Driving fast-spiking cells induces gamma rhythm and controls sensory responses — TEI-tagged view

Cardin, Carlén, Meletis, Knoblich, Zhang, Deisseroth, Tsai, Moore · 2009 · neuroscience · doi:10.1038/nature08002 · full text at the source · TEI xml · tagged edition · index · concepts · authors
Where this record's text came from. faceted 2026-08 by reading the locally held text (xml); every evidence string verified as an exact substring of that text before merging. limitations is EMPTY: the paper nowhere states a limit on its own conclusions. The nearest candidate, 'We did not observe light activation of layer 5 FS cells ( n =12 sites in 7 animals).', is reported as a result of the preparation and is never framed as a constraint on the claims, so under rule 6 I did not convert it into a limitation. The single claim_relation is 'builds-on' because the paper positions itself as the first causal test of an existing hypothesis rather than as a repetition of a prior experiment; the hypothesis is named in the authors' own words even though its sources are cited only by numeral. method is 'electrophysiology' (in vivo extracellular single-unit, intracellular whole-cell and LFP recording combined with channelrhodopsin-2 stimulation) - the facet vocabulary has no separate optogenetics value. 2026-08-12, 2026-08-14 and 2026-08-15 schema-0.3 passes: every quote verified as an exact substring of the staged text and anchored at merge time; concept terms verified present; every edge endpoint an existing node.
3 quotes on this page break a word across a line. The PDF this text was extracted from hyphenated those words at the end of a printed line — adversar- ial, repre- sentations — and the extractor kept the hyphen and the space. The quotes keep them because a quote is reproduced exactly or it proves nothing: the break is the typesetter’s, not the author’s. A search of this page will not find the affected words.
1 quotation on this page contains a reference number where the paper printed a superscript. This journal style prints citations as raised numerals — parameters12,13 — and the extraction flattened them into the line, so the sentence reads parameters 12 , 13 . The digits are citation markers and not part of what the author wrote. The quotes keep them for the same reason they keep every other extraction fault: a quote is reproduced exactly or it proves nothing.
2 quotes on this page may have lost a superscript, a subscript or a fraction slash. Nothing in them is corrupt — every character survived. What did not survive is POSITION: whether a digit sat above the line, below it, or between two others. So x 10 9 may be x 10⁹, chi 2 5 may be chi-squared with five degrees of freedom, and 1 2 may be one half. Read any expression here against the published paper before relying on it.
Other fields define these differently the same word, defined another way in another discipline
precision 10 fields · standard deviation 3 fields · cell type 2 fields
Tags on this paper every tag the record carries, whether or not the words occur in the text below — a number is how many papers in the corpus carry that tag; a tag with no number is unique to this paper
gamma oscillations fast-spiking5 regular spiking2 channelrhodopsin-23 optogenetic16 parvalbumin8 local field potential7 double dissociation4 resonant circuit property inhibitory postsynaptic potentials barrel cortex2 vibrissa phase5 Cre precision27 AMPA3 spike probability electrophysiology110

Our tag layer for this paper

Cross-disciplinary analysis
content-tags & facets: phenomenon · claim-type · cross-domain-transfer · mechanism · claim-relation · replication-status · limitation — grounded in the full text
phenomenoncortical gamma oscillations— “Cortical gamma oscillations (20–80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease.”
claim-typemechanism— “Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.”
method — evidence— “We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons.”
object of study — evidence— “We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons.”
transferfrom microbial/algal photobiology (a light-gated ion channel from the green alga Chlamydomonas reinhardtii): a microbial light-sensitive cation channel is imported as the tool for driving a specific mammalian cortical cell type in vivo— “we used the light-sensitive bacteriorhodopsin Chlamydomonas reinhardtii channelrhodopsin-2 (ChR2), a cation channel activated by ~470 nm blue light”transfers[0]
mechanismRhythmic FS-generated IPSPs gate sensory transmission: inhibition blocks input at its peak and releases it during decay, temporally sharpening cortical responses— “Our results indicate that the rhythmic, FS-induced IPSP restricts sensory transmission during its peak, and permits transmission after its decay, leading to a temporal sharpening of cortical sensory responses”mechanisms[0]
mechanismIncreased FS firing recruits a resonance in the surrounding cortical network whose preferred band is set by the circuit's synaptic and biophysical properties— “One possible explanation for these results is that increased FS firing recruits resonant gamma-range activity in the surrounding local network as a function of the synaptic and biophysical properties of the cortical circuit.”mechanisms[1]
mechanismSynchronous inhibition from fast-spiking cells opens a narrow window in which excitation is effective, which is what synchronises the ensemble— “Current theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for effective excitation.”mechanisms[2]
mechanismThe gamma band is a property of the circuit rather than of the drive: changing light intensity changes how much amplification occurs but not which frequencies are amplified— “Whereas drive affected the amplitude of enhancement, LFP power was selectively amplified within the gamma range regardless of light intensity or spike probability ( Fig. 3h ), indicating that the gamma oscillations evoked by FS activity are a resonant circuit property.”mechanisms[3]
mechanismStimulating at random frequencies still produces gamma, so the rhythm is emergent and does not have to be imposed— “In addition, randomly patterned light stimulation of FS cells with frequencies evenly distributed across a broad range evoked a significant increase in LFP power specific to the gamma range ( n =7 sites in 4…mechanisms[4]
mechanismThe induced rhythm still needs excitatory feedback - blocking glutamate receptors abolishes it even while the interneurons keep firing
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
mechanisms[5]
mechanismThe functional consequence: inhibition blocks input at its peak and permits it after decay, which sharpens the timing of sensory responses
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
mechanisms[6]
mechanismCell-type targeting works through Cre-dependent expression, so the light acts only on neurons that already carry the driver
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
mechanisms[7]
builds-on the fast-spiking-gamma hypothesis (prior computational models and recordings holding that gamma is generated by synchronous fast-spiking interneuron activity)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
claim_relations[0]
supports the fast-spiking-gamma hypothesis derived from computational modelling
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
claim_relations[1]
supports the account of gamma as gating synaptic input rhythmically to synchronise cell assemblies
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
claim_relations[2]
extends prior in vivo recordings showing sensory-evoked gamma and phase-locked pyramidal firing
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
claim_relations[3]
sensethe causal claim - SUFFICIENCY: driving fast-spiking cells is enough to produce gamma, which is what the optogenetic activation shows
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
senses[0]
sensethe causal claim - NECESSITY: naturally occurring gamma depends on the same cells, shown by shifting its phase with a single pulse
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
senses[1]
sensegamma - INDUCED by light: the rhythm created by driving interneurons, which is what most of the paper measures
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
senses[2]
sensegamma - NATURALLY occurring: the spontaneous rhythm, a different object that the induced one is shown to connect with
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
senses[3]
sensethe frequency band - as set by the DRIVE: the alternative in which spike probability determines which band is enhanced
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
senses[4]
sensethe frequency band - as set by the CIRCUIT: resonance, which is what varying light intensity showed
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
senses[5]
controleach imaging channel collected in MULTI-TRACK mode rather than simultaneously — held — rules out optical cross-talk between channels - bleed from one fluorophore into another channel would appear as co-labelling that is not there
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
controls[0]
effect directionfast-spiking —causes→ gamma oscillations — increases
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[0]
relationfast-spiking —causes→ gamma oscillations — driving the interneurons AMPLIFIES gamma, selectively across a wide drive range
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[0]
auditregular spiking —distinct-from→ gamma oscillations — Audit 2026-09-28: DOUBTFUL - read against its full span and kept, but pyramidal activation amplifies ONLY LOWER-frequency oscillations, a double dissociation; distinct-from gamma is loose.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[1]
weightregular spiking —distinct-from→ gamma oscillations — 0.9
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[1]
edgefast-spiking —causes→ inhibitory postsynaptic potentials
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[2]
edgeinhibitory postsynaptic potentials —causes→ precision
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[3]
auditphase —causes→ precision — Audit 2026-09-28: DOUBTFUL - read against its span and kept, but the span says precision was enhanced in a gamma-phase-dependent manner; 'phase causes precision' is loose.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[4]
weightphase —causes→ precision — 0.9
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[4]
weightAMPA —causes→ gamma oscillations — 0.9
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[5]
edgeresonant circuit property —contrasted-with→ spike probability
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concept_edges[6]
outcome (stated by the tagger, no quotation)control — heldcontrols[0]
for which uselimitation — the laminar scope of the effect: WE DID NOT OBSERVE LIGHT ACTIVATION OF LAYER 5 FS CELLS (n=12 SITES IN 7 ANIMALS)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[0]
for which uselimitation — what 'the PV population' means at any distance from the injection: THE LABELLING EFFICIENCY OF AAV DIO ChR2-mCHERRY VARIED OVER DISTANCE FROM THE INJECTION SITE; CLOSE TO THE CENTRE OF THE INJECTION, >97% OF THE PV+ INTERNEURONS EXPRESSED ChR2-mCHERRY
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[1]
evidence status notelimitation — FLATTENED EXPONENT IN THIS QUOTE - THE NUMBER IS WRONG BY ORDERS OF MAGNITUDE AS IT STANDS. The staged text reads '8.4×10 6', where the paper writes 10 to the power 6. The superscript was pushed onto the line by the PDF extractor. The quote is verbatim to the staged text and its anchor is sound; the STAGED TEXT is what is damaged. NOT repaired - repair means re-staging the body and re-anchoring the record.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[2]
for which uselimitation — the excitatory arm of the FS-versus-RS comparison, which is covered less completely than the inhibitory arm: AT LEAST 50% OF THE aCamKII+ NEURONS IN LAYER 2/3 EXPRESSED ChR2-mCHERRY (913 OF 1,638 CELLS)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[2]
for which use evidence status notelimitation — FLATTENED EXPONENT IN THIS QUOTE - THE NUMBER IS WRONG BY ORDERS OF MAGNITUDE AS IT STANDS. The staged text reads '8.4×10 6', where the paper writes 10 to the power 6. The superscript was pushed onto the line by the PDF extractor. The quote is verbatim to the staged text and its anchor is sound; the STAGED TEXT is what is damaged. NOT repaired - repair means re-staging the body and re-anchoring the record.limitations[2]
for which uselimitation — the frequency specificity of the dissociation: RS STIMULATION AT 8 Hz CAUSED A SIGNIFICANT INCREASE OF LFP POWER AT 8 Hz (P<0.001), WHEREAS RS STIMULATION AT 40 Hz CAUSED ONLY A SMALL, NONSIGNIFICANT INCREASE IN 40-Hz LFP POWER
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[3]
for which uselimitation — the phase-gating result: n=20 CELLS IN 3 ANIMALS, responses to a single vibrissa deflection at one of five phases relative to a single gamma cycle
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[4]
replicationuntested
limitationThe effect was not obtained in layer 5, so the result is confined to the layers where activation was observed
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[0]
limitationLabelling efficiency falls off with distance from the injection, so the manipulated population is not uniform across the field
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[1]
limitationThe excitatory comparison covers at most half the target population, against near-complete coverage on the inhibitory side
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[2]
limitationThe pyramidal-drive comparison at 40 Hz produced a small increase that did not reach significance, so the dissociation is asymmetric in strength
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[3]
limitationThe phase-gating experiment rests on twenty cells in three animals
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
limitations[4]
Content tags
content-observations: finding · quantity · variable · definition · key-term — grounded in the full text
findingOptogenetically driving fast-spiking interneurons across a wide frequency range amplified oscillations selectively in the gamma band.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[0]
findingDriving FS cells at 20-80 Hz significantly amplified local field potential power at those frequencies.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[1]
findingLFP power was selectively amplified in the gamma range whatever the light intensity or spike probability, though the drive affected the size of the enhancement.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[2]
findingA single 1-ms light pulse to FS cells produced large fast IPSPs in nearby regular-spiking neurons, confirming direct monosynaptic inhibition.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[3]
findingActivating FS cells suppressed whisker-evoked responses in neighbouring excitatory neurons.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[4]
findingThe phase of the gamma cycle at which a whisker deflection arrived determined the amplitude, latency and temporal precision of the resulting cortical response.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[5]
findingLight-induced gamma depended on fast excitatory synaptic transmission, since blocking AMPA and NMDA receptors abolished it even while FS cells still fired strongly.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[6]
findingA brief FS activation reset the phase of spontaneously occurring gamma oscillations, linking naturally occurring gamma to FS activity.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[7]
findingdriving fast-spiking interneurons amplified the local field potential selectively in the 20-80 Hz band
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[8]
findingdriving excitatory neurons at 8-24 Hz raised LFP power at those frequencies but not at higher ones
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[9]
findingthe amplified band did not move with light intensity or spike probability, so it is set by the circuit
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[10]
findingsingle pulses shifted the phase of naturally occurring gamma, linking the induced rhythm to the spontaneous one
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[11]
findingthe position of a whisker deflection within the gamma cycle changed the amplitude, latency and precision of the response
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[12]
findingactivating the interneurons blocked whisker-evoked responses in neighbouring excitatory cells
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.findings[13]
quantity96.7±1.0% — proportion of ChR2-mCherry-expressing neurons that were parvalbumin-positive, confirming targeting specificity
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[0]
quantity−67.6±1.9 mV — mean reversal potential of the light-evoked IPSPs, consistent with a GABA-A chloride conductance
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[1]
quantity2.7±1.0 mV — mean peak amplitude of the light-evoked IPSP measured near −55 to −60 mV
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[2]
quantity0.5 to 0.75 ms — lead time by which light-evoked FS spikes preceded the onset of the postsynaptic IPSP
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[3]
quantityn =64 FS cells in 15 animals — number of fast-spiking single units recorded in PV–Cre mice (against 56 RS cells in 7 αCamKII–Cre mice)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[4]
quantity9.1 ± 0.08 ms — onset latency of layer 4 regular-spiking responses to whisker deflection
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[5]
quantity20–80 Hz — the gamma band, the frequency range selectively amplified
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[6]
quantity96.7±1.0% — specificity of the targeting - labelled cells that really were parvalbumin-positive
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[7]
quantityn =64 FS cells in 15 animals — the inhibitory recording sample
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[8]
quantity0.5 to 0.75 ms — how far the interneuron spike preceded the inhibitory potential it caused
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[9]
quantity−67.6±1.9 mV — the reversal potential identifying the current as GABA-A mediated
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[10]
quantityfive phases — the positions in the gamma cycle at which the whisker was deflected
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.quantities[11]
variablecell type (independent)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[1]
variabletiming of the whisker deflection (independent)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[3]
variablerelative power (dependent)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[4]
variablespike probability (dependent)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[5]
variableprecision of sensory-evoked spikes (dependent)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[6]
variableLFP power (dependent)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[11]
variablelight intensity (control)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[12]
variableuntransduced contralateral barrel cortex (control)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.variables[13]
definitionchannelrhodopsin-2 (ChR2)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[0]
definitioncortical gamma oscillations (20–80 Hz)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[1]
definitionlocal field potential (LFP)
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[2]
definitiondouble dissociation of cell-type-specific state induction
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[3]
definitionchannelrhodopsin-2
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[4]
definitiongamma oscillations
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[5]
definitionlocal field potential
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.definitions[6]
key-termsgamma oscillations, fast-spiking, regular spiking, channelrhodopsin-2, optogenetic, parvalbumin, local field potential, double dissociation, resonant circuit property, inhibitory postsynaptic potentials, barrel cortex, vibrissa, phase, precision, spike probability
Concepts
terms this paper carries, each with the sentence it was cut from — the layer that joins one paper to another. Terms with no quote yet are on CONCEPTS.html.
conceptgamma oscillations — not defined in this paper's own words; 20-80 Hz cortical rhythm, associated with attention and disrupted in disease
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[0]
conceptfast-spiking — not defined in this paper's own words; the parvalbumin-positive inhibitory interneuron class whose synchrony is hypothesised to generate gamma
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
concepts[1]
Statistics — cross-field join keys
field-invariant statistical terms, used in their statistical sense (gated on a number / symbol / test). A p-value or a standard deviation means the SAME thing in physics, biology, psychology and sociology — so these are the strongest cross-field join keys. Grounded verbatim.
t-test P as written: paired t -test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[0]
ANOVA P as written: 1-way ANOVA with Dunnett's post-test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[1]
Kruskal-Wallis test P as written: Kruskal–Wallis test with Dunn's post-test
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[2]
standard error of the mean as written: mean ± s.e.m.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[3]
standard deviation as written: mean±s.d.
Quotation withheld — this paper is not ours to reproduce, and the page has already quoted as much of it as the rights layer allows. The tag, its field and its confidence stand; the sentence is at the publisher.
content_tags.statistics[4]

When we have changed our mind. Some entries in the table begin with a word in capitals and the reason for it. EVIDENCE CORRECTED — the finding still stands, but we had quoted the wrong sentence from the paper, and the quotation has been replaced with the right one. RETRACTED — the entry itself was wrong; it stays on the page, marked, with the reason, rather than being deleted. WITHDRAWN AND REPLACED — the entry was wrong, and a corrected version of it appears in the entries below. Each mark carries its own reason, in brackets, because the reasons differ from one entry to the next. An entry we have WITHDRAWN is removed from this page and kept in the record, with its reason. A line reading Audit and a date is a later re-reading of the entry against its whole sentence: DOUBTFUL means it was kept, and the reason says what is loose about it. Quotation marks inside the tagger's sentence. Where a tag is the tagger's own sentence, a phrase in quotation marks inside it is borrowed from the paper — the tagger's wording around it is not. The paper's own sentence is the evidence quote for that row; on this page it is withheld with the article, and the article is at its publisher. Nothing inside quotation marks anywhere on this page is ours: if it is quoted, it is the paper's. Whose words a concept carries. A concept entry records a term the paper itself uses, so the term, the sense given for it, and its evidence are the paper's own words, quoted where the paper fixes them. This is the opposite of a sense entry in the tag table, which is the tagger's sentence about how the paper uses a term. Where a concept entry could not be grounded in the paper's words, the entry says so on its own row.

Tag layer © the Meta-Tagging Project, CC BY 4.0. The paper text is © its authors/publisher and is linked, not reproduced. Excerpts shown are short quotations for identification and verification. · back to index · concepts · authors · עברית
© 2026 Shir Sivroni · ORCID 0009-0000-2597-2824