Stress facilitates classical conditioning in males, but impairs classical conditioning in females through activational effects of ovarian hormones — TEI-tagged view

Gwendolyn E. Wood, Tracey J. Shors · 1998 · neuroscience · doi:10.1073/pnas.95.7.4066 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (html); every evidence string verified as an exact substring of that text before merging. Claim relations is empty: the article uses numbered reference markers throughout and never names a prior author or study in the running text when relating its own findings to earlier work, so no relation could be anchored to named prior work without inference. The paper does mention a subsequent proestrus study ('a study subsequent to those presented here established...'), but that is a later study citing this one rather than a relation this paper draws to named prior work. Claim type was set to 'mechanism' rather than 'existence' because the paper's stated advance is the hormonal dependence, not merely the occurrence of the sex difference. 2026-08-12, 2026-08-13 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
2 quotations on this page contain a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
Other fields define these differently the same word, defined another way in another discipline
sex 3 fields · standard deviation 3 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
classical conditioning2 operant conditioning4 instrumental conditioning3 learned helplessness3 conditioned eyeblink response conditioned stimulus2 unconditioned stimulus2 sensitized responses pseudoconditioning delay paradigm stressor2 ovarian hormones estrogen progesterone ovariectomized tamoxifen estrogen receptors estrous cycle2 proestrus diestrus vaginal cytology activational effects tailflick response analgesia hypothalamic-pituitary-adrenal axis glucocorticoids dendritic spine density NMDA receptor spontaneous blink rate active avoidance2 pseudopregnancy passive avoidance behavioural-experiment117

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenonsexually dimorphic stress effects on classical eyeblink conditioning— “Based on evidence of sex differences in learning and responses to stressful events, we investigated sexually dimorphic effects of a stressor of restraint and intermittent tailshock on classical eyeblink conditioning 24 h after stressor cessation.”
claim-typemechanism— “We further demonstrate that the stress-induced impairment in female conditioning is dependent on the presence of ovarian hormones.”
method — evidence— “Male and female, stressed and unstressed rats were presented with paired ( n = 7) or explicitly unpaired ( n = 4) conditioning stimuli.”
object of study — evidence— “we investigated sexually dimorphic effects of a stressor of restraint and intermittent tailshock on classical eyeblink conditioning 24 h after stressor cessation”
research question — evidence— “Based on these differences in learning and the apparent lack of stress-induced helplessness symptomatology in females, we tested whether stress would enhance classical eyeblink conditioning in females, as it does in males ( 10 – 13 ).”
contribution — evidence— “In summary, these results indicate that exposure to the same aversive event can induce opposite behavioral responses in males vs. females.”
transferfrom reproductive endocrinology / clinical cytology: vaginal smear staging, imported as an independent readout of hormonal state so that a behavioural manipulation can be checked against circulating estrogen— “For the TAM study, vaginal cytology was obtained through daily vaginal smears (12:00 to 14:00).”transfers[0]
transferfrom oncology pharmacology: tamoxifen, a clinical antiestrogen, repurposed as a laboratory tool for asking whether a behaviour requires estrogen receptors— “Based on its antiestrogenic properties, TAM has been used as a tool to evaluate the role of estrogen in sexually dimorphic behaviors such as anxiety ( 47 ), agonistic behavior (e.g., ref. 48 ), and sexual receptivity (e.g., ref. 49 ).”transfers[1]
mechanismStress impairs female conditioning by acting through circulating estrogen binding to available estrogen receptors, so removing either the hormone or the receptor blocks the impairment— “In combination with the ovariectomy results, these data suggest that the stress-induced impairment of classical conditioning in females is dependent on the presence of estrogen and the availability of estrogen receptors.”mechanisms[0]
mechanismStress disrupts ovarian hormone levels, and that disruption in turn impairs learning— “The stress-induced impairment of learning in females may be mediated by a stress-induced disruption of ovarian hormones.”mechanisms[1]
mechanismStress raises glucocorticoids through a sexually dimorphic hypothalamic-pituitary-adrenal response, and the glucocorticoid rise disrupts estrogen and progesterone— “A disruption of estrogen and progesterone could be mediated by a rise in other stress-induced hormones, such as glucocorticoids.”mechanisms[2]
mechanismEstrogen changes intracellular calcium through L-type calcium channels and NMDA receptor activation, altering synaptic density and efficacy and thereby the rate of learning— “Thus, changes in intracellular calcium via calcium channels or NMDA receptor activation are likely contributors to the effects of estrogen on synaptic density and efficacy, as well as the stress effects on learning reported here ( 12 ).”mechanisms[3]
mechanismthe paper's premise is a stated absence: the experiment exists because the question had never been asked of females— “To our knowledge, the effects of stress on classical conditioning have not been examined in females.”mechanisms[4]
mechanismthe ceiling explanation is not argued away but engineered away: the CS intensity is lowered until unstressed females start where unstressed males started, and the impairment survives— “To evaluate this explanation for the sexually opposed effects of stress on classical conditioning, we reduced the initial rate of acquisition in the unstressed females by decreasing the intensity of the CS ( 38 ).”mechanisms[5]
mechanismtwo independent routes to the same conclusion: take out the organ that makes the hormone, then leave the organ and block the receptor instead— “In combination with the ovariectomy results, these data suggest that the stress-induced impairment of classical conditioning in females is dependent on the presence of estrogen and the availability of estrogen receptors.”mechanisms[6]
mechanismthe two converging routes do not agree in every detail, and the paper reports the disagreement rather than resolving it by preference— “These results suggest that removal of estrogen hormone and blockade of its receptor…mechanisms[7]
mechanisma ladder of nonspecific explanations is eliminated one at a time with its own control — pseudoconditioning, sensitization, spontaneous blinking, first-trial responding, analgesia and motor activitymechanisms[8]
mechanismthe first trial is used as a control on the manipulation itself: if the stressor made animals respond to the tone directly, it would show before any learning was possible
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mechanisms[9]
mechanismthe reflex itself is used as an argument that motor differences cannot explain the result, since every animal must produce the unconditioned response
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mechanisms[10]
mechanismthe hormonal state is read out independently of the manipulation, by vaginal cytology, so the antagonist's effect can be confirmed rather than assumed
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mechanisms[11]
mechanisma continuous cycle is collapsed into three stages by the authors, chosen to correspond to circulating hormone levels rather than to the underlying cytological detail
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mechanisms[12]
mechanisma transient effect and a persistent one are separated by looking at where each has gone by the end of training: the baseline sex difference washes out, the stress effect does not
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mechanisms[13]
mechanisman unexpected reversal is reported rather than buried: ovariectomised females responded MORE after stress, putting them on the male side of the effect
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mechanisms[14]
extends the male-only literature on stress-induced facilitation of classical conditioning (refs 10–15), by asking the same question of females for the first time
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claim_relations[0]
extends reports that stress-induced helplessness is reduced or absent in females (refs 6–9)
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claim_relations[1]
contradicts the expectation, stated as the paper's own hypothesis, that stress would enhance conditioning in females as it does in males
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claim_relations[2]
supports the body of evidence implicating estrogen in memory formation, including clinical work on estrogen and Alzheimer's
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claim_relations[3]
supports a later study establishing that the female impairment occurs preferentially in proestrus
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claim_relations[4]
critiques an activity-difference explanation of sex effects in learning tasks
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claim_relations[5]
senseconditioning — classical versus operant/instrumental; stress moves them in opposite directions, which is the dissociation the paper is built on
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senses[0]
senseeyeblink — conditioned response (at least 80 ms after CS onset, before US onset) versus sensitized response (within 80 ms of CS onset); the same movement counted as two different things by latency
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senses[1]
senseimpairment — as a stress effect within females, versus as an ovariectomy effect in unstressed females; the paper finds both and keeps them apart
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senses[2]
senseremoving estrogen — by taking out the source (ovariectomy) versus by blocking the receptor (tamoxifen); the paper shows these are not equivalent operations
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senses[3]
sensesex difference — the baseline one (unstressed females learn faster, and it washes out with training) versus the stress-induced one (opposite signs, and it persists)
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senses[4]
senseestrous stage — the full cytological sequence versus the simplified three-stage scheme the authors impose to track circulating hormone levels
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senses[5]
sensehormone effects — activational, depending on what circulates in the adult, as against the organisational sense implied by the title's contrast
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senses[6]
controlsham surgery reproducing every part of the ovariectomy except the removal itself — held — rules out the surgery, anaesthesia and handling as the cause of any difference attributed to loss of the ovaries - the single difference is named in the sentence
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controls[0]
controlmeasurements of spontaneous blinking, sensitization and pseudoconditioning alongside the conditioning result — held
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— rules out three alternatives at once - nonspecific effects of stressor exposure on blinking, sensitization, and pseudoconditioning
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controls[1]
controlcomparison of analgesia following tailshock between males and females — held — rules out a sex difference in stress-induced analgesia as the reason the conditioning effects run in opposite directions
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controls[2]
weightclassical conditioning —contrasted-with→ instrumental conditioning — 0.95
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concept_edges[0]
auditlearned helplessness —operationalised-as→ operant conditioning — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but endpoint by anaphora: 'The impairment' = learned helplessness (previous sentence); operationalised-as is loose.
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concept_edges[1]
weightlearned helplessness —operationalised-as→ operant conditioning — 0.85
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concept_edges[1]
auditestrogen —part-of→ ovarian hormones — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span writes 'Female sex hormones ... produced by the ovaries', not 'ovarian hormones'.
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concept_edges[2]
weightestrogen —part-of→ ovarian hormones — 0.95
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concept_edges[2]
auditconditioned eyeblink response —distinct-from→ sensitized responses — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span writes 'Conditioned responses (CRs)', not 'conditioned eyeblink response'.
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concept_edges[4]
edgeestrous cycle —operationalised-as→ vaginal cytology
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concept_edges[5]
auditanalgesia —operationalised-as→ tailflick response — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span writes 'analgesic responses', not 'analgesia'.
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concept_edges[7]
auditEVIDENCE CORRECTED (RE-GROUNDED) · estrogen —causes→ dendritic spine density — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but attributed/hedged: estrogen is REPORTED to enhance spine density.
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concept_edges[8]
retractedEVIDENCE CORRECTED (RE-GROUNDED) · estrogen —causes→ dendritic spine density — RE-GROUNDED. The old span said 'the density of…', which does not attest the endpoint 'dendritic spine density' as a word. This sentence uses the paper's own compact form and states the effect: estrogen 'is reported to ENHANCE…'.
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concept_edges[8]
weightEVIDENCE CORRECTED (RE-GROUNDED) · estrogen —causes→ dendritic spine density — 0.9
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concept_edges[8]
auditovarian hormones —causes→ hypothalamic-pituitary-adrenal axis — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but endpoint by anaphora: 'these sex differences in the stress response' = HPA axis activation (previous sentence); the span says DEPENDENT ON, causes is loose.
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concept_edges[9]
weightovarian hormones —causes→ hypothalamic-pituitary-adrenal axis — 0.7
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concept_edges[9]
auditclassical conditioning —operationalised-as→ delay paradigm — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but the span writes 'A delay paradigm was used', not 'classical conditioning'.
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concept_edges[11]
weightclassical conditioning —operationalised-as→ delay paradigm — 0.95
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concept_edges[11]
weightactive avoidance —contrasted-with→ passive avoidance — 0.95
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concept_edges[12]
outcome (stated by the tagger, no quotation)control — heldcontrols[0]
outcomecontrol — held
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controls[1]
outcome (stated by the tagger, no quotation)control — heldcontrols[2]
for which uselimitation — any attribution of the effect to sex or to stress singly: EVALUATING THE CONTRIBUTION OF SEX AND STRESS TO LEARNING IS COMPLICATED BY THE FACT THAT BOTH VARIABLES ALTER PERFORMANCE IN LEARNING TASKS
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limitations[0]
for which uselimitation — the estrogen interpretation of the ovariectomy result: THE RESULTS MAY SUGGEST A CRITICAL ROLE FOR PROGESTERONE IN THE IMPAIRED PERFORMANCE ASSOCIATED WITH OVARIECTOMY
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limitations[1]
for which uselimitation — any inference that treats hormone removal and receptor blockade as the same evidence: REMOVAL OF ESTROGEN HORMONE AND BLOCKADE OF ITS RECEPTOR DO NOT NECESSARILY HAVE SIMILAR CONSEQUENCES ON LEARNING AND MAY ACTIVATE DIFFERENT CELLULAR PROCESSES
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limitations[2]
for which uselimitation — the same scope as limitations[1] - ovariectomy removes estrogen and progesterone together, so the two hormones cannot be separated by it
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limitations[3]
for which uselimitation — the receptor-specificity of the pharmacological result: ESTROGEN HAS AT LEAST TWO TYPES OF NUCLEAR RECEPTORS ... AND TAM HAS BINDING AFFINITY FOR BOTH TYPES OF RECEPTORS TO VARYING DEGREES
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limitations[4]
for which uselimitation — the main stress effect, which may be carried by one phase of the cycle: THE EFFECTS OF STRESS ON ACQUISITION OF THE CR [may be] MEDIATED BY THE STAGE OF ESTROUS AND LEVELS OF CIRCULATING ESTROGEN
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limitations[5]
for which uselimitation — the sensitization comparison specifically: OVARIECTOMY ALONE ENHANCED THE NUMBER OF SENSITIZED RESPONSES ... [called] THIS MINOR INCREASE - the surgery moved the baseline it was meant to hold still
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limitations[6]
duplicate oflimitation — limitations[0]
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limitations[7]
for which uselimitation — the same scope as limitations[0] - sex and stress are entangled because each alters performance on its own
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limitations[7]
for which uselimitation — the mechanistic account only: THE STRESS-INDUCED IMPAIRMENT OF LEARNING IN FEMALES MAY BE MEDIATED BY A STRESS-INDUCED DISRUPTION OF OVARIAN HORMONES - proposed, not shown
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limitations[8]
replicationuntested
limitationSex and stress each independently affect performance in learning tasks, which complicates attributing the observed differences to learning.
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limitations[0]
limitationThe ovariectomy result may reflect progesterone rather than estrogen, since removal of the hormone and blockade of its receptor gave different outcomes.
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limitations[1]
limitationHormone removal and receptor blockade did not have equivalent consequences for learning, so the cellular route of the effect is unresolved.
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limitations[2]
limitationthe two hormones cannot be separated by ovariectomy, which removes both estrogen and progesterone
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limitations[3]
limitationthe antagonist is not clean at the receptor-subtype level
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limitations[4]
limitationthe estrous stage was not controlled in the main experiments, so the effect may be carried by one phase of the cycle
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limitations[5]
limitationovariectomy itself was not inert — it raised sensitized responding, and the paper has to argue that the increase is too small to matter
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limitations[6]
limitationsex and stress are entangled as explanatory variables because each alters performance on its own
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limitations[7]
limitationthe mechanism linking stress to the hormones is proposed, not shown
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limitations[8]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingThe same stressor had opposite effects by sex: it speeded acquisition of the conditioned eyeblink response in males and slowed it in females, each relative to its own unstressed controls.
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content_tags.findings[0]
findingWithout stress, females acquired the conditioned response faster than males.
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content_tags.findings[1]
findingRemoving the ovaries abolished the stress-induced impairment: stress impaired acquisition in females with intact ovaries but not in ovariectomized females.
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content_tags.findings[2]
findingBlocking estrogen receptors with tamoxifen also abolished the impairment: stress impaired acquisition in vehicle-injected females but not in tamoxifen-injected females.
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content_tags.findings[3]
findingThe opposite effects of stress on the two sexes were not caused by changes in spontaneous blinking, sensitization or pseudoconditioning.
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content_tags.findings[4]
findingAfter stressor exposure, females remained significantly impaired relative to unstressed females.
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content_tags.findings[5]
findingStressed males and stressed females did not differ in pain sensitivity as measured by tailflick latency, so the sex-opposite learning effects were not caused by differences in analgesia.
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content_tags.findings[6]
findingLate in training, stressed ovariectomized females actually responded more than unstressed ovariectomized females, that is, they showed the male-like facilitation once ovarian hormones were gone.
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content_tags.findings[7]
findingOvariectomy on its own impaired learning in unstressed females during the later part of acquisition.
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content_tags.findings[8]
findingBy the last 100 trials, unstressed males performed at a similar rate to unstressed females.
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content_tags.findings[9]
findingthe same stressor had opposite effects by sex — facilitating acquisition in males and impairing it in females
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content_tags.findings[10]
findingunstressed females outperformed unstressed males
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content_tags.findings[11]
findingthe baseline sex difference was gone by the last 100 trials
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content_tags.findings[12]
findingafter stressor exposure females were still significantly impaired relative to unstressed females
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content_tags.findings[13]
findingstress impaired acquisition in females with intact ovaries but not in ovariectomised females
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content_tags.findings[14]
findingovariectomised females went the other way late in training, responding more after stress — the male pattern
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content_tags.findings[15]
findingblocking estrogen receptors with tamoxifen prevented the stress-induced impairment, while the injections alone had no effect on acquisition
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content_tags.findings[16]
findingremoving ovarian hormones impaired performance in the last 100 trials of training
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content_tags.findings[17]
findingno sex difference in spontaneous blink rate, in responses to the tone before training, or to explicitly unpaired stimuli
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content_tags.findings[18]
findingstressed males and stressed females did not differ in tailflick analgesia, so the effect is not a pain-sensitivity difference
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content_tags.findings[19]
findingunstressed females reached 72% responding in the first 20 trials against 37% for unstressed males
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content_tags.findings[20]
findingtamoxifen produced a diestrus cytology in 20 of 21 females, confirming the intended low-estrogen state
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content_tags.findings[21]
findingovariectomy alone roughly doubled sensitized responding, from under 1 in 10 to 2 in 10
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content_tags.findings[22]
findingthe stressor did not produce responses to the tone on the very first trial, before learning was possible
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content_tags.findings[23]
quantityForty-four — male and female rats used in the first sex-by-stress experiment
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content_tags.quantities[0]
quantity30 shocks (1 s, 1 mA, 60 Hz, 1 per min for 30 min) — the stressor administered to stressed rats 24 h before conditioning
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content_tags.quantities[1]
quantity300 trials a day for 2 days — the conditioning schedule in the first experiment
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content_tags.quantities[2]
quantity72% ± 11 versus 37% ± 8% — conditioned responding over the first 20 trials in unstressed females versus unstressed males
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content_tags.quantities[3]
quantity47% ± 7 — first-20-trial acquisition rate of unstressed females once the CS was lowered to 80 dB, close to the male rate of 37%
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content_tags.quantities[4]
quantityF (1, 36) = 14.28; P < 0.001 — the sex-by-stress interaction on acquisition of the conditioned response
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content_tags.quantities[5]
quantityF (1, 37) = 3.93; P = 0.05 — the effect of estrogen-receptor blockade on the stress-induced impairment of acquisition
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content_tags.quantities[6]
quantity20 of 21 — tamoxifen-treated females whose vaginal cytology indicated diestrus and low estrogen
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content_tags.quantities[7]
quantityfrom <1 of 10, to 2 of 10 — increase in sensitized responses to the white-noise stimulus produced by ovariectomy alone
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content_tags.quantities[8]
quantityF (1, 36) = 14.28; P < 0.001 — the sex-by-stress interaction on acquisition, the paper's central result
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content_tags.quantities[9]
quantity72% ± 11 vs 37% ± 8% — first-20-trial acquisition, unstressed females against unstressed males
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content_tags.quantities[10]
quantity47% ± 7 — unstressed female acquisition after the CS was lowered to 80 dB, matched to the male rate
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content_tags.quantities[11]
quantity30 shocks — the stressor: 1 s, 1 mA, 60 Hz, one per minute for 30 minutes
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content_tags.quantities[12]
quantity24 h — delay between stressor cessation and conditioning
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content_tags.quantities[13]
quantity300 trials a day for 2 days — training schedule in the first experiment
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content_tags.quantities[14]
quantity85-dB, 240-ms — the white noise conditioned stimulus
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content_tags.quantities[15]
quantity0.7-mA, 80-ms — the periorbital shock unconditioned stimulus
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content_tags.quantities[16]
quantity20 ± 10 s — intertrial interval
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content_tags.quantities[17]
quantity80 ms — the latency boundary separating conditioned from sensitized responses
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content_tags.quantities[18]
quantityF (1, 34)= 10.42; P < 0.005 — the ovariectomy-by-stress interaction
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content_tags.quantities[19]
quantityF (1, 37) = 3.93; P = 0.05 — the tamoxifen-by-stress interaction
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content_tags.quantities[20]
quantity1.5 mg — daily tamoxifen dose in sesame oil, for 4 days
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content_tags.quantities[21]
quantity44 male and female — sample in the first experiment
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content_tags.quantities[22]
quantity37 adult female — sample in the ovariectomy experiment
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content_tags.quantities[23]
quantity41 adult female — sample in the tamoxifen experiment
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content_tags.quantities[24]
quantity20 of 21 — tamoxifen-treated females whose cytology indicated diestrus
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content_tags.quantities[25]
quantity0.3–1.0 kHz, amplified 10,000× — electromyograph filter band and gain
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content_tags.quantities[26]
variablesex (moderator)
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content_tags.variables[1]
variableacquisition of the conditioned eyeblink response (dependent)
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content_tags.variables[6]
variableanalgesic responses (dependent)
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content_tags.variables[7]
variablespontaneous blink rate (dependent)
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content_tags.variables[8]
variableSham surgery (control)
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content_tags.variables[10]
variableintertrial interval (control)
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content_tags.variables[11]
variablerate of acquisition of the conditioned response
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content_tags.variables[12]
variablesex
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content_tags.variables[13]
variablestressor exposure
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content_tags.variables[14]
variableCS intensity
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content_tags.variables[15]
variablespontaneous blink rate
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content_tags.variables[16]
variablepaired ( n = 7) or explicitly unpaired ( n = 4) conditioning stimuli
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content_tags.variables[17]
variabletailflick response
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content_tags.variables[18]
definitionlearned helplessness
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content_tags.definitions[0]
definitionconditioned response
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content_tags.definitions[1]
definitionsensitized response
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content_tags.definitions[2]
definitionlearned helplessness
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content_tags.definitions[4]
definitionConditioned responses
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content_tags.definitions[5]
definitionsensitized responses
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content_tags.definitions[6]
definitiondelay paradigm
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content_tags.definitions[7]
definitioneyeblinks
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content_tags.definitions[8]
definitionSham surgery
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content_tags.definitions[9]
definitionpseudopregnancy
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content_tags.definitions[10]
definitionceiling effect
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content_tags.definitions[11]
definitionProestrus
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content_tags.definitions[12]
definitionestrus
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content_tags.definitions[13]
definitiondiestrus
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content_tags.definitions[14]
key-termsclassical conditioning, operant conditioning, instrumental conditioning, learned helplessness, conditioned eyeblink response, conditioned stimulus, unconditioned stimulus, sensitized responses, pseudoconditioning, delay paradigm, stressor, tailshock, ovarian hormones, estrogen, progesterone, ovariectomized, tamoxifen, estrogen receptors, estrous cycle, proestrus, diestrus, vaginal cytology, activational effects, tailflick response, analgesia, glucocorticoids, dendritic spine density, NMDA, spontaneous blink rate, active avoidance, pseudopregnancy, sexually dimorphic, electromyographic, obicularis oculi
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
ANOVA F as written: F (1, 36) = 14.28; P < 0.001
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content_tags.statistics[0]
interaction effect F as written: A significant interaction between stress, sex, and paired vs. unpaired training
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content_tags.statistics[1]
post hoc multiple comparison test as written: Newman–Keuls comparison test
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content_tags.statistics[2]
Cochran's Q test Q as written: Cochran Q test
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content_tags.statistics[3]
standard deviation SD as written: 4 times its SD
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content_tags.statistics[4]
p-value P as written: ( P < 0.01)
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content_tags.statistics[5]
F
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content_tags.statistics[6]
Newman–Keuls comparison test
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content_tags.statistics[7]
Cochran Q test
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content_tags.statistics[8]
significant interaction
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content_tags.statistics[9]
SD
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content_tags.statistics[10]
Second readings
a facet read a second time, independently, from its own sentence — and whether the two readings agree
claim typeexistence — a second reading DIFFERING from the recorded value; recorded: mechanism
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alternatives.claim_type
methodclassical eyeblink conditioning in rats with implanted periorbital electrodes, 24 h after restraint-and-tailshock stress, crossed with ovariectomy and with estrogen-receptor blockade — a second reading DIFFERING from the recorded value; recorded: behavioural-experiment
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alternatives.method
phenomenonsexually dimorphic effects of stress on associative learning — a second reading DIFFERING from the recorded value; recorded: sexually dimorphic stress effects on classical eyeblink conditioning
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alternatives.phenomenon

When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

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