Engaging in an auditory task suppresses responses in auditory cortex — TEI-tagged view

Otazu, Tai, Yang, Zador · 2009 · neuroscience · doi:10.1038/nn.2306 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. The article text uses numbered superscript citations rather than author names, so claim relations targets are described by content plus reference number; only the two places where the paper explicitly aligns or contrasts itself with prior work are recorded. Replication status is 'contested' because the paper states its spontaneous-activity result runs against other engagement studies while its suppression result agrees with the barrel-cortex literature. The paper also carries a critique element ('These results demonstrate that in auditory cortex, neural activity cannot be viewed simply as a limited resource allocated in greater measure as the state of the animal passes from somnolent to passively listening to engaged and attentive.'), but the primary shape of the contribution is the demonstration that the suppression occurs, so claim type is 'existence'. Several evidence quotes contain curly quotation marks and en-dashes exactly as they appear in the source. 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
8 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
Other fields define these differently the same word, defined another way in another discipline
arousal 2 fields · anesthesia 2 fields · selective attention 2 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
selective attention7 engaged passive7 modulation index5 auditory cortex19 auditory thalamus spontaneous activity5 synaptic depression2 kurtosis2 arousal10 anesthesia14 repetition rate electrophysiology110

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenontask-engagement suppression of sound-evoked responses in auditory cortex— “To study these preparatory mechanisms, we compared activity in auditory cortex elicited by sounds while rats performed an auditory task (“engaged”) with activity elicited by identical stimuli while subjects were awake but not performing a task (“passive”).”
claim-typeexistence— “Surprisingly, we found that engagement suppressed responses, an effect opposite in sign to that elicited by selective attention.”
method — evidence— “After animals reached criterion performance (> 95% correct; ~1 week), we implanted movable tetrodes in the left primary auditory cortex (area A1) to record neural activity, including single unit responses, multi-unit responses and local field potentials (LFPs).”
object of study — evidence— “To study the neural correlates of one of these non-selective components in auditory cortex, we compared cortical activity elicited by auditory stimuli in animals engaged in an auditory task with activity elicited by identical stimuli when an animal was passive but wakeful; we use the term”
research question — evidence— “Attention is itself complex, consisting of a well-defined selective component and a much less well-defined component encompassing arousal, vigilance and sustained attention.”
contribution — evidence— “We propose that suppression represents the wakeful baseline condition upon which other forms of attentional and non-attentional modulation are superimposed.”
transferfrom somatosensory physiology: the whisking-versus-quiet suppression in barrel cortex, used as the cross-modal parallel for the same effect— “Synaptic depression has also been implicated in the barrel cortex, where suppression has been observed during whisking (“engaged”) compared with quiet wakefulness (“passive”), consistent with the present findings”transfers[0]
transferfrom synaptic physiology: short-term synaptic depression and the inverse relation between release probability and presynaptic rate, imported as the circuit explanation— “Synaptic depression of the thalamocortical inputs 15 , 35 could explain how the relative enhancement of the thalamic spontaneous rate in the engaged condition might lead to suppression of the cortical evoked response, without changing the cortical spontaneous activity.”transfers[1]
mechanismRaised thalamic spontaneous firing depresses thalamocortical synapses, which suppresses the cortical evoked response while leaving cortical spontaneous rate unchanged— “Synaptic depression of the thalamocortical inputs 15 , 35 could explain how the relative enhancement of the thalamic spontaneous rate in the engaged condition might lead to suppression of the cortical evoked response, without changing the cortical spontaneous activity.”mechanisms[0]
mechanismPreceding spontaneous activity leaves thalamocortical synapses in a depleted state, so identical thalamic evoked responses drive smaller cortical responses— “Furthermore, evoked responses of identical magnitude in thalamus would lead to relatively depressed responses in the cortex in the engaged condition, because the thalamocortical synapses would be in a more depleted state due to the preceding spontaneous activity (for details, see SM8: Thalamocortical depression model).”mechanisms[1]
mechanismRelease probability falls inversely with presynaptic rate, so a higher thalamic firing rate does not translate into a higher cortical spontaneous rate— “At sufficiently high firing rates, synaptic release probability is inversely proportional to the presynaptic firing rate 36 (P release ∝ 1/F thalamic ).”mechanisms[2]
mechanismSuppression functions as an early stage of routing the sensory signal to motor centres by silencing neurons irrelevant to the current task— “Task-engaged suppression may represent an initial stage of this routing, in which activity in neurons irrelevant to the task is reduced.”mechanisms[3]
mechanismthalamic spontaneous rate rises during engagement while thalamic evoked responses do not change— “In contrast to cortex, there was no difference (p=0.80) in the thalamic evoked response ( Fig. 6a ) between the engaged and passive conditions. However, the thalamic spontaneous activity showed a robust and consistent elevation in the engaged condition”mechanisms[4]
mechanismsynaptic depression at thalamocortical synapses could convert a raised thalamic spontaneous rate into a suppressed cortical evoked response without raising cortical spontaneous rate— “Synaptic depression of the thalamocortical inputs 15 , 35 could explain how the relative enhancement of the thalamic spontaneous rate in the engaged condition might lead to suppression of the cortical evoked response, without changing the cortical spontaneous activity.”mechanisms[5]
mechanismsuppression concentrates the same stimulus into fewer, harder-firing neurons - the representation becomes sparser by kurtosis— “The kurtosis of the firing rate distribution in the engaged condition was greater than in the passive condition (kurtosis engaged = 8.4 ± 2.4 vs. kurtosis passive = 4.1 ± 0.7; p <0.05; see SM5: Kurtosis of firing rate distribution), indicating that the stimulus representation in the engaged condition was sparser.”mechanisms[6]
mechanismheadphones deliver identical stimuli regardless of the animal's position, so any difference must come from the animal's state— “Because the sounds were delivered through headphones, differences in neural activity in this paradigm must be due to differences in the animal’s behavior or state, rather than to differences in the stimulus itself arising from uncontrolled changes in the sound path from speaker to the ear.”mechanisms[7]
mechanismsuppression correlates with a cell's spontaneous rate, a property independent of the stimulus used— “Interestingly, suppression was correlated with spontaneous activity, a property of the cells that does not depend on the stimulus used during the task”mechanisms[8]
mechanismsynaptic depression is argued to cover the steady-state effects, with other mechanisms left open for the first few stimulimechanisms[9]
contradicts prior studies reporting increased spontaneous activity with task engagement (cited as reference 19)claim_relations[0]
builds-on rat barrel cortex whisking-versus-quiet-wakefulness studies (cited as references 37–39)
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claim_relations[1]
contradicts the expectation that engagement, like selective attention, enhances cortical responses
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claim_relations[2]
contradicts the account of neural activity as a resource allocated in greater measure with increasing arousal
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claim_relations[3]
qualifies studies reporting increased spontaneous activity with task engagement
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claim_relations[4]
supports barrel cortex reports of suppression during whisking relative to quiet wakefulness
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claim_relations[5]
distinguishes-from sleep and anaesthesia, which have their own distinct signatures
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claim_relations[6]
senseattention is split into a well-defined SELECTIVE component and a much less well-defined non-selective one covering arousal, vigilance and sustained attention - and the two have OPPOSITE signs in this cortex
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senses[0]
senseengaged is coined here for the non-selective component: performing a task, as against being awake and not performing one
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senses[1]
sensemodulation index is defined twice in this paper with different contents - engaged versus passive in the main experiment, auditory versus olfactory block in the intermodal one
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senses[2]
sensesuppression is proposed not as an effect but as the BASELINE on which other attentional and non-attentional modulations are superimposed
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senses[3]
controlthe tetrodes advanced at least 40 micrometres EVERY DAY — held — rules out the same cells being counted as independent observations across sessions - without moving the electrode, a strong effect in one neuron is re-measured daily and the sample size is a fiction
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controls[0]
differs insleep and anaesthesia, which have their own distinct signatures — THE AXIS IS THE SIGNATURE EACH STATE LEAVES. 'Spontaneous and evoked cortical activity showed A CHARACTERISTIC NEURAL SIGNATURE UNDER EACH CONDITION: SPONTANEOUS CORTICAL ACTIVITY WAS REDUCED IN THE LESS AROUSED STATES (SLEEP AND ANESTHETIZED) compared with the awake but passive condition.' Task engagement is distinguished from sleep and anaesthesia not by the direction of the effect on evoked responses - which can look alike - but by what happens to SPONTANEOUS activity at the same time.
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claim_relations[6]
noteengaged —distinct-from→ selective attention — OPPOSITE IN SIGN in the same cortex - the sharpest sign contrast in the corpus, and the reason the construct has to be split
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concept_edges[0]
auditsynaptic depression —causes→ auditory cortex — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but synaptic depression 'COULD EXPLAIN' suppression of the cortical evoked response; causes is hedged and 'auditory cortex' drops the response.
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concept_edges[3]
notesynaptic depression —causes→ auditory cortex — could explain - proposed, not tested here
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concept_edges[3]
weightsynaptic depression —causes→ auditory cortex — 0.7
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concept_edges[3]
auditengaged —distinct-from→ arousal — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span argues arousal would not explain the suppression; distinct-from is loose.
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concept_edges[4]
noteengaged —distinct-from→ arousal — argued from the SIGN: raised arousal would raise firing, and firing fell
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concept_edges[4]
weightengaged —distinct-from→ arousal — 0.95
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concept_edges[4]
outcome (stated by the tagger, no quotation)control — heldcontrols[0]
for which uselimitation — every response-magnitude comparison: BECAUSE ... WE RECORDED FROM SEVERAL NEURONS SIMULTANEOUSLY, WE COULD NOT OPTIMIZE THE STIMULUS PROPERTIES TO MATCH THE RECEPTIVE FIELD PROPERTIES of the recorded neurons
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limitations[0]
for which uselimitation — any comparison with the barrel-cortex literature: DIFFERENCES IN THE BEHAVIORAL PARADIGMS USED IN THE PRESENT WORK ... AND THE PARADIGMS USED IN THE BARREL SYSTEM prevent it
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limitations[1]
for which uselimitation — the size and sign of the suppression: the attentional load was modest, and a harder task might have reduced or reversed it
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limitations[2]
for which uselimitation — the mechanistic reading of the suppression: OUR RESULTS REPRESENT A FIRST STEP TOWARD UNDERSTANDING THE SYNAPTIC AND CIRCUIT MECHANISMS - the mechanism is not established here
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limitations[3]
duplicate oflimitation — limitations[2]
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limitations[4]
for which uselimitation — the same scope as limitations[2] - the absence of target enhancement is attributed to a modest attentional load, so a harder task might have changed the result
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limitations[4]
for which uselimitation — the word 'suppression' as a description of the population: A MINORITY SHOWED AN INCREASE (8/32 UNITS). THIS HAD THE EFFECT OF CONCENTRATING THE STIMULUS-EVOKED SPIKES INTO [a] SMALLER POPULATION OF NEURONS
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limitations[5]
for which uselimitation — the stimulus range over which the effect holds: AT ALL BUT THE HIGHEST REPETITION RATES, THE RESPONSES IN THE ENGAGED CONDITION WERE RELATIVELY SUPPRESSED ... THUS SUPPRESSION INTERACTS WITH REPETITION RATE
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limitations[6]
for which uselimitation — the thalamocortical mechanism: SYNAPTIC DEPRESSION OF THE THALAMOCORTICAL INPUTS COULD EXPLAIN HOW THE RELATIVE ENHANCEMENT ... MIGHT LEAD TO SUPPRESSION - offered, not tested here
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limitations[7]
for which uselimitation — any comparison between the intermodal experiments and the main one: WE USED A TONE DISCRIMINATION TASK WHICH WAS SUBSTANTIALLY MORE CHALLENGING (~3 WEEKS TRAINING, PERFORMANCE ~80%)
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limitations[8]
replicationcontested
limitationSimultaneous multi-neuron recording meant stimuli could not be matched to each neuron's receptive field.
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limitations[0]
limitationThe paradigm differs enough from barrel-cortex whisking studies that the two sets of results cannot be compared in detail.
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limitations[1]
limitationThe attentional load of the task was modest, and a harder task might have reduced or reversed the suppression.
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limitations[2]
limitationThe synaptic and circuit mechanism of the suppression is not established.
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limitations[3]
limitationthe absence of target enhancement is attributed to a modest attentional load, so a harder task might have changed the result
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limitations[4]
limitationa minority of units, 8 of 32, showed the opposite effect
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limitations[5]
limitationsuppression interacts with repetition rate and disappears at the highest rates
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limitations[6]
limitationthe thalamocortical depression account is offered as an explanation that could work, not one that was tested here
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limitations[7]
limitationthe two intermodal experiments used a harder task and longer training than the main experiment
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limitations[8]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingEngaging in an auditory task suppressed sound-evoked responses in auditory cortex, the opposite sign of the enhancement produced by selective attention.
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content_tags.findings[0]
findingThe suppression of evoked responses occurred with no accompanying change in pre-stimulus spontaneous cortical activity.
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content_tags.findings[1]
findingResponses to the task-relevant target sound were suppressed as much as responses to the last non-target sound.
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content_tags.findings[2]
findingSound-evoked responses during auditory-attention blocks were not suppressed relative to olfactory-attention blocks.
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content_tags.findings[3]
findingThe amount of suppression was unrelated to a neuron's spatial selectivity, frequency selectivity, or the octave distance between its best frequency and the attended frequency.
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content_tags.findings[4]
findingThe authors conclude that the suppression in the engaged condition does not depend on the animal triggering the stimulus.
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content_tags.findings[5]
findingFiring-rate kurtosis rose from 4.1 (passive) to 8.4 (engaged), indicating a sparser stimulus representation during engagement.
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content_tags.findings[6]
findingIn the auditory thalamus engagement left evoked responses unchanged but raised spontaneous firing rates, the opposite pattern to cortex.
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content_tags.findings[7]
findingThalamic evoked responses did not differ between engaged and passive conditions (p=0.80).
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content_tags.findings[8]
findingSleep and ketamine anesthesia reduced spontaneous cortical activity relative to the awake passive state, giving those low-arousal states a neural signature distinct from passive wakefulness.
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content_tags.findings[9]
findingNeural activity did not differ between the passive blocks recorded before and after the task, excluding recording drift, satiety and reward expectation as explanations for the suppression.
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content_tags.findings[10]
findingtask engagement suppressed evoked responses across single units, multiunit activity and LFP
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content_tags.findings[11]
findingcortical spontaneous activity did not change, unlike other reports
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content_tags.findings[12]
findingtask-relevant target and irrelevant non-target stimuli were suppressed equally
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content_tags.findings[13]
findingthe representation became sparser, kurtosis 8.4 engaged against 4.1 passive
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content_tags.findings[14]
findingno suppression of auditory responses in an auditory block relative to an olfactory block
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content_tags.findings[15]
findingsuppression appeared in both blocks relative to passive, so it does not depend on the task's modality
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content_tags.findings[16]
findingsuppression was unrelated to spatial selectivity, frequency selectivity or distance from the attended frequency
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content_tags.findings[17]
findingthe same suppression appeared when the animal did not trigger the stimulus, with a nearly identical modulation index
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content_tags.findings[18]
findingsleep and anaesthesia have their own distinct signatures, with reduced spontaneous activity
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content_tags.findings[19]
findingin thalamus, spontaneous activity rose during engagement while evoked responses were unchanged
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content_tags.findings[20]
findingthalamic burstiness did not change, unlike in sleep or reduced arousal
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content_tags.findings[21]
quantity−0.20 ± 0.03 vs −0.19±0.02 — modulation index of the multiunit evoked response in the head-fixed task compared with the freely moving task
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content_tags.quantities[0]
quantity8.4 ± 2.4 vs 4.1 ± 0.7 — kurtosis of the firing-rate distribution when engaged versus passive
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content_tags.quantities[1]
quantity8/32 units — minority of single units whose evoked activity increased rather than decreased when the animal was engaged
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content_tags.quantities[2]
quantityp<1e–16 — significance of the engagement-related suppression for multiunit activity and evoked LFP
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content_tags.quantities[3]
quantityp=0.80 — test of the difference in thalamic evoked response between engaged and passive conditions (no difference)
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content_tags.quantities[4]
quantityp<0.001 — significance of the elevation of thalamic spontaneous activity during engagement
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content_tags.quantities[5]
quantity81% / 91% — behavioural accuracy during auditory versus olfactory blocks of the intermodal attention task
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content_tags.quantities[6]
quantity> 95% correct; ~1 week — criterion performance and training time on the two-alternative choice task before electrode implantation
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content_tags.quantities[7]
quantitykurtosis 8.4 plus or minus 2.4 engaged versus 4.1 plus or minus 0.7 passive — sparseness of the representation
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content_tags.quantities[8]
quantity8 of 32 units — the minority showing enhancement rather than suppression
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content_tags.quantities[9]
quantity-0.20 plus or minus 0.03 head-fixed versus -0.19 plus or minus 0.02 self-triggered — modulation indices, showing self-triggering does not explain the effect
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[10]
quantityp = 0.80 — the thalamic evoked-response null
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[11]
quantityabout 80% correct after three weeks versus over 95% after one week — the harder intermodal task against the main task
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[12]
variableevoked response (dependent)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[3]
variablethalamic spontaneous firing rate (dependent)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[4]
variableintertrial interval (control)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[6]
variablerepetition rate
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content_tags.variables[8]
variablespontaneous firing rate
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[9]
definitionmodulation index
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content_tags.definitions[1]
definitionmodulation index range
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content_tags.definitions[2]
definitionkurtosis
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content_tags.definitions[4]
definitionisolation distance
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content_tags.definitions[5]
definitionselective component
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content_tags.definitions[9]
definitionnon-selective component
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content_tags.definitions[10]
key-termsselective attention, engaged, passive, modulation index, auditory cortex, auditory thalamus, spontaneous activity, synaptic depression, kurtosis, arousal, anesthesia, repetition rate, evoked response, multiunit, local field potentials, medial geniculate, sparser, non-selective, two-alternative choice, head-fixed
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
paired t-test as written: paired t-test, p>0.1
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[0]
kurtosis as written: kurtosis of the firing rate distribution
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[1]
standard error of the mean s.e.m as written: mean±s.e.m
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[2]
correlation as written: suppression was correlated with spontaneous activity
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[3]
p-value p as written: p<1e–16
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content_tags.statistics[4]
Mahalanobis distance (spike-cluster quality metric) ID as written: Mahalanobis distance from the center of an identified cluster
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[5]
modulation index
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[6]
kurtosis of the firing rate distribution
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[7]
paired t-test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[8]
Second readings
a facet read a second time, independently, from its own sentence — and whether the two readings agree
methodtetrode recording in rat A1 and auditory thalamus across four task variants, comparing engaged and passive conditions with identical headphone-delivered stimuli — a second reading DIFFERING from the recorded value; recorded: electrophysiology
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.method
phenomenonbehavioural-state modulation of sensory cortex — a second reading DIFFERING from the recorded value; recorded: task-engagement suppression of sound-evoked responses in auditory cortex
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
alternatives.phenomenon

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