
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claim_relations[3]
qualifies the claim that only the ventral stream produces representations accessible to consciousness
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claim_relations[4]
extends the original two-stream anatomy of Ungerleider and Mishkin
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claim_relations[5]
supports the parieto-medial temporal pathway, previously not well characterised in primates
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claim_relations[6]
sensethe same anatomical stream has carried three successive names - Where, How, and now a trifurcated framework - and each name IS a functional theory rather than a label
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senses[0]
sensedorsal stream is explicitly REDEFINED here: originally the pathway from striate cortex to the posterior inferior parietal lobule, now a widespread system across frontal, temporal and limbic lobes
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senses[1]
senseegocentric and allocentric are the two reference frames whose transformation is the pathway's proposed job, and the mechanism of transformation is stated to be unknown
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senses[2]
sensetopographic disorientation is not one syndrome but a family, subdivided by which part of the pathway is damaged
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senses[3]
edgedorsal stream —contrasted-with→ ventral stream
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concept_edges[0]
differs inegocentric —contrasted-with→ allocentric — THE AXIS IS THE REFERENCE FRAME, AND BOTH SIDES ARE HEDGED. 'The posterior parietal region seems to contain predominantly egocentric representations of space, whereas the MTL contains spatial representations of scenes that are mainly allocentric.' Note 'predominantly' and 'mainly' on either side: the division is a tendency, not a partition, and a join that treats it as a partition will find counterexamples in both regions and call them contradictions.
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concept_edges[1]
noteegocentric —contrasted-with→ allocentric — and the mechanism converting one to the other is stated to be unknown
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concept_edges[1]
notespatial working memory —distinct-from→ visually guided action — the two functions the old single dorsal stream had to carry at once
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concept_edges[3]
for which uselimitation — comparisons between functional properties within a region: THERE HAS BEEN LITTLE RESEARCH THAT DIRECTLY COMPARES THE RELATIVE IMPORTANCE OF THESE DIFFERENT FUNCTIONAL PROPERTIES (FOR EXAMPLE, PERIPERSONAL VERSUS EXTRAPERSONAL CODING) WITHIN THE SAME REGION
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limitations[0]
for which uselimitation — the intermediate areas of the pathway: THIS NEW FRAMEWORK ALSO HIGHLIGHTS THE PAUCITY OF EMPIRICAL DATA REGARDING THE INTERMEDIATE AREAS IN THE PARIETO-MEDIAL TEMPORAL PATHWAY
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limitations[1]
for which uselimitation — the trifurcation as a complete list: WE DO NOT MEAN TO IMPLY THAT THERE ARE THREE PATHWAYS ONLY, FOR THERE MAY WELL BE OTHERS
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limitations[2]
for which uselimitation — other modalities, excluded by design: IN LIMITING THIS REVIEW TO VISUOSPATIAL PROCESSING, WE RECOGNIZE THAT WE HAVE LARGELY NEGLECTED THE ROLE THAT THE POSTERIOR PARIETAL CORTEX PLAYS IN SPATIAL PROCESSING IN OTHER MODALITIES
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limitations[3]
for which uselimitation — everything the framework infers from anatomy: A MAJOR PREMISE IN THIS PERSPECTIVE IS THAT THE FUNCTION OF A REGION EMERGES FROM ITS PARTICULAR PATTERN OF CONNECTIVITY
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limitations[4]
for which uselimitation — the area-by-area presentation: THIS APPROACH IS PURELY DIDACTIC. IN FACT, WE ASSUME THAT THERE ARE GRADIENTS OF FUNCTION WITHIN AND BETWEEN areas
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limitations[5]
for which uselimitation — the reference-frame account: IT IS STILL UNCLEAR HOW THESE TRANSFORMATIONS BETWEEN REFERENCE FRAMES occur
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limitations[6]
duplicate oflimitation — limitations[2]
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limitations[7]
for which uselimitation — the same scope as limitations[2] - the trifurcation is not claimed to be exhaustive
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limitations[7]
for which uselimitation — the granular-versus-agranular explanation: WHETHER OR NOT THESE DIFFERENCES IN THE MAKEUP OF THEIR CORTICAL TARGETS HELP TO ACCOUNT FOR THE STRIKING DIFFERENCES IN THE FUNCTIONAL CHARACTERISTICS IS A MATTER FOR FUTURE RESEARCH
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limitations[8]
for which uselimitation — the navigation account of the pathway: THE EXISTENCE OF THESE MULTIPLE [routes] leaves other visuospatial functions available to it
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limitations[9]
for which uselimitation — the layout-over-semantics claim about PPA, which is contested: SEE REFS 173, 174 FOR OPPOSING VIEWS
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limitations[10]
evidential statusmechanism — the paper's own words: we suggest that
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mechanisms[0]
replicationuntested
limitationNo research directly compares the relative importance of the different functional properties within the same parietal region, so the proposed anatomical divisions are not yet functionally adjudicated.
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limitations[0]
limitationEmpirical data on the intermediate relay areas (PCC, RSC) of the proposed parieto-medial temporal pathway are sparse.
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limitations[1]
limitationThe trifurcation is not claimed to be exhaustive; further pathways may exist.
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limitations[2]
limitationScope is restricted to visuospatial processing, neglecting parietal contributions to spatial processing in other modalities.
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limitations[3]
limitationthe framework's central premise - that function follows connectivity - is stated as a premise rather than demonstrated
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limitations[4]
limitationthe area-by-area exposition is described by the authors as purely didactic, with gradients assumed instead
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limitations[5]
limitationhow the reference-frame transformations are actually performed remains unclear
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limitations[6]
limitationthere may be more than three pathways; the trifurcation is not claimed to be exhaustive
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limitations[7]
limitationthe granular versus agranular account is explicitly left for future research
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limitations[8]
limitationnavigation evidence does not exclude other visuospatial functions for the pathway
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limitations[9]
limitationthe claim that the parahippocampal place area tracks layout over semantic content has published opposing views
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limitations[10]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingThe dorsal stream is shown to trifurcate beyond parietal cortex into parieto-prefrontal, parieto-premotor and parieto-medial temporal pathways, the last running through posterior cingulate and retrosplenial cortex to the medial temporal lobe.
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content_tags.findings[0]
findingBecause each of the three pathways serves a different class of visuospatial function, neither the 'Where' nor the 'How' characterisation of the dorsal stream is adequate.
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content_tags.findings[1]
findingThe site of damage along the parieto-medial temporal pathway predicts which specific form of topographic disorientation a patient shows.
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content_tags.findings[2]
findingHuman resting-state fMRI connectivity between IPL, PCC, RSC and parahippocampal cortex converges with the monkey tract-tracing evidence for the proposed pathway.
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content_tags.findings[3]
findingWithin the IPL, only the rostral part (area 7b) is specialized for guiding action in peripersonal space.
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content_tags.findings[4]
findingThe dorsal stream is reconceived as a widespread visuospatial system across frontal, temporal and limbic cortex, contributing to both spatial perception and non-conscious spatial processing.
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content_tags.findings[5]
findingThe review suggests, as one potential answer, the MTL as a major point of convergence and perceptual integration for the ventral stream and the parieto-medial temporal pathway.
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content_tags.findings[6]
findingthe dorsal stream trifurcates beyond parietal cortex into prefrontal, premotor and medial temporal pathways
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content_tags.findings[7]
findingresting-state fMRI time courses correlate strongly among IPL, PCC, RSC and parahippocampal cortex
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content_tags.findings[8]
findingdamage at different points along the pathway yields predictably different topographic disorientations
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content_tags.findings[9]
findinglandmark agnosia leaves orientation and map-making intact but destroys landmark recognition
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content_tags.findings[10]
findinganterograde topographic disorientation leaves patients unable to form representations of new environments
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content_tags.findings[11]
findingthe parahippocampal place area responds equally to furnished and emptied rooms, tracking layout rather than content
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content_tags.findings[12]
findingpatient D.F. can reach accurately for objects she cannot consciously perceive
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content_tags.findings[13]
findingbut D.F. can also make conscious depth judgments that probably depend on the dorsal stream
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content_tags.findings[14]
quantitythree pathways, not claimed to be exhaustive — the proposed trifurcation, with the authors noting there may well be others
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content_tags.quantities[0]
variablereference frame
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content_tags.variables[1]
definitionparieto–medial temporal pathway
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content_tags.definitions[0]
definitionretrosplenial complex
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content_tags.definitions[1]
definitionhead-direction cells
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content_tags.definitions[2]
definitionplace cells
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content_tags.definitions[3]
definitionallocentric spatial view cells
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content_tags.definitions[4]
definitionheading disorientation
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content_tags.definitions[5]
definitionlandmark agnosia
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content_tags.definitions[6]
definitionanterograde topographic disorientation
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content_tags.definitions[7]
definitioncross-modal extinction
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content_tags.definitions[8]
definitionparahippocampal place area
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content_tags.definitions[9]
definitiondorsal stream
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content_tags.definitions[10]
definitiondorsal stream
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content_tags.definitions[11]
key-termsdorsal stream, ventral stream, egocentric, allocentric, navigation, spatial working memory, visually guided action, retrosplenial, posterior cingulate, topographic disorientation, parahippocampal place area, head-direction cells, place cells, agranular, koniocortex, inferior parietal lobule, presubiculum, tract-tracing, connectivity, landmark
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
conceptdorsal stream — not defined in this paper's own words; the pathway being redefined - originally striate to inferior parietal lobule, now a widespread system
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concepts[0]
Second readings
a facet read a second time, independently, from its own sentence — and whether the two readings agree
claim typecritique — a second reading DIFFERING from the recorded value; recorded: existence
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.claim_type
methodreview of monkey tract-tracing anatomy, primate and human functional data, and human lesion syndromes, organised around a proposed trifurcation — a second reading DIFFERING from the recorded value; recorded: review
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.method
phenomenonvisuospatial processing across cortex — a second reading DIFFERING from the recorded value; recorded: dorsal-stream visuospatial processing
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.phenomenon

When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

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